Scientists / Our Scientists
Bob Yauch - Executive Director, Discovery Oncology, Research Biology

Bob Yauch

Executive Director, Discovery Oncology, Research Biology

Postdoc Mentor
"Working at Genentech has been an incredibly rewarding experience, as I have seen first-hand how the fruits of our labor have made a difference in patients’ lives"
22
Years at Genentech
47
Publications at Genentech
3
Awards & Honors

I joined Genentech in January 2004, following five years at a biotechnology company. I was attracted to Genentech based on their commitment to maintain a cutting-edge research environment, in addition to their emphasis on the clinical development of targeted therapies for the treatment of cancer.

My laboratory at Genentech has focused on the intersection of translational oncology and novel target/drug discovery to drive the next generation of precision oncology. We are dedicated to discovering novel cancer cell dependencies and synthetic lethal interactions that offer high potential for therapeutic exploitation. Our recent focus has involved uncovering cancer cell vulnerabilities in the context of chromatin regulation defects and protein phosphatase signaling; accompanied by the employment of innovative chemical biology approaches to target these signaling nodes.

Postdoctoral Mentor

Genentech’s post-doctoral research program is an excellent opportunity for post-graduates to carry out cutting-edge scientific research in a highly collaborative environment that simultaneously exposes them to the drug development process. This experience is incredibly valuable in making the most informed future career decisions. Post-doctoral fellows in my laboratory have the ability to pursue independent cancer cell biology projects, leveraging the state-of-the-art technologies at Genentech.

Featured Publication

Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.

SCIENCE, 2009, ISSN: 0036-8075

YAUCH, R.L.; DIJKGRAAF, G.J.P.; ALICKE, B.; JANUARIO,T.; AHN, C.P.; HOLCOMB, T.; PUJARA, K.; STINSON, J.; CALLAHAN, C.A.; TANG, T.; BAZAN, J.F.; KAN, Z.; SESHAGIRI, S.; HANN, C.L.; GOULD, S.E.; LOW, J.A.; RUDIN, C.M.; DE SAUVAGE, F.J.

View Abstract on Pubmed

My Focus
Genentech Publications
Education
Awards & Honors
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