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Brad Friedman - Principal Scientist, Bioinformatics & Computational Biology

Brad Friedman

Principal Scientist, Bioinformatics & Computational Biology

Postdoc Mentor
"Genomics brings new insights to neurodegenerative disease."
Years at Genentech
Awards & Honors

I joined Genentech in 2011 and led the development of software infrastructure which continues to underlie much of our company’s gene expression research. In 2014 I began collaborating with the Neuroscience department to study the role of non-neuronal cells (“glia”) in neurodegenerative diseases, with a particular emphasis on Alzheimer’s and Parkinson’s diseases. We combine human genetics, gene expression and other types of data to identify and understand novel therapeutic targets and biomarkers.

At Genentech I have access to both industry-leading databases and information systems as well as world-class neuroscientists with whom I collaborate to develop and test hypotheses emerging from these data. This highly collaborative research environment is an exciting place to do science.

Featured Publication

Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer0s Disease Not Evident in Mouse Models.

Cell Rep. 2018 Jan 16;22(3):832-847.

Friedman BA, Srinivasan K, Ayalon G, Meilandt WJ, Lin H, Huntley MA, Cao Y, Lee SH, Haddick PCG, Ngu H, Modrusan Z, Larson JL, Kaminker JS, van der Brug MP, Hansen DV.