Brad Friedman
Senior Principal Scientist, Bioinformatics & Computational Biology
Postdoc Mentor
"Genomics brings new insights to neurodegenerative disease."
12
Years at Genentech
28
Publications at Genentech
1
Awards & Honors
I joined Genentech in 2011 and led the development of software infrastructure which continues to underlie much of our company’s gene expression research. In 2014 I began collaborating with the Neuroscience department to study the role of non-neuronal cells (“glia”) in neurodegenerative diseases, with a particular emphasis on Alzheimer’s and Parkinson’s diseases. We combine human genetics, gene expression and other types of data to identify and understand novel therapeutic targets and biomarkers.
At Genentech I have access to both industry-leading databases and information systems as well as world-class neuroscientists with whom I collaborate to develop and test hypotheses emerging from these data. This highly collaborative research environment is an exciting place to do science.
Featured Publication
Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer0s Disease Not Evident in Mouse Models.
Cell Rep. 2018 Jan 16;22(3):832-847.
Friedman BA, Srinivasan K, Ayalon G, Meilandt WJ, Lin H, Huntley MA, Cao Y, Lee SH, Haddick PCG, Ngu H, Modrusan Z, Larson JL, Kaminker JS, van der Brug MP, Hansen DV.
My Focus
Human genetics and neuropathology point to a role for glial cells in the development of Alzheimer’s and other neurodegenerative diseases. Microglia in particular are thought to have both “good” aspects, such phagocytosis of lipids, protein aggregates and apoptotic cells, and “bad” aspects, such as secretion of toxic inflammatory factors, actively spreading prion-like protein species, or aberrant engulfment of not-yet-dead synapses or neurons. I combine human genetics and gene expression to understand which of these pathways are most important for disease progression, and which might be amenable to therapeutic intervention.
Genentech Publications
Molecular Therapy - Nucleic Acids,
Amy E. Byrnes; Sara L. Dominguez; Chun-Wan Yen; Benjamin I. Laufer; Oded Foreman; Mike Reichelt; Han Lin; Meredith Sagolla; Kathy Hötzel; Hai Ngu; Christoffer Soendergaard; Alberto Estevez; Hsiu-Chao Lin; Alexandre Goyon; Juan Bian; Jessica Lin; Flora I. Hinz; Brad A. Friedman; Amy Easton; Casper C Hoogenraad
Nature Aging, ISSN: 26628465
Borislav Dejanovic; Tiffany Wu; Ming-Chi Tsai; David Graykowski; Vineela D. Gandham; Christopher M. Rose; Corey Bakalarski; Hai Ngu; Yuanyuan Wang; Shristi Pandey; Mitchell G. Rezzonico; Brad A. Friedman; Rose Edmonds; Ann De Mazière; Raphael Rakosi-Schmidt; Tarjinder Singh; Judith Klumperman; Oded Foreman; Michael C. Chang; Luke Xie; Morgan Sheng; Jesse E. Hanson
Cell Reports, ISSN: 22111247
Shristi Pandey; Kimberle Shen; Seung-Hye Lee; Yun-An A. Shen; Yuanyuan Wang; Marcos Otero-Garcia; Natalya Kotova; Stephen T. Vito; Benjamin I. Laufer; Dwight F. Newton; Mitchell G. Rezzonico; Jesse E. Hanson; Joshua S. Kaminker; Christopher J. Bohlen; Tracy J. Yuen; Brad A. Friedman
Cell Reports,
Shristi Pandey; Kimberle Shen; Seung-Hye Lee; Yun-An A. Shen; Yuanyuan Wang; Marcos Otero-Garcia; Natalya Kotova; Stephen T. Vito; Benjamin I. Laufer; Dwight F. Newton; Mitchell G. Rezzonico; Jesse E. Hanson; Joshua S. Kaminker; Christopher J. Bohlen; Tracy J. Yuen; Brad A. Friedman
Nature Aging,
Borislav Dejanovic; Tiffany Wu; Ming-Chi Tsai; David Graykowski; Vineela D. Gandham; Christopher M. Rose; Corey Bakalarski; Hai Ngu; Yuanyuan Wang; Shristi Pandey; Mitchell G. Rezzonico; Brad A. Friedman; Rose Edmonds; Ann De Mazière; Raphael Rakosi-Schmidt; Tarjinder Singh; Judith Klumperman; Oded Foreman; Michael C. Chang; Luke Xie; Morgan Sheng; Jesse E. Hanson
Cell Reports, ISSN: 22111247
Seung-Hye Lee; Mitchell G. Rezzonico; Brad A. Friedman; Melanie A. Huntley; William J. Meilandt; Shristi Pandey; Ying-Jiun J. Chen; Amy Easton; Zora Modrusan; David V. Hansen; Morgan Sheng; Christopher J. Bohlen
Neurobiology of Disease, ISSN: 1095953X 09699961
Robert Brendza; Han Lin; Kimberly L. Stark; Oded Foreman; Janet Tao; Andrew A Pierce; Hai Ngu; Kimberle Shen; Amy Easton; Tushar Bhangale; Diana Chang; Baris Bingol; Brad A. Friedman
Neuron, ISSN: 10974199 08966273
Seung-Hye Lee; William J. Meilandt; Luke Xie; Vineela D. Gandham; Hai Ngu; Kai H. Barck; Mitchell G. Rezzonico; Jose Imperio; Guita Lalehzadeh; Melanie A. Huntley; Kimberly L. Stark; Oded Foreman; Richard A. D. Carano; Brad A. Friedman; Morgan Sheng; Amy Easton; Christopher J. Bohlen; David V. Hansen
Cell Reports, ISSN: 22111247
Kimberle Shen; Mike Reichelt; Roxanne Kyauk; Hai Ngu; Yun-An A. Shen; Oded Foreman; Zora Modrusan; Brad A. Friedman; Morgan Sheng; Tracy J. Yuen
Cell Reports, ISSN: 22111247
Karpagam Srinivasan; Brad A. Friedman; Ainhoa Etxeberria; Melanie A. Huntley; Marcel P Van Der Brug; Oded Foreman; Jonathan S. Paw; Zora Modrusan; Thomas G. Beach; Geidy E. Serrano; David V. Hansen
Journal of Neuroscience, ISSN: 15292401 02706474
William J. Meilandt; Hai Ngu; Alvin Gogineni; Guita Lalehzadeh; Seung-Hye Lee; Karpagam Srinivasan; Jose Imperio; Tiffany Wu; Martin Weber; Agatha J. Kruse; Kimberly L. Stark; Pamela Chan; Mandy Kwong; Zora Modrusan; Brad A. Friedman; Justin Elstrott; Oded Foreman; Amy Easton; Morgan Sheng; X David V. Hansen
Journal of Neuroscience, ISSN: 15292401 02706474
Melanie A. Huntley; Karpagam Srinivasan; Brad A. Friedman; Tzu-Ming Wang; Ada X. Yee; Yuanyuan Wang; Joshua S. Kaminker; Morgan Sheng; David V. Hansen; Jesse E. Hanson
Annual Review of Genetics, ISSN: 15452948 00664197
Christopher J. Bohlen; Brad A. Friedman; Borislav Dejanovic; Morgan Sheng
Neuron, ISSN: 10974199 08966273
Borislav Dejanovic; Melanie A. Huntley; Ann De Mazière; William J. Meilandt; Tiffany Wu; Karpagam Srinivasan; Zhiyu Jiang; Vineela D. Gandham; Brad A. Friedman; Hai Ngu; Oded Foreman; Richard A. D. Carano; Ben Chih; Judith Klumperman; Corey Bakalarski; Jesse E. Hanson; Morgan Sheng
Scientific Reports, ISSN: 20452322
Hsu-Hsin Chen; Peter S. Liu; Paul Auger; Seung-Hye Lee; Oskar Adolfsson; Lorianne Rey-Bellet; Julien Lafrance-Vanasse; Brad A. Friedman; Maria Pihlgren; Andreas Muhs; Andrea Pfeifer; James A. Ernst; Gai Ayalon; Kristin R. Wildsmith; Thomas G. Beach; Marcel P Van Der Brug
Cell Reports, ISSN: 22111247
Brad A. Friedman; Karpagam Srinivasan; Gai Ayalon; William J. Meilandt; Han Lin; Melanie A. Huntley; Yi Cao; Seung-Hye Lee; Patrick C. G. Haddick; Hai Ngu; Zora Modrusan; Jessica L. Larson; Joshua S. Kaminker; Marcel P Van Der Brug; David V. Hansen
Journal of Cell Biology, ISSN: 15408140 00219525
Trinna L. Cuellar; Anna-Maria Herzner; Xiaotian Zhang; Yogesh Goyal; Colin K. Watanabe; Brad A. Friedman; Vasantharajan Janakiraman; Durinck; Stinson; David Arnott; Tommy K. Cheung; Subhra Chaudhuri; Zora Modrusan; Jonas Martin Doerr; Marie Classon; Benjamin Haley
Nature Immunology, ISSN: 15292916 15292908
Kit Wong; Rajkumar Noubade; Paolo Manzanillo; Naruhisa Ota; Oded Foreman; Jason A. Hackney; Brad A. Friedman; Rajita Pappu; Kimberly Scearce-Levie; Wenjun Ouyang
Scientific Reports, ISSN: 20452322
Ying-Jiun J. Chen; Brad A. Friedman; Connie Ha; Durinck; Jinfeng Liu; John L. R. Rubenstein; Somasekar Seshagiri; Zora Modrusan
Journal of Experimental Medicine, ISSN: 15409538 00221007
Michael C. Chang; Karpagam Srinivasan; Brad A. Friedman; Eric Suto; Zora Modrusan; Wyne P. Lee; Joshua S. Kaminker; David V. Hansen; Morgan Sheng
Cell Reports, ISSN: 22111247
Karen Yap; Yixin Xiao; Brad A. Friedman; H. Shawn Je; Eugene V. Makeyev
Nature Communications, ISSN: 20411723
Karpagam Srinivasan; Brad A. Friedman; Jessica L. Larson; Benjamin E. Lauffer; Leonard D. Goldstein; Laurie L. Appling; Jovencio Borneo; Chungkee Poon; Terence Ho; Fang Cai; Pascal Steiner; Marcel P Van Der Brug; Zora Modrusan; Joshua S. Kaminker; David V. Hansen
Cell Reports, ISSN: 22111247
Mark J. Solloway; Azadeh Madjidi; Chunyan Gu; Jeffrey Eastham-Anderson; Holly J. Clarke; Noelyn Kljavin; Jose Zavala-Solorio; Lance Kates; Brad A. Friedman; Matthew J. Brauer; Jianyong Wang; Oliver Fiehn; Ganesh Kolumam; Howard M. Stern; John Lowe; Andrew S. Peterson; Bernard B. Allan
Clinical Cancer Research, ISSN: 15573265 10780432
Jyoti Asundi; Lisa Crocker; Jarrod Tremayne; Peter Chang; Sakanaka; Josh Tanguay; Spencer; Sreedevi Chalasani; Luis; Karen Gascoigne; Rupal Desai; Rajiv Raja; Brad A. Friedman; Matthias Peter; Paul G. Polakis; Ron Firestein
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Hemali P. Phatnani; Paolo Guarnieri; Brad A. Friedman; Monica A. Carrasco; Michael Muratet; Sean O'Keeffe; Chiamaka Nwakeze; Florencia Pauli-Behn; Kimberly M. Newberry; Sarah K. Meadows; Juan Carlos Tapia; Richard M. Myers; Tom Maniatis
Neuron, ISSN: 08966273 10974199
Weisheng V. Chen; Francisco J. Alvarez; Julie L. Lefebvre; Brad A. Friedman; Chiamaka Nwakeze; Eric Geiman; Courtney Smith; Chan Aye Thu; Juan Carlos Tapia; Bosiljka Tasic; Joshua R. Sanes; Tom Maniatis
Genes and Development, ISSN: 08909369 15495477
Karen Yap; Zhao Qin Lim; Piyush Khandelia; Brad A. Friedman; Eugene V. Makeyev
Genome Biology, ISSN: 14747596 1474760X
Brad A. Friedman; Tom Maniatis
Education
- Harvard University, Postdoctoral Fellow in Molecular and Cell Biology – 2011
- MIT, PhD in Applied Mathematics – 2006
- Cambridge University, Certificate of Advanced Study in Mathematics – 2001
- University of Illinois at Urbana, B. Music in Piano – 2000
- University of Illinois at Urbana, B. Science in Mathematics – 1999
Awards & Honors
- Churchill Scholar – 2000-2001