Brian Yaspan - Senior Scientist, OMNI Human Genetics

Brian Yaspan

Senior Scientist, OMNI Human Genetics

Postdoc Mentor
6
Years at Genentech
14
Publications
3
Awards & Honors

I joined Genentech in the summer of 2012 after completing my MPH in epidemiology at San Diego State University and my PhD and postdoctoral studies at the Vanderbilt University Medical Center. Since joining Genentech, my laboratory has focused on understanding the genetic architecture of common pulmonary and ophthalmic diseases. Here, we are especially interested in looking at disease subtypes through a genetic lens in order to enable the right medication to get to the right patient.

Postdoctoral Mentor

Being a mentor is one of the most rewarding experiences I have had in science to date. Here at Genentech we are fortunate to have a post-doctoral program focusing on basic research projects. In my lab, we are working on understanding the biologic effect of variants we find that are associated with risk, progression and sub-phenotypes of disease. Merging the large scale human genetic data with novel in vitro and in vivo models will provide illumination on the function of these variants and how they may affect human health.

Featured Publication

Targeting factor D of the alternative complement pathway reduces geographic atrophy progression secondary to age-related macular degeneration.

Sci Transl Med. 2017 Jun 21;9(395). pii: eaaf1443.

Yaspan BL, Williams DF, Holz FG, Regillo CD, Li Z, Dressen A, van Lookeren Campagne M, Le KN, Graham RR, Beres T, Bhangale TR, Honigberg LA, Smith A, Henry EC, Ho C, Strauss EC; MAHALO Study Investigators.