Brian Yaspan - Distinguished Scientist, Human Genetics, Research Biology

Brian Yaspan

Distinguished Scientist, Human Genetics, Research Biology

Postdoc Mentor
Years at Genentech
Publications at Genentech
Awards & Honors

I joined Genentech in the summer of 2012 after completing my MPH in epidemiology at San Diego State University and my PhD and postdoctoral studies at the Vanderbilt University Medical Center. Since joining Genentech, my laboratory has focused on understanding the genetic architecture of common pulmonary and ophthalmic diseases. Here, we are especially interested in looking at disease subtypes through a genetic lens in order to enable the right medication to get to the right patient.

Postdoctoral Mentor

Being a mentor is one of the most rewarding experiences I have had in science to date. Here at Genentech we are fortunate to have a post-doctoral program focusing on basic research projects. In my lab, we are working on understanding the biologic effect of variants we find that are associated with risk, progression and sub-phenotypes of disease. Merging the large scale human genetic data with novel in vitro and in vivo models will provide illumination on the function of these variants and how they may affect human health.

Featured Publication

Analysis of protein-altering variants in telomerase genes and their association with MUC5B common variant status in patients with idiopathic pulmonary fibrosis: a candidate gene sequencing study.

Lancet Respir Med. 2018 Aug;6(8):603-614.

Dressen A, Abbas AR, Cabanski C, Reeder J, Ramalingam TR, Neighbors M, Bhangale TR, Brauer MJ, Hunkapiller J, Reeder J, Mukhyala K, Cuenco K, Tom J, Cowgill A, Vogel J, Forrest WF, Collard HR, Wolters PJ, Kropski JA, Lancaster LH, Blackwell TS, Arron JR, Yaspan BL.