Genentech: Brian Yaspan | Senior Scientist, OMNI Human Genetics

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Scientists / Our Scientists

Years at Genentech

Publications

Awards & Honors

I joined Genentech in the summer of 2012 after completing my MPH in epidemiology at San Diego State University and my PhD and postdoctoral studies at the Vanderbilt University Medical Center. Since joining Genentech, my laboratory has focused on understanding the genetic architecture of common pulmonary and ophthalmic diseases. Here, we are especially interested in looking at disease subtypes through a genetic lens in order to enable the right medication to get to the right patient.

Postdoctoral Mentor

Being a mentor is one of the most rewarding experiences I have had in science to date. Here at Genentech we are fortunate to have a post-doctoral program focusing on basic research projects. In my lab, we are working on understanding the biologic effect of variants we find that are associated with risk, progression and sub-phenotypes of disease. Merging the large scale human genetic data with novel in vitro and in vivo models will provide illumination on the function of these variants and how they may affect human health.

Featured Publication

Targeting factor D of the alternative complement pathway reduces geographic atrophy progression secondary to age-related macular degeneration.

Sci Transl Med. 2017 Jun 21;9(395). pii: eaaf1443.

Yaspan BL, Williams DF, Holz FG, Regillo CD, Li Z, Dressen A, van Lookeren Campagne M, Le KN, Graham RR, Beres T, Bhangale TR, Honigberg LA, Smith A, Henry EC, Ho C, Strauss EC; MAHALO Study Investigators.

View Abstract

The Genentech OMNI Human Genetics group uses information from the human genome to discover and verify candidate biomarkers, to understand disease pathogenesis and heterogeneity, and to discover new drug targets. We are coming at this using several approaches with genetic data from consenting individuals in our clinical trials and through external collaborative studies.

My laboratory focuses on understanding common ophthalmic diseases, including age-related macular degeneration and glaucoma, and pulmonary diseases, such as asthma, COPD and idiopathic pulmonary fibrosis (IPF).

Targeting factor D of the alternative complement pathway reduces geographic atrophy progression secondary to age-related macular degeneration

Science Translational Medicine, ISSN: 19466234

Brian Yaspan; David F. Williams; Frank G. Holz; Carl D. Regillo; Zhengrong Li; Amy Dressen; Menno van Lookeren Campagne; Kha Le; Robert R. Graham; Tatiana Beres; Tushar Bhangale; Lee Honigberg; Ashley Smith; Erin Henry; Carole Ho; Erich Strauss

Pathway analysis by randomization incorporating structure - Paris: An update

Bioinformatics, ISSN: 14602059

Mariusz Butkiewicz; Jessica Cooke Bailey; Alex Frase; Scott Dudek; Brian Yaspan; Marylyn Ritchie; Sarah A. Pendergrass; Jonathan L. Haines

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Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open-angle glaucoma

Nature Genetics, ISSN: 15461718

Jessica Cooke Bailey; Stephanie J. Loomis; Jae H. Kang; R. Rand Allingham; Puya Gharahkhani; Chiea Chuen Khor; Kathryn P. Burdon; Hugues Aschard; Daniel I. Chasman; Robert P. Igo; Pirro G. Hysi; Craig A. Glastonbury; Allison Ashley-Koch; Murray Brilliant; Andrew A. Brown; Donald L. Budenz; Alfonso Buil; Ching-Yu Cheng; Hyon Choi; William G. Christen; Gary Curhan; Immaculata De Vivo; John Fingert; Paul J. Foster; Charles Fuchs; Douglas Gaasterland; Terry Gaasterland; Alex W. Hewitt; Frank Hu; David J. Hunter; Anthony P. Khawaja; Richard K. Lee; Zheng Li; Paul R. Lichter; David A. Mackey; Peter McGuffin; Paul Mitchell; Sayoko E. Moroi; Shamira A. Perera; Keating W. Pepper; Qibin Qi; Tony Realini; Julia E. Richards; Paul M. Ridker; Eric Rimm; Robert Ritch; Marylyn Ritchie; Joel S. Schuman; William K. Scott; Kuldev Singh; Arthur J. Sit; Yeunjoo E. Song; Rulla M. Tamimi; Fotis Topouzis; Ananth C. Viswanathan; Shefali Setia Verma; Douglas Vollrath; Jie Jin Wang; Nicole Weisschuh; Bernd Wissinger; Gadi Wollstein; Ti

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Regulation of T Cell Receptor Signaling by DENND1B in TH2 Cells and Allergic Disease

Cell, ISSN: 10974172

Chiao-Wen Yang; Caroline D Hojer; Meijuan Zhou; Xiumin Wu; Art Wuster; Wyne Lee; Brian Yaspan; Andrew C. Chan

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Stratified medicine in inflammatory disorders: From theory to practice

Clinical Immunology, ISSN: 15217035

Joe Arron; Michael Townsend; Mary Keir; Brian Yaspan; Andrew C. Chan

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Age-related macular degeneration: Complement in action

Immunobiology, ISSN: 18783279

Menno van Lookeren Campagne; Erich Strauss; Brian Yaspan

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Functional analysis of protective IL1RL1 variants associated with asthma risk: To the editor

Journal of Allergy and Clinical Immunology, ISSN: 10976825

Vladimir Ramirez Carrozzi; Amy Dressen; Patrick Lupardus; Brian Yaspan; Rajita Pappu

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Association of CAV1/CAV2 genomic variants with primary open-angle glaucoma overall and by gender and pattern of visual field loss

Ophthalmology, ISSN: 01616420

Stephanie J. Loomis; Jae H. Kang; Robert N. Weinreb; Brian Yaspan; Jessica Cooke Bailey; Douglas Gaasterland; Terry Gaasterland; Richard K. Lee; Paul R. Lichter; Donald L. Budenz; Yutao Liu; Tony Realini; Friedman; Catherine A. McCarty; Sayoko E. Moroi; Olson; Schuman; Kuldev Singh; Douglas Vollrath; Gadi Wollstein; Donald J. Zack; Murray Brilliant; Arthur J. Sit; Christen; John Fingert; Peter Kraft; Kang Zhang; R. Rand Allingham; Margaret A. Pericak-Vance; Julia E. Richards; Michael A. Hauser; Jonathan L. Haines; Louis R. Pasquale; Janey L. Wiggs

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Hypothesis-independent pathway analysis implicates GABA and Acetyl-CoA metabolism in primary open-angle glaucoma and normal-pressure glaucoma

Human Genetics, ISSN: 14321203

Jessica Cooke Bailey; Brian Yaspan; Louis R. Pasquale; Michael A. Hauser; Jae H. Kang; Stephanie J. Loomis; Murray Brilliant; Donald L. Budenz; William G. Christen; John Fingert; Douglas Gaasterland; Terry Gaasterland; Peter Kraft; Richard K. Lee; Paul R. Lichter; Yutao Liu; Catherine A. McCarty; Sayoko E. Moroi; Julia E. Richards; Tony Realini; Joel S. Schuman; William K. Scott; Kuldev Singh; Arthur J. Sit; Douglas Vollrath; Gadi Wollstein; Donald J. Zack; Kang Zhang; Margaret A. Pericak-Vance; R. Rand Allingham; Robert N. Weinreb; Jonathan L. Haines; Janey L. Wiggs

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Mechanisms of age-related macular degeneration and therapeutic opportunities

Journal of Pathology, ISSN: 00223417

Menno van Lookeren Campagne; Jennifer Lecouter; Brian Yaspan; Weilan Ye

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Vascular tone pathway polymorphisms in relation to primary open-angle glaucoma

Eye, ISSN: 14765454

Jae H. Kang; Stephanie J. Loomis; Brian Yaspan; Jessica Cooke Bailey; Robert N. Weinreb; Richard K. Lee; Paul R. Lichter; Donald L. Budenz; Yutao Liu; Tony Realini; Douglas Gaasterland; Terry Gaasterland; Friedman; Catherine A. McCarty; Sayoko E. Moroi; Olson; Schuman; Kuldev Singh; Douglas Vollrath; Gadi Wollstein; Donald J. Zack; Murray Brilliant; Arthur J. Sit; Christen; John Fingert; Forman; Buys; Peter Kraft; Kang Zhang; R. Rand Allingham; Margaret A. Pericak-Vance; Julia E. Richards; Michael A. Hauser; Jonathan L. Haines; Wiggs; Louis R. Pasquale

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Estrogen pathway polymorphisms in relation to primary open angle glaucoma: An analysis accounting for gender from the United States

Molecular Vision, ISSN: 10900535

Louis R. Pasquale; Stephanie J. Loomis; Robert N. Weinreb; Jae H. Kang; Brian Yaspan; Jessica Cooke Bailey; Douglas Gaasterland; Terry Gaasterland; Richard K. Lee; William K. Scott; Paul R. Lichter; Donald L. Budenz; Yutao Liu; Tony Realini; Friedman; Catherine A. McCarty; Sayoko E. Moroi; Olson; Schuman; Kuldev Singh; Douglas Vollrath; Gadi Wollstein; Donald J. Zack; Murray Brilliant; Arthur J. Sit; Christen; John Fingert; Peter Kraft; Kang Zhang; R. Rand Allingham; Margaret A. Pericak-Vance; Julia E. Richards; Michael A. Hauser; Jonathan L. Haines; Janey L. Wiggs

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CDKN2B-AS1 genotype-glaucoma feature correlations in primary open-angle glaucoma patients from the United States

American Journal of Ophthalmology, ISSN: 00029394

Louis R. Pasquale; Stephanie J. Loomis; Jae H. Kang; Brian Yaspan; Wael Abdrabou; Donald L. Budenz; Teresa C. Chen; Elizabeth Delbono; Friedman; Douglas Gaasterland; Terry Gaasterland; Cynthia L. Grosskreutz; Richard K. Lee; Paul R. Lichter; Yutao Liu; Catherine A. McCarty; Sayoko E. Moroi; Olson; Tony Realini; Douglas J. Rhee; Schuman; Kuldev Singh; Douglas Vollrath; Gadi Wollstein; Donald J. Zack; R. Rand Allingham; Margaret A. Pericak-Vance; Robert N. Weinreb; Kang Zhang; Michael A. Hauser; Julia E. Richards; Jonathan L. Haines; Janey L. Wiggs

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Previously reported placebo-response-associated variants do not predict patient outcomes in inflammatory disease Phase III trial placebo arms

Genes and Immunity, ISSN: 14664879

Asher Haug-Baltzell; Tushar Bhangale; Diana Chang; Amy Dressen; Brian Yaspan; Ward Ortmann; Matt Brauer; Julie Hunkapiller; Jens Reeder; Kiran Mukhyala; Karen T. Cuenco; Jennifer A. Tom; Amy Cowgill; Jan Vogel; Bill Forrest; Timothy W. Behrens; Rob Graham; Art Wuster

Analysis of protein-altering variants in telomerase genes and their association with MUC5B common variant status in patients with idiopathic pulmonary fibrosis: a candidate gene sequencing study

The Lancet Respiratory Medicine, ISSN: 22132619 22132600

Amy Dressen; Alexander Abbas; Christopher R. Cabanski; Janina Reeder; Thiru Ramalingam; Margaret Neighbors; Tushar Bhangale; Matt Brauer; Julie Hunkapiller; Jens Reeder; Kiran Mukhyala; Karen T. Cuenco; Jennifer A. Tom; Amy Cowgill; Jan Vogel; Bill Forrest; Harold R. Collard; Paul J. Wolters; Jonathan A Kropski; Lisa H Lancaster; Timothy S. Blackwell; Joe Arron; Brian Yaspan

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Vanderbilt University, PhD in Cancer Biology – 2008
San Diego State University, MPH in Epidemiology – 2002
University of California at San Diego, BS in Biochemistry – 1995

Training program in quantitative ocular genomics postdoctoral traineeship – 2011-2012
US Department of Defense Prostate Cancer Research Program training grant – 2005-2008
Vanderbilt Department of Cancer Biology Predoctoral traineeship – 2003-2005

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Brian Yaspan

Senior Scientist, OMNI Human Genetics

Featured Publication

Targeting factor D of the alternative complement pathway reduces geographic atrophy progression secondary to age-related macular degeneration.