Brian Yaspan
Senior Scientist, OMNI Human Genetics
Postdoc Mentor
8
Years at Genentech
21
Publications
3
Awards & Honors
I joined Genentech in the summer of 2012 after completing my MPH in epidemiology at San Diego State University and my PhD and postdoctoral studies at the Vanderbilt University Medical Center. Since joining Genentech, my laboratory has focused on understanding the genetic architecture of common pulmonary and ophthalmic diseases. Here, we are especially interested in looking at disease subtypes through a genetic lens in order to enable the right medication to get to the right patient.
Postdoctoral Mentor
Being a mentor is one of the most rewarding experiences I have had in science to date. Here at Genentech we are fortunate to have a post-doctoral program focusing on basic research projects. In my lab, we are working on understanding the biologic effect of variants we find that are associated with risk, progression and sub-phenotypes of disease. Merging the large scale human genetic data with novel in vitro and in vivo models will provide illumination on the function of these variants and how they may affect human health.
Featured Publication
Analysis of protein-altering variants in telomerase genes and their association with MUC5B common variant status in patients with idiopathic pulmonary fibrosis: a candidate gene sequencing study.
Lancet Respir Med. 2018 Aug;6(8):603-614.
Dressen A, Abbas AR, Cabanski C, Reeder J, Ramalingam TR, Neighbors M, Bhangale TR, Brauer MJ, Hunkapiller J, Reeder J, Mukhyala K, Cuenco K, Tom J, Cowgill A, Vogel J, Forrest WF, Collard HR, Wolters PJ, Kropski JA, Lancaster LH, Blackwell TS, Arron JR, Yaspan BL.
My Focus
The Genentech OMNI Human Genetics group uses information from the human genome to discover and verify candidate biomarkers, to understand disease pathogenesis and heterogeneity, and to discover new drug targets. We are coming at this using several approaches with genetic data from consenting individuals in our clinical trials and through external collaborative studies.
My laboratory focuses on understanding common ophthalmic diseases, including age-related macular degeneration and glaucoma, and pulmonary diseases, such as asthma, COPD and idiopathic pulmonary fibrosis (IPF).
Publications
Rare Protein-Altering Telomere-related Gene Variants in Patients with Chronic Hypersensitivity Pneumonitis
American Journal of Respiratory and Critical Care Medicine,
Brett Ley; Dara G Torgerson; Justin M. Oldham; Ayodeji Adegunsoye; Shuo Liu; Jie Li; Brett Elicker; Travis S. Henry; Jeffrey A. Golden; Kirk D. Jones; Amy Dressen; Brian Yaspan; Joe Arron; Imre Noth; Thomas J. Hoffmann; Paul J. Wolters
Cell, ISSN: 10974172 00928674
Henry Maun; Janet Jackman; David Choy; Kelly Loyet; Tracy Staton; Jim Jia; Amy Dressen; Jason A. Hackney; Meire Bremer; Ben Walters; Rajesh Vij; Xiaocheng Chen; Neil N. Trivedi; Ashley Morando; Terry Lipari; Yvonne Franke; Xiumin Wu; Juan Zhang; John Liu; Ping Wu; Diana Chang; Luz D. Orozco; Erin Christensen; Manda Wong; Racquel Corpuz; Julie Q. Hang; Jeff Lutman; Sid Sukumaran; Yan Wu; Savita Ubhayakar; Xiaorong Liang; Lawrence B. Schwartz; Magda Babina; Prescott G. Woodruff; John V. Fahy; Rahul Ahuja; George H. Caughey; Aija Kusi; Mark Dennis; Charles Eigenbrot; Daniel Kirchhofer; Cary Austin; Lawren Wu; JT Koerber; Wyne P. Lee; Brian Yaspan; Kathila Alatsis; Joe Arron; Bob Lazarus; Tangsheng Yi
Gene, ISSN: 18790038 03781119
Jennifer A. Tom; Diana Chang; Art Wuster; Kiran Mukhyala; Karen T. Cuenco; Amy Cowgill; Jan Vogel; Jens Reeder; Brian Yaspan; Julie Hunkapiller; Matt Brauer; Tim Behrens; Bill Forrest; Tushar Bhangale
Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control
Diabetes,
Samuela Pollack; Robert P. Igo; Richard A. Jensen; Mark Christiansen; Xiaohui Li; Ching-Yu Cheng; Maggie C Y Ng; Albert V. Smith; Elizabeth Rossin; Ayellet V. Segrè; Samaneh Davoudi; Gavin S. Tan; Yii-Der Ida Chen; Jane Z. Kuo; Latchezar M. Dimitrov; Lynn K. Stanwyck; Weihua Meng; S Mohsen Hosseini; Minako Imamura; Darryl Nousome; Jihye Kim; Yang Hai; Yucheng Jia; Jeeyun Ahn; Aaron Leong; Kaanan Shah; Kyu Hyung Park; Xiuqing Guo; Eli Ipp; Kent D. Taylor; Sharon G. Adler; John R. Sedor; Barry I. Freedman; I-Te Lee; Wayne H-H Sheu; Michiaki Kubo; Atsushi Takahashi; Samy Hadjadj; Michel Marre; David-Alexandre Trégouët; Roberta Mckean-Cowdin; Rohit Varma; Mark I. McCarthy; Leif Groop; Emma Ahlqvist; Valeriya Lyssenko; Elisabet Agardh; Andrew Morris; Alex S F Doney; Helen M. Colhoun; Iiro Toppila; Niina Sandholm; Per-Henrik Groop; Shiro Maeda; Craig L. Hanis; Alan Penman; Ching J. Chen; Heather Hancock; Paul Mitchell; Jamie E. Craig; Emily Y. Chew; Andrew D. Paterson; Michael A. Grassi; Colin Palmer; Donald W.
Imaging, Genetic, and Demographic Factors Associated with Conversion to Neovascular Age-Related Macular Degeneration: Secondary Analysis of a Randomized Clinical Trial
JAMA Ophthalmology, ISSN: 21686165
Joelle A. Hallak; Luis De Sisternes; Aaron Osborne; Brian Yaspan; Daniel L. Rubin; Theodore Leng
Previously reported placebo-response-associated variants do not predict patient outcomes in inflammatory disease Phase III trial placebo arms
Genes and Immunity, ISSN: 14664879
Asher Haug-Baltzell; Tushar Bhangale; Diana Chang; Amy Dressen; Brian Yaspan; Ward Ortmann; Matt Brauer; Julie Hunkapiller; Jens Reeder; Kiran Mukhyala; Karen T. Cuenco; Jennifer A. Tom; Amy Cowgill; Jan Vogel; Bill Forrest; Timothy W. Behrens; Rob Graham; Art Wuster
Current Protocols in Human Genetics, ISSN: 19348258 19348266
Marquitta J White; Brian Yaspan; Olivia J. Veatch; Paǵe Goddard; Oona S. Risse-Adams; Maria G. Contreras
The Lancet Respiratory Medicine, ISSN: 22132619 22132600
Amy Dressen; Alexander Abbas; Christopher R. Cabanski; Janina Reeder; Thiru Ramalingam; Margaret Neighbors; Tushar Bhangale; Matt Brauer; Julie Hunkapiller; Jens Reeder; Kiran Mukhyala; Karen T. Cuenco; Jennifer A. Tom; Amy Cowgill; Jan Vogel; Bill Forrest; Harold R. Collard; Paul J. Wolters; Jonathan A Kropski; Lisa H Lancaster; Timothy S. Blackwell; Joe Arron; Brian Yaspan
Targeting factor D of the alternative complement pathway reduces geographic atrophy progression secondary to age-related macular degeneration
Science Translational Medicine, ISSN: 19466234
Brian Yaspan; David F. Williams; Frank G. Holz; Carl D. Regillo; Zhengrong Li; Amy Dressen; Menno van Lookeren Campagne; Kha Le; Robert R. Graham; Tatiana Beres; Tushar Bhangale; Lee Honigberg; Ashley Smith; Erin Henry; Carole Ho; Erich Strauss
Bioinformatics, ISSN: 14602059
Mariusz Butkiewicz; Jessica Cooke Bailey; Alex Frase; Scott Dudek; Brian Yaspan; Marylyn Ritchie; Sarah A. Pendergrass; Jonathan L. Haines
Immunobiology, ISSN: 18783279
Menno van Lookeren Campagne; Erich Strauss; Brian Yaspan
Nature Genetics, ISSN: 15461718
Jessica Cooke Bailey; Stephanie J. Loomis; Jae H. Kang; R. Rand Allingham; Puya Gharahkhani; Chiea Chuen Khor; Kathryn P. Burdon; Hugues Aschard; Daniel I. Chasman; Robert P. Igo; Pirro G. Hysi; Craig A. Glastonbury; Allison Ashley-Koch; Murray Brilliant; Andrew A. Brown; Donald L. Budenz; Alfonso Buil; Ching-Yu Cheng; Hyon Choi; William G. Christen; Gary Curhan; Immaculata De Vivo; John Fingert; Paul J. Foster; Charles Fuchs; Douglas Gaasterland; Terry Gaasterland; Alex W. Hewitt; Frank Hu; David J. Hunter; Anthony P. Khawaja; Richard K. Lee; Zheng Li; Paul R. Lichter; David A. Mackey; Peter McGuffin; Paul Mitchell; Sayoko E. Moroi; Shamira A. Perera; Keating W. Pepper; Qibin Qi; Tony Realini; Julia E. Richards; Paul M. Ridker; Eric Rimm; Robert Ritch; Marylyn Ritchie; Joel S. Schuman; William K. Scott; Kuldev Singh; Arthur J. Sit; Yeunjoo E. Song; Rulla M. Tamimi; Fotis Topouzis; Ananth C. Viswanathan; Shefali Setia Verma; Douglas Vollrath; Jie Jin Wang; Nicole Weisschuh; Bernd Wissinger; Gadi Wollstein; Ti
Cell, ISSN: 10974172
Chiao-Wen Yang; Caroline D Hojer; Meijuan Zhou; Xiumin Wu; Art Wuster; Wyne Lee; Brian Yaspan; Andrew C. Chan
Clinical Immunology, ISSN: 15217035
Joe Arron; Michael Townsend; Mary Keir; Brian Yaspan; Andrew C. Chan
Journal of Allergy and Clinical Immunology, ISSN: 10976825
Vladimir Ramirez Carrozzi; Amy Dressen; Patrick Lupardus; Brian Yaspan; Rajita Pappu
Ophthalmology, ISSN: 01616420
Stephanie J. Loomis; Jae H. Kang; Robert N. Weinreb; Brian Yaspan; Jessica Cooke Bailey; Douglas Gaasterland; Terry Gaasterland; Richard K. Lee; Paul R. Lichter; Donald L. Budenz; Yutao Liu; Tony Realini; Friedman; Catherine A. McCarty; Sayoko E. Moroi; Olson; Schuman; Kuldev Singh; Douglas Vollrath; Gadi Wollstein; Donald J. Zack; Murray Brilliant; Arthur J. Sit; Christen; John Fingert; Peter Kraft; Kang Zhang; R. Rand Allingham; Margaret A. Pericak-Vance; Julia E. Richards; Michael A. Hauser; Jonathan L. Haines; Louis R. Pasquale; Janey L. Wiggs
Human Genetics, ISSN: 14321203
Jessica Cooke Bailey; Brian Yaspan; Louis R. Pasquale; Michael A. Hauser; Jae H. Kang; Stephanie J. Loomis; Murray Brilliant; Donald L. Budenz; William G. Christen; John Fingert; Douglas Gaasterland; Terry Gaasterland; Peter Kraft; Richard K. Lee; Paul R. Lichter; Yutao Liu; Catherine A. McCarty; Sayoko E. Moroi; Julia E. Richards; Tony Realini; Joel S. Schuman; William K. Scott; Kuldev Singh; Arthur J. Sit; Douglas Vollrath; Gadi Wollstein; Donald J. Zack; Kang Zhang; Margaret A. Pericak-Vance; R. Rand Allingham; Robert N. Weinreb; Jonathan L. Haines; Janey L. Wiggs
Journal of Pathology, ISSN: 00223417
Menno van Lookeren Campagne; Jennifer Lecouter; Brian Yaspan; Weilan Ye
Eye, ISSN: 14765454
Jae H. Kang; Stephanie J. Loomis; Brian Yaspan; Jessica Cooke Bailey; Robert N. Weinreb; Richard K. Lee; Paul R. Lichter; Donald L. Budenz; Yutao Liu; Tony Realini; Douglas Gaasterland; Terry Gaasterland; Friedman; Catherine A. McCarty; Sayoko E. Moroi; Olson; Schuman; Kuldev Singh; Douglas Vollrath; Gadi Wollstein; Donald J. Zack; Murray Brilliant; Arthur J. Sit; Christen; John Fingert; Forman; Buys; Peter Kraft; Kang Zhang; R. Rand Allingham; Margaret A. Pericak-Vance; Julia E. Richards; Michael A. Hauser; Jonathan L. Haines; Wiggs; Louis R. Pasquale
Molecular Vision, ISSN: 10900535
Louis R. Pasquale; Stephanie J. Loomis; Robert N. Weinreb; Jae H. Kang; Brian Yaspan; Jessica Cooke Bailey; Douglas Gaasterland; Terry Gaasterland; Richard K. Lee; William K. Scott; Paul R. Lichter; Donald L. Budenz; Yutao Liu; Tony Realini; Friedman; Catherine A. McCarty; Sayoko E. Moroi; Olson; Schuman; Kuldev Singh; Douglas Vollrath; Gadi Wollstein; Donald J. Zack; Murray Brilliant; Arthur J. Sit; Christen; John Fingert; Peter Kraft; Kang Zhang; R. Rand Allingham; Margaret A. Pericak-Vance; Julia E. Richards; Michael A. Hauser; Jonathan L. Haines; Janey L. Wiggs
American Journal of Ophthalmology, ISSN: 00029394
Louis R. Pasquale; Stephanie J. Loomis; Jae H. Kang; Brian Yaspan; Wael Abdrabou; Donald L. Budenz; Teresa C. Chen; Elizabeth Delbono; Friedman; Douglas Gaasterland; Terry Gaasterland; Cynthia L. Grosskreutz; Richard K. Lee; Paul R. Lichter; Yutao Liu; Catherine A. McCarty; Sayoko E. Moroi; Olson; Tony Realini; Douglas J. Rhee; Schuman; Kuldev Singh; Douglas Vollrath; Gadi Wollstein; Donald J. Zack; R. Rand Allingham; Margaret A. Pericak-Vance; Robert N. Weinreb; Kang Zhang; Michael A. Hauser; Julia E. Richards; Jonathan L. Haines; Janey L. Wiggs
Education
- Vanderbilt University, PhD in Cancer Biology – 2008
- San Diego State University, MPH in Epidemiology – 2002
- University of California at San Diego, BS in Biochemistry – 1995
Awards & Honors
- Training program in quantitative ocular genomics postdoctoral traineeship – 2011-2012
- US Department of Defense Prostate Cancer Research Program training grant – 2005-2008
- Vanderbilt Department of Cancer Biology Predoctoral traineeship – 2003-2005