Scientists / Our Scientists

Chris Rose

Distinguished Scientist and Senior Director, Proteomic and Genomic Technologies, Research Biology

Postdoc Mentor

"Genentech has given me the opportunity to perform translation research and lead technological innovation driven by a pursuit of understanding mechanistic biology."

Years at Genentech

Publications at Genentech

Awards & Honors

I joined Genentech to combine my passion for developing proteomic technologies with a desire to perform translational science. My research career has focused on developing and applying cutting-edge proteomics approaches to improve the identification and quantification of proteins, peptides, and post-translational modifications. I have continued these activities within the Proteomic and Genomic Technologies department within the Translational Genomic and Proteomic Center at Genentech. Here, collaborations with biological researchers define the current limitations of our proteomic technologies. Once defined, my lab develops and implements new approaches that enable biological research and therapeutic discovery.

Currently, the two main focuses of my lab are: 1) development of mass spectrometry based real-time data analysis approaches to improve the throughput and quantitative depth of single-cell and spatial proteomics, and 2) development and application of MHC-I and MHC-II peptide analysis to better understand processing and presentation of cancer specific antigens within a tumor setting.

Postdoctoral Mentor

Genentech’s Postdoctoral Fellow program provides an excellent opportunity to perform basic research activities that lay the foundation for future translational studies. Postdoctoral projects are highly collaborative and offer the opportunity to work together with thought leaders across multiple disciplines. In my group, postdocs will explore mechanistic biology by employing innovative proteomics analyses.

Featured Publication

Systematic discovery of neoepitope-HLA pairs for neoantigens shared among patients and tumor types

Nat Biotechnol. 2024 Jul;42(7):1107-1117.

Hem R Gurung. et al.

View Abstract

My lab is interested in developing and applying quantitative proteomics methods to explore biological pathways related to potential therapeutic targets. Technology development in the lab focuses on the use of real-time data analysis to improve the quantification of low-level proteomes. Specifically, we are developing methods to improve the depth and throughput of single cell and spatial proteomics analysis to enable quantification of therapeutically relevant target proteins. My lab also focuses on understanding protein processing and MHC presentation of peptides to the immune system. Working closely with collaborators in Cancer Immunology, we are developing methods to analyze MHC-I and MHC-II associated peptidomes to better understand antigen presentation by tumor cells.

A microbiota-derived bile acid modulates biofilm formation by the probiotic strain Escherichia coli Nissle 1917

npj Biofilms and Microbiomes,

Elena K. Perry; Barath Udayasuryan; Elias K. Zegeye; Christopher M. Rose; Mike Reichelt; Man Wah Tan

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Chris Rose

Distinguished Scientist and Senior Director, Proteomic and Genomic Technologies, Research Biology

Postdoctoral Mentor

Featured Publication

Systematic discovery of neoepitope-HLA pairs for neoantigens shared among patients and tumor types