"My lab uses cryo electron microscopy (Cryo-EM) to investigate the structure and function of challenging protein targets that are intractable with other structural biology techniques."
I came to Genentech in 2014, after a Post-doc at the University of California at Berkeley in cryo-EM and a first appointment in Industry, where I used X-ray crystallography and electron microscopy to guide structure-based vaccine development against human cytomegalovirus (HCMV).
I joined our Structural Biology Department determined to establish a world-class cryo-EM group. This represents one of the very first cryo-EM groups in industry, worldwide. I feel incredibly fortunate to have received this opportunity and to work every day with such a pool of phenomenal and passionate scientists.
“Every so often a scientific field makes huge progress in a relatively short amount of time. Such is the case for Cryo-EM, where a ‘Resolution Revolution’, made possible by recent technical and computational developments, allows atomic structure determination of many previously intractable complexes (R. A. Crowther).”
At Genentech, our newly established Cryo-EM group provides a unique opportunity for Post-doctoral Fellows joining our team. This will include state-of-the-art technology for high-resolution data collection (Titan Krios equipped with K2 Direct Detector and Energy Filter & Talos Screening Microscope), a virtually unlimited computer cluster for data processing and the opportunity to be fostered in one of the most productive and scientifically stimulating research environments.
Nat Commun. 2017 Jan 19;8:14234.
Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):7858-63.
My group uses a combination of protein biochemistry and cryo-EM to determine the structure of pharmacologically relevant protein complexes, to support small and large molecule projects as well as basic research.
Active research projects include membrane protein complexes, receptor-ligand interactions and structural biology of multi-protein complexes and antibody-antigen complexes in several disease areas.