Cleopatra Kozlowski - Senior Principal Scientist (Bioinformatics), Oncology Biomarker Development

Cleopatra Kozlowski

Senior Principal Scientist (Bioinformatics), Oncology Biomarker Development

"I believe Digital Pathology will become the next big ‘OMICS’ that will revolutionize the way we extract information from patient tissues, that should help us make better and faster treatment decisions."
Years at Genentech
Publications at Genentech
Awards & Honors

My driving interest has been in understanding and quantifying biomedical images through various computational feature extraction techniques. I joined Genentech in 2008 as a postdoc in the Weimer lab, in the department of the Biomedical Imaging. There, I explored the relationship between microglia morphology, gene expression and behavior in the living mouse brain, by analyzing data from 2-photon imaging and histology. Afterwards I spent 7 years in the pre-clinical Safety Assessment department, developing image analysis algorithms to quantitatively characterize the extent of toxicities observed in animals after experimental drug treatment. In 2018 I joined the Oncology Biomarker Group, and started building up a digital pathology group with the focus of applying advanced computer vision / deep learning methods to extract information from patient tumors based on histology, to enable better treatment decisions for our patients.

Featured Publication

Computational pathology definitions, best practices, and recommendations for regulatory guidance: a white paper from the Digital Pathology Association.

J Pathol. 2019 Nov;249(3):286-294. doi: 10.1002/path.5331. Epub 2019 Sep 3.

Abels E, Pantanowitz L, Aeffner F, Zarella MD, van der Laak J, Bui MM, Vemuri VN, Parwani AV, Gibbs J, Agosto-Arroyo E, Beck AH, Kozlowski C*.

Integrated digital pathology and transcriptome analysis identifies molecular mediators of T-cell exclusion in ovarian cancer.

Nat Commun. 2020 Nov 4;11(1):5583. doi: 10.1038/s41467-020-19408-2.

Desbois M, Udyavar AR, Ryner L, Kozlowski C, Guan Y, Dürrbaum M, Lu S, Fortin JP, Koeppen H, Ziai J, Chang CW, Keerthivasan S, Plante M, Bourgon R, Bais C, Hegde P, Daemen A, Turley S, Wang Y.