Dan Sutherlin
Vice President, Small Molecule Discovery Chemistry
20
Years at Genentech
49
Publications
I started at Genentech in 1999 in what was then the Bioorganic Chemistry Department. I was attracted to Genentech based primarily on the people that were here, their enthusiasm for science, and the opportunity to work closely with world-class biologists. Since that time I have enjoyed the experience of working in many therapeutic areas (cardiovascular, oncology, immunology, and neuroscience) and on many different target classes including kinases, proteases, integrins, and ion-channels. In each project there have always been new and interesting challenges to overcome that has kept me curious about and engaged in the science of drug discovery.
Featured Publication
My Focus
I am currently the research and development project leader of a new and exciting Pain target. Mutations in this ion channel have profound effects on pain.
The chance to participate in such an exciting area of science while being focused on a serious unmet medical need has been motivating.
Publications
Clinical Drug Investigation, ISSN: 11791918 11732563
Michael E. Rothenberg; Tagen; Jae H. Chang; Janel Boyce-Rustay; Michel Friesenhahn; David Hackos; Avis Hains; Dan Sutherlin; Michael Ward; William Cho
The Discovery of the Nav1.7 Inhibitor GDC-0276 and Development of an Efficient Large-Scale Synthesis
ACS Symposium Series, ISSN: 19475918 00976156
Andy Stumpf; Dan Sutherlin; Christoph Dehnhardt; Remy Angelaud
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Steven J. McKerrall; Teresa Nguyen; Kwong Wah Lai; Philippe Bergeron; Lunbin Deng; Antonio DiPasquale; Jae Chang; Jun Chen; Tania Chernov-Rogan; David Hackos; Jonathan M. Maher; Dan Ortwine; Jodie Pang; Jian Payandeh; Will Proctor; Shannon Shields; Jennifer Vogt; Pengfei Ji; Wenfeng Liu; Elisa Ballini; Lilia Schumann; Glauco Tarozzo; Girish Bankar; Sultan Chowdhury; Abid Hasan; Johnson; Kuldip Khakh; Sophia Lin; Charles J. Cohen; Christoph Dehnhardt; Brian Safina; Dan Sutherlin
Safety, Tolerability, and Pharmacokinetics of GDC-0276, a Novel NaV 1.7 Inhibitor, in a First-in-Human, Single- and Multiple-Dose Study in Healthy Volunteers
Clinical Drug Investigation, ISSN: 11732563
Michael E. Rothenberg; Tagen; Jae H. Chang; Janel Boyce-Rustay; Michel Friesenhahn; David Hackos; Avis Hains; Dan Sutherlin; Michael Ward; William Cho
Cell Reports, ISSN: 22111247
Girish Bankar; Samuel J. Goodchild; Sarah Howard; Karen Nelkenbrecher; Matthew Waldbrook; Michelle Dourado; Noah Shuart; Sophia Lin; Clint Young; Zhiwei Xie; Kuldip Khakh; Elaine Chang; Luis E. Sojo; Andrea Lindgren; Sultan Chowdhury; Shannon M. Decker; Michael Grimwood; Jean-Christophe Andrez; Christoph Dehnhardt; Jodie Pang; Jae H. Chang; Brian Safina; Dan Sutherlin; James P. Johnson; David Hackos; C. Lee Robinette; Charles J. Cohen
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Thilo Focken; Sultan Chowdhury; Alla Zenova; Michael Grimwood; Christine Chabot; Tao Sheng; Ivan Hemeon; Shannon M. Decker; Michael Wilson; Paul Bichler; Qi Jia; Shaoyi Sun; Clint Young; Sophia Lin; Samuel J. Goodchild; Noah Shuart; Elaine Chang; Zhiwei Xie; Bowen Li; Kuldip Khakh; Girish Bankar; Matthew Waldbrook; Rainbow Kwan; Karen Nelkenbrecher; Parisa Karimi Tari; Navjot Chahal; Luis E. Sojo; C. Lee Robinette; Andrew D. White; Chien-An Chen; Yi Zhang; Jodie Pang; Jae Chang; David Hackos; Johnson; Charles J. Cohen; Dan Ortwine; Dan Sutherlin; Christoph Dehnhardt; Brian Safina
Mechanism-specific assay design facilitates the discovery of Nav1.7-selective inhibitors
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424
Tania Chernov-Rogan; Tianbo Li; Gang Lu; Henry Verschoof; Kuldip Khakh; Steven W Jones; Maureen Beresini; Chang Liu; Dan Ortwine; Steven J. McKerrall; David Hackos; Dan Sutherlin; Charles J. Cohen; Jun Chen
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Shaoyi Sun; Qi Jia; Alla Zenova; Michael S. Wilson; Sultan Chowdhury; Thilo Focken; Jun Li; Shannon M. Decker; Michael Grimwood; Jean-Christophe Andrez; Ivan Hemeon; Tao Sheng; Chien-An Chen; Andrew D. White; David Hackos; Lunbin Deng; Girish Bankar; Kuldip Khakh; Elaine Chang; Rainbow Kwan; Sophia Lin; Karen Nelkenbrecher; Ben Sellers; Antonio DiPasquale; Jae H. Chang; Jodie Pang; Luis E. Sojo; Andrea Lindgren; Matthew Waldbrook; Zhiwei Xie; Clint Young; James P. Johnson; C. Lee Robinette; Charles J. Cohen; Brian Safina; Dan Sutherlin; Dan Ortwine; Christoph Dehnhardt
Design of Selective Benzoxazepin PI3Kδ Inhibitors Through Control of Dihedral Angles
ACS Medicinal Chemistry Letters,
Brian Safina; Richard Elliott; Andrew K. Forrest; Robert Heald; Jeremy Murray; Jim Nonomiya; Jodie Pang; Laurent Salphati; Eileen M. Seward; Steven Staben; Mark Ultsch; Binqing Wei; Wenqian Yang; Dan Sutherlin
Journal of Pharmaceutical Sciences, ISSN: 15206017
Po-Chang Chiang; Dan Sutherlin; Jodie Pang; Laurent Salphati
Journal of Biological Chemistry, ISSN: 1083351X
Diana Ronai Dunshee; Travis Bainbridge; Noelyn Kljavin; Jose Zavala-Solorio; Amy Schroeder; Ruby Chan; Racquel Corpuz; Manda Wong; Wei Zhou; Gauri Deshmukh; Justin Ly; Dan Sutherlin; James Ernst; Jun Sonoda
ACS Medicinal Chemistry Letters, ISSN: 19485875
Thilo Focken; Shifeng Liu; Navjot Chahal; Maxim Dauphinais; Michael Grimwood; Sultan Chowdhury; Ivan Hemeon; Paul Bichler; David Bogucki; Matthew Waldbrook; Girish Bankar; Luis E. Sojo; Clint Young; Sophia Lin; Noah Shuart; Rainbow Kwan; Jodie Pang; Jae Chang; Brian Safina; Dan Sutherlin; Johnson; Christoph Dehnhardt; Tarek S. Mansour; Renata M. Oballa; Charles J. Cohen; C. Lee Robinette
ACS Symposium Series, ISSN: 19475918
Srinivasan Babu; Francis Gosselin; Theresa Cravillion; Alan Olivero; Dan Sutherlin; Qingping Tian
ACS Symposium Series, ISSN: 19475918
Remy Angelaud; Dan Sutherlin; Mark Reynolds; Scott Savage; Andy Stumpf
Science, ISSN: 10959203
Shivani Ahuja; Susmith Mukund; Lunbin Deng; Kuldip Khakh; Elaine Chang; Hoangdung Ho; Stephanie Shriver; Clint Young; Sophia Lin; Johnson; Ping Wu; Jun Li; Mary Coons; Christine Tam; Bobby Brillantes; Honorio Sampang; Kyle Mortara; Krista Bowman; Kevin Clark; Alberto Estevez; Zhiwei Xie; Henry Verschoof; Michael Grimwood; Christoph Dehnhardt; Jean-Christophe Andrez; Thilo Focken; Dan Sutherlin; Brian Safina; Melissa Starovasnik; Dan Ortwine; Yvonne Franke; Charles J. Cohen; David Hackos; Chris Koth; Jian Payandeh
Expert Opinion on Drug Discovery, ISSN: 1746045X
Stephen Gould; Jennifer Low; James Marsters; Kirk Robarge; Lee L. Rubin; Frederic De Sauvage; Dan Sutherlin; Harvey Wong; Bob Yauch
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Brian Safina; Zach Sweeney; Jun Li; Bryan Chan; Angelina Bisconte; Diane Carrera; Georgette Castanedo; Mike Flagella; Robert Heald; Cris Lewis; Jeremy Murray; Jim Nonomiya; Jodie Pang; Steve Price; Karin Reif; Laurent Salphati; Eileen M. Seward; Binqing Wei; Dan Sutherlin
Toxicology and Applied Pharmacology, ISSN: 0041008X
Dolo Diaz; Kevin Ford; Dylan Hartley; Eric Harstad; Gary Cain; Kirsten Achilles Poon; Trung Nguyen; Jing Peng; Zhong Zheng; Mark Merchant; Dan Sutherlin; John J. Gaudino; Robert Kaus; Sock-Cheng Lewin-Koh; Edna Choo; Bianca Liederer; Donna Dambach
Journal of Medicinal Chemistry, ISSN: 00222623
Jeremy Murray; Zach Sweeney; Bryan Chan; Mercedesz Balazs; Erin Bradley; Georgette Castanedo; Christine Chabot; David Chantry; Mike Flagella; David M. Goldstein; Rama Kondru; John Lesnick; Jun Li; Matthew C. Lucas; Jim Nonomiya; Jodie Pang; Stephen Price; Laurent Salphati; Brian Safina; Pascal P. A. Savy; Eileen M. Seward; Mark Ultsch; Dan Sutherlin
Nature, ISSN: 00280836
Tim Wilson; Jane (Zhenya) Fridlyand; Yibing Yan; Elicia Penuel; Luciana Burton; Emily Chan; Jing Peng; Eva Lin; Yulei Wang; Jeffrey A. Sosman; Antoni Ribas; Jiang Li; John Moffat; Dan Sutherlin; Hartmut Koeppen; Mark Merchant; Rich Neve; Jeffrey Settleman
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Dan Sutherlin; Stewart Baker; Angelina Bisconte; Paul M. Blaney; Anthony Brown; Bryan Chan; David Chantry; Georgette Castanedo; Paul Depledge; Paul Goldsmith; David M. Goldstein; Timothy Hancox; Jasmit Kaur; David Knowles; Rama Kondru; John Lesnick; Matthew C. Lucas; Cris Lewis; Jeremy Murray; Alan J. Nadin; Jim Nonomiya; Jodie Pang; Neil Pegg; Steve Price; Karin Reif; Brian Safina; Laurent Salphati; Steven Staben; Eileen M. Seward; Stephen Shuttleworth; Sukhjit Sohal; Zach Sweeney; Mark Ultsch; Bohdan Waszkowycz; Binqing Wei
Journal of Medicinal Chemistry, ISSN: 00222623
Brian Safina; Stewart Baker; Matt Baumgardner; Paul M. Blaney; Bryan Chan; John Chen; Matthew W. Cartwright; Georgette Castanedo; Christine Chabot; Arnaud J. Cheguillaume; Paul Goldsmith; David M. Goldstein; Bindu Goyal; Timothy Hancox; Raj K. Handa; Pravin S Iyer; Jasmit Kaur; Rama Kondru; Jane Kenny; Sussie L. Krintel; Jun Li; John Lesnick; Matthew C. Lucas; Cris Lewis; Sophie Aurangabadwala; Jeremy Murray; Alan J. Nadin; Jim Nonomiya; Fernando Padilla; Wylie S. Palmer; Jodie Pang; Neil Pegg; Steve Price; Karin Reif; Laurent Salphati; Pascal P. A. Savy; Eileen M. Seward; Stephen Shuttleworth; Sukhjit Sohal; Zach Sweeney; Suzanne Brown; Parcharee Tivitmahaisoon; Bohdan Waszkowycz; Binqing Wei; Qin Yue; Chenghong Zhang; Dan Sutherlin
Xenobiotica, ISSN: 00498254
Bianca Liederer; Xingrong Liu; Leo Berezhkovskiy; Gary Cain; Xiao Ding; John J. Gaudino; Robert Kaus; Emile Plise; Dan Sutherlin; Eric Harstad
Molecular Cancer Therapeutics, ISSN: 15357163
Jeffrey Wallin; Kyle Edgar; Jane Guan; Megan Berry Swadell; Wei Wei Prior; Leslie Lee; John Lesnick; Cris Lewis; Jim Nonomiya; Jodie Pang; Laurent Salphati; Alan Olivero; Dan Sutherlin; Carol O'Brien; Jill Spoerke; Sonal Patel; Letitia Lensun; Robert Kassees; Leanne Ross; Mark Lackner; Deepak Sampath; Marcia Belvin; Lori Friedman
Advanced Synthesis and Catalysis, ISSN: 16154150
Andy Stumpf; Mark Reynolds; Dan Sutherlin; Srinivasan Babu; Erhard Bappert; Felix Spindler; Michael Welch; John J. Gaudino
Journal of Medicinal Chemistry, ISSN: 00222623
Tim Heffron; Binqing Wei; Alan Olivero; Steven Staben; Vickie Tsui; Steven Do; Jenna Dotson; Adrian J. Folkes; Paul Goldsmith; Rich Goldsmith; Janet Gunzner-Toste; John Lesnick; Cris Lewis; Simon Mathieu; Jim Nonomiya; Stephen Shuttleworth; Dan Sutherlin; Nan Chi Wan; Shumei Wang; Christian Wiesmann; Bing-Yan Zhu
Journal of Medicinal Chemistry, ISSN: 00222623
Dan Sutherlin; Linda Bao; Megan Berry Swadell; Georgette Castanedo; Irina Chuckowree; Jenna Dotson; Adrian Folks; Lori Friedman; Rich Goldsmith; Janet Gunzner-Toste; Tim Heffron; John Lesnick; Cris Lewis; Simon Mathieu; Jeremy Murray; Jim Nonomiya; Jodie Pang; Neil Pegg; Wei Wei Prior; Lionel Rouge; Laurent Salphati; Deepak Sampath; Qingping Tian; Vickie Tsui; Nan Chi Wan; Shumei Wang; Binqing Wei; Christian Wiesmann; Ping Wu; Bing-Yan Zhu; Alan Olivero
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Steven Staben; Mike Siu; Rich Goldsmith; Alan Olivero; Steven Do; Dan Burdick; Tim Heffron; Jenna Dotson; Dan Sutherlin; Bing-Yan Zhu; Vickie Tsui; Hoa Le; Leslie Lee; John Lesnick; Cris Lewis; Jeremy Murray; Jim Nonomiya; Jodie Pang; Wei Wei Prior; Laurent Salphati; Lionel Rouge; Deepak Sampath; Steve Sideris; Christian Wiesmann; Ping Wu
Cancer Research, ISSN: 00085472
Peter Dijkgraaf; Bruno Alicke; Lasse Weinmann; Tom Januario; Kristina West; Zora Modrusan; Dan Burdick; Rich Goldsmith; Kirk Robarge; Dan Sutherlin; Suzie Scales; Stephen Gould; Bob Yauch; Frederic De Sauvage
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Georgette Castanedo; Shumei Wang; Kirk Robarge; Beth Blackwood; Dan Burdick; Christine Chang; Peter Dijkgraaf; Stephen Gould; Janet Gunzner-Toste; Oivin Guichert; Jason Halladay; Cyrus Khojasteh; Leslie Lee; James Marsters; Lesley Murray; David Peterson; Emile Plise; Laurent Salphati; Frederic De Sauvage; Susan Wong; Dan Sutherlin
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Steven Staben; Tim Heffron; Dan Sutherlin; Seema Bhat; Georgette Castanedo; Irina Chuckowree; Jenna Dotson; Adrian J. Folkes; Lori Friedman; Leslie Lee; John Lesnick; Cris Lewis; Jeremy Murray; Jim Nonomiya; Alan Olivero; Emile Plise; Jodie Pang; Wei Wei Prior; Laurent Salphati; Lionel Rouge; Deepak Sampath; Vickie Tsui; Nan Chi Wan; Shumei Wang; Christian Weismann; Ping Wu; Bing-Yan Zhu
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Tim Heffron; Megan Berry Swadell; Georgette Castanedo; Christine Chang; Irina Chuckowree; Jenna Dotson; Adrian J. Folkes; Janet Gunzner-Toste; John Lesnick; Cris Lewis; Simon Mathieu; Jim Nonomiya; Alan Olivero; Jodie Pang; David Peterson; Laurent Salphati; Deepak Sampath; Steve Sideris; Dan Sutherlin; Vickie Tsui; Nan Chi Wan; Shumei Wang; Susan Wong; Bing-Yan Zhu
Journal of Medicinal Chemistry, ISSN: 00222623
Dan Sutherlin; Deepak Sampath; Megan Berry Swadell; Georgette Castanedo; Zhigang Chang; Irina Chuckowree; Jenna Dotson; Adrian J. Folkes; Lori Friedman; Rich Goldsmith; Tim Heffron; Leslie Lee; John Lesnick; Cris Lewis; Simon Mathieu; Jim Nonomiya; Alan Olivero; Jodie Pang; Wei Wei Prior; Laurent Salphati; Steve Sideris; Qingping Tian; Vickie Tsui; Nan Chi Wan; Shumei Wang; Christian Wiesmann; Susan Wong; Bing-Yan Zhu
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Kirk Robarge; Shirley A. Brunton; Georgette Castanedo; Yong Cui; Michael Dina; Rich Goldsmith; Stephen Gould; Oivin Guichert; Janet Gunzner-Toste; Jason Halladay; Wei Jia; Cyrus Khojasteh; Michael Koehler; Karen Kotkow; Hank La; Rebecca Lyn K. LaLonde; Kevin Lau; Leslie Lee; Derek Marshall; James Marsters; Lesley Murray; Changgeng Qian; Lee L. Rubin; Laurent Salphati; Mark Stanley; John H.A. Stibbard; Dan Sutherlin; Savita Ubhayakar; Shumei Wang; Susan Wong; Minli Xie
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Kirk Robarge; Shirley A. Brunton; Georgette Castanedo; Yong Cui; Michael Dina; Rich Goldsmith; Stephen Gould; Oivin Guichert; Janet Gunzner-Toste; Jason Halladay; Wei Jia; Cyrus Khojasteh; Michael Koehler; Karen Kotkow; Hank La; Rebecca Lyn K. LaLonde; Kevin Lau; Leslie Lee; Derek Marshall; James Marsters; Lesley Murray; Changgeng Qian; Lee L. Rubin; Laurent Salphati; Mark Stanley; John H.A. Stibbard; Dan Sutherlin; Savita Ubhayakar; Shumei Wang; Susan Wong; Minli Xie
Mini-Reviews in Medicinal Chemistry, ISSN: 13895575
Beni Wolf; Clifford Quan; Thuy Tran; Christian Wiesmann; Dan Sutherlin
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Thuy Tran; Clifford Quan; Conrad Edosada; Mark Mayeda; Christian Wiesmann; Dan Sutherlin; Beni Wolf
Journal of Biological Chemistry, ISSN: 00219258
Conrad Edosada; Clifford Quan; Christian Wiesmann; Thuy Tran; Dan Sutherlin; Mark Reynolds; Mike Elliott; Helga Raab; Wayne Fairbrother; Beni Wolf
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Georgette Castanedo; Kevin Clark; Shumei Wang; Vickie Tsui; Mengling Wong; John Nicholas; Dineli M. Wickramasinghe; James Marsters; Dan Sutherlin
Journal of Biological Chemistry, ISSN: 00219258
Alan Olivero; Charles Eigenbrot; Rich Goldsmith; Kirk Robarge; Dean R. Artis; John Flygare; Thomas Rawson; Dan Sutherlin; Saloumeh Kadkhodayan; Maureen Beresini; Linda Orren; Geralyn G. Deguzman; David W. Banner; Mark Ultsch; Ulla Marzec; Stephen R. Hanson; Ken Refino; Stuart Bunting; Daniel Kirchhofer
Biochemical Journal, ISSN: 02646021
Kelly M. Boatright; Cristina Deis; Jean-Bernard Denault; Dan Sutherlin; Guy S. Salvesen
Biochemistry, ISSN: 00062960
Jowita Mikolajczyk; Fiona L. Scott; Stan Krajewski; Dan Sutherlin; Guy S. Salvesen
Protein Journal, ISSN: 15723887
Samantha Lien; Rich Pastor; Dan Sutherlin; Henry Lowman
Molecular Cell, ISSN: 10972765
Kelly M. Boatright; Martin Renatus; Fiona L. Scott; Sabina Sperandio; Hwain Shin; Irene M. Pedersen; Jean-Ehrland Ricci; Wade A. Edris; Dan Sutherlin; Douglas R. Green; Guy S. Salvesen
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Georgette Castanedo; Fredrick C. Sailes; Dubree; John Nicholas; Lisa D. Caris; Kevin Clark; Susan Keating; Maureen Beresini; Henry Chiu; Sherman Fong; James Marsters; David Jackson; Dan Sutherlin
Journal of Medicinal Chemistry, ISSN: 00222623
Dubree; Dean R. Artis; Georgette Castanedo; James Marsters; Dan Sutherlin; Lisa D. Caris; Kevin Clark; Susan Keating; Maureen Beresini; Henry Chiu; Sherman Fong; Henry Lowman; Nicholas Skelton; David Jackson
Tetrahedron Letters, ISSN: 00404039
Georgette Castanedo; Dan Sutherlin
Methods in Molecular Biology, ISSN: 10643745
John Flygare; Dan Sutherlin; Brown
Nature Biotechnology, ISSN: 10870156
Gustavo R. Rosania; Young-Tae Chang; Omar Perez; Dan Sutherlin; Helin Dong; David J. Lockhart; Peter G. Schultz
Education
- University of California Berkeley, post doctoral research –, Postdoctoral Research – 1996-1998
- University of California Los Angeles, Ph.D. in Organic Chemistry – 1996
- Eckerd College, B.S. in Chemistry – 1991