Dan Sutherlin
Vice President, Small Molecule Discovery Chemistry
20
Years at Genentech
45
Publications
I started at Genentech in 1999 in what was then the Bioorganic Chemistry Department. I was attracted to Genentech based primarily on the people that were here, their enthusiasm for science, and the opportunity to work closely with world-class biologists. Since that time I have enjoyed the experience of working in many therapeutic areas (cardiovascular, oncology, immunology, and neuroscience) and on many different target classes including kinases, proteases, integrins, and ion-channels. In each project there have always been new and interesting challenges to overcome that has kept me curious about and engaged in the science of drug discovery.
Featured Publication
Discovery of a Potent, Selective, and Orally Available Class I Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor (GDC-0980) for the Treatment of Cancer.
J. Med. Chem. 2011, 54:7579.
Daniel P Sutherlin, Linda Bao, Megan Berry, Georgette Castanedo, Irina Chuckowree, Jenna Dotson, Adrian Folks, Lori Friedman, Richard Goldsmith, Janet Gunzner, Timothy Heffron, John Lesnick, Cristina Lewis, Simon Mathieu, Jeremy Murray, Jim Nonomiya, Jodie Pang, Niel Pegg, Wei Wei Prior, Lionel Rouge, Laurent Salphati, Deepak Sampath, Qingping Tian, Vickie Tsui, Nan Chi Wan, Shumei Wang, Binqing Wei, Christian Wiesmann, Ping Wu, Bing-Yan Zhu, Alan Olivero.
My Focus
I am currently the research and development project leader of a new and exciting Pain target. Mutations in this ion channel have profound effects on pain.
The chance to participate in such an exciting area of science while being focused on a serious unmet medical need has been motivating.
Publications
Journal of Pharmaceutical Sciences, ISSN: 15206017
Po-Chang Chiang; Dan Sutherlin; Jodie Pang; Laurent Salphati
Journal of Biological Chemistry, ISSN: 1083351X
Diana Ronai Dunshee; Travis Bainbridge; Noelyn Kljavin; Jose Zavala-Solorio; Amy Schroeder; Ruby Chan; Racquel Corpuz; Manda Wong; Wei Zhou; Gauri Deshmukh; Justin Ly; Dan Sutherlin; James Ernst; Jun Sonoda
ACS Medicinal Chemistry Letters, ISSN: 19485875
Thilo Focken; Shifeng Liu; Navjot Chahal; Maxim Dauphinais; Michael Grimwood; Sultan Chowdhury; Ivan Hemeon; Paul Bichler; David Bogucki; Matthew Waldbrook; Girish Bankar; Luis E. Sojo; Clint Young; Sophia Lin; Noah Shuart; Rainbow Kwan; Jodie Pang; Jae Chang; Brian Safina; Dan Sutherlin; Johnson; Christoph Dehnhardt; Tarek S. Mansour; Renata M. Oballa; Charles J. Cohen; C. Lee Robinette
ACS Symposium Series, ISSN: 19475918
Srinivasan Babu; Francis Gosselin; Theresa Cravillion; Alan Olivero; Dan Sutherlin; Qingping Tian
ACS Symposium Series, ISSN: 19475918
Remy Angelaud; Dan Sutherlin; Mark Reynolds; Scott Savage; Andy Stumpf
Science, ISSN: 10959203
Shivani Ahuja; Susmith Mukund; Lunbin Deng; Kuldip Khakh; Elaine Chang; Hoangdung Ho; Stephanie Shriver; Clint Young; Sophia Lin; Johnson; Ping Wu; Jun Li; Mary Coons; Christine Tam; Bobby Brillantes; Honorio Sampang; Kyle Mortara; Krista Bowman; Kevin Clark; Alberto Estevez; Zhiwei Xie; Henry Verschoof; Michael Grimwood; Christoph Dehnhardt; Jean-Christophe Andrez; Thilo Focken; Dan Sutherlin; Brian Safina; Melissa Starovasnik; Dan Ortwine; Yvonne Franke; Charles J. Cohen; David Hackos; Chris Koth; Jian Payandeh
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Brian Safina; Zach Sweeney; Jun Li; Bryan Chan; Angelina Bisconte; Diane Carrera; Georgette Castanedo; Mike Flagella; Robert Heald; Cris Lewis; Jeremy Murray; Jim Nonomiya; Jodie Pang; Steve Price; Karin Reif; Laurent Salphati; Eileen M. Seward; Binqing Wei; Dan Sutherlin
Toxicology and Applied Pharmacology, ISSN: 0041008X
Dolo Diaz; Kevin Ford; Dylan Hartley; Eric Harstad; Gary Cain; Kirsten Achilles Poon; Trung Nguyen; Jing Peng; Zhong Zheng; Mark Merchant; Dan Sutherlin; John J. Gaudino; Robert Kaus; Sock-Cheng Lewin-Koh; Edna Choo; Bianca Liederer; Donna Dambach
Journal of Medicinal Chemistry, ISSN: 00222623
Jeremy Murray; Zach Sweeney; Bryan Chan; Mercedesz Balazs; Erin Bradley; Georgette Castanedo; Christine Chabot; David Chantry; Mike Flagella; David M. Goldstein; Rama Kondru; John Lesnick; Jun Li; Matthew C. Lucas; Jim Nonomiya; Jodie Pang; Stephen Price; Laurent Salphati; Brian Safina; Pascal P. A. Savy; Eileen M. Seward; Mark Ultsch; Dan Sutherlin
Nature, ISSN: 00280836
Tim Wilson; Jane (Zhenya) Fridlyand; Yibing Yan; Elicia Penuel; Luciana Burton; Emily Chan; Jing Peng; Eva Lin; Yulei Wang; Jeffrey A. Sosman; Antoni Ribas; Jiang Li; John Moffat; Dan Sutherlin; Hartmut Koeppen; Mark Merchant; Rich Neve; Jeffrey Settleman
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Dan Sutherlin; Stewart Baker; Angelina Bisconte; Paul M. Blaney; Anthony Brown; Bryan Chan; David Chantry; Georgette Castanedo; Paul Depledge; Paul Goldsmith; David M. Goldstein; Timothy Hancox; Jasmit Kaur; David Knowles; Rama Kondru; John Lesnick; Matthew C. Lucas; Cris Lewis; Jeremy Murray; Alan J. Nadin; Jim Nonomiya; Jodie Pang; Neil Pegg; Steve Price; Karin Reif; Brian Safina; Laurent Salphati; Steven Staben; Eileen M. Seward; Stephen Shuttleworth; Sukhjit Sohal; Zach Sweeney; Mark Ultsch; Bohdan Waszkowycz; Binqing Wei
Journal of Medicinal Chemistry, ISSN: 00222623
Brian Safina; Stewart Baker; Matt Baumgardner; Paul M. Blaney; Bryan Chan; John Chen; Matthew W. Cartwright; Georgette Castanedo; Christine Chabot; Arnaud J. Cheguillaume; Paul Goldsmith; David M. Goldstein; Bindu Goyal; Timothy Hancox; Raj K. Handa; Pravin S Iyer; Jasmit Kaur; Rama Kondru; Jane Kenny; Sussie L. Krintel; Jun Li; John Lesnick; Matthew C. Lucas; Cris Lewis; Sophie Aurangabadwala; Jeremy Murray; Alan J. Nadin; Jim Nonomiya; Fernando Padilla; Wylie S. Palmer; Jodie Pang; Neil Pegg; Steve Price; Karin Reif; Laurent Salphati; Pascal P. A. Savy; Eileen M. Seward; Stephen Shuttleworth; Sukhjit Sohal; Zach Sweeney; Suzanne Brown; Parcharee Tivitmahaisoon; Bohdan Waszkowycz; Binqing Wei; Qin Yue; Chenghong Zhang; Dan Sutherlin
Xenobiotica, ISSN: 00498254
Bianca Liederer; Xingrong Liu; Leo Berezhkovskiy; Gary Cain; Xiao Ding; John J. Gaudino; Robert Kaus; Emile Plise; Dan Sutherlin; Eric Harstad
Molecular Cancer Therapeutics, ISSN: 15357163
Jeffrey Wallin; Kyle Edgar; Jane Guan; Megan Berry Swadell; Wei Wei Prior; Leslie Lee; John Lesnick; Cris Lewis; Jim Nonomiya; Jodie Pang; Laurent Salphati; Alan Olivero; Dan Sutherlin; Carol O'Brien; Jill Spoerke; Sonal Patel; Letitia Lensun; Robert Kassees; Leanne Ross; Mark Lackner; Deepak Sampath; Marcia Belvin; Lori Friedman
Advanced Synthesis and Catalysis, ISSN: 16154150
Andy Stumpf; Mark Reynolds; Dan Sutherlin; Srinivasan Babu; Erhard Bappert; Felix Spindler; Michael Welch; John J. Gaudino
Journal of Medicinal Chemistry, ISSN: 00222623
Tim Heffron; Binqing Wei; Alan Olivero; Steven Staben; Vickie Tsui; Steven Do; Jenna Dotson; Adrian J. Folkes; Paul Goldsmith; Rich Goldsmith; Janet Gunzner-Toste; John Lesnick; Cris Lewis; Simon Mathieu; Jim Nonomiya; Stephen Shuttleworth; Dan Sutherlin; Nan Chi Wan; Shumei Wang; Christian Wiesmann; Bing-Yan Zhu
Journal of Medicinal Chemistry, ISSN: 00222623
Dan Sutherlin; Linda Bao; Megan Berry Swadell; Georgette Castanedo; Irina Chuckowree; Jenna Dotson; Adrian Folks; Lori Friedman; Rich Goldsmith; Janet Gunzner-Toste; Tim Heffron; John Lesnick; Cris Lewis; Simon Mathieu; Jeremy Murray; Jim Nonomiya; Jodie Pang; Neil Pegg; Wei Wei Prior; Lionel Rouge; Laurent Salphati; Deepak Sampath; Qingping Tian; Vickie Tsui; Nan Chi Wan; Shumei Wang; Binqing Wei; Christian Wiesmann; Ping Wu; Bing-Yan Zhu; Alan Olivero
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Steven Staben; Mike Siu; Rich Goldsmith; Alan Olivero; Steven Do; Dan Burdick; Tim Heffron; Jenna Dotson; Dan Sutherlin; Bing-Yan Zhu; Vickie Tsui; Hoa Le; Leslie Lee; John Lesnick; Cris Lewis; Jeremy Murray; Jim Nonomiya; Jodie Pang; Wei Wei Prior; Laurent Salphati; Lionel Rouge; Deepak Sampath; Steve Sideris; Christian Wiesmann; Ping Wu
Cancer Research, ISSN: 00085472
Peter Dijkgraaf; Bruno Alicke; Lasse Weinmann; Tom Januario; Kristina West; Zora Modrusan; Dan Burdick; Rich Goldsmith; Kirk Robarge; Dan Sutherlin; Suzie Scales; Stephen Gould; Bob Yauch; Frederic De Sauvage
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Georgette Castanedo; Shumei Wang; Kirk Robarge; Beth Blackwood; Dan Burdick; Christine Chang; Peter Dijkgraaf; Stephen Gould; Janet Gunzner-Toste; Oivin Guichert; Jason Halladay; Cyrus Khojasteh; Leslie Lee; James Marsters; Lesley Murray; David Peterson; Emile Plise; Laurent Salphati; Frederic De Sauvage; Susan Wong; Dan Sutherlin
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Steven Staben; Tim Heffron; Dan Sutherlin; Seema Bhat; Georgette Castanedo; Irina Chuckowree; Jenna Dotson; Adrian J. Folkes; Lori Friedman; Leslie Lee; John Lesnick; Cris Lewis; Jeremy Murray; Jim Nonomiya; Alan Olivero; Emile Plise; Jodie Pang; Wei Wei Prior; Laurent Salphati; Lionel Rouge; Deepak Sampath; Vickie Tsui; Nan Chi Wan; Shumei Wang; Christian Weismann; Ping Wu; Bing-Yan Zhu
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Tim Heffron; Megan Berry Swadell; Georgette Castanedo; Christine Chang; Irina Chuckowree; Jenna Dotson; Adrian J. Folkes; Janet Gunzner-Toste; John Lesnick; Cris Lewis; Simon Mathieu; Jim Nonomiya; Alan Olivero; Jodie Pang; David Peterson; Laurent Salphati; Deepak Sampath; Steve Sideris; Dan Sutherlin; Vickie Tsui; Nan Chi Wan; Shumei Wang; Susan Wong; Bing-Yan Zhu
Journal of Medicinal Chemistry, ISSN: 00222623
Dan Sutherlin; Deepak Sampath; Megan Berry Swadell; Georgette Castanedo; Zhigang Chang; Irina Chuckowree; Jenna Dotson; Adrian J. Folkes; Lori Friedman; Rich Goldsmith; Tim Heffron; Leslie Lee; John Lesnick; Cris Lewis; Simon Mathieu; Jim Nonomiya; Alan Olivero; Jodie Pang; Wei Wei Prior; Laurent Salphati; Steve Sideris; Qingping Tian; Vickie Tsui; Nan Chi Wan; Shumei Wang; Christian Wiesmann; Susan Wong; Bing-Yan Zhu
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Kirk Robarge; Shirley A. Brunton; Georgette Castanedo; Yong Cui; Michael Dina; Rich Goldsmith; Stephen Gould; Oivin Guichert; Janet Gunzner-Toste; Jason Halladay; Wei Jia; Cyrus Khojasteh; Michael Koehler; Karen Kotkow; Hank La; Rebecca Lyn K. LaLonde; Kevin Lau; Leslie Lee; Derek Marshall; James Marsters; Lesley Murray; Changgeng Qian; Lee L. Rubin; Laurent Salphati; Mark Stanley; John H.A. Stibbard; Dan Sutherlin; Savita Ubhayakar; Shumei Wang; Susan Wong; Minli Xie
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Kirk Robarge; Shirley A. Brunton; Georgette Castanedo; Yong Cui; Michael Dina; Rich Goldsmith; Stephen Gould; Oivin Guichert; Janet Gunzner-Toste; Jason Halladay; Wei Jia; Cyrus Khojasteh; Michael Koehler; Karen Kotkow; Hank La; Rebecca Lyn K. LaLonde; Kevin Lau; Leslie Lee; Derek Marshall; James Marsters; Lesley Murray; Changgeng Qian; Lee L. Rubin; Laurent Salphati; Mark Stanley; John H.A. Stibbard; Dan Sutherlin; Savita Ubhayakar; Shumei Wang; Susan Wong; Minli Xie
Mini-Reviews in Medicinal Chemistry, ISSN: 13895575
Beni Wolf; Clifford Quan; Thuy Tran; Christian Wiesmann; Dan Sutherlin
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Thuy Tran; Clifford Quan; Conrad Edosada; Mark Mayeda; Christian Wiesmann; Dan Sutherlin; Beni Wolf
Journal of Biological Chemistry, ISSN: 00219258
Conrad Edosada; Clifford Quan; Christian Wiesmann; Thuy Tran; Dan Sutherlin; Mark Reynolds; Mike Elliott; Helga Raab; Wayne Fairbrother; Beni Wolf
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Georgette Castanedo; Kevin Clark; Shumei Wang; Vickie Tsui; Mengling Wong; John Nicholas; Dineli M. Wickramasinghe; James Marsters; Dan Sutherlin
Journal of Biological Chemistry, ISSN: 00219258
Alan Olivero; Charles Eigenbrot; Rich Goldsmith; Kirk Robarge; Dean R. Artis; John Flygare; Thomas Rawson; Dan Sutherlin; Saloumeh Kadkhodayan; Maureen Beresini; Linda Orren; Geralyn G. Deguzman; David W. Banner; Mark Ultsch; Ulla Marzec; Stephen R. Hanson; Ken Refino; Stuart Bunting; Daniel Kirchhofer
Biochemical Journal, ISSN: 02646021
Kelly M. Boatright; Cristina Deis; Jean-Bernard Denault; Dan Sutherlin; Guy S. Salvesen
Biochemistry, ISSN: 00062960
Jowita Mikolajczyk; Fiona L. Scott; Stan Krajewski; Dan Sutherlin; Guy S. Salvesen
Protein Journal, ISSN: 15723887
Samantha Lien; Rich Pastor; Dan Sutherlin; Henry Lowman
Molecular Cell, ISSN: 10972765
Kelly M. Boatright; Martin Renatus; Fiona L. Scott; Sabina Sperandio; Hwain Shin; Irene M. Pedersen; Jean-Ehrland Ricci; Wade A. Edris; Dan Sutherlin; Douglas R. Green; Guy S. Salvesen
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Georgette Castanedo; Fredrick C. Sailes; Dubree; John Nicholas; Lisa D. Caris; Kevin Clark; Susan Keating; Maureen Beresini; Henry Chiu; Sherman Fong; James Marsters; David Jackson; Dan Sutherlin
Journal of Medicinal Chemistry, ISSN: 00222623
Dubree; Dean R. Artis; Georgette Castanedo; James Marsters; Dan Sutherlin; Lisa D. Caris; Kevin Clark; Susan Keating; Maureen Beresini; Henry Chiu; Sherman Fong; Henry Lowman; Nicholas Skelton; David Jackson
Tetrahedron Letters, ISSN: 00404039
Georgette Castanedo; Dan Sutherlin
Methods in Molecular Biology, ISSN: 10643745
John Flygare; Dan Sutherlin; Brown
Nature Biotechnology, ISSN: 10870156
Gustavo R. Rosania; Young-Tae Chang; Omar Perez; Dan Sutherlin; Helin Dong; David J. Lockhart; Peter G. Schultz
Expert Opinion on Drug Discovery, ISSN: 1746045X
Stephen Gould; Jennifer Low; James Marsters; Kirk Robarge; Lee L. Rubin; Frederic De Sauvage; Dan Sutherlin; Harvey Wong; Bob Yauch
Design of Selective Benzoxazepin PI3Kδ Inhibitors Through Control of Dihedral Angles
ACS Medicinal Chemistry Letters,
Brian Safina; Richard Elliott; Andrew K. Forrest; Robert Heald; Jeremy Murray; Jim Nonomiya; Jodie Pang; Laurent Salphati; Eileen M. Seward; Steven Staben; Mark Ultsch; Binqing Wei; Wenqian Yang; Dan Sutherlin
Mechanism-specific assay design facilitates the discovery of Nav1.7-selective inhibitors
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424
Tania Chernov-Rogan; Tianbo Li; Gang Lu; Henry Verschoof; Kuldip Khakh; Steven W Jones; Maureen Beresini; Chang Liu; Dan Ortwine; Steven J. McKerrall; David Hackos; Dan Sutherlin; Charles J. Cohen; Jun Chen
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Thilo Focken; Sultan Chowdhury; Alla Zenova; Michael Grimwood; Christine Chabot; Tao Sheng; Ivan Hemeon; Shannon M. Decker; Michael Wilson; Paul Bichler; Qi Jia; Shaoyi Sun; Clint Young; Sophia Lin; Samuel J. Goodchild; Noah Shuart; Elaine Chang; Zhiwei Xie; Bowen Li; Kuldip Khakh; Girish Bankar; Matthew Waldbrook; Rainbow Kwan; Karen Nelkenbrecher; Parisa Karimi Tari; Navjot Chahal; Luis E. Sojo; C. Lee Robinette; Andrew D. White; Chien-An Chen; Yi Zhang; Jodie Pang; Jae Chang; David Hackos; Johnson; Charles J. Cohen; Dan Ortwine; Dan Sutherlin; Christoph Dehnhardt; Brian Safina
Cell Reports, ISSN: 22111247
Girish Bankar; Samuel J. Goodchild; Sarah Howard; Karen Nelkenbrecher; Matthew Waldbrook; Michelle Dourado; Noah Shuart; Sophia Lin; Clint Young; Zhiwei Xie; Kuldip Khakh; Elaine Chang; Luis E. Sojo; Andrea Lindgren; Sultan Chowdhury; Shannon M. Decker; Michael Grimwood; Jean-Christophe Andrez; Christoph Dehnhardt; Jodie Pang; Jae H. Chang; Brian Safina; Dan Sutherlin; James P. Johnson; David Hackos; C. Lee Robinette; Charles J. Cohen
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Shaoyi Sun; Qi Jia; Alla Zenova; Michael S. Wilson; Sultan Chowdhury; Thilo Focken; Jun Li; Shannon M. Decker; Michael Grimwood; Jean-Christophe Andrez; Ivan Hemeon; Tao Sheng; Chien-An Chen; Andrew D. White; David Hackos; Lunbin Deng; Girish Bankar; Kuldip Khakh; Elaine Chang; Rainbow Kwan; Sophia Lin; Karen Nelkenbrecher; Ben Sellers; Antonio DiPasquale; Jae H. Chang; Jodie Pang; Luis E. Sojo; Andrea Lindgren; Matthew Waldbrook; Zhiwei Xie; Clint Young; James P. Johnson; C. Lee Robinette; Charles J. Cohen; Brian Safina; Dan Sutherlin; Dan Ortwine; Christoph Dehnhardt
Education
- University of California Berkeley, post doctoral research –, Postdoctoral Research – 1996-1998
- University of California Los Angeles, Ph.D. in Organic Chemistry – 1996
- Eckerd College, B.S. in Chemistry – 1991
