"At Genentech, helping patients becomes a reality through innovation and high performing teamwork."
I am a stem cell and developmental biologist interested in the fundamental processes underlying tissue regeneration and degeneration. My lab aims to elucidate the signaling circuits that regulate the interaction between stem cells and their surroundings, which are responsible for homeostasis and regeneration. We test our hypothesis using our expertise in developing and applying genetic and pharmacology tools to manipulate cell decisions with unprecedented regional, cell type, and temporal specificity. Our ultimate goal is to utilize fundamental discoveries to develop therapeutics to regenerate and rejuvenate epithelial tissues, including the intestine, during disease-driven injury and aging.
J Clin Invest. 2023.
Cell Stem Cell. 2023.
EMBO J.. 2019.
My lab efforts are concentrated on revealing fundamental cellular mechanisms that regulate tissue cell flux balance and providing clinically relevant insights for regenerative and geriatric medicine. Current projects focus on: