Deepak A. Lamba - Distinguished Scientist/Retinal Pathobiology, Immunology, Regenerative Medicine, Research Biology

Deepak A. Lamba

Distinguished Scientist/Retinal Pathobiology, Immunology, Regenerative Medicine, Research Biology

Postdoc Mentor
"Vision is one of our most valuable senses, shaping how we experience and navigate life. I am excited to apply my medical and research expertise to develop novel therapeutics to improve vision outcomes in the community. "
Awards & Honors

My journey began in Mumbai, India where I received my medical training. Early in my practice, I developed an interest into the future of medicine and moved to the US to pursue it. I received a Master's degree in Bioengineering from the University of Illinois, Chicago that then culminated in a PhD from the University of Washington, Seattle. Before joining Genentech, I had the privilege of directing academic labs at the Buck Institute for Research on Aging and the University of California, San Francisco. 

My focus has been on pioneering stem cell therapies and advancing human retinal disease modeling to identify targeted therapies. My research interests are anchored in emergent innovative therapies and developing 3D disease model systems to validate them. Genentech, with its innovative spirit and collaborative nature, has provided me with the perfect platform to do this. My goal is to push boundaries of scientific discovery to improve the lives of individuals impacted by different forms of blindness.

Postdoctoral Mentor

Innovations in my lab have always been driven through basic research by an amazing group of technicians, students and fellows in the lab. As a postdoctoral mentor, my philosophy is to tailor mentorship to each individual. My goal is to encourage independence and initiative, fostering a sense of autonomy and self-direction while working in a collaborative and inclusive environment with respect. Postdoc projects are focused on developing novel in vitro disease models for understanding disease pathogenesis and/or test novel therapeutic hypothesis for retinal diseases.

Featured Publication

Allele-specific gene editing to rescue dominant CRX-associated Leber congenital amaurosis (LCA7) phenotypes in a retinal organoid model.

Stem Cell Reports 16, 1–13, 2021

Chirco, K.R., Chew, S., Moore, A.T., Duncan, J.L., Lamba, DA.

MANF regulates metabolic and immune homeostasis in ageing and protects against liver damage.

Nature Metabolism. (1):276-290, 2019

Sousa-Victor P, Neves J, Cedron-Craft W, Ventura PB, Liao CY, Riley RR, Soifer I, van Bruggen N, Kolumam GA, Villeda SA, Lamba DA, Jasper H.

Immunosuppression via loss of IL2rγ enhances long-term functional integration of hESC-derived photoreceptors in mouse retina.

Cell Stem Cell. 20(3):374-384.e5, 2017

Zhu J, Cifuentes H, Reynolds J, Lamba DA.

Immune modulation by MANF promotes tissue repair and regenerative success in the retina.

Science. Jul 1;353(6294), 2016

Neves J, Zhu J, Sousa-Victor P, Konjikusic M, Riley R, Chew S, Qi Y, Jasper H, Lamba DA.