Domagoj Vucic
Principal Scientist, Early Discovery Biochemistry
Postdoc Mentor
Staff Scientist
"Blocking cell death to prevent tissue damage"
21
Years at Genentech
78
Publications
My laboratory studies the biological role of regulators of cell death and signaling pathways (e.g. ubiquitination-mediated regulation of NF-κB pathways), and their involvement in cellular processes triggered by TNF family ligands and other pro-inflammatory stimuli. As part of this effort we are studying how ubiquitination, phosphorylation and other post-translational modifications affect functional properties of mediators of various signaling pathways including apoptosis, necroptosis and NF-κB activation. To this end we are exploring the therapeutic potential of targeting select kinases and ubiquitin ligases for the treatment of uncontrolled inflammatory responses and/or enhancement of the survival of damaged tissues.
Postdoctoral Mentor
I cherish the opportunity to coach young scientists and guide their energy and enthusiasm for science into well organized thoughts and carefully planned experiments that will lay the foundation for their future scientific careers.
Featured Publication
RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury.
Cell Death Differ. 2016 Sep 1;23(9):1565-76.
Newton K, Dugger DL, Maltzman A, Greve JM, Hedehus M, Martin-McNulty B, Carano RA, Cao TC, van Bruggen N, Bernstein L, Lee WP, Wu X, DeVoss J, Zhang J, Jeet S, Peng I, McKenzie BS, Roose-Girma M, Caplazi P, Diehl L, Webster JD, Vucic D.
My Focus
We are investigating the physiological role of RIP family of kinases and inhibitors of apoptosis (IAP) proteins in modulation of immune responses. IAP proteins physically interact with a variety of mediators of inflammation and cell death and they regulate these signaling pathways by promoting ubiquitination of RIP1 and RIP2 kinases. In collaboration with other groups at Genentech we are developing genetic models and small-molecule compounds to evaluate the physiological contribution and therapeutic potential of distinct IAP proteins and RIP kinases in diseases impacted by inflammatory and cell death.
Publications
Cell Reports, ISSN: 22111247
Jieqiong Zhang; Webster; Debbie Dugger; Tanya Goncharov; Meron Roose-Girma; Jeffrey Hung; Youngsu Kwon; Domagoj Vucic; Kim Newton; Vishva Dixit
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Gregory L. Hamilton; Huifen Chen; Gauri Deshmukh; Charles Eigenbrot; Rina Fong; Adam Johnson; Pawan Bir Kohli; Patrick Lupardus; Bianca Liederer; Sreema Ramaswamy; Haowei Wang; Jian Wang; Zhaowu Xu; Yunliang Zhu; Domagoj Vucic; Snahel Patel
RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases
Cell Death and Differentiation, ISSN: 13509047
Snahel Patel; Webster; Eugene Varfolomeev; Youngsu Kwon; Jason Cheng; Juan Zhang; Debbie Dugger; Kate Wickliffe; Maltzman; Swathi Sujatha-Bhaskar; Pawan Bir Kohli; Sreema Ramaswamy; Gauri Deshmukh; Bianca Liederer; Rina Fong; Gregory L. Hamilton; Patrick Lupardus; Patrick Caplazi; Wyne P. Lee; Menno van Lookeren Campagne; Adam Johnson; Brent McKenzie; Melissa Junttila; Kim Newton; Domagoj Vucic
Nature, ISSN: 14764687 00280836
Klaus Heger; Kate Wickliffe; Ada Ndoja; Juan Zhang; Aditya Murthy; Debbie Dugger; Maltzman; Felipe de Sousa e Melo; Jeffrey Hung; Yi Zeng; Erik Verschueren; Don Kirkpatrick; Domagoj Vucic; Wyne Lee; Meron Roose-Girma; Robert J (Research) Newman; Soren Warming; Yi-Chun Hsiao; László Kömüves; Webster; Kim Newton; Vishva Dixit
Oncotarget, ISSN: 19492553
Domagoj Vucic
Molecular Cell, ISSN: 10974164 10972765
Tanya Goncharov; Stefanie Hedayati; Melinda M. Mulvihill; Anita Izrael-Tomasevic; Kerry Zobel; Surinder Jeet; Anna Fedorova; Celine Eidenschenk; Jason DeVoss; Kebing Yu; Andrey S. Shaw; Don Kirkpatrick; Wayne Fairbrother; Kurt Deshayes; Domagoj Vucic
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
Cell Death and Differentiation, ISSN: 13509047
Galluzzi; Vitale; Aaronson; Abrams; Dieter Adam; Patrizia Agostinis; Alnemri; Altucci; Ivano Amelio; Andrews; Margherita Annicchiarico-Petruzzelli; Antonov; Eli Arama; Eric H. Baehrecke; Barlev; Bazan; Francesca Bernassola; Bertrand; Bianchi; Blagosklonny; Blomgren; Borner; Patricia Boya; Catherine Brenner; Michelangelo Campanella; Eleonora Candi; Didac Carmona-Gutierrez; Francesco Cecconi; Chan; Navdeep S. Chandel; Cheng; Chipuk; Cidlowski; Ciechanover; Cohen; Marcus Conrad; Cubillos-Ruiz; Czabotar; Vincenzo D’Angiolella; Dawson; Dawson; De Laurenzi; De Maria; Debatin; DeBerardinis; Mohanish Deshmukh; Di Daniele; Francesco Di Virgilio; Dixit; Dixon; Duckett; Dynlacht; Wafik S. El-Deiry; Elrod; Gian Maria Fimia; Fulda; García-Sáez; Abhishek D. Garg; Carmen Garrido; Evripidis Gavathiotis; Pierre Golstein; Eyal Gottlieb; Green; Greene; Gronemeyer; Atan Gross; Hajnoczky; Hardwick; Harris; Hengartner; Claudio Hetz; Hidenori Ichijo; Marja Jäättelä; Bertrand Joseph
Cell Death and Differentiation, ISSN: 14765403 13509047
Axel Witt; Domagoj Vucic
The kinase TPL2 activates ERK and p38 signaling to promote neutrophilic inflammation
Science Signaling, ISSN: 19450877
Kate Senger; Victoria Pham; Eugene Varfolomeev; Jason Hackney; Alex Corzo; Jenna Collier; Vivian W. C. Lau; Zhiyu Huang; Kajal Hamidzhadeh; Patrick Caplazi; Ivan Peng; Francesca Setiadi; Ross Francis; Andres Paler Martinez; Youngsu Kwon; Vladimir Ramirez Carrozzi; Yonglian Sun; Patricia Grigg; Meron Roose-Girma; Surinder Jeet; Kai Barck; Anna Pham; Ota; Connie Ha; Jeremy Stinson; Joe Guillory; Lucinda Tam; Zora Modrusan; Claire Emson; Brent McKenzie; Michael Townsend; Rick Carano; Soren Warming; Domagoj Vucic; Jason De Voss; Wyne Lee; Jennie Lill; Ali Zarrin
Science Signaling, ISSN: 19379145
Kate Senger; Victoria Pham; Eugene Varfolomeev; Jason Hackney; Alex Corzo; Jenna Collier; Vivian W. C. Lau; Zhiyu Huang; Kajal Hamidzhadeh; Patrick Caplazi; Ivan Peng; Francesca Setiadi; Ross Francis; Andres Paler Martinez; Youngsu Kwon; Vladimir Ramirez Carrozzi; Yonglian Sun; Patricia Grigg; Meron Roose-Girma; Surinder Jeet; Kai Barck; Anna Pham; Neko Ota; Connie Ha; Jeremy Stinson; Joe Guillory; Lucinda Tam; Zora Modrusan; Claire Emson; Brent McKenzie; Michael Townsend; Rick Carano; Soren Warming; Domagoj Vucic; Jason De Voss; Wyne Lee; Jennie Lill; Ali Zarrin
Cell Death and Differentiation, ISSN: 14765403
Maria Cristina De Almagro; Tanya Goncharov; Anita Izrael-Tomasevic; Stefanie Duttler; Matthias Kist; Eugene Varfolomeev; Xiumin Wu; Wyne Lee; Jeremy Murray; Joshua Webster; Kebing Yu; Don Kirkpatrick; Kim Newton; Domagoj Vucic
Cell Death and Differentiation, ISSN: 14765403
Kim Newton; Debbie Dugger; Maltzman; Joan Greve; Maj Hedehus; Baby Martin-Mcnulty; Rick Carano; Cao; Nick Van Bruggen; Bernstein; Wyne Lee; Xiumin Wu; Jason DeVoss; Zhang; Surinder Jeet; Peng; Brent McKenzie; Meron Roose-Girma; Patrick Caplazi; Lauri Diehl; Webster; Vucic
Cytokine, ISSN: 10960023
Eugene Varfolomeev; Domagoj Vucic
Seminars in Nephrology, ISSN: 15584488
Jay Garg; Domagoj Vucic
Oncotarget, ISSN: 19492553
Sonja C. Lueck; Annika C. Russ; Ursula Botzenhardt; Richard F. Schlenk; Kerry Zobel; Kurt Deshayes; Domagoj Vucic; Hartmut Doḧner; Konstanze Döhner; Simone Fulda; Lars Bullinger
Cell Death and Disease, ISSN: 20414889
Maria Cristina De Almagro; Tanya Goncharov; Kim Newton; Domagoj Vucic
Journal of Molecular Biology, ISSN: 10898638
Kebing Yu; Lilian Phu; Eugene Varfolomeev; Daisy Bustos; Domagoj Vucic; Don Kirkpatrick
Cell Death and Disease, ISSN: 20414889
Cristofanon; Behnaz Ahangarian Abhari; Krueger; Tchoghandjian; Momma; Calaminus; Domagoj Vucic; Pichler; Fulda
Biochemical Journal, ISSN: 14708728
Eugene Varfolomeev; Anita Izrael-Tomasevic; Kebing Yu; Daisy Bustos; Tanya Goncharov; Lisa Belmont; Alexandre Masselot; Corey Bakalarski; Don Kirkpatrick; Domagoj Vucic
Encyclopedia of Cell Biology,
Cristina de Almagro; Domagoj Vucic
Seminars in Cell and Developmental Biology, ISSN: 10963634
Maria Cristina De Almagro; Domagoj Vucic
Cell Death: Mechanism and Disease,
Domagoj Vucic
Nature Medicine, ISSN: 1546170X
Doris Popovic; Domagoj Vucic; Ivan Dikic
Science, ISSN: 10959203
Kim Newton; Debbie Dugger; Kate Wickliffe; Neeraj Kapoor; Maria Cristina De Almagro; Domagoj Vucic; László Kömüves; Ronald Ferrando; Dorothy French; Webster; Meron Roose-Girma; Soren Warming; Vishva Dixit
Methods in Enzymology, ISSN: 15577988
John Silke; Domagoj Vucic
Nature Structural and Molecular Biology, ISSN: 15459985
Jacob Corn; Domagoj Vucic
Frontiers in Immunology, ISSN: 16643224
Domagoj Vucic
Cancer Cell, ISSN: 15356108
Ariel Pribluda; Ela Elyada; Zoltan Wiener; Haya Hamza; RobertE. Goldstein; Moshe Biton; Ido Burstain; Yael Morgenstern; Guy Brachya; Hana Billauer; Sharon Biton; Irit Snir-Alkalay; Domagoj Vucic; Katharina Schlereth; Marco Mernberger; Thorsten Stiewe; Moshe Oren; Kari Alitalo; Eli Pikarsky; Yinon Ben-Neriah
Cancer Letters, ISSN: 03043835
Jasmin Dynek; Domagoj Vucic
EMBO Journal, ISSN: 02614189
Tanya Goncharov; Kyle Niessen; Maria Cristina De Almagro; Anita Izrael-Tomasevic; Anna Fedorova; Eugene Varfolomeev; David Arnott; Kurt Deshayes; Don Kirkpatrick; Domagoj Vucic
Oncogene, ISSN: 09509232
Wagner; Marschall; Karl; Cristofanon; Kerry Zobel; Kurt Deshayes; Domagoj Vucic; Debatin; Fulda
Journal of Biological Chemistry, ISSN: 00219258
Conor J. Kearney; Clare Sheridan; Sean P. Cullen; Graham A. Tynan; Susan E. Logue; Inna S. Afonina; Domagoj Vucic; Ed C. Lavelle; Seamus J. Martin
Biochemical Journal, ISSN: 02646021
Eugene Varfolomeev; Elham Moradi; Jasmin Dynek; Jiping Zha; Anna Fedorova; Kurt Deshayes; Wayne Fairbrother; Kim Newton; Jenn Le Couter; Domagoj Vucic
Experimental Oncology, ISSN: 18129269
Maria Cristina De Almagro; Domagoj Vucic
Topics in Medicinal Chemistry, ISSN: 18622461
Kurt Deshayes; Jeremy Murray; Domagoj Vucic
Biochemical Journal, ISSN: 02646021
Daniel Kirchhofer; Domagoj Vucic
Journal of Medicinal Chemistry, ISSN: 00222623
John Flygare; Maureen Beresini; Nageshwar Budha; Helen Chan; Iris Chan; Sravanthi Cheeti; Fred Cohen; Kurt Deshayes; Karl Doerner; Gail Eckhardt; Linda Orren; Bainian Feng; Matthew C. Franklin; Stacy Reisner; Lewis Gazzard; Jason Halladay; Sarah Hymowitz; Hank La; Patricia M. LoRusso; Brigitte Maurer; Lesley Murray; Emile Plise; Clifford Quan; Daniel Stephan; Young Shin; Jeffrey Tom; Vickie Tsui; Joann M. Um; Eugene Varfolomeev; Domagoj Vucic; Andrew Wagner; Heidi Ackerly Wallweber; Lan Wang; Joseph Ware; Kobe Wen; Harvey Wong; Jonathan Wong; Melisa Wong; Susan Wong; Ron Yu; Kerry Zobel; Wayne Fairbrother
Science Signaling, ISSN: 19450877
Eugene Varfolomeev; Tanya Goncharov; Heather Maecker; Kerry Zobel; László Kömüves; Kurt Deshayes; Domagoj Vucic
Nature Reviews Drug Discovery, ISSN: 14741776
Fulda; Domagoj Vucic
Advances in Experimental Medicine and Biology, ISSN: 00652598
Domagoj Vucic
Advances in Experimental Medicine and Biology, ISSN: 00652598
John Silke; Domagoj Vucic
Neoplasia (United States), ISSN: 15228002
Dominic Stadel; Cristofanon; Behnaz Ahangarian Abhari; Kurt Deshayes; Kerry Zobel; Domagoj Vucic; Debatin; Fulda
Science, ISSN: 10959203
Erin Dueber; Allyn Schoeffler; Andreas Lingel; Mike Elliott; Anna Fedorova; Tony Giannetti; Kerry Zobel; Brigitte Maurer; Eugene Varfolomeev; Ping Wu; Heidi Ackerly Wallweber; Sarah Hymowitz; Kurt Deshayes; Domagoj Vucic; Wayne Fairbrother
Neoplasia (United States), ISSN: 15228002
Bram Laukens; Claudia Jennewein; Barbara Schenk; Nele Vanlangenakker; Alexander Schier; Cristofanon; Kerry Zobel; Kurt Deshayes; Domagoj Vucic; Irmela Jeremias; Mathieu J.M. Bertrand; Vandenabeele; Fulda
Nature Reviews Molecular Cell Biology, ISSN: 14710072
Domagoj Vucic; Vishva Dixit; Ingrid Wertz
Molecular and Cellular Proteomics, ISSN: 15359476
Lilian Phu; Anita Izrael-Tomasevic; Marissa Matsumoto; Daisy Bustos; Jasmin Dynek; Anna Fedorova; Corey Bakalarski; David Arnott; Kurt Deshayes; Vishva Dixit; Robert Kelley; Domagoj Vucic; Don Kirkpatrick
Future Oncology, ISSN: 14796694
Eugene Varfolomeev; Domagoj Vucic
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424
Christy Ong; Adrian Jubb; Pete Haverty; Wei Zhou; Victoria Tran; Tom Truong; Helen Turley; Thomas O'Brien; Domagoj Vucic; Adrian L. Harris; Marcia Belvin; Lori Friedman; Beth Blackwood; Hartmut Koeppen; Klaus Hoeflich
Cell Death and Differentiation, ISSN: 13509047
Nele Vanlangenakker; Vanden Berghe; Bogaert; Bram Laukens; Kerry Zobel; Kurt Deshayes; Domagoj Vucic; Fulda; Vandenabeele; Mathieu J.M. Bertrand
EMBO Journal, ISSN: 02614189
Jasmin Dynek; Tanya Goncharov; Erin Dueber; Anna Fedorova; Anita Izrael-Tomasevic; Lilian Phu; Elizabeth Helgason; Wayne Fairbrother; Kurt Deshayes; Don Kirkpatrick; Domagoj Vucic
IDrugs, ISSN: 13697056
Domagoj Vucic
Targeting inhibitor of apoptosis (IAP) proteins in cancer
Apoptosis: Modern Insights into Disease from Molecules to Man,
Eugene Varfolomeev; Domagoj Vucic
Journal of Biological Chemistry, ISSN: 00219258
Eugene Varfolomeev; Bruno Alicke; Mike Elliott; Kerry Zobel; Kristina West; Harvey Wong; Justin Scheer; Avi Ashkenazi; Stephen Gould; Wayne Fairbrother; Domagoj Vucic
Future Medicinal Chemistry, ISSN: 17568919
Chudi Ndubaku; Fred Cohen; Eugene Varfolomeev; Domagoj Vucic
Journal of Experimental Medicine, ISSN: 00221007
Domagoj Vucic; Vishva Dixit
ACS Chemical Biology, ISSN: 15548929
Chudi Ndubaku; Eugene Varfolomeev; Lan Wang; Kerry Zobel; Kevin Lau; Linda Orren; Brigitte Maurer; Anna Fedorova; Jasmin Dynek; Michael Koehler; Sarah Hymowitz; Vickie Tsui; Kurt Deshayes; Wayne Fairbrother; John Flygare; Domagoj Vucic
Future Oncology, ISSN: 14796694
John Flygare; Domagoj Vucic
Journal of Medicinal Chemistry, ISSN: 00222623
Fred Cohen; Bruno Alicke; Linda Orren; John Flygare; Tanya Goncharov; Stephen Keteltas; Matthew C. Franklin; Stacy Frankovitz; Daniel Stephan; Vickie Tsui; Domagoj Vucic; Harvey Wong; Wayne Fairbrother
Biochemical Journal, ISSN: 02646021
John Blankenship; Eugene Varfolomeev; Tanya Goncharov; Anna Fedorova; Don Kirkpatrick; Anita Izrael-Tomasevic; Lilian Phu; David Arnott; Mariam Aghajan; Kerry Zobel; Fernando Bazan; Wayne Fairbrother; Kurt Deshayes; Domagoj Vucic
Journal of Biological Chemistry, ISSN: 00219258
Eugene Varfolomeev; Tanya Goncharov; Anna Fedorova; Jasmin Dynek; Kerry Zobel; Kurt Deshayes; Wayne Fairbrother; Domagoj Vucic
Cell Cycle, ISSN: 15514005
Eugene Varfolomeev; Domagoj Vucic
Cancer Research, ISSN: 00085472
Jasmin Dynek; Sara Chan; Jinfeng Liu; Jiping Zha; Wayne Fairbrother; Domagoj Vucic
Current Cancer Drug Targets, ISSN: 15680096
Domagoj Vucic
Current Cancer Drug Targets, ISSN: 15680096
Domagoj Vucic
Cell, ISSN: 00928674
Eugene Varfolomeev; John Blankenship; Sarah Wayson; Anna Fedorova; Nobuhiko Kayagaki; Parie Garg; Kerry Zobel; Jasmin Dynek; Linda Orren; Heidi Ackerly Wallweber; John Flygare; Wayne Fairbrother; Kurt Deshayes; Vishva Dixit; Domagoj Vucic
Clinical Cancer Research, ISSN: 10780432
Domagoj Vucic; Wayne Fairbrother
Cancer Investigation, ISSN: 07357907
Kim Newton; Domagoj Vucic
Journal of Biological Chemistry, ISSN: 00219258
Eugene Varfolomeev; Sarah Wayson; Vishva Dixit; Wayne Fairbrother; Domagoj Vucic
ACS Chemical Biology, ISSN: 15548937
Kerry Zobel; Lan Wang; Eugene Varfolomeev; Matthew C. Franklin; Linda Orren; Heidi Ackerly Wallweber; David C. Okawa; John Flygare; Domagoj Vucic; Wayne Fairbrother; Kurt Deshayes
Journal of Biological Chemistry, ISSN: 00219258
Eugene Varfolomeev; Heather Maecker; Darcie Sharp; David Lawrence; Mark Renz; Domagoj Vucic; Avi Ashkenazi
Biochemical Journal, ISSN: 02646021
Domagoj Vucic; Matthew C. Franklin; Heidi Ackerly Wallweber; Kanad Das; Brendan P. Eckelman; Hwain Shin; Linda Orren; Saloumeh Kadkhodayan; Kurt Deshayes; Guy S. Salvesen; Wayne Fairbrother
Nature, ISSN: 00280836
Sanjeev Mariathasan; Kim Hewton; Denise M. Monack; Domagoj Vucic; Dorothy French; Wyne Lee; Meron Roose-Girma; Sharon Erickson; Vishva Dixit
Biochemistry, ISSN: 00062960
Matthew C. Franklin; Saloumeh Kadkhodayan; Heidi Ackerly Wallweber; Daniela Alexandru; Natascha Di Stefano; Linda Orren; John Flygare; Grace J. Mausisa; David C. Okawa; Danny Ong; Domagoj Vucic; Kurt Deshayes; Wayne Fairbrother
Biochemical Journal, ISSN: 14708728
Sanjeev Mariathasan; Domagoj Vucic
Journal of Biological Chemistry, ISSN: 00219258
Domagoj Vucic; Kurt Deshayes; Heidi Ackerly Wallweber; Maria T. Pisabarro; Saloumeh Kadkhodayan; Wayne Fairbrother; Vishva Dixit
Current Biology, ISSN: 09609822
Domagoj Vucic; Henning R. Stennicke; Maria T. Pisabarro; Guy S. Salvesen; Vishva Dixit
Journal of Biological Chemistry, ISSN: 00219258
Somasekar Seshagiri; Domagoj Vucic; James Lee; Vishva Dixit
FEBS Letters, ISSN: 00145793
William J. Kaiser; Domagoj Vucic; Lois K. Miller
Education
- Genentech, Inc., Postdoctoral Fellow – 1998-2001
- University of Georgia, Athens, GA, USA, Ph.D. in Genetics – 1998
- University of Zagreb, Zagreb, Croatia, B.S. in Molecular Biology – 1992