Scientists / Our Scientists

Donglu Zhang

Senior Fellow, Drug Metabolism & Pharmacokinetics

"Innovation and collaboration drive pharmaceutical breakthroughs."

Years at Genentech

Awards & Honors

It is a privilege to work at Genentech with highly motivated and talented scientists who transform science, medicine, and society through innovation and deep commitment to patients.

Featured Publication

Industry Perspective on the Pharmacokinetic and ADME Characterization of Heterobifunctional Protein Degraders.

Drug Metab Dispos.

Zhang et al., (2023)

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Design and Measurement of Drug Tissue Concentration Asymmetry and Tissue Exposure-Effect (Tissue PK-PD) Evaluation.

J Med Chem.

Zhang et al., (2022)

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Intestinal excretion, enteroenteric recirculation and renal tubule recirculation are a under-appreciated pharmacokinetic driver for small molecule drugs.

J Med Chem.

Zhang et al., (2021)

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Intestinal Excretion, Intestinal Recirculation, and Renal Tubule Reabsorption Are Underappreciated Mechanisms That Drive the Distribution and Pharmacokinetic Behavior of Small Molecule Drugs.

J Med Chem.

Zhang et al., (2021)

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Linker Design Impacts Antibody-Drug Conjugate Pharmacokinetics and Efficacy via Modulating the Stability and Payload Release Efficiency.

Front Pharmacol.

Zhang, d.; Su, d. (2021)

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Exposure-effect analysis of antibody-drug conjugates delivering an excess level of payload to tumors.

Drug Metab Dispos, 47:1146.

Zhang et al., (2019)

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Tissue concentration asymmetry for novel therapeutic modalities.

Drug Metab Dispos, 47:1122.

Zhang et al., (2019)

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At Genentech, working together with many dedicated scientists, I am motivated to apply state-of-the-art technologies to deepen understanding of mechanisms of action and drivers of drug metabolism and pharmacokinetics for discovery and development of small molecules and antibody-drug conjugates.

University of Utah, Salt Lake City, Ph.D. in Organic Chemistry –

Sir James Black award – 2018
Ondetti and Cushman award – 2007

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Donglu Zhang

Senior Fellow, Drug Metabolism & Pharmacokinetics

Featured Publication

Industry Perspective on the Pharmacokinetic and ADME Characterization of Heterobifunctional Protein Degraders.

Design and Measurement of Drug Tissue Concentration Asymmetry and Tissue Exposure-Effect (Tissue PK-PD) Evaluation.

Intestinal excretion, enteroenteric recirculation and renal tubule recirculation are a under-appreciated pharmacokinetic driver for small molecule drugs.

Intestinal Excretion, Intestinal Recirculation, and Renal Tubule Reabsorption Are Underappreciated Mechanisms That Drive the Distribution and Pharmacokinetic Behavior of Small Molecule Drugs.

Linker Design Impacts Antibody-Drug Conjugate Pharmacokinetics and Efficacy via Modulating the Stability and Payload Release Efficiency.

Exposure-effect analysis of antibody-drug conjugates delivering an excess level of payload to tumors.

Tissue concentration asymmetry for novel therapeutic modalities.