Scientists / Our Scientists

Erin Dueber

Distinguished Scientist and Director, Biological Chemistry, Early Discovery Biochemistry, Drug Discovery

Postdoc Mentor

16

Years at Genentech

23

Publications at Genentech

4

Awards & Honors

I joined Genentech as a Principal Scientist in 2008 after completing a postdoctoral fellowship at the Miller Institute for Basic Research in Science at UC Berkeley. I was drawn to the position in the Early Discovery Biochemistry Department as it promised to be a great opportunity to use my skills as a biophysicist to study molecular mechanisms that underlie complex biology and to work with very smart, talented people—all while having the potential to impact patients. Genentech did not disappoint. The emphasis on basic research and the highly collaborative environment makes this a great place to do interesting and meaningful science.

Postdoctoral Mentor

Genentech has a very strong postdoc program that helps drive our basic research efforts. I feel very fortunate to have the opportunity to mentor postdoctoral fellows in my lab.

Featured Publication

Targeted degradation via direct 26S proteasome recruitment.

Nat Chem Biol. 2023

Charlene Bashore, Sumit Prakash, Matthew C Johnson, Ryan J Conrad, Ivy A Kekessie, Suzie J Scales, Noriko Ishisoko, Tracy Kleinheinz, Peter S Liu, Nataliya Popovych, Aaron T Wecksler, Lijuan Zhou, Christine Tam, Inna Zilberleyb, Rajini Srinivasan, Robert A Blake, Aimin Song, Steven T Staben , Yingnan Zhang, David Arnott, Wayne J Fairbrother, Scott A Foster, Ingrid E Wertz, Claudio Ciferri, Erin C Dueber

My lab uses a combination of biochemical, biophysical and structural methods to investigate how proteins function in both normal biology and disease states. We usually take a reductionist approach, utilizing purified components to study the detailed molecular mechanisms of proteins and larger complexes, which we then put into the context of the more complex cellular environment through close collaboration with expert biologists. Currently, we have research projects in the areas of oncology, innate immunity, and infectious disease, with a special interest in how post-translational modifications, allostery, and dynamics impact molecular interactions and cellular signaling.

N-tert-Butoxycarbonyl-N-(2-(tritylthio)ethoxy)glycine as a Building Block for Peptide Ubiquitination

Bioconjugate Chemistry, ISSN: 10431802

Lingling Peng; Elizabeth Helgason; Rafael Miranda; Jeffrey Tom; Jennifer Zhang; Erin C. Dueber; Aimin Song

Targeted degradation via direct 26S proteasome recruitment

Nature Chemical Biology, ISSN: 15524469 15524450

Charlene Bashore; Sumit Prakash; Matthew C. Johnson; Ryan J. Conrad; Ivy Kekessie; Suzie J. Scales; Noriko Ishisoko; Tracy L. Kleinheinz; Peter S. Liu; Nataliya Popovych; Aaron T. Wecksler; Lijuan Zhou; Christine Tam; Inna Zilberleyb; Rajini Srinivasan; Robert A. Blake; Aimin Song; Steven T. Staben; Yingnan Zhang; David Arnott; Wayne J. Fairbrother; Scott A. Foster; Ingrid E. Wertz; Claudio Ciferri; Erin C. Dueber

Diagnosing and mitigating method-based avidity artifacts that confound polyubiquitin-binding assays

Biophysical Reports, ISSN: 26670747

Allyn J. Schoeffler; Elizabeth Helgason; Nataliya Popovych; Erin C. Dueber

Diagnosing and mitigating method-based avidity artifacts that confound polyubiquitin-binding assays

Biophysical Reports,

Allyn J. Schoeffler; Elizabeth Helgason; Nataliya Popovych; Erin C. Dueber

Primary Amine Tethered Small Molecules Promote the Degradation of X-Linked Inhibitor of Apoptosis Protein

Journal of the American Chemical Society, ISSN: 15205126 00027863

Willem Den Besten; Kshitij Verma; Sayumi Yamazoe; Nicole Blaquiere; Wilson Phung; Anita Izrael-Tomasevic; Melinda M. Mulvihill; Elizabeth Helgason; Sumit Prakash; Tatiana Goncharov; Domagoj Vucic; Erin C. Dueber; Wayne J. Fairbrother; Ingrid E. Wertz; Kebing Yu; Steven T. Staben

A Multifaceted Hit-Finding Approach Reveals Novel LC3 Family Ligands

Biochemistry, ISSN: 15204995 00062960

Micah Steffek; Elizabeth Helgason; Nataliya Popovych; Lionel Rouge; John M. Bruning; Ke Sherry Li; Burdick; Jianping Cai; Terry Crawford; Jing Xue; Willy Decurtins; Chunlin Fang; Felix Grubers; Michael J. Holliday; Allyson Langley; Ann Petersen; Alexander Lee Satz; Aimin Song; Daniel Stoffler; Quentin Strebel; Jeffrey Tom; Nicholas J. Skelton; Steven T. Staben; Moreno Wichert; Melinda M. Mulvihill; Erin C. Dueber

Cyanopyrrolidine Inhibitors of Ubiquitin Specific Protease 7 Mediate Desulfhydration of the Active-Site Cysteine

ACS Chemical Biology, ISSN: 15548937 15548929

Charlene Bashore; Priyadarshini Jaishankar; Nicholas J. Skelton; Jakob Fuhrmann; Brian R. Hearn; Peter S. Liu; Adam R. Renslo; Erin C. Dueber

Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation

Nature Communications, ISSN: 20411723

Michael J. Holliday; Axel Witt; Alejandro Rodríguez Gama; Benjamin T. Walters; Christopher P. Arthur; Randal Halfmann; Alexis Rohou; Erin C. Dueber; Wayne J. Fairbrother

Picomolar zinc binding modulates formation of Bcl10-nucleating assemblies of the caspase recruitment domain (CARD) of CARD9

Journal of Biological Chemistry, ISSN: 1083351X 00219258

Michael J. Holliday; Ryan Ferrao; Gladys De Leon Boenig; Alberto Estevez; Elizabeth Helgason; Alexis Rohou; Erin C. Dueber; Wayne J. Fairbrother

Selectively Modulating Conformational States of USP7 Catalytic Domain for Activation

Structure, ISSN: 18784186 09692126

Ayşegül Özen; Lionel Rouge; Charlene Bashore; Brian R. Hearn; Nicholas J. Skelton; Erin C. Dueber

Recent Insights into the Molecular Mechanisms Underlying Pyroptosis and Gasdermin Family Functions

Trends in Immunology, ISSN: 14714981 14714906

Robin A. Aglietti; Erin C. Dueber

GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424

Robin A. Aglietti; Alberto Estevez; Aaron Gupta; Monica Gonzalez Ramirez; Peter S. Liu; Nobuhiko Kayagaki; Claudio Ciferri; Vishva M. Dixit; Erin C. Dueber

Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation

Nature, ISSN: 14764687 00280836

Ingrid E. Wertz; Kim Newton; Dhaya Seshasayee; Saritha Kusam; Cynthia Lam; Juan Zhang; Nataliya Popovych; Elizabeth Helgason; Allyn J. Schoeffler; Surinc Er Jeet; Nandhini Ramamoorthi; Kategaya; Robert J. Newman; Keisuke Horikawa; Dugger; Wendy N. Sandoval; Susmith Mukund; Anuradha Zindal; Flavius Martin; Quan; Jeffrey Tom; Wayne J. Fairbrother; Michael J. Townsend; Søren Warming; Jason Devoss; Jinfeng Liu; Erin C. Dueber; Patrick Caplazi; Wyne P. Lee; Christopher C. Goodnow; Mercedesz Balazs; Kebing Yu; Ganesh Kolumam; Vishva M. Dixit

Structural Insights into WD-Repeat 48 Activation of Ubiquitin-Specific Protease 46

Structure, ISSN: 18784186 09692126

Jianping Yin; Allyn J. Schoeffler; Katherine E. Wickliffe; Kim Newton; Melissa A. Starovasnik; Erin C. Dueber; Seth F. Harris

Internal motions prime cIAP1 for rapid activation

Nature Structural and Molecular Biology, ISSN: 15459985 15459993

Aaron H. Phillips; Allyn J. Schoeffler; Tsutomu Matsui; Thomas M. Weiss; John W. Blankenship; Zobel; Anthony M. Giannetti; Erin C. Dueber; Wayne J. Fairbrother

Recent insights into the complexity of Tank-binding kinase 1 signaling networks: The emerging role of cellular localization in the activation and substrate specificity of TBK1

FEBS Letters, ISSN: 00145793 18733468

Elizabeth Helgason; Qui Phung; Erin C. Dueber

Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Xiaolei Ma; Elizabeth Helgason; Qui Phung; Quan; Rekha S. Iyer; Michelle W. Lee; Krista K. Bowman; Melissa A. Starovasnik; Erin C. Dueber

Antagonists induce a conformational change in cIAP1 that promotes autoubiquitination

Science, ISSN: 10959203 00368075

Erin C. Dueber; Allyn J. Schoeffler; Andreas Lingel; J. Michael Elliott; Anna V. Fedorova; Anthony M. Giannetti; Zobel; Brigitte Maurer; Eugene Varfolomeev; Ping Wu; Heidi J. A. Wallweber; Sarah G. Hymowitz; Deshayes; Domagoj Vucic; Wayne J. Fairbrother

Preparation of distinct ubiquitin chain reagents of high purity and yield

Structure, ISSN: 09692126 18784186

Ken Dong; Elizabeth Helgason; Christine Yu; Lilian Phu; David Arnott; Ivan Bosanac; Deanne M. Compaan; Oscar W Huang; Anna V. Fedorova; Donald S. Kirkpatrick; Sarah G. Hymowitz; Erin C. Dueber

Molecular determinants of origin discrimination by Orc1 initiators in archaea

Nucleic Acids Research, ISSN: 03051048 13624962

Erin C. Dueber; Alessandro Costa; Jacob E. Corn; Stephen D. Bell; James M. Berger

Identification, characterization, and implications of species-dependent plasma protein binding for the oral Hedgehog pathway inhibitor vismodegib (GDC-0449)

Journal of Medicinal Chemistry, ISSN: 00222623 15204804

Anthony M. Giannetti; Harvey Wong; Gerrit J. P. Dijkgraaf; Erin C. Dueber; Daniel F. Ortwine; Brandon Bravo; Stephen Gould; Emile G. Plise; Bert L. Lum; Vikram Malhi; Richard A. Graham

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7

Nature, ISSN: 00280836 14764687

Ingrid E. Wertz; Saritha Kusam; Cynthia Lam; Toru Okamoto; Wendy N. Sandoval; Daniel J Anderson; Elizabeth Helgason; James A. Ernst; Mike Eby; Jinfeng Liu; Lisa D. Belmont; Joshua S. Kaminker; Karen M. O'Rourke; Kanan Pujara; Pawan Bir Kohli; Adam R. Johnson; Mark L. Chiu; Jennie R. Lill; Peter K Jackson; Wayne J. Fairbrother; Somasekar Seshagiri; Mary J. C. Ludlam; Kevin G. Leong; Erin C. Dueber; Heather Maecker; David C.S. Huang; Vishva M. Dixit

C-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling

EMBO Journal, ISSN: 02614189 14602075

Jasmin N. Dynek; Tatiana Goncharov; Erin C. Dueber; Anna V. Fedorova; Anita Izrael-Tomasevic; Lilian Phu; Elizabeth Helgason; Wayne J. Fairbrother; Deshayes; Donald S. Kirkpatrick; Domagoj Vucic

University of California, Berkeley, Miller Postdoctoral Fellow – 2004
University of California, San Francisco, Biophysics, Ph.D. – 2003
Gustavus Adolphus College, Chemistry and Biochemistry, B.A. – 1995

Genentech Research Scientific Mentorship Awardee – 2020
Miller Postdoctoral Research Fellowship – 2004
Rupert T. Anderson Award for Outstanding Research, Gustavus Adolphus College – 1995
Barry M. Goldwater Scholarship – 1993