I joined Genentech as a Scientist in 2008 after completing a postdoctoral fellowship at the Miller Institute for Basic Research in Science at UC Berkeley. I was drawn to the position in the Early Discovery Biochemistry Department as it promised to be a great opportunity to use my skills as a biophysicist to study molecular mechanisms that underlie complex biology and to work with very smart, talented people—all while having the potential to impact patients. Genentech did not disappoint. The emphasis on basic research and the highly collaborative environment makes this a great place to do interesting and meaningful science.
Genentech has a very strong postdoc program that helps drive our basic research efforts. I feel very fortunate to have the opportunity to mentor postdoctoral fellows in my lab.
My lab uses a combination of biochemical, biophysical and structural methods to investigate how proteins function in both normal biology and disease states. We usually take a reductionist approach, utilizing purified components to study the detailed molecular mechanisms of proteins and larger complexes, which we then put into the context of the more complex cellular environment through close collaboration with expert biologists. Currently, we have research projects in the areas of oncology, innate immunity, and infectious disease, with a special interest in how post-translational modifications, allostery, and dynamics impact molecular interactions and cellular signaling.