Gina Xiaojing Wang
Senior Principal Scientist (Chemistry), Discovery Chemistry
"Helping patients is my mission and innovation is the strategy. Innovating for life is especially meaningful and gratifying."
15
Years at Genentech
19
Publications
6
Awards & Honors
I decided to join Genentech at 2006 as a scientist. What appealed me particularly to work at Genentech was the casual yet intense science-driven culture. Over the years, I led multiple disciplinary teams in driving projects towards deliveries into our pipeline of experimental therapies. It has been so much fun doing science together with super talented colleagues from all levels.
Today, I am a Principal Scientist and Project Team Lead, mentoring junior scientists and leading teams in discovering therapeutics of novel targets. What we are working on is often very challenging but we are fully motivated by patients who are waiting for breakthrough medicines.
Featured Publication
From Discovery to Bedside: Targeting the Ubiquitin System.
Cell Chem Biol. 2018 Nov 28. pii: S2451-9456(18)30382-9.
Wertz IE, Wang X.
Discovery of Potent and Selective Tricyclic Inhibitors of Bruton0s Tyrosine Kinase with Improved Druglike Properties.
ACS Med Chem Lett. 2017 May 3;8(6):608-613.
Wang X, Barbosa J, Blomgren P, Bremer MC, Chen J, Crawford JJ, Deng W, Dong L, Eigenbrot C, Gallion S, Hau J, Hu H, Johnson AR, Katewa A, Kropf JE, Lee SH, Liu L, Lubach JW, Macaluso J, Maciejewski P, Mitchell SA, Ortwine DF, DiPaolo J, Reif K, Scheerens H, Schmitt A, Wong H, Xiong JM, Xu J, Zhao Z, Zhou F, Currie KS, Young WB.
My Focus
As a medicinal chemist, my focus is to invent novel therapeutic modalities for the treatment of various disease areas through hit identification and lead optimization integrating efficacy, pharmacokinetics and safety profile. The innovation includes new chemical matters and novel mode or mechanism of action. I am also interested in investigating tissue specific delivery to maximize safety margin of effective therapies.
Publications
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Emily Hanan; Jun Liang; Xiaojing Wang; Robert Blake; Nicole Blaquiere; Steven Staben
ACS Medicinal Chemistry Letters, ISSN: 19485875
Jun Liang; Robert Blake; Jae Chang; Lori Friedman; Simon Goodacre; Steven J. Hartman; Ellen Ingalla; James Kiefer; Tracy Kleinheinz; Sharada Labadie; Jun Li; Kwong Wah Lai; Jiangpeng Liao; Vidhi Mody; Neville J. McLean; Ciara Metcalfe; Michelle Nannini; Daniel Otwine; Yingqing Ran; Nicholas C. Ray; Fabien Roussel; Amy Sambrone; Deepak Sampath; Maia Vinogradova; John Wai; Tao Wang; Kuen Yeap; Amy Young; Jason Zbieg; Birong Zhang; Xiaoping Zheng; Yu Zhong; Gina Wang
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Aaron G. Bart; Ryan Takahashi; Gina Wang; Emily E. Scott
Cell, ISSN: 10974172
Jane Guan; Wei Zhou; Marc Hafner; Robert Blake; Cecile Chalouni; Irene P. Chen; Tom De Bruyn; Jennifer Giltnane; Steven J. Hartman; Amy Heidersbach; Rene Houtman; Ellen Ingalla; Kategaya; Tracy Kleinheinz; Jun Li; Scott E. Martin; Zora Modrusan; Michelle Nannini; Jason Oeh; Savita Ubhayakar; Xiaojing Wang; Ingrid Wertz; Amy Young; Mamie Yu; Deepak Sampath; Jeffrey H. Hager; Lori Friedman; Anneleen Daemen; Ciara Metcalfe
Cell Chemical Biology, ISSN: 24519448 24519456
Ingrid Wertz; Gina Wang
Unexpected equivalent potency of a constrained chromene enantiomeric pair rationalized by co-crystal structures in complex with estrogen receptor alpha
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Birong Zhang; James Kiefer; Robert Blake; Jae H. Chang; Steven J. Hartman; Ellen Ingalla; Tracy Kleinheinz; Vidhi Mody; Michelle Nannini; Dan Ortwine; Yingqing Ran; Amy Sambrone; Deepak Sampath; Maia Vinogradova; Yu Zhong Yao; Jerome C. Nwachukwu; Kendall W. Nettles; Tommy Lai; Jiangpeng Liao; Xiaoping Zheng; Hai Chen; Xiaojing Wang; Jun Liang
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Gina Wang; Wesley P. Blackaby; Vivienne Allen; Grace Chan; Jae Chang; Po-Chang Chiang; Coura Diène; Jake Drummond; Steven Do; Eric Fan; Eric Harstad; Alastair J. Hodges; Huiyong Hu; Wei Jia; William Kofie; Aleksandr Kolesnikov; Joe Lyssikatos; Justin Ly; Mizio Matteucci; John Moffat; Veerendra Munugalavadla; Jeremy Murray; David Nash; Cameron Noland; Geoff Del Rosario; Leanne Ross; Craig Rouse; Andrew Sharpe; Dion Slaga; Minghua Sun; Vickie Tsui; Heidi Ackerly Wallweber; Shang-Fan Yu; Allen Ebens
Discovery of a C-8 hydroxychromene as a potent degrader of estrogen receptor alpha with improved rat oral exposure over GDC-0927
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Sharada Labadie; Jun Li; Robert Blake; Jae H. Chang; Simon Goodacre; Steven J. Hartman; Weiling Liang; James Kiefer; Tracy Kleinheinz; Tommy Lai; Jiangpeng Liao; Dan Ortwine; Vidhi Mody; Nicholas C. Ray; Fabien Roussel; Maia Vinogradova; Siew Kuen Yeap; Birong Zhang; Xiaoping Zheng; Jason Zbieg; Jun Liang; Gina Wang
Cis -Selective synthesis of 1,3-disubstituted tetrahydro-β-carbolines from N -sulfonyl N, S -acetals
Organic and Biomolecular Chemistry, ISSN: 14770520
Shao-Xiong Luo; Yanzhou Liu; Michael J. Lambrecht; Dan Ortwine; Antonio DiPasquale; Jun Liang; Xiaojing Wang; Jason Zbieg; Jun Li
Nature, ISSN: 14764687 00280836
Kategaya; Paola Di Lello; Lionel Rouge; Rich Pastor; Kevin Clark; Jake Drummond; Tracy Kleinheinz; Eva Lin; John-Paul Upton; Sumit Prakash; Johanna Heideker; Mark McCleland; Maria Stella Ritorto; Dario R. Alessi; Matthias Trost; Travis Bainbridge; Michael Kwok; Taylur P. Ma; Zachary Stiffler; Bradley Brasher; Yinyan Tang; Priyadarshini Jaishankar; Brian R. Hearn; Adam R. Renslo; Michelle Arkin; Fred Cohen; Kebing Yu; Frank Peale; Florian Gnad; Matthew T. Chang; Christiaan Klijn; Beth Blackwood; Scott Martin; Bill Forrest; James Ernst; Chudi Ndubaku; Gina Wang; Maureen Beresini; Vickie Tsui; Carsten Schwerdtfeger; Robert Blake; Jeremy Murray; Till Maurer; Ingrid Wertz
CYP1A1-mediated intramolecular rearrangement of aminoazepane in GDC-0339
Drug Metabolism and Disposition, ISSN: 00909556
Ryan Takahashi; Gina Wang; Nathaniel Segraves; Jing Wang; Jae Chang; Cyrus Khojasteh; Shuguang Ma
Xenobiotica, ISSN: 13665928 00498254
Molly Lin; Justin Ly; Ryan Takahashi; John Chen; Alan Deese; Sarah Robinson; Aleksandr Kolesnikov; Susan Wong; Gina Wang; Jae Chang
ACS Medicinal Chemistry Letters, ISSN: 19485875
Gina Wang; Jim Barbosa; Peter Blomgren; Meire Bremer; Jacob Chen; James Crawford; Wei Deng; Liming Dong; Charles Eigenbrot; Steven L. Gallion; Jonathon Hau; Huiyong Hu; Adam Johnson; Arna Katewa; Jeffrey E. Kropf; Seung H. Lee; Lichuan Liu; Joe Lubach; Jen MacAluso; Patricia M. MacIejewski; Scott A. Mitchell; Dan Ortwine; Julie Dipaolo; Karin Reif; Heleen Scheerens; Aaron Schmitt; Harvey Wong; Jin-Ming Xiong; Jianjun Xu; Zhongdong Zhao; Fusheng Zhou; Kevin S. Currie; Wendy Young
Journal of Medicinal Chemistry, ISSN: 15204804
Gina Wang; Aleksandr Kolesnikov; Suzanne Brown; Grace Chan; Qi Chao; Steven Do; Jake Drummond; Allen Ebens; Ning Liu; Justin Ly; Eric Harstad; Huiyong Hu; John Moffat; Veerendra Munugalavadla; Jeremy Murray; Dion Slaga; Vickie Tsui; Matthew Volgraf; Heidi Ackerly Wallweber; Jae Chang
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405
Wendy Young; Jim Barbosa; Peter Blomgren; Meire Bremer; James Crawford; Donna Dambach; Charles Eigenbrot; Steven L. Gallion; Adam Johnson; Jeffrey E. Kropf; Seung H. Lee; Lichuan Liu; Joe Lubach; Jen MacAluso; Patricia M. MacIejewski; Scott A. Mitchell; Dan Ortwine; Julie Di Paolo; Karin Reif; Heleen Scheerens; Aaron Schmitt; Xiaojing Wang; Harvey Wong; Jin-Ming Xiong; Jianjun Xu; Christine Yu; Zhongdong Zhao; Kevin S. Currie
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405
Huiyong Hu; Gina Wang; Grace Chan; Jae Chang; Steven Do; Jake Drummond; Allen Ebens; Wendy Lee; Justin Ly; Joe Lyssikatos; Jeremy Murray; John Moffat; Qi Chao; Vickie Tsui; Heidi Ackerly Wallweber; Aleksandr Kolesnikov
ACS Medicinal Chemistry Letters, ISSN: 19485875
Gina Wang; Minghua Sun; Connie New; Spencer Nam; Wesley P. Blackaby; Alastair J. Hodges; David Nash; Mizio Matteucci; Joe Lyssikatos; Peter Fan; Suzanne Brown; Jae Chang
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405
Wendy Young; Jim Barbosa; Peter Blomgren; Meire Bremer; James Crawford; Donna Dambach; Steven L. Gallion; Sarah Hymowitz; Jeffrey E. Kropf; Seung H. Lee; Lichuan Liu; Joe Lubach; Jen MacAluso; Patricia M. MacIejewski; Brigitte Maurer; Scott A. Mitchell; Dan Ortwine; Julie Di Paolo; Karin Reif; Heleen Scheerens; Aaron Schmitt; Greg Sowell; Xiaojing Wang; Harvey Wong; Jin-Ming Xiong; Jianjun Xu; Zhongdong Zhao; Kevin S. Currie
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Gina Wang; Steven Magnuson; Rich Pastor; Eric Fan; Huiyong Hu; Vickie Tsui; Wei Deng; Jeremy Murray; Micah Steffek; Heidi Ackerly Wallweber; John Moffat; Jake Drummond; Grace Chan; Eric Harstad; Allen Ebens
Education
- Research Triangle Institute, Postdoctoral Fellow – 2002
- University of Florida, Ph.D. in Chemistry – 2000
- Peking University, B.S. in Chemistry – 1996
Awards & Honors
- Appointed to the Steering Committee of CICR of AACR – 2019
- Phi Beta Kappa for scholastic achievements – 2000
- Outstanding Academic Accomplishment – 1997
- Triple-A Outstanding Student Award of Beijing – 1994
- Triple-A Outstanding Student First Prize of Peking University – 1994
- Triple-A Outstanding Student Second Prize of Peking University – 1993