Genentech: Gina Xiaojing Wang | Principal Scientist, Discovery Chemistry

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Scientists / Our Scientists

"Helping patients is my mission and innovation is the strategy. Innovating for life is especially meaningful and gratifying."

Years at Genentech

Publications

Awards & Honors

I decided to join Genentech at 2006 as a scientist. What appealed me particularly to work at Genentech was the casual yet intense science-driven culture. Over the years, I led multiple disciplinary teams in driving projects towards deliveries into our pipeline of experimental therapies. It has been so much fun doing science together with super talented colleagues from all levels.

Today, I am a Principal Scientist and Project Team Lead, mentoring junior scientists and leading teams in discovering therapeutics of novel targets. What we are working on is often very challenging but we are fully motivated by patients who are waiting for breakthrough medicines.

Featured Publication

From Discovery to Bedside: Targeting the Ubiquitin System.

Cell Chem Biol. 2018 Nov 28. pii: S2451-9456(18)30382-9.

Wertz IE, Wang X.

View Abstract

Discovery of Potent and Selective Tricyclic Inhibitors of Bruton's Tyrosine Kinase with Improved Druglike Properties.

ACS Med Chem Lett. 2017 May 3;8(6):608-613.

Wang X, Barbosa J, Blomgren P, Bremer MC, Chen J, Crawford JJ, Deng W, Dong L, Eigenbrot C, Gallion S, Hau J, Hu H, Johnson AR, Katewa A, Kropf JE, Lee SH, Liu L, Lubach JW, Macaluso J, Maciejewski P, Mitchell SA, Ortwine DF, DiPaolo J, Reif K, Scheerens H, Schmitt A, Wong H, Xiong JM, Xu J, Zhao Z, Zhou F, Currie KS, Young WB.

View Abstract

As a medicinal chemist, my focus is to invent novel therapeutic modalities for the treatment of various disease areas through hit identification and lead optimization integrating efficacy, pharmacokinetics and safety profile. The innovation includes new chemical matters and novel mode or mechanism of action. I am also interested in investigating tissue specific delivery to maximize safety margin of effective therapies.

From Discovery to Bedside: Targeting the Ubiquitin System

Cell Chemical Biology, ISSN: 24519448 24519456

Ingrid Wertz; Gina Wang

View on Scopus

Optimization of Pan-Pim Kinase Activity and Oral Bioavailability Leading to Diaminopyrazole (GDC-0339) for the Treatment of Multiple Myeloma

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Gina Wang; Wesley P. Blackaby; Vivienne Allen; Grace Chan; Jae Chang; Po-Chang Chiang; Coura Diène; Jake Drummond; Steven Do; Eric Fan; Eric Harstad; Alastair J. Hodges; Huiyong Hu; Wei Jia; William Kofie; Aleksandr Kolesnikov; Joe Lyssikatos; Justin Ly; Mizio Matteucci; John Moffat; Veerendra Munugalavadla; Jeremy Murray; David Nash; Cameron Noland; Geoff Del Rosario; Leanne Ross; Craig Rouse; Andrew Sharpe; Dion Slaga; Minghua Sun; Vickie Tsui; Heidi Ackerly Wallweber; Shang-Fan Yu; Allen Ebens

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Unexpected equivalent potency of a constrained chromene enantiomeric pair rationalized by co-crystal structures in complex with estrogen receptor alpha

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X

Birong Zhang; James Kiefer; Robert Blake; Jae H. Chang; Steven J. Hartman; Ellen Ingalla; Tracy Kleinheinz; Vidhi Mody; Michelle Nannini; Dan Ortwine; Yingqing Ran; Amy Sambrone; Deepak Sampath; Maia Vinogradova; Yu Zhong Yao; Jerome C. Nwachukwu; Kendall W. Nettles; Tommy Lai; Jiangpeng Liao; Xiaoping Zheng; Hai Chen; Xiaojing Wang; Jun Liang

USP7 small-molecule inhibitors interfere with ubiquitin binding

Nature, ISSN: 14764687 00280836

Kategaya; Paola Di Lello; Lionel Rouge; Rich Pastor; Kevin Clark; Jake Drummond; Tracy Kleinheinz; Eva Lin; John-Paul Upton; Sumit Prakash; Johanna Heideker; Mark McCleland; Maria Stella Ritorto; Dario R. Alessi; Matthias Trost; Travis Bainbridge; Michael Kwok; Taylur P. Ma; Zachary Stiffler; Bradley Brasher; Yinyan Tang; Priyadarshini Jaishankar; Brian R. Hearn; Adam R. Renslo; Michelle Arkin; Fred Cohen; Kebing Yu; Frank Peale; Florian Gnad; Matthew T. Chang; Christiaan Klijn; Beth Blackwood; Scott Martin; Bill Forrest; James Ernst; Chudi Ndubaku; Gina Wang; Maureen Beresini; Vickie Tsui; Carsten Schwerdtfeger; Robert Blake; Jeremy Murray; Till Maurer; Ingrid Wertz

View on Scopus

CYP1A1-mediated intramolecular rearrangement of aminoazepane in GDC-0339

Drug Metabolism and Disposition, ISSN: 00909556

Ryan Takahashi; Gina Wang; Nathaniel Segraves; Jing Wang; Jae Chang; Cyrus Khojasteh; Shuguang Ma

Characterizing the in vitro species differences in N-glucuronidation of a potent pan-PIM inhibitor GNE-924 containing a 3,5-substituted 6-azaindazole

Xenobiotica, ISSN: 13665928 00498254

Molly Lin; Justin Ly; Ryan Takahashi; John Chen; Alan Deese; Sarah Robinson; Aleksandr Kolesnikov; Susan Wong; Gina Wang; Jae Chang

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Discovery of Potent and Selective Tricyclic Inhibitors of Bruton's Tyrosine Kinase with Improved Druglike Properties

ACS Medicinal Chemistry Letters, ISSN: 19485875

Gina Wang; Jim Barbosa; Peter Blomgren; Meire Bremer; Jacob Chen; James Crawford; Wei Deng; Liming Dong; Charles Eigenbrot; Steven L. Gallion; Jonathon Hau; Huiyong Hu; Adam Johnson; Arna Katewa; Jeffrey E. Kropf; Seung H. Lee; Lichuan Liu; Joe Lubach; Jen MacAluso; Patricia M. MacIejewski; Scott A. Mitchell; Dan Ortwine; Julie Dipaolo; Karin Reif; Heleen Scheerens; Aaron Schmitt; Harvey Wong; Jin-Ming Xiong; Jianjun Xu; Zhongdong Zhao; Fusheng Zhou; Kevin S. Currie; Wendy Young

View on Scopus

Discovery of 5-Azaindazole (GNE-955) as a Potent Pan-Pim Inhibitor with Optimized Bioavailability

Journal of Medicinal Chemistry, ISSN: 15204804

Gina Wang; Aleksandr Kolesnikov; Suzanne Brown; Grace Chan; Qi Chao; Steven Do; Jake Drummond; Allen Ebens; Ning Liu; Justin Ly; Eric Harstad; Huiyong Hu; John Moffat; Veerendra Munugalavadla; Jeremy Murray; Dion Slaga; Vickie Tsui; Matthew Volgraf; Heidi Ackerly Wallweber; Jae Chang

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Discovery of highly potent and selective Bruton's tyrosine kinase inhibitors: Pyridazinone analogs with improved metabolic stability

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405

Wendy Young; Jim Barbosa; Peter Blomgren; Meire Bremer; James Crawford; Donna Dambach; Charles Eigenbrot; Steven L. Gallion; Adam Johnson; Jeffrey E. Kropf; Seung H. Lee; Lichuan Liu; Joe Lubach; Jen MacAluso; Patricia M. MacIejewski; Scott A. Mitchell; Dan Ortwine; Julie Di Paolo; Karin Reif; Heleen Scheerens; Aaron Schmitt; Xiaojing Wang; Harvey Wong; Jin-Ming Xiong; Jianjun Xu; Christine Yu; Zhongdong Zhao; Kevin S. Currie

View on Scopus

Discovery of 3,5-substituted 6-azaindazoles as potent pan-Pim inhibitors

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405

Huiyong Hu; Gina Wang; Grace Chan; Jae Chang; Steven Do; Jake Drummond; Allen Ebens; Wendy Lee; Justin Ly; Joe Lyssikatos; Jeremy Murray; John Moffat; Qi Chao; Vickie Tsui; Heidi Ackerly Wallweber; Aleksandr Kolesnikov

View on Scopus

Probing Mechanisms of CYP3A Time-Dependent Inhibition Using a Truncated Model System

ACS Medicinal Chemistry Letters, ISSN: 19485875

Gina Wang; Minghua Sun; Connie New; Spencer Nam; Wesley P. Blackaby; Alastair J. Hodges; David Nash; Mizio Matteucci; Joe Lyssikatos; Peter Fan; Suzanne Brown; Jae Chang

View on Scopus

Potent and selective Bruton's tyrosine kinase inhibitors: Discovery of GDC-0834

Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405

Wendy Young; Jim Barbosa; Peter Blomgren; Meire Bremer; James Crawford; Donna Dambach; Steven L. Gallion; Sarah Hymowitz; Jeffrey E. Kropf; Seung H. Lee; Lichuan Liu; Joe Lubach; Jen MacAluso; Patricia M. MacIejewski; Brigitte Maurer; Scott A. Mitchell; Dan Ortwine; Julie Di Paolo; Karin Reif; Heleen Scheerens; Aaron Schmitt; Greg Sowell; Xiaojing Wang; Harvey Wong; Jin-Ming Xiong; Jianjun Xu; Zhongdong Zhao; Kevin S. Currie

View on Scopus

Discovery of novel pyrazolo[1,5-a]pyrimidines as potent pan-Pim inhibitors by structure- and property-based drug design

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X

Gina Wang; Steven Magnuson; Rich Pastor; Eric Fan; Huiyong Hu; Vickie Tsui; Wei Deng; Jeremy Murray; Micah Steffek; Heidi Ackerly Wallweber; John Moffat; Jake Drummond; Grace Chan; Eric Harstad; Allen Ebens

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Research Triangle Institute, Postdoctoral Fellow – 2002
University of Florida, Ph.D. in Chemistry – 2000
Peking University, B.S. in Chemistry – 1996

Appointed to the Steering Committee of CICR of AACR – 2019
Phi Beta Kappa for scholastic achievements – 2000
Outstanding Academic Accomplishment – 1997
Triple-A Outstanding Student Award of Beijing – 1994
Triple-A Outstanding Student First Prize of Peking University – 1994
Triple-A Outstanding Student Second Prize of Peking University – 1993

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Gina Xiaojing Wang

Principal Scientist, Discovery Chemistry

Featured Publication

From Discovery to Bedside: Targeting the Ubiquitin System.

Discovery of Potent and Selective Tricyclic Inhibitors of Bruton's Tyrosine Kinase with Improved Druglike Properties.