Gina Xiaojing Wang
Senior Principal Scientist (Chemistry) and Director of Research, Discovery Chemistry
"Helping patients is my mission and innovation is the strategy. Innovating for life is especially meaningful and gratifying."
17
Years at Genentech
26
Publications at Genentech
6
Awards & Honors
I decided to join Genentech at 2006 as a scientist. What appealed me particularly to work at Genentech was the casual yet intense science-driven culture. Over the years, I led multiple disciplinary teams in driving projects towards deliveries into our pipeline of experimental therapies. It has been so much fun doing science together with super talented colleagues from all levels.
Today, I am a Principal Scientist and Project Team Lead, mentoring junior scientists and leading teams in discovering therapeutics of novel targets. What we are working on is often very challenging but we are fully motivated by patients who are waiting for breakthrough medicines.
Featured Publication
From Discovery to Bedside: Targeting the Ubiquitin System.
Cell Chem Biol. 2018 Nov 28. pii: S2451-9456(18)30382-9.
Wertz IE, Wang X.
Discovery of Potent and Selective Tricyclic Inhibitors of Bruton0s Tyrosine Kinase with Improved Druglike Properties.
ACS Med Chem Lett. 2017 May 3;8(6):608-613.
Wang X, Barbosa J, Blomgren P, Bremer MC, Chen J, Crawford JJ, Deng W, Dong L, Eigenbrot C, Gallion S, Hau J, Hu H, Johnson AR, Katewa A, Kropf JE, Lee SH, Liu L, Lubach JW, Macaluso J, Maciejewski P, Mitchell SA, Ortwine DF, DiPaolo J, Reif K, Scheerens H, Schmitt A, Wong H, Xiong JM, Xu J, Zhao Z, Zhou F, Currie KS, Young WB.
My Focus
As a medicinal chemist, my focus is to invent novel therapeutic modalities for the treatment of various disease areas through hit identification and lead optimization integrating efficacy, pharmacokinetics and safety profile. The innovation includes new chemical matters and novel mode or mechanism of action. I am also interested in investigating tissue specific delivery to maximize safety margin of effective therapies.
Genentech Publications
Nature Communications, ISSN: 20411723
Kristin M. Zimmerman Savill; Brian B. Lee; Jason Oeh; Jie Lin; Eva Lin; Wei-Jen Chung; Amy Young; Wennie Chen; Monika Miś; Kathryn Mesh; Jeffrey Eastham; Florian Gnad; Zhaoshi Jiang; Eric Stawiski; Benjamin Haley; Anneleen Daemen; Xiaojing Wang; Koeppen; Zora Modrusan; Scott E. Martin; Deepak Sampath; Kui Lin
Expert Opinion on Investigational Drugs, ISSN: 17447658 13543784
Ya-Chi Chen; Jiajie Yu; Ciara Metcalfe; Tom De Bruyn; Thomas R. Gelzleichter; Vikram Malhi; Pablo Perez-Moreno; Xiaojing Wang
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Jason R. Zbieg; Jun Liang; Jun Li; Robert A. Blake; Jae H. Chang; Lori S. Friedman; Simon Goodacre; Steven J. Hartman; Ellen Rei Ingalla; James R. Kiefer; Tracy L. Kleinheinz; Sharada Labadie; Tommy Lai; Jiangpeng Liao; Neville J. McLean; Ciara Metcalfe; Vidhi Mody; Michelle Nannini; Daniel F. Ortwine; Yingqing Ran; Nicholas C. Ray; Fabien Roussel; Amy Sambrone; Deepak Sampath; Maia Vinogradova; John Wai; Tao Wang; Kuen Yeap; Birong Zhang; Xiaoping Zheng; Yu Zhong; Xiaojing Wang
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Jason R. Zbieg; Jun Liang; Jun Li; Robert A. Blake; Jae Chang; Lori S. Friedman; Simon Goodacre; Steven J. Hartman; Ellen Rei Ingalla; James R. Kiefer; Tracy L. Kleinheinz; Sharada Labadie; Tommy Lai; Jiangpeng Liao; Neville J. McLean; Ciara Metcalfe; Vidhi Mody; Michelle Nannini; Daniel F. Ortwine; Yingqing Ran; Nicholas C. Ray; Fabien Roussel; Amy Sambrone; Deepak Sampath; Maia Vinogradova; John Wai; Tao Wang; Kuen Yeap; Birong Zhang; Xiaoping Zheng; Yu Zhong; Xiaojing Wang
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Jun Liang; Jason R. Zbieg; Robert A. Blake; Jae H. Chang; Stephen Daly; Antonio G. DiPasquale; Lori S. Friedman; Thomas R. Gelzleichter; Matthew Gill; Jennifer M. Giltnane; Simon Goodacre; Jane Guan; Steven J. Hartman; Ellen Ingalla; Kategaya; James R. Kiefer; Tracy L. Kleinheinz; Sharada Labadie; Tommy Lai; Jun Li; Jiangpeng Liao; Zhiguo Liu; Vidhi Mody; Neville J. McLean; Ciara Metcalfe; Michelle Nannini; Jason Oeh; Martin G. O'Rourke; Daniel F. Ortwine; Yingqing Ran; Nicholas C. Ray; Fabien Roussel; Amy Sambrone; Deepak Sampath; Leah Schutt; Maia Vinogradova; John Wai; Tao Wang; Ingrid E. Wertz; Jonathan R. White; Siew Kuen Yeap; Amy Young; Birong Zhang; Xiaoping Zheng; Wei Zhou; Yu Zhong; Xiaojing Wang
Expert Opinion on Investigational Drugs, ISSN: 17447658 13543784
Ya-Chi Chen; Jiajie Yu; Ciara Metcalfe; Tom De Bruyn; Thomas R. Gelzleichter; Vikram Malhi; Pablo Perez-Moreno; Xiaojing Wang
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Emily J. Hanan; Jun Liang; Xiaojing Wang; Robert A. Blake; Nicole Blaquiere; Steven T. Staben
ACS Medicinal Chemistry Letters, ISSN: 19485875
Jun Liang; Robert A. Blake; Jae H. Chang; Lori S. Friedman; Simon Goodacre; Steven J. Hartman; Ellen Ingalla; James R. Kiefer; Tracy L. Kleinheinz; Sharada Labadie; Jun Li; Kwong Wah Lai; Jiangpeng Liao; Vidhi Mody; Neville J. McLean; Ciara Metcalfe; Michelle Nannini; Daniel Otwine; Yingqing Ran; Nicholas C. Ray; Fabien Roussel; Amy Sambrone; Deepak Sampath; Maia Vinogradova; John Wai; Tao Wang; Kuen Yeap; Amy Young; Jason R. Zbieg; Birong Zhang; Xiaoping Zheng; Yu Zhong; Xiaojing Wang
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Aaron G. Bart; Ryan Takahashi; Xiaojing Wang; Emily E. Scott
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Sharada Labadie; Jun Li; Robert A. Blake; Jae H. Chang; Simon Goodacre; Steven J. Hartman; Weiling Liang; James R. Kiefer; Tracy L. Kleinheinz; Tommy Lai; Jiangpeng Liao; Daniel F. Ortwine; Vidhi Mody; Nicholas C. Ray; Fabien Roussel; Maia Vinogradova; Siew Kuen Yeap; Birong Zhang; Xiaoping Zheng; Jason R. Zbieg; Jun Liang; Xiaojing Wang
Cell, ISSN: 10974172 00928674
Jane Guan; Wei Zhou; Marc Hafner; Robert A. Blake; Cecile Chalouni; Irene P. Chen; Tom De Bruyn; Jennifer M. Giltnane; Steven J. Hartman; Amy Heidersbach; Rene Houtman; Ellen Ingalla; Kategaya; Tracy L. Kleinheinz; Jun Li; Scott E. Martin; Zora Modrusan; Michelle Nannini; Jason Oeh; Savita Ubhayakar; Xiaojing Wang; Ingrid E. Wertz; Amy Young; Mamie Yu; Deepak Sampath; Jeffrey H. Hager; Lori S. Friedman; Anneleen Daemen; Ciara Metcalfe
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Birong Zhang; James R. Kiefer; Robert A. Blake; Jae H. Chang; Steven J. Hartman; Ellen Ingalla; Tracy L. Kleinheinz; Vidhi Mody; Michelle Nannini; Daniel F. Ortwine; Yingqing Ran; Amy Sambrone; Deepak Sampath; Maia Vinogradova; Yu Zhong; Jerome C. Nwachukwu; Kendall W. Nettles; Tommy Lai; Jiangpeng Liao; Xiaoping Zheng; Hai Chen; Xiaojing Wang; Jun Liang
Cell Chemical Biology, ISSN: 24519448 24519456
Ingrid E. Wertz; Xiaojing Wang
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Xiaojing Wang; Wesley P. Blackaby; Vivienne Allen; Grace Chan; Jae H. Chang; Po-Chang Chiang; Coura Diène; Jason H. Drummond; Steven Do; Eric Fan; Eric Harstad; Alastair J. Hodges; Huiyong Hu; Wei Jia; William Kofie; Aleksandr Kolesnikov; Joseph P. Lyssikatos; Justin Ly; Mizio Matteucci; John Moffat; Veerendra Munugalavadla; Jeremy Murray; David Nash; Cameron Noland; Geoffrey Del Rosario; Leanne Ross; Craig Rouse; Andrew Sharpe; Dionysos S. Slaga; Minghua Sun; Vickie Tsui; Heidi J. A. Wallweber; Shang-Fan Yu; Allen Ebens
Cis -Selective synthesis of 1,3-disubstituted tetrahydro-β-carbolines from N -sulfonyl N, S -acetals
Organic and Biomolecular Chemistry, ISSN: 14770520
Shao-Xiong Luo; Yanzhou Liu; Michael J. Lambrecht; Daniel F. Ortwine; Antonio G. DiPasquale; Jun Liang; Xiaojing Wang; Jason R. Zbieg; Jun Li
Xenobiotica, ISSN: 13665928 00498254
Molly Lin; Justin Ly; Ryan Takahashi; John Chen; Alan Deese; Sarah J. Robinson; Aleksandr Kolesnikov; Susan C. Wong; Xiaojing Wang; Jae H. Chang
Nature, ISSN: 14764687 00280836
Kategaya; Paola Di Lello; Lionel Rouge; Richard Pastor; Clark; Jason H. Drummond; Tracy L. Kleinheinz; Eva Lin; John-Paul Upton; Sumit Prakash; Johanna Heideker; Mark L. McCleland; Maria Stella Ritorto; Dario R. Alessi; Matthias Trost; Travis W. Bainbridge; Michael Kwok; Taylur P. Ma; Zachary Stiffler; Bradley Brasher; Yinyan Tang; Priyadarshini Jaishankar; Brian R. Hearn; Adam R. Renslo; Michelle R. Arkin; Frederick Cohen; Kebing Yu; Franklin V. Peale Jr.; Florian Gnad; Matthew T. Chang; Christiaan N. Klijn; Elizabeth M. Blackwood; Scott E. Martin; William F. Forrest; James A. Ernst; Chudi O. Ndubaku; Xiaojing Wang; Beresini; Vickie Tsui; Carsten Schwerdtfeger; Robert A. Blake; Jeremy Murray; Till Maurer; Ingrid E. Wertz
ACS Medicinal Chemistry Letters, ISSN: 19485875
Xiaojing Wang; Jim Barbosa; Peter Blomgren; Meire C. Bremer; Jacob Z. Chen; James J. Crawford; Wei Deng; Liming Dong; Eigenbrot; Steven L. Gallion; Jonathan Hau; Huiyong Hu; Adam R. Johnson; Arna Katewa; Jeffrey E. Kropf; Seung H. Lee; Lichuan Liu; Joseph W. Lubach; Jen MacAluso; Patricia M. MacIejewski; Scott A. Mitchell; Daniel F. Ortwine; Julie Dipaolo; Karin Reif; Heleen Scheerens; Aaron Schmitt; Harvey Wong; Jin-Ming Xiong; Jianjun Xu; Zhongdong Zhao; Fusheng Zhou; Kevin S. Currie; Wendy B. Young
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Xiaojing Wang; Aleksandr Kolesnikov; Suzanne Tay; Grace Chan; Qi Chao; Steven Do; Jason H. Drummond; Allen Ebens; Ning Liu; Justin Ly; Eric Harstad; Huiyong Hu; John Moffat; Veerendra Munugalavadla; Jeremy Murray; Dionysos S. Slaga; Vickie Tsui; Matthew Volgraf; Heidi J. A. Wallweber; Jae H. Chang
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Ryan Takahashi; Xiaojing Wang; Nathaniel Segraves; Jing Wang; Jae H. Chang; S. Cyrus Khojasteh; Shuguang Ma
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Wendy B. Young; Jim Barbosa; Peter Blomgren; Meire C. Bremer; James J. Crawford; Donna M. Dambach; Eigenbrot; Steven L. Gallion; Adam R. Johnson; Jeffrey E. Kropf; Seung H. Lee; Lichuan Liu; Joseph W. Lubach; Jen MacAluso; Patricia M. MacIejewski; Scott A. Mitchell; Daniel F. Ortwine; Julie Di Paolo; Karin Reif; Heleen Scheerens; Aaron Schmitt; Xiaojing Wang; Harvey Wong; Jin-Ming Xiong; Jianjun Xu; Christine Yu; Zhongdong Zhao; Kevin S. Currie
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Huiyong Hu; Xiaojing Wang; Grace Chan; Jae H. Chang; Steven Do; Jake Drummond; Allen Ebens; Wendy Lee; Justin Ly; Joseph P. Lyssikatos; Jeremy Murray; John Moffat; Qi Chao; Vickie Tsui; Heidi J. A. Wallweber; Aleksandr Kolesnikov
ACS Medicinal Chemistry Letters, ISSN: 19485875
Xiaojing Wang; Minghua Sun; Connie New; Spencer Nam; Wesley P. Blackaby; Alastair J. Hodges; David Nash; Mizio Matteucci; Joseph P. Lyssikatos; Peter W. Fan; Suzanne Tay; Jae H. Chang
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Wendy B. Young; Jim Barbosa; Peter Blomgren; Meire C. Bremer; James J. Crawford; Donna M. Dambach; Steven L. Gallion; Sarah G. Hymowitz; Jeffrey E. Kropf; Seung H. Lee; Lichuan Liu; Joseph W. Lubach; Jen MacAluso; Patricia M. MacIejewski; Brigitte Maurer; Scott A. Mitchell; Daniel F. Ortwine; Julie Di Paolo; Karin Reif; Heleen Scheerens; Aaron Schmitt; C. Gregory Sowell; Xiaojing Wang; Harvey Wong; Jin-Ming Xiong; Jianjun Xu; Zhongdong Zhao; Kevin S. Currie
Xenobiotica, ISSN: 00498254 13665928
Evan A Thackaberry; Xiaojing Wang; Michelle G. Schweiger; Kirsten Messick; Nicole R. Valle; Brian J. Dean; Amy Sambrone; Terri Bowman; Minli Xie
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Xiaojing Wang; Steven Magnuson; Richard Pastor; Eric Fan; Huiyong Hu; Vickie Tsui; Wei Deng; Jeremy Murray; Micah Steffek; Heidi J. A. Wallweber; John Moffat; Jason H. Drummond; Grace Chan; Eric Harstad; Allen Ebens
Education
- Research Triangle Institute, Postdoctoral Fellow – 2002
- University of Florida, Ph.D. in Chemistry – 2000
- Peking University, B.S. in Chemistry – 1996
Awards & Honors
- Appointed to the Steering Committee of CICR of AACR – 2019
- Phi Beta Kappa for scholastic achievements – 2000
- Outstanding Academic Accomplishment – 1997
- Triple-A Outstanding Student Award of Beijing – 1994
- Triple-A Outstanding Student First Prize of Peking University – 1994
- Triple-A Outstanding Student Second Prize of Peking University – 1993