Haiming Zhang
Director & Distinguished Scientist - Chemistry, Small Molecule Process Chemistry
"Advancing science for the benefit of patients."
12
Years at Genentech
37
Publications at Genentech
3
Awards & Honors
Haiming obtained both his B.S. and M.S. degrees from the University of Science and Technology of China and his Ph.D. from Iowa State University under the direction of Prof. Richard Larock. He then did two years of postdoc with Prof. Brian Stoltz at Caltech working on CH Functionalization chemistry and total synthesis of natural product Telomestatin. Haiming started his industrial career at Lexicon Pharmaceuticals in Princeton NJ in 2005 and moved to Genentech in 2010. He is currently a Sr. Pr. Scientist and Group Leader in the Small Molecule Process Chemistry department at Genentech.
Featured Publication
Asymmetric Hydrogenation of Unfunctionalized, Tetrasubstituted, Acyclic Olefins
Int. Ed. 2020, 59, 2844.
Bigler, R.;* Mack, K. A.; Shen, J.; Tosatti, P.; Han, C.; Bachmann, S.; Zhang, H.;* Scalone, M.; Pfaltz, A.; Denmark, S. E.; Hildbrand, S.; Gosselin, F.* Angew.
Convergent Synthesis of PI3K Inhibitor GDC-0908 Featuring Palladium-Catalyzed Direct C-H Arylation toward Dihydrobenzothienooxepines
Org. Chem. 2019, 84, 4796.
Zhang, H.;* Li, B. X.; Wong, B.; Stumpf, A.; Sowell, C. G.; Gosselin, F. J.
Catalytic Enantioselective Synthesis of Acyclic Quaternary Centers: Palladium-Catalyzed Decarboxylative Allylic Alkylation of Fully Substituted Acyclic Enol Carbonates
J. Am. Chem. Soc. 2018, 140, 10109.
Alexy, E. J.; Zhang, H.*, Stoltz, B. M.
Development of an Efficient Manufacturing Process for Reversible Bruton’s Tyrosine Kinase Inhibitor GDC-0853
Process Res. Dev. 2018, 22, 978.
Zhang, H.;* Cravillion, T.; Lim, N.-K.; Tian, Q.; Beaudry, D.; Defreese, J.; Fettes, A.; James, P.; Linder, D.; Malhotra, S.; Han, C.; Gosselin, F.
Synthesis of Highly Stereodefined Tetrasubstituted Acyclic All-carbon Olefins via a syn-Elimination Approach
Org. Lett. 2017, 19, 6212.
Lim, N.-K.;* Weiss, P.; Li, B. X.; McCulley, C. H.; Hare, S. R.; Bensema, B. L.; Palazzo, T. A.; Tantillo, D. J.;* Zhang, H.;* Gosselin, F.
Lithium Hexamethyldisilazide-Mediated Enolization of Highly Substituted Aryl Ketones: Structural and Mechanistic Basis of the E/Z Selectivities
J. Am. Chem. Soc. 2017, 139, 12181.
Mack, K. A.; McClory, A.; Zhang, H.;* Gosselin, F.; Collum, D. B.*
Highly Stereoselective Synthesis of Tetrasubstituted Acyclic All-carbon Olefins via Enol Tosylation and Suzuki‒Miyaura Coupling
J. Am. Chem. Soc. 2017, 139, 10777.
Li, B. X.; Le, D. N.; Mack, K. A.; McClory, A.; Lim, N.-K.; Cravillion, T.; Savage, S.; Han, C.; Collum, D. B.; Zhang, H.;* Gosselin, F.
My Focus
Strategic planning, route scouting and process development of various small molecule development candidates ranging from LSR to Ph3.
Genentech Publications
Synthesis (Germany), ISSN: 1437210X 00397881
Andreas Stumpf; Di Xu; Tyler A. Tuck; Haiming Zhang
Organic Process Research and Development, ISSN: 1520586X 10836160
Jie Xu; Cheol K. Chung; Andrew McClory; Kyle A. Mack; Michael E. Dalziel; Alec Fettes; Kyle Clagg; Ngiap-Kie Lim; Georg Wuitschik; Christian Jenny; Laure Finet; Michael Kammerer; Haiming Zhang; Remy Angelaud; Francis Gosselin
Organic Process Research and Development, ISSN: 1520586X 10836160
Jie Xu; Kyle Clagg; Ngiap-Kie Lim; Georg Wuitschik; Cheol K. Chung; Haiming Zhang; Francis Gosselin
Synthesis (Germany), ISSN: 1437210X 00397881
Andreas Stumpf; Di Xu; Tyler A. Tuck; Haiming Zhang
Synthesis (Germany), ISSN: 00397881
Andreas Stumpf; Di Xu; Tyler A. Tuck; Haiming Zhang
Journal of the American Chemical Society, ISSN: 15205126 00027863
Daniel Zell; Cian Kingston; Janis Jermaks; Sleight R. Smith; Natalie Seeger; Jana Wassmer; Lauren E. Sirois; Chong Han; Haiming Zhang; Matthew S. Sigman; Francis Gosselin
Organic Process Research and Development, ISSN: 1520586X 10836160
Daniel Zell; Michael E. Dalziel; Diane Carrera; Andreas Stumpf; Stephan Bachmann; Eduardo V. Mercado-Marin; Stefan G. Koenig; Haiming Zhang; Francis Gosselin
Organic Process Research and Development, ISSN: 1520586X 10836160
Jie Xu; Cheol K. Chung; Andrew McClory; Kyle A. Mack; Michael E. Dalziel; Alec Fettes; Kyle Clagg; Ngiap-Kie Lim; Georg Wuitschik; Christian Jenny; Laure Finet; Michael Kammerer; Haiming Zhang; Remy Angelaud; Francis Gosselin
Organic Process Research and Development, ISSN: 1520586X 10836160
Jie Xu; Kyle Clagg; Ngiap-Kie Lim; Georg Wuitschik; Cheol K. Chung; Haiming Zhang; Francis Gosselin
Tetrahedron Letters, ISSN: 18733581 00404039
Ngiap-Kie Lim; Haiming Zhang; C. Gregory Sowell; Francis Gosselin
Organic Process Research and Development, ISSN: 1520586X 10836160
Nicholas A. White; Kyle Clagg; Lauren E. Sirois; Ngiap-Kie Lim; William A. Nack; Paul D. O'Shea; Haiming Zhang; Francis Gosselin
Angewandte Chemie - International Edition, ISSN: 15213773 14337851
Raphael Bigler; Kyle A. Mack; Jeff Shen; Paolo Tosatti; Chong Han; Stephan Bachmann; Haiming Zhang; Michelangelo Scalone; Andreas Pfaltz; Scott E. Denmark; Stefan Hildbrand; Francis Gosselin
Advanced Synthesis and Catalysis, ISSN: 16154169 16154150
Rémi Lavernhe; Eric J. Alexy; Haiming Zhang; Brian M. Stoltz
Organic Letters, ISSN: 15237052 15237060
Nicholas A. White; Kyle Clagg; Lauren E. Sirois; Kyle A. Mack; Mohammad Al-Sayah; William A. Nack; Paul D. O'Shea; Haiming Zhang; Francis Gosselin
Tetrahedron, ISSN: 14645416 00404020
Tyler J. Fulton; Brenda Wu; Eric J. Alexy; Haiming Zhang; Brian M. Stoltz
Journal of Organic Chemistry, ISSN: 15206904 00223263
Haiming Zhang; Beryl X. Li; Brian Wong; Andreas Stumpf; C. Gregory Sowell; Francis Gosselin
Organic Letters, ISSN: 15237052 15237060
Ngiap-Kie Lim; Xin Linghu; Nicholas Wong; Haiming Zhang; C. Gregory Sowell; Francis Gosselin
ACS Symposium Series, ISSN: 19475918 00976156
James J. Crawford; Haiming Zhang
Journal of Organic Chemistry, ISSN: 15206904 00223263
Scott Savage; Andrew McClory; Haiming Zhang; Theresa Cravillion; Ngiap-Kie Lim; Colin Masui; Sarah J. Robinson; Chong Han; Christoph Ochs; Pankaj D. Rege; Francis Gosselin
Organic Process Research and Development, ISSN: 1520586X 10836160
Haiming Zhang; Theresa Cravillion; Ngiap-Kie Lim; Qingping Tian; Danial Beaudry; Jessica L. Defreese; Alec Fettes; Philippe James; David Linder; Sushant Malhotra; Chong Han; Remy Angelaud; Francis Gosselin
Organic Letters, ISSN: 15237052 15237060
Ian S. Young; Anna-Lena Glass; Theresa Cravillion; Chong Han; Haiming Zhang; Francis Gosselin
Organic Letters, ISSN: 15237052 15237060
Michael E. Dalziel; Julie A. Deichert; Diane Carrera; Danial Beaudry; Chong Han; Haiming Zhang; Remy Angelaud
Organic Letters, ISSN: 15237052 15237060
Ngiap-Kie Lim; Theresa Cravillion; Scott Savage; Andrew McClory; Chong Han; Haiming Zhang; Antonio G. DiPasquale; Francis Gosselin
Organic Letters, ISSN: 15237052 15237060
Cosme Sandoval; Ngiap-Kie Lim; Haiming Zhang
Organic Letters, ISSN: 15237052 15237060
Ngiap-Kie Lim; Patrick Weiss; Beryl X. Li; Christina H. McCulley; Stephanie R. Hare; Bronwyn L. Bensema; Teresa A. Palazzo; Dean J. Tantillo; Haiming Zhang; Francis Gosselin
Journal of the American Chemical Society, ISSN: 15205126 00027863
Kyle A. Mack; Andrew McClory; Haiming Zhang; Francis Gosselin; David B. Collum
Journal of the American Chemical Society, ISSN: 15205126 00027863
Beryl X. Li; Diane N. Le; Kyle A. Mack; Andrew McClory; Ngiap-Kie Lim; Theresa Cravillion; Scott Savage; Chong Han; David B. Collum; Haiming Zhang; Francis Gosselin
Organic Letters, ISSN: 15237052 15237060
Michael E. Dalziel; Penghao Chen; Diane Carrera; Haiming Zhang; Francis Gosselin
Organic Process Research and Development, ISSN: 1520586X 10836160
Xin Linghu; Nicholas Wong; Hans Iding; Vera Jost; Haiming Zhang; Stefan G. Koenig; C. Gregory Sowell; Francis Gosselin
Tetrahedron Letters, ISSN: 18733581 00404039
Ken Cheng; Andrew McClory; Whitney Walker; Jie Xu; Haiming Zhang; Remy Angelaud; Francis Gosselin
Tetrahedron Letters, ISSN: 18733581 00404039
Eugenia Pushkarskaya; Brian Wong; Chong Han; Simona S. Capomolla; Christine Gu; Brian M. Stoltz; Haiming Zhang
Organic Letters, ISSN: 15237052 15237060
Jeff Shen; Brian Wong; Christine Gu; Haiming Zhang
Tetrahedron, ISSN: 14645416 00404020
Jeff Shen; Haiming Zhang
Organic Letters, ISSN: 15237052 15237060
Simona S. Capomolla; Ngiap-Kie Lim; Haiming Zhang
Tetrahedron, ISSN: 00404020 14645416
Brian Wong; Xin Linghu; James J. Crawford; Joy Drobnick; Wendy Lee; Haiming Zhang
Molecular Pharmaceutics, ISSN: 15438384 15438392
Po-Chang Chiang; Hank La; Haiming Zhang; Harvey Wong
Synthesis (Germany), ISSN: 00397881 1437210X
Brian Wong; Andreas Stumpf; Diane Carrera; Christine Gu; Haiming Zhang
Education
- Iowa State University, Ph.D. / Organic Chemistry – 2003
- University of Science and Technology of China, M.S. / Organic Chemistry – 1998
- University of Science and Technology of China, B.S. / Chemical Physics – 1996
Awards & Honors
- Roche Environmental Awareness in Chemical Technology (REACT) Award, Process Development of GDC-9545 – 2020
- Roche Environmental Awareness in Chemical Technology (REACT) Award, Process Development of GDC-0853 – 2020
- ACS Young Investigator Award, Division of Organic Chemistry – 2016