Genentech: Haiming Zhang | Distinguished Scientist and Director, Small Molecule Process Chemistry

Scientists / Our Scientists

"Advancing science for the benefit of patients."

Years at Genentech

Publications at Genentech

Awards & Honors

Haiming obtained both his B.S. and M.S. degrees from the University of Science and Technology of China and his Ph.D. from Iowa State University under the direction of Prof. Richard Larock. He then did two years of postdoc with Prof. Brian Stoltz at Caltech. Haiming started his industrial career at Lexicon Pharmaceuticals in Princeton NJ in 2005 and joined Genentech in 2010. He is currently a Distinguished Scientist and Director in the Small Molecule Process Chemistry department at Genentech.

Featured Publication

Second-Generation Atroposelective Synthesis of KRAS G12C Inhibitor GDC-6036

Org. Lett. 2023, 25, 3417.

Xu, J.; Lim, N.-K.; Timmerman, J. C.; Clagg, K.; Shen, J.; White, N. A.; Sirois, L. E.; Orcel, U.; Bigler, R.; Trachsel, E.; Bachmann, S.;^* Zhang, H.;^* Angelaud, R.; Gosselin F.

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Atroposelective Negishi Coupling Development Guided by Multivariate Linear Regression Analysis: Asymmetric Synthesis of KRAS G12C Inhibitor GDC-6036

J. Am. Chem. Soc. 2022, 144, 20955.

Xu, J.; Grosslight, S.; Mack, K. A.; Nguyen S. C.; Clagg, C.; Lim, N.-K.; Timmerman, J. C.; Shen, J.; White, N. A.; Sirois, L. E.; Han, C.; Sigman, M. S.^* Zhang, H.;^* Gosselin, F.

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Asymmetric Hydrogenation of Unfunctionalized, Tetrasubstituted, Acyclic Olefins

Angew. Chem., Int. Ed. 2020, 59, 2844.

Bigler, R.;^* Mack, K. A.; Shen, J.; Tosatti, P.; Han, C.; Bachmann, S.; Zhang, H.;^* Scalone, M.; Pfaltz, A.; Denmark, S. E.; Hildbrand, S.; Gosselin, F.^*

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Catalytic Enantioselective Synthesis of Acyclic Quaternary Centers: Palladium-Catalyzed Decarboxylative Allylic Alkylation of Fully Substituted Acyclic Enol Carbonates

J. Am. Chem. Soc. 2018, 140, 10109.

Alexy, E. J.; Zhang, H.^*, Stoltz, B. M.^*

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Development of an Efficient Manufacturing Process for Reversible Bruton’s Tyrosine Kinase Inhibitor GDC-0853

Org. Process Res. Dev. 2018, 22, 978.

Zhang, H.;^* Cravillion, T.; Lim, N.-K.; Tian, Q.; Beaudry, D.; Defreese, J.; Fettes, A.; James, P.; Linder, D.; Malhotra, S.; Han, C.; Gosselin, F.

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Lithium Hexamethyldisilazide-Mediated Enolization of Highly Substituted Aryl Ketones: Structural and Mechanistic Basis of the E/Z Selectivities

J. Am. Chem. Soc. 2017, 139, 12181.

Mack, K. A.; McClory, A.; Zhang, H.;^* Gosselin, F.; Collum, D. B.^*

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Highly Stereoselective Synthesis of Tetrasubstituted Acyclic All-carbon Olefins via Enol Tosylation and Suzuki‒Miyaura Coupling

J. Am. Chem. Soc. 2017, 139, 10777.

Li, B. X.; Le, D. N.; Mack, K. A.; McClory, A.; Lim, N.-K.; Cravillion, T.; Savage, S.; Han, C.; Collum, D. B.; Zhang, H.;^* Gosselin, F.^*

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Strategic planning, route scouting and process development of various small molecule development candidates ranging from LSR to Ph3.

Atroposelective Negishi Coupling Optimization Guided by Multivariate Linear Regression Analysis: Asymmetric Synthesis of KRAS G12C Covalent Inhibitor GDC-6036

Journal of the American Chemical Society, ISSN: 15205126 00027863

Jie Xu; Samantha Grosslight; Kyle A. Mack; Sierra C. Nguyen; Kyle Clagg; Ngiap-Kie Lim; Jacob C. Timmerman; Jeff Shen; Nicholas A. White; Lauren E. Sirois; Chong Han; Haiming Zhang; Matthew S. Sigman; Francis Gosselin

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Haiming Zhang

Distinguished Scientist and Director, Small Molecule Process Chemistry

Featured Publication

Second-Generation Atroposelective Synthesis of KRAS G12C Inhibitor GDC-6036

Atroposelective Negishi Coupling Development Guided by Multivariate Linear Regression Analysis: Asymmetric Synthesis of KRAS G12C Inhibitor GDC-6036

Asymmetric Hydrogenation of Unfunctionalized, Tetrasubstituted, Acyclic Olefins

Catalytic Enantioselective Synthesis of Acyclic Quaternary Centers: Palladium-Catalyzed Decarboxylative Allylic Alkylation of Fully Substituted Acyclic Enol Carbonates

Development of an Efficient Manufacturing Process for Reversible Bruton’s Tyrosine Kinase Inhibitor GDC-0853

Lithium Hexamethyldisilazide-Mediated Enolization of Highly Substituted Aryl Ketones: Structural and Mechanistic Basis of the E/Z Selectivities

Highly Stereoselective Synthesis of Tetrasubstituted Acyclic All-carbon Olefins via Enol Tosylation and Suzuki‒Miyaura Coupling