Haiming Zhang - Director & Distinguished Scientist - Chemistry, Small Molecule Process Chemistry

Haiming Zhang

Director & Distinguished Scientist - Chemistry, Small Molecule Process Chemistry

"Advancing science for the benefit of patients."
Years at Genentech
Publications at Genentech
Awards & Honors

Haiming obtained both his B.S. and M.S. degrees from the University of Science and Technology of China and his Ph.D. from Iowa State University under the direction of Prof. Richard Larock. He then did two years of postdoc with Prof. Brian Stoltz at Caltech working on CH Functionalization chemistry and total synthesis of natural product Telomestatin. Haiming started his industrial career at Lexicon Pharmaceuticals in Princeton NJ in 2005 and moved to Genentech in 2010. He is currently a Sr. Pr. Scientist and Group Leader in the Small Molecule Process Chemistry department at Genentech.

Featured Publication

Asymmetric Hydrogenation of Unfunctionalized, Tetrasubstituted, Acyclic Olefins

Int. Ed. 2020, 59, 2844.

Bigler, R.;* Mack, K. A.; Shen, J.; Tosatti, P.; Han, C.; Bachmann, S.; Zhang, H.;* Scalone, M.; Pfaltz, A.; Denmark, S. E.; Hildbrand, S.; Gosselin, F.* Angew.

Convergent Synthesis of PI3K Inhibitor GDC-0908 Featuring Palladium-Catalyzed Direct C-H Arylation toward Dihydrobenzothienooxepines

Org. Chem. 2019, 84, 4796.

Zhang, H.;* Li, B. X.; Wong, B.; Stumpf, A.; Sowell, C. G.; Gosselin, F. J.

Catalytic Enantioselective Synthesis of Acyclic Quaternary Centers: Palladium-Catalyzed Decarboxylative Allylic Alkylation of Fully Substituted Acyclic Enol Carbonates

J. Am. Chem. Soc. 2018, 140, 10109.

Alexy, E. J.; Zhang, H.*, Stoltz, B. M.

Development of an Efficient Manufacturing Process for Reversible Bruton’s Tyrosine Kinase Inhibitor GDC-0853

Process Res. Dev. 2018, 22, 978.

Zhang, H.;* Cravillion, T.; Lim, N.-K.; Tian, Q.; Beaudry, D.; Defreese, J.; Fettes, A.; James, P.; Linder, D.; Malhotra, S.; Han, C.; Gosselin, F.

Synthesis of Highly Stereodefined Tetrasubstituted Acyclic All-carbon Olefins via a syn-Elimination Approach

Org. Lett. 2017, 19, 6212.

Lim, N.-K.;* Weiss, P.; Li, B. X.; McCulley, C. H.; Hare, S. R.; Bensema, B. L.; Palazzo, T. A.; Tantillo, D. J.;* Zhang, H.;* Gosselin, F.

Lithium Hexamethyldisilazide-Mediated Enolization of Highly Substituted Aryl Ketones: Structural and Mechanistic Basis of the E/Z Selectivities

J. Am. Chem. Soc. 2017, 139, 12181.

Mack, K. A.; McClory, A.; Zhang, H.;* Gosselin, F.; Collum, D. B.*

Highly Stereoselective Synthesis of Tetrasubstituted Acyclic All-carbon Olefins via Enol Tosylation and Suzuki‒Miyaura Coupling

J. Am. Chem. Soc. 2017, 139, 10777.

Li, B. X.; Le, D. N.; Mack, K. A.; McClory, A.; Lim, N.-K.; Cravillion, T.; Savage, S.; Han, C.; Collum, D. B.; Zhang, H.;* Gosselin, F.