Isidro Hötzel
Distinguished Scientist (Technology), Antibody Engineering, Drug Discovery
"Being part of the postdoctoral program has been one of the most rewarding aspects of my work at Genentech."
19
Years at Genentech
47
Publications at Genentech
I started working at Genentech in 2005 as a Scientist to develop technologies for antibody discovery against challenging targets. An exciting aspect of this work has been the opportunity for extensive collaborations with scientists in the molecular biology, oncology, infectious diseases, structural biology, protein engineering groups within Genentech to apply these technologies to the development of potential therapeutic molecules.
Featured Publication
Modular protein expression by RNA trans-splicing enables flexible expression of antibody formats in mammalian cells from a dual-host phage display vector.
Protein Eng Des Sel. 2015; 28(10):437-44
Shang Y, Tesar D, Hötzel I.
My Focus
My research focuses on technologies for antibody discovery and optimization. Active areas of work in my group include phage display, next-generation sequencing of antibody repertoires and antibody libraries, streamlined protein expression processes, assays and methods to assess drug-like properties of therapeutic antibody candidates and bioinformatics tools for antibody engineering.
Genentech Publications
Nature Communications,
Yi-Chun Hsiao; Heidi J. A. Wallweber; Robert G. Alberstein; Zhonghua Lin; Du; Ainhoa Etxeberria; Theint Aung; Yonglei Shang; Dhaya Seshasayee; Franziska Seeger; Andrew M. Watkins; David V. Hansen; Christopher J. Bohlen; Peter L. Hsu; Isidro Hötzel
Journal of Neuroscience, ISSN: 02706474
Ainhoa Etxeberria; Yun-An A. Shen; Stephen T. Vito; Sean M. Silverman; Jose Imperio; Guita Lalehzadeh; Allison L. Soung; Du; Luke Xie; Man Kin Choy; Yi-Chun Hsiao; Hai Ngu; Chang Hoon Cho; Soumitra Ghosh; Gloriia Novikova; Mitchell G. Rezzonico; Rebecca Leahey; Martin Weber; Alvin Gogineni; Justin Elstrott; Monica Xiong; Jacob J. Greene; Kimberly L. Stark; Pamela Chan; Gillie A. Roth; Max Adrian; Qingling Li; Meena Choi; Weng Ruh Wong; Wendy N. Sandoval; Oded Foreman; Alicia A. Nugent; Brad A. Friedman; Shraddha Sadekar; Isidro Hötzel; David V. Hansen; Ben Chih; Tracy J. Yuen; Robby M. Weimer; Amy Easton; William J. Meilandt; Christopher J. Bohlen
Protein Engineering, Design and Selection, ISSN: 17410126
Shuang Wu; Joni Tsukuda; Nancy Y. Chiang; To Hao; Yongmei Chen; Isidro Hötzel; Sowmya Balasubramanian; Nakamura; Ryan Kelly
12th International Conference on Learning Representations, ICLR 2024,
Nathan C. Frey; Daniel Berenberg; Karina Zadorozhny; Joseph Kleinhenz; Julien Lafrance-Vanasse; Isidro Hötzel; Yan Wu; Stephen Ra; Richard Bonneau; Kyunghyun Cho; Andreas Loukas; Vladimir Gligorijevic; Saeed Saremi
Alzheimer's and Dementia, ISSN: 15525260
Stephen P. Schauer; Chang Hoon Cho; Gloriia Novikova; Gillie A. Roth; Julie Lee; Anup D. Sharma; Alejandro R Foley; Carl Ng; Philip Shen; Meena Choi; Taylur P. Ma; Lilian Phu; Hanna G. Budayeva; Tommy K. Cheung; Guita Lalehzadeh; Jose Imperio; Hai Ngu; Ainhoa Etxeberria; Yuxin Liang; Mitchell G. Rezzonico; Michelle Dourado; Kevin Huang; Zijuan Lai; Martha Hokom; Nikhil J. Pandya; Dwight F. Newton; Alyaa M. Abdel-Haleem; Pamela Chan; Donna W. Lee; Nardos G. Tassew; Dewakar Sangaraju; Deborah O'Connor; Isidro Hötzel; Kimberly L. Stark; Carolina Chou; Oded Foreman; Amy Easton; Kristin R. Wildsmith; Gizette Sperinde; Christopher M. Rose; Brad A. Friedman; Reina N. Fuji; Robby M. Weimer; William J. Meilandt; Shraddha Sadekar; Alicia A. Nugent; Anne Biever
Scientific Reports,
Isidro Hötzel; Carlos E. Suarez
Neurobiology of Disease, ISSN: 1095953X 09699961
Robert Brendza; Xiaoying Gao; Kimberly L. Stark; Han Lin; Seung-Hye Lee; Changyun Hu; Hao Cai; Danielle DiCara; Yi-Chun Hsiao; Hai Ngu; Oded Foreman; Miriam Baca; Monika Dohse; Jean-Philippe Fortin; Corpuz; Dhaya Seshasayee; Amy Easton; Gai Ayalon; Isidro Hötzel; Ben Chih
Advances in Neural Information Processing Systems, ISSN: 10495258
Nate Gruver; Samuel Stanton; Nathan C. Frey; Tim G.J. Rudner; Isidro Hötzel; Julien Lafrance-Vanasse; Arvind Rajpal; Kyunghyun Cho; Andrew Gordon Wilson
Advances in Neural Information Processing Systems, ISSN: 10495258
Karolis Martinkus; Jan Ludwiczak; Kyunghyun Cho; Wei-Ching Liang; Julien Lafrance-Vanasse; Isidro Hötzel; Arvind Rajpal; Yan Wu; Richard Bonneau; Vladimir Gligorijevic; Andreas Loukas
Analytical and Bioanalytical Chemistry, ISSN: 16182650 16182642
Cong Wu; Ryan Cook; Ping Wu; Neha Srikumar; Elin Chee; William S. Sawyer; Hua Wang; Meredith Hazen; Isidro Hötzel; Elsa-Noah N’Diaye; Ning Ding; Yichin Liu; John C. Tran; Zhengmao Ye
Nature Immunology, ISSN: 15292916 15292908
Rosa Barreira da Silva; Ricardo M. Leitao; Ximo Pechuan-Jorge; Scott Werneke; Jason Oeh; Vincent Javinal; Yingyun Wang; Wilson Phung; Christine Everett; Jim Nonomiya; David Arnott; Cheng Lu; Yi-Chun Hsiao; James T. Koerber; Isidro Hötzel; James Ziai; Zora Modrusan; Thomas H. Pillow; Merone Roose-Girma; Jill Schartner; Mark Merchant; Sascha Rutz; Celine Eidenschenk; Ira Mellman; Matthew L. Albert
Journal of Virology, ISSN: 10985514 0022538X
Isidro Hötzel
Nature Immunology, ISSN: 15292916 15292908
Barreira da Silva; Ricardo M. Leitao; Ximo Pechuan-Jorge; Scott Werneke; Jason Oeh; Vincent Javinal; Yingyun Wang; Wilson Phung; Christine Everett; Jim Nonomiya; David Arnott; Cheng Lu; Yi-Chun Hsiao; James T. Koerber; Isidro Hötzel; James Ziai; Zora Modrusan; Thomas H. Pillow; Merone Roose-Girma; Jill Schartner; Mark Merchant; Sascha Rutz; Celine Eidenschenk; Ira Mellman; Matthew L. Albert
Analytical and Bioanalytical Chemistry, ISSN: 16182650 16182642
Cong Wu; Ryan Cook; Ping Wu; Neha Srikumar; Elin Chee; William S. Sawyer; Hua Wang; Meredith Hazen; Isidro Hötzel; Elsa-Noah N’Diaye; Ning Ding; Yichin Liu; John C. Tran; Zhengmao Ye
Analytical and Bioanalytical Chemistry, ISSN: 16182642
Cong Wu; Ryan Cook; Ping Wu; Neha Srikumar; Elin Chee; William S. Sawyer; Hua Wang; Meredith Hazen; Isidro Hötzel; Elsa-Noah N’Diaye; Ning Ding; Yichin Liu; John C. Tran; Zhengmao Ye
Nature Immunology, ISSN: 15292908
Barreira da Silva; Ricardo M. Leitao; Ximo Pechuan-Jorge; Scott Werneke; Jason Oeh; Vincent Javinal; Yingyun Wang; Wilson Phung; Christine Everett; Jim Nonomiya; David Arnott; Cheng Lu; Yi-Chun Hsiao; James T. Koerber; Isidro Hötzel; James Ziai; Zora Modrusan; Thomas H. Pillow; Merone Roose-Girma; Jill Schartner; Mark Merchant; Sascha Rutz; Celine Eidenschenk; Ira Mellman; Matthew L. Albert
Journal of Virology, ISSN: 10985514 0022538X
Isidro Hötzel
Science Translational Medicine, ISSN: 19466242 19466234
Gai Ayalon; Seung-Hye Lee; Oskar Adolfsson; Corinne Foo-Atkins; Jasvinder K. Atwal; Mira Blendstrup; Helen Booler; Joseph Bravo; Robert Brendza; Flavia Brunstein; Ruby Chan; Priya Chandra; Jessica A. Couch; Akash Datwani; Barthélemy Demeule; Danielle DiCara; Erickson; James A. Ernst; Oded Foreman; Dongping He; Isidro Hötzel; Michael Keeley; Michael Kwok; Julien Lafrance-Vanasse; Han Lin; Yanmei Lu; Wilman Luk; Paul T. Manser; Andreas Muhs; Hai Ngu; Andrea Pfeifer; Maria Pihlgren; Gautham K. Rao; Kimberly Scearce-Levie; Stephen P. Schauer; William Smith; Hilda Solanoy; Edmond Teng; Kristin R. Wildsmith; Daniela Bumbaca Yadav; Yong Ying; Reina N. Fuji; Geoffrey A. Kerchner
American Journal of Physiology - Cell Physiology, ISSN: 15221563 03636143
Elsa-Noah N’Diaye; Ryan Cook; Hua Wang; Ping Wu; Ryan LaCanna; Cong Wu; Zhengmao Ye; Dhaya Seshasayee; Meredith Hazen; Wei Yu Lin; Tulika Tyagi; Isidro Hötzel; Lucinda Tam; Robert J. Newman; Merone Roose-Girma; Paul J. Wolters; Ning Ding
Communications Biology, ISSN: 23993642
Kannan Sankar; Kam Hon Hoi; Isidro Hötzel
mAbs, ISSN: 19420870 19420862
Yi-Chun Hsiao; Ying-Jiun J. Chen; Leonard D. Goldstein; Jia Wu; Zhonghua Lin; Kellen Schneider; Subhra Chaudhuri; Aju Antony; Kanika Bajaj Pahuja; Zora Modrusan; Dhaya Seshasayee; Somasekar Seshagiri; Isidro Hötzel
Neurobiology of Disease, ISSN: 1095953X 09699961
Arundhati Sengupta Ghosh; Sara L. Dominguez; Luke Xie; Kai H. Barck; Zhiyu Jiang; Timothy K. Earr; Jose Imperio; Lilian Phu; Hanna G. Budayeva; Donald S. Kirkpatrick; Hao Cai; Dongping He; Jeffrey Eastham-Anderson; Hai Ngu; Oded Foreman; Maj Hedehus; Mike Reichelt; Isidro Hötzel; Yonglei Shang; Richard A. D. Carano; Gai Ayalon; Amy Easton
Communications Biology, ISSN: 23993642
Leonard D. Goldstein; Ying-Jiun J. Chen; Jia Wu; Subhra Chaudhuri; Yi-Chun Hsiao; Kellen Schneider; Kam Hon Hoi; Zhonghua Lin; Steve Guerrero; Bijay S. Jaiswal; Stinson; Aju Antony; Kanika Bajaj Pahuja; Dhaya Seshasayee; Zora Modrusan; Isidro Hötzel; Somasekar Seshagiri
mAbs, ISSN: 19420870 19420862
Yi-Chun Hsiao; Yonglei Shang; Danielle DiCara; Angie Yee; Joyce Lai; Si Hyun Kim; Diego Ellerman; Corpuz; Yongmei Chen; Sharmila Rajan; Hao Cai; Yan Wu; Dhaya Seshasayee; Isidro Hötzel
Neurobiology of Disease, ISSN: 1095953X 09699961
Arundhati Sengupta Ghosh; Sara L. Dominguez; Luke Xie; Kai H. Barck; Zhiyu Jiang; Timothy K. Earr; Jose Imperio; Lilian Phu; Hanna G. Budayeva; Donald S. Kirkpatrick; Hao Cai; Jeffrey Eastham-Anderson; Hai Ngu; Oded Foreman; Maj Hedehus; Mike Reichelt; Isidro Hötzel; Yonglei Shang; Richard A. D. Carano; Gai Ayalon; Amy Easton
mAbs, ISSN: 19420870 19420862
Danielle DiCara; Nisana Andersen; Ruby Chan; James A. Ernst; Gai Ayalon; Greg A. Lazar; Nick Agard; Amy Hilderbrand; Isidro Hötzel
mAbs, ISSN: 19420870 19420862
Rina Fong; Kimberly K. Kajihara; Matthew Chen; Isidro Hötzel; Sanjeev Mariathasan; Wouter L. W. Hazenbos; Patrick J. Lupardus
Molecular Pharmaceutics, ISSN: 15438392 15438384
Ankai Xu; Hok Seon Kim; Samarkand Estee; Sharon Viajar; William J. Galush; Avinash Gill; Isidro Hötzel; Greg A. Lazar; Paul McDonald; Nisana Andersen; Christoph Spiess
Journal of Immunological Methods, ISSN: 18727905 00221759
Yongmei Chen; Si Hyun Kim; Yonglei Shang; Joseph Guillory; Stinson; Qing Zhang; Isidro Hötzel; Kam Hon Hoi
Cancer Cell, ISSN: 18783686 15356108
Ji Li; Nicola J. Stagg; Jennifer A. Johnston; Michael J. Harris; Sam A. Menzies; Danielle DiCara; Vanessa Clark; Maria Hristopoulos; Ryan Cook; Dionysos S. Slaga; Rin Nakamura; Luke McCarty; Siddharth Sukumaran; Luis; Zhengmao Ye; Thomas D Wu; Teiko Sumiyoshi; Dimitry Danilenko; Genee Y. Lee; Klara Totpal; Diego Ellerman; Isidro Hötzel; John R. James; Teemu T. Junttila
Analytical Chemistry, ISSN: 15206882 00032700
John C. Tran; Daniel Tran; Amy Hilderbrand; Nisana Andersen; Tao Huang; Karin Reif; Isidro Hötzel; Stefanich; Yichin Liu; Jianyong Wang
Cell Reports, ISSN: 22111247
Seung-Hye Lee; Claire E. Le Pichon; Oskar Adolfsson; Valerie Gafner; Maria Pihlgren; Han Lin; Hilda Solanoy; Robert Brendza; Hai Ngu; Oded Foreman; Ruby Chan; James A. Ernst; Danielle DiCara; Isidro Hötzel; Karpagam Srinivasan; David V. Hansen; Jasvinder K. Atwal; Yanmei Lu; Daniela Bumbaca; Andrea Pfeifer; Ryan J. Watts; Andreas Muhs; Kimberly Scearce-Levie; Gai Ayalon
Toxicological Sciences, ISSN: 10960929 10966080
Kathila S. Rajapaksa; Tao Huang; Neeraj Sharma; Shannon Liu; Margaret Solon; Arthur Reyes; Sarah Paul; Angie Yee; Janet Tao; Sreedevi Chalasani; Nga Bien-Ly; Kai H. Barck; Richard A. D. Carano; Jianyong Wang; Linda Rangell; Meire C. Bremer; Dimitry Danilenko; Paula Katavolos; Isidro Hötzel; Karin Reif; Cary D. Austin
JCI insight, ISSN: 23793708
Tao Huang; Meredith Hazen; Yonglei Shang; Meijuan Zhou; Xiumin Wu; Donghong Yan; Zhonghua Lin; Margaret Solon; Luis; Hai Ngu; Yongchang Shi; Arna Katewa; David F. Choy; Nandhini Ramamoorthi; Erick R. Castellanos; Mercedesz Balazs; Min Xu; Wyne P. Lee; Marissa L. Matsumoto; Jian Payandeh; Joseph R. Arron; Hongo; Jianyong Wang; Isidro Hötzel; Cary D. Austin; Karin Reif
JCI insight,
Tao Huang; Meredith Hazen; Yonglei Shang; Meijuan Zhou; Xiumin Wu; Donghong Yan; Zhonghua Lin; Margaret Solon; Luis; Hai Ngu; Yongchang Shi; Arna Katewa; David F. Choy; Nandhini Ramamoorthi; Erick R. Castellanos; Mercedesz Balazs; Min Xu; Wyne P. Lee; Marissa L. Matsumoto; Jian Payandeh; Joseph R. Arron; Jo-Anne Hongo; Jianyong Wang; Isidro Hötzel; Cary D. Austin; Karin Reif
JCI insight, ISSN: 23793708
Tao Huang; Meredith Hazen; Yonglei Shang; Meijuan Zhou; Xiumin Wu; Donghong Yan; Zhonghua Lin; Margaret Solon; Luis; Hai Ngu; Yongchang Shi; Arna Katewa; David F. Choy; Nandhini Ramamoorthi; Erick R. Castellanos; Mercedesz Balazs; Min Xu; Wyne P. Lee; Marissa L. Matsumoto; Jian Payandeh; Joseph R. Arron; Jo-Anne Hongo; Jianyong Wang; Isidro Hötzel; Cary D. Austin; Karin Reif
mAbs, ISSN: 19420870 19420862
Tim D. Jones; Paul J. Carter; Pluckthun; Max Vásquez; Robert G. E. Holgate; Isidro Hötzel; Andrew G. Popplewell; Paul W. H. I. Parren; Markus Enzelberger; Hendrik J. Rademaker; Michael R. Clark; David C. Lowe; Bassil I. Dahiyat; Victoria Smith; John M. Lambert; Herren Wu; Mary Reilly; John S. Haurum; Stefan Dübel; James S. Huston; Thomas Schirrmann; Richard A. J. Janssen; Martin Steegmaier; Jane A. Gross; Andrew Bradbury; Dennis R. Burton; Dimiter S. Dimitrov; Kerry A. Chester; Martin J. Glennie; Julian Davies; Adam Walker; Steve Martin; John McCafferty; Matthew P. Baker
Journal of Biological Chemistry, ISSN: 1083351X 00219258
Daniela Bumbaca; Vikas Sharma; C. Andrew Boswell; Isidro Hötzel; Devin B. Tesar; Yonglei Shang; Yong Ying; Saloumeh Kadkhodayan Fischer; Jane L. Grogan; Eugene Y. Chiang; Konnie Urban; Sheila Ulufatu; Leslie A. Khawli; Saileta Prabhu; Sean B. Joseph; Robert F. Kelley
Protein Engineering, Design and Selection, ISSN: 17410134 17410126
Yonglei Shang; Devin B. Tesar; Isidro Hötzel
mAbs, ISSN: 19420870 19420862
Bing Li; Ashley Fouts; Katharina F. Stengel; Patricia Luhn; Michael Dillon; Wei-Ching Liang; Becket Feierbach; Robert F. Kelley; Isidro Hötzel
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Susmith Mukund; Yonglei Shang; Holly J. Clarke; Azadeh Madjidi; Jacob E. Corn; Lance Kates; Ganesh Kolumam; Vicki Chiang; Luis; Jeremy Murray; Yingnan Zhang; Isidro Hötzel; Christopher M. Koth; Bernard B. Allan
Protein Engineering, Design and Selection, ISSN: 17410126 17410134
Devin B. Tesar; Isidro Hötzel
mAbs, ISSN: 19420862 19420870
Xiangdan Wang; Quarmby; Carl Ng; Anan Chuntharapai; Theresa Shek; Eigenbrot; Robert F. Kelley; Steven Shia; Krista McCutcheon; John Lowe; Cecilia Leddy; Kyle Coachman; Cain; Felix Chu; Isidro Hötzel; Mauricio Maia; Eric Wakshull; Yang
mAbs, ISSN: 19420862 19420870
Isidro Hötzel; Frank-Peter Theil; Lisa J. Bernstein; Saileta Prabhu; Rong Deng; Leah Quintana; Jeff Lutman; Renuka Sibia; Pamela Chan; Daniela Bumbaca; Fielder; Paul J. Carter; Robert F. Kelley
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Christopher M. Koth; Jeremy Murray; Susmith Mukund; Azadeh Madjidi; Alexandra Minn; Holly J. Clarke; Wong; Vicki Chiang; Luis; Alberto Estevez; Jesus Rondon; Yingnan Zhang; Isidro Hötzel; Bernard B. Allan
Protein Engineering, Design and Selection, ISSN: 17410126 17410134
Isidro Hötzel; Vicki Chiang; Jingyu Diao; Homer Pantua; Henry R. Maun; Sharookh B. Kapadia
Virology, ISSN: 00426822 10960341
Isidro Hötzel
Education
- Washington State University, Department of Veterinary Microbiology and Pathology, Postdoctoral Fellow – 2003
- Washington State University, Department of Veterinary Microbiology and Pathology, Ph.D. – 1997
- Universidade Federal do Rio Grande do Sul, Brazil, DVM – 1992
