"I’m excited for the opportunity to discover new aspects of disease biology and then translate that insight into therapeutic approaches."
Since joining Genentech, I’ve engaged in research aimed at understanding the basis of neural circuit dysfunction in diseases such as Alzheimer’s. Based on this research, my lab has pursued therapeutic approaches for modulating synapse function. A more recent focus of my lab is to understand the interaction of glial cells with neurons during disease pathogenesis. While glial cell activation can have aspects that are beneficial in the diseased brain, current projects focus on identifying the pathways that mediate damaging attack on neurons by activated glial cells. This research is identifying potential points of therapeutic intervention for protecting against the harmful aspects of neuroinflammation.
The Genentech postdoc program provides a unique opportunity to pursue fundamental research, much as in a well-resourced academic setting, while at the same time being immersed in a cutting-edge drug discovery environment. Projects in my lab focus on using the latest tools to uncover new insight into the neurobiology of disease.
Nature Aging. 2022 Sep;2(9):837-850
Cell Rep. 2020 Jan 14;30(2):381-396.e4.
Cell Rep. 2019 Aug 20;28(8):2111-2123.e6.
Neuron. 2018 Dec 19;100(6):1322-1336.e7.
Neuron. 2016 Mar 2;89(5):983-99.
A current focus of my group is understanding the role of the immune response in the central nervous system during neurodegeneration. We are particularly interested in how activated microglia and astrocytes interact with neural circuits and which pathways could be targeted for neuronal protection.