JT Koerber
Senior Scientist, Antibody Engineering
"We work to collaboratively discover and engineer novel antibody solutions as biological tools and next-generation therapeutics."
7
Years at Genentech
12
Publications
4
Awards & Honors
I joined Genentech as a Scientist in Fall 2014 in the Department of Antibody Engineering after completing graduate and postdoctoral studies in protein engineering focused on viral gene delivery and rationally designed antibodies. At Genentech, I enjoy working in the collaborative environment to discover novel biology and transformative drugs. We work to advance new therapies to patients by tackling challenging targets and engineering around drug delivery barriers.
My Focus
My group seeks to discover and engineer novel antibody solutions as biological tools and next-generation therapeutics. We focus mainly on two areas: complex membrane proteins and engineered antibody formats.
- Many complex membrane proteins, such as multi-transmembrane or disulfide-rich proteins, are often mutated or dysregulated in human disease, and as a whole, comprise a largely untapped target class. My group works in collaboration with structural biology and other biology groups to develop new technologies to advance therapeutic development in this area and unlock this challenging target space.
- Many biological barriers exist that prevent efficient drug delivery to a tissue of interest. We work to engineer novel antibody formats capable of overcoming these barriers.
Publications
mAbs, ISSN: 19420870 19420862
Josefa Dela Cruz Chuh; MaryAnn Go; Yvonne Chen; Jun Guo; Hanine Rafidi; Danielle Mandikian; Yonglian Sun; Zhonghua Lin; Kellen Schneider; Pamela Zhang; Rajesh Vij; Danielle Sharpnack; Pamela Chan; Cecile de la Cruz; Jack D. Sadowsky; Dhaya Seshasayee; JT Koerber; Thomas Pillow; Gail D. Phillips; Rebecca K. Rowntree; Andy Boswell; Kathy Kozak; Andy Polson; Paul Polakis; Shang-Fan Yu; Peter Dragovich; Nick Agard
Bivalent antibody pliers inhibit β-tryptase by an allosteric mechanism dependent on the IgG hinge
Nature Communications,
Henry Maun; Rajesh Vij; Ben Walters; Ashley Morando; Janet Jackman; Ping Wu; Alberto Estevez; Xiaocheng Chen; Yvonne Franke; Terry Lipari; Mark Dennis; Daniel Kirchhofer; Claudio Ciferri; Kelly Loyet; Tangsheng Yi; Charles Eigenbrot; Bob Lazarus; JT Koerber
Bioanalysis, ISSN: 17576199 17576180
Gizette Sperinde; Meire Bremer; Henry Maun; Amos Baruch; Bob Lazarus; JT Koerber; Rajesh Vij; Tangsheng Yi; Sally Fischer; Tracy Staton
Molecular Cancer Therapeutics, ISSN: 15388514
Lidia Nazarova; Hanine Rafidi; Danielle Mandikian; Greg Ferl; JT Koerber; Christopher W. Davies; Sheila Ulufatu; Jason Ho; Jeffrey Lau; Shang-Fan Yu; James A. Ernst; Jack D. Sadowsky; Andy Boswell
Structure of CD20 in complex with the therapeutic monoclonal antibody rituximab
Science, ISSN: 00368075
Lionel Rouge; Nancy Chiang; Micah Steffek; Christine Kugel; Tristan I. Croll; Christine Tam; Alberto Estevez; Chris Arthur; Chris Koth; Claudio Ciferri; Edward Kraft; Jian Payandeh; Gerry Nakamura; JT Koerber; Alexis Rohou
Cell, ISSN: 10974172 00928674
Henry Maun; Janet Jackman; David Choy; Kelly Loyet; Tracy Staton; Jim Jia; Amy Dressen; Jason A. Hackney; Meire Bremer; Ben Walters; Rajesh Vij; Xiaocheng Chen; Neil N. Trivedi; Ashley Morando; Terry Lipari; Yvonne Franke; Xiumin Wu; Juan Zhang; John Liu; Ping Wu; Diana Chang; Luz D. Orozco; Erin Christensen; Manda Wong; Racquel Corpuz; Julie Q. Hang; Jeff Lutman; Sid Sukumaran; Yan Wu; Savita Ubhayakar; Xiaorong Liang; Lawrence B. Schwartz; Magda Babina; Prescott G. Woodruff; John V. Fahy; Rahul Ahuja; George H. Caughey; Aija Kusi; Mark Dennis; Charles Eigenbrot; Daniel Kirchhofer; Cary Austin; Lawren Wu; JT Koerber; Wyne P. Lee; Brian Yaspan; Kathila Alatsis; Joe Arron; Bob Lazarus; Tangsheng Yi
Massive antibody discovery used to probe structure-function relationships of the essential outer membrane protein LptD
eLife,
Kelly Storek; Joyce Chan; Rajesh Vij; Nancy Chiang; Zhonghua Lin; Jack Bevers; Chris Koth; Jean-Michel Vernes; Gloria Meng; Peter Yin; Heidi Ackerly Wallweber; Olivier Dalmas; Stephanie Shriver; Christine Tam; Kellen Schneider; Dhaya Seshasayee; Gerry Nakamura; Peter Smith; Jian Payandeh; JT Koerber; Laetitia Comps-Agrar; Steven Rutherford
The Escherichia coli -barrel assembly machinery is sensitized to perturbations under high membrane fluidity
Journal of Bacteriology, ISSN: 00219193
Kelly M. Storek; Rajesh Vij; Dawei Sun; Peter Smith; James T. Koerber; Steven T. Rutherford
Scientific Reports, ISSN: 20452322
Rajesh Vij; Zhonghua Lin; Nancy Chiang; Jean-Michel Vernes; Kelly M. Storek; Summer Park; Joyce Chan; Y. Gloria Meng; Laetitia Comps-Agrar; Tricia Luhn; Sophia Lee; Kellen Schneider; Jack Bevers; Inna Zilberleyb; Christine Tam; Chris Koth; Min Xu; Avinash Gill; Marcy Auerbach; Peter Smith; Steven T. Rutherford; Gerry Nakamura; Dhaya Seshasayee; Jian Payandeh; James T. Koerber
Science Translational Medicine, ISSN: 19466242 19466234
Dion Slaga; Diego Ellerman; Twyla Lombana; Rajesh Vij; Ji Li; Maria Hristopoulos; Robyn Clark; Jennifer Johnston; Amy Shelton; Elaine Mai; Kapil Gadkar; Amy A. Lo; James T. Koerber; Klara Totpal; Prell; Genee Lee; Christoph Spiess; Teemu Junttila
PLoS ONE, ISSN: 19326203
Rajesh Vij; Zhonghua Lin; Kellen Schneider; Dhaya Seshasayee; James T. Koerber
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Kelly M. Storek; Marcy Auerbach; Handuo Shi; Natalie K. Garcia; Dawei Sun; Nicholas N. Nickerson; Rajesh Vij; Zhonghua Lin; Nancy Chiang; Kellen Schneider; Aaron Wecksler; Elizabeth Skippington; Gerry Nakamura; Dhaya Seshasayee; James T. Koerber; Jian Payandeh; Peter Smith; Steven T. Rutherford
Education
- University of California, Berkeley, PhD – 2008
- University of Illinois, Urbana-Champaign, B.S. – 2003
Awards & Honors
- Roche Key Contributor – 2017
- Roche Key Contributor – 2016
- Life Sciences Research Foundational Postdoctoral Fellowship – 2009
- National Science Foundation Graduate Fellowship – 2003