JT Koerber
Distinguished Scientist and Director, Antibody Engineering, Drug Discovery
"We work to collaboratively discover and engineer novel antibody solutions as biological tools and next-generation therapeutics."
11
Years at Genentech
39
Publications at Genentech
4
Awards & Honors
I joined Genentech as a Scientist in Fall 2014 in the Department of Antibody Engineering after completing graduate and postdoctoral studies in protein engineering focused on viral gene delivery and rationally designed antibodies. At Genentech, I enjoy working in the collaborative environment to discover novel biology and transformative drugs. We work to advance new therapies to patients by tackling challenging targets and engineering around drug delivery barriers.
My Focus
My group seeks to discover and engineer novel antibody solutions as biological tools and next-generation therapeutics. We focus mainly on two areas: complex membrane proteins and engineered antibody formats.
- Many complex membrane proteins, such as multi-transmembrane or disulfide-rich proteins, are often mutated or dysregulated in human disease, and as a whole, comprise a largely untapped target class. My group works in collaboration with structural biology and other biology groups to develop new technologies to advance therapeutic development in this area and unlock this challenging target space.
- Many biological barriers exist that prevent efficient drug delivery to a tissue of interest. We work to engineer novel antibody formats capable of overcoming these barriers.
Genentech Publications
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424
Naruhisa Ota; Christopher W. Davies; Jing Kang; Donghong Yan; Alexis Scherl; Anne Wong; Ryan Cook; Xun Tao; Debra Dunlap; Sha Klabunde; Priscilla Mantik; Vishnu Mohanan; WeiYu Lin; Jacqueline McBride; Shraddha Sadekar; Kelly M. Storek; Patrick J. Lupardus; Zhengmao Ye; Heidi J. A. Wallweber; James R. Kiefer; Min Xu; Pamela Chan; Karthik Nagapudi; Tangsheng Yi; James T. Koerber
Journal of Immunological Methods, ISSN: 00221759
Yongchang Shi; Yonglian Sun; Akiko Seki; Sascha Rutz; James T. Koerber; Jianyong Wang
British Journal of Pharmacology, ISSN: 00071188
Gautham Gampa; Phillip Spinosa; Jennifer A. Getz; Yu Zhong; Wendy Halpern; Emel Esen; John Davies; Cassie Chou; Mandy Kwong; Yingyun Wang; Teresita L. Arenzana; Vittal Shivva; Mahrukh Huseni; Robert Hsieh; Jill Schartner; James T. Koerber; Sascha Rutz; Iraj Hosseini
Nature Communications,
Alessandra Castiglioni; Yagai Yang; Katherine Williams; Alvin Gogineni; Ryan Lane; Amber W. Wang; Justin A. Shyer; Zhe Zhang; Stephanie Mittman; Alan Gutierrez; Jillian L. Astarita; Minh Thai; Jeffrey Hung; Yeqing Angela Yang; Tony Pourmohamad; Patricia Himmels; Marco De Simone; Justin Elstrott; Aude-Hélène Capietto; Rafael Cubas; Zora Modrusan; Wendy N. Sandoval; James Ziai; Stephen Gould; Wenxian Fu; Wang; James T. Koerber; Shomyseh Sanjabi; Ira Mellman; Shannon J. Turley; Sören Müller
Nature Communications,
Dawei Sun; Yonglian Sun; Eric Janezic; Tricia Zhou; Matthew C. Johnson; Caleigh Azumaya; Sigrid Noreng; Cecilia Chiu; Akiko Seki; Teresita L. Arenzana; John M. Nicoludis; Yongchang Shi; Baomei Wang; Hoangdung Ho; Prajakta Joshi; Christine Tam; Jian Payandeh; Laetitia Comps-Agrar; Jianyong Wang; Sascha Rutz; James T. Koerber; Matthieu Masureel
AAPS Journal,
Hao Cai; Xun Tao; Jeongsup Shim; Rebecca N. Bauer; Meire C. Bremer; Wei Bu; Jason LaMar; Rachel Basile; Edward Dere; Tien Nguyen; Steven T. Laing; Pamela Chan; Tangsheng Yi; James T. Koerber; Gizette Sperinde; Stefanich
European Journal of Nuclear Medicine and Molecular Imaging, ISSN: 16197089 16197070
Shravan Sriraman; Christopher W. Davies; Herman S. Gill; James R. Kiefer; Jianping Yin; Annie Ogasawara; Alejandra Urrutia; Vincent Javinal; Zhonghua Lin; Dhaya Seshasayee; Ryan Abraham; Phil Haas; Christopher M. Koth; Jan Marik; James T. Koerber; Simon P. Williams
Analytical Chemistry, ISSN: 00032700
Rachel Liuqing Shi; Michael A. Dillon; Philip D. Compton; William S. Sawyer; John R. Thorup; Mandy Kwong; Pamela Chan; Cecilia Chiu; Ran Li; Rajbharan Yadav; Genee Y. Lee; Joshua G. Gober; Zhiyu Li; Adel ElSohly; Ayse Meric Ovacik; James T. Koerber; Christoph Spiess; Jonathan L. Josephs; John C. Tran
Bioconjugate Chemistry, ISSN: 10431802
Xiangdan Wang; Wenping Chang; Mehraban Khosraviani; Wilson Phung; Lingling Peng; Sivan Cohen; Ben Andrews; Yonglian Sun; Christopher W. Davies; James T. Koerber; Yang; Aimin Song
British Journal of Pharmacology, ISSN: 00071188
Eric Janezic; Alexander Doan; Elaine Mai; Daniel D. Bravo; Jianyong Wang; Hok Seon Kim; Christoph Spiess; Kathryn Bewley; Adel ElSohly; Wei-Ching Liang; James T. Koerber; Pascale Richalet; Marc Vanhove; Laetitia Comps-Agrar
Journal of Biological Chemistry, ISSN: 1083351X 00219258
Jocelyn Chan; Joyce Chan; Lily Shao; Scott Stawicki; Victoria Pham; Robert W. Akita; Marc Hafner; Lisa Crocker; Kebing Yu; James T. Koerber; Gabriele Schaefer; Laetitia Comps-Agrar
Science Translational Medicine, ISSN: 19466242 19466234
Joseph Chavarria-Smith; Cecilia P.C. Chiu; Janet Jackman; Jianping Yin; Juan Zhang; Jason A. Hackney; Wei-Yu Lin; Tulika Tyagi; Yonglian Sun; Janet Tao; Debra Dunlap; William D. Morton; Swapnil V. Ghodge; Henry R. Maun; Hong Li; Hilda Hernandez-Barry; Kelly M. Loyet; Emily Chen; John Liu; Christine Tam; Brian L. Yaspan; Hao Cai; Mercedesz Balazs; Joseph R. Arron; Jing Li; Arthur J. Wittwer; Rajita Pappu; Cary D. Austin; Wyne P. Lee; Robert A. Lazarus; Jawahar Sudhamsu; James T. Koerber; Tangsheng Yi
Nature Communications, ISSN: 20411723
Sigrid Noreng; Naruhisa Ota; Yonglian Sun; Hoangdung Ho; Matthew C. Johnson; Christopher P. Arthur; Kellen Schneider; Isabelle Lehoux; Christopher W. Davies; Kyle Mortara; Kit Wong; Dhaya Seshasayee; Matthieu Masureel; Jian Payandeh; Tangsheng Yi; James T. Koerber
Nature Communications,
Sigrid Noreng; Naruhisa Ota; Yonglian Sun; Hoangdung Ho; Matthew C. Johnson; Christopher P. Arthur; Kellen Schneider; Isabelle Lehoux; Christopher W. Davies; Kyle Mortara; Kit Wong; Dhaya Seshasayee; Matthieu Masureel; Jian Payandeh; Tangsheng Yi; James T. Koerber
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Janet Jackman; Amy Stockwell; David F. Choy; Markus M. Xie; Peipei Lu; Guiquan Jia; Hong Li; Abbas Alexander; Paola G. Bronson; Wei-Yu Lin; Cecilia P.C. Chiu; Henry R. Maun; Merone Roose-Girma; Lucinda Tam; Juan Zhang; Zora Modrusan; Robert R. Graham; Timothy Behrens; Steven R. White; Ted Naureckas; Carole Ober; Manuel A. R. Ferreira; Radislav Sedlacek; Jiansheng Wu; Wyne P. Lee; Robert A. Lazarus; James T. Koerber; Joseph R. Arron; Brian L. Yaspan; Tangsheng Yi
Analytical Biochemistry, ISSN: 10960309 00032697
Xiangdan Wang; Minh Michael Phan; Yonglian Sun; James T. Koerber; Hoangdung Ho; Yongmei Chen; Yang
Nature Biotechnology, ISSN: 15461696 10870156
Christopher W. Davies; Angela Oh; Rana Mroue; Micah Steffek; John M. Bruning; Yang Xiao; Siyu Feng; Sangeeta Jayakar; Emily Chan; Vidhyalakshmi Arumugam; Sean Carlo Uribe; Jake Drummond; Alexandra Frommlet; Cheng Lu; Yvonne Franke; Mark Merchant; Koeppen; John Quinn; Sushant Malhotra; Steven Do; Lewis Gazzard; Hans E. Purkey; Joachim Rudolph; Melinda M. Mulvihill; James T. Koerber; Weiru Wang; Marie Evangelista
Nature Immunology, ISSN: 15292916 15292908
Barreira da Silva; Ricardo M. Leitao; Ximo Pechuan-Jorge; Scott Werneke; Jason Oeh; Vincent Javinal; Yingyun Wang; Wilson Phung; Christine Everett; Jim Nonomiya; David Arnott; Cheng Lu; Yi-Chun Hsiao; James T. Koerber; Isidro Hötzel; James Ziai; Zora Modrusan; Thomas H. Pillow; Merone Roose-Girma; Jill Schartner; Mark Merchant; Sascha Rutz; Celine Eidenschenk; Ira Mellman; Matthew L. Albert
Nature Immunology, ISSN: 15292916 15292908
Rosa Barreira da Silva; Ricardo M. Leitao; Ximo Pechuan-Jorge; Scott Werneke; Jason Oeh; Vincent Javinal; Yingyun Wang; Wilson Phung; Christine Everett; Jim Nonomiya; David Arnott; Cheng Lu; Yi-Chun Hsiao; James T. Koerber; Isidro Hötzel; James Ziai; Zora Modrusan; Thomas H. Pillow; Merone Roose-Girma; Jill Schartner; Mark Merchant; Sascha Rutz; Celine Eidenschenk; Ira Mellman; Matthew L. Albert
Nature Immunology, ISSN: 15292908
Barreira da Silva; Ricardo M. Leitao; Ximo Pechuan-Jorge; Scott Werneke; Jason Oeh; Vincent Javinal; Yingyun Wang; Wilson Phung; Christine Everett; Jim Nonomiya; David Arnott; Cheng Lu; Yi-Chun Hsiao; James T. Koerber; Isidro Hötzel; James Ziai; Zora Modrusan; Thomas H. Pillow; Merone Roose-Girma; Jill Schartner; Mark Merchant; Sascha Rutz; Celine Eidenschenk; Ira Mellman; Matthew L. Albert
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Janet Jackman; Amy Stockwell; David F. Choy; Markus M. Xie; Peipei Lu; Guiquan Jia; Hong Li; Abbas Alexander; Paola G. Bronson; Wei-Yu Lin; Cecilia P.C. Chiu; Henry R. Maun; Merone Roose-Girma; Lucinda Tam; Juan Zhang; Zora Modrusan; Robert R. Graham; Timothy Behrens; Steven R. White; Ted Naureckas; Carole Ober; Manuel A. R. Ferreira; Radislav Sedlacek; Jiansheng Wu; Wyne P. Lee; Robert A. Lazarus; James T. Koerber; Joseph R. Arron; Brian L. Yaspan; Tangsheng Yi
Analytical Biochemistry, ISSN: 10960309 00032697
Xiangdan Wang; Minh Michael Phan; Yonglian Sun; James T. Koerber; Hoangdung Ho; Yongmei Chen; Yang
Nature Biotechnology, ISSN: 15461696 10870156
Christopher W. Davies; Angela Oh; Rana Mroue; Micah Steffek; John M. Bruning; Yang Xiao; Siyu Feng; Sangeeta Jayakar; Emily Chan; Vidhyalakshmi Arumugam; Sean Carlo Uribe; Jake Drummond; Alexandra Frommlet; Cheng Lu; Yvonne Franke; Mark Merchant; Koeppen; John Quinn; Sushant Malhotra; Steven Do; Lewis Gazzard; Hans E. Purkey; Joachim Rudolph; Melinda M. Mulvihill; James T. Koerber; Weiru Wang; Marie Evangelista
Nature Communications, ISSN: 20411723
Christopher W. Davies; Simon E. Vidal; Lilian Phu; Jawahar Sudhamsu; Trent Hinkle; Scott Chan Rosenberg; Frances-Rose Schumacher; Yi Jimmy Zeng; Carsten Schwerdtfeger; Andrew S. Peterson; Jennie R. Lill; Christopher M. Rose; Andrey S. Shaw; Ingrid E. Wertz; Donald S. Kirkpatrick; James T. Koerber
Molecular Cancer Therapeutics, ISSN: 15388514 15357163
Hanine Rafidi; Alberto Estevez; Gregory Z. Ferl; Danielle Mandikian; Shannon Stainton; Lauren N. Sermeño; Simon P. Williams; Amrita Kamath; James T. Koerber; C. Andrew Boswell
Immunity, ISSN: 10974180 10747613
Shilpa Keerthivasan; Yasin Senbabaoglu; Nadia Martinez-Martin; Bushra Husain; Erik Verschueren; Anne Wong; Yeqing Angela Yang; Yonglian Sun; Victoria Pham; Trent Hinkle; Yoko Oei; Shravan Madireddi; Corpuz; Lucinda Tam; Samantha Carlisle; Merone Roose-Girma; Zora Modrusan; Zhengmao Ye; James T. Koerber; Shannon J. Turley
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Christopher W. Davies; Irma B. Stowe; Qui Phung; Hoangdung Ho; Corey Bakalarski; Aaron Gupta; Yingnan Zhang; Jennie R. Lill; Jian Payandeh; Nobuhiko Kayagaki; James T. Koerber
mAbs, ISSN: 19420870 19420862
Josefa Dela Cruz Chuh; MaryAnn Go; Chen; Jun Guo; Hanine Rafidi; Danielle Mandikian; Yonglian Sun; Zhonghua Lin; Kellen Schneider; Pamela Zhang; Rajesh Vij; Danielle Sharpnack; Pamela Chan; Cecile C. de la Cruz; Jack D. Sadowsky; Dhaya Seshasayee; James T. Koerber; Thomas H. Pillow; Gail L. Phillips; Rebecca K. Rowntree; C. Andrew Boswell; Katherine R. Kozak; Andrew G. Polson; Paul G. Polakis; Shang-Fan Yu; Peter Dragovich; Nick Agard
Nature Communications, ISSN: 20411723
Henry R. Maun; Rajesh Vij; Benjamin T. Walters; Ashley Morando; Janet Jackman; Ping Wu; Alberto Estevez; Xiaocheng Chen; Yvonne Franke; Michael T. Lipari; Dennis; Daniel Kirchhofer; Claudio Ciferri; Kelly M. Loyet; Tangsheng Yi; Eigenbrot; Lazarus; James T. Koerber
Bioanalysis, ISSN: 17576199 17576180
Gizette Sperinde; Meire C. Bremer; Henry R. Maun; Amos Baruch; Lazarus; James T. Koerber; Rajesh Vij; Tangsheng Yi; Saloumeh Kadkhodayan Fischer; Tracy Staton
Molecular Cancer Therapeutics, ISSN: 15388514 15357163
Lidia Nazarova; Hanine Rafidi; Danielle Mandikian; Gregory Z. Ferl; James T. Koerber; Christopher W. Davies; Sheila Ulufatu; Jason Ho; Jeffrey Lau; Shang-Fan Yu; James A. Ernst; Jack D. Sadowsky; C. Andrew Boswell
Science, ISSN: 10959203 00368075
Lionel Rouge; Nancy Y. Chiang; Micah Steffek; Christine Kugel; Tristan I. Croll; Christine Tam; Alberto Estevez; Christopher P. Arthur; Christopher M. Koth; Claudio Ciferri; Edward Kraft; Jian Payandeh; Nakamura; James T. Koerber; Alexis Rohou
Cell, ISSN: 10974172 00928674
Henry R. Maun; Janet Jackman; David F. Choy; Kelly M. Loyet; Tracy Staton; Guiquan Jia; Amy Dressen; Jason A. Hackney; Meire C. Bremer; Benjamin T. Walters; Rajesh Vij; Xiaocheng Chen; Neil N. Trivedi; Ashley Morando; Michael T. Lipari; Yvonne Franke; Xiumin Wu; Juan Zhang; John Liu; Ping Wu; Diana Chang; Luz D. Orozco; Erin Christensen; Manda Wong; Corpuz; Julie Qi Hang; Jeff Lutman; Siddharth Sukumaran; Yan Wu; Savita Ubhayakar; Xiaorong Liang; Lawrence B. Schwartz; Magda Babina; Prescott G. Woodruff; John V. Fahy; Rahul Ahuja; George H. Caughey; Aija Kusi; Dennis; Eigenbrot; Daniel Kirchhofer; Cary D. Austin; Lawren C. Wu; James T. Koerber; Wyne P. Lee; Brian L. Yaspan; Kathila R. Alatsis; Joseph R. Arron; Lazarus; Tangsheng Yi
eLife, ISSN: 2050084X
Kelly M. Storek; Joyce Chan; Rajesh Vij; Nancy Y. Chiang; Zhonghua Lin; Jack Bevers; Christopher M. Koth; Jean-Michel Vernes; Y. Gloria Meng; Jianping Yin; Heidi J. A. Wallweber; Olivier Dalmas; Stephanie K. Shriver; Christine Tam; Kellen Schneider; Dhaya Seshasayee; Nakamura; Peter A. Smith; Jian Payandeh; James T. Koerber; Laetitia Comps-Agrar; Steven T. Rutherford
Journal of Bacteriology, ISSN: 10985530 00219193
Kelly M. Storek; Rajesh Vij; Dawei Sun; Peter A. Smith; James T. Koerber; Steven T. Rutherford
Scientific Reports, ISSN: 20452322
Rajesh Vij; Zhonghua Lin; Nancy Y. Chiang; Jean-Michel Vernes; Kelly M. Storek; Summer Park; Joyce Chan; Y. Gloria Meng; Laetitia Comps-Agrar; Patricia Luhn; Sophia Lee; Kellen Schneider; Jack Bevers; Inna Zilberleyb; Christine Tam; Christopher M. Koth; Min Xu; Avinash Gill; Marcy Auerbach; Peter A. Smith; Steven T. Rutherford; Nakamura; Dhaya Seshasayee; Jian Payandeh; James T. Koerber
Science Translational Medicine, ISSN: 19466242 19466234
Dionysos S. Slaga; Diego Ellerman; T. Noelle Lombana; Rajesh Vij; Ji Li; Maria Hristopoulos; Robyn Clark; Jennifer A. Johnston; Amy Shelton; Elaine Mai; Kapil Gadkar; Amy Lo; James T. Koerber; Klara Totpal; Prell; Genee Y. Lee; Christoph Spiess; Teemu T. Junttila
PLoS ONE, ISSN: 19326203
Rajesh Vij; Zhonghua Lin; Kellen Schneider; Dhaya Seshasayee; James T. Koerber
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Kelly M. Storek; Marcy Auerbach; Handuo Shi; Natalie K. Garcia; Dawei Sun; Nicholas N. Nickerson; Rajesh Vij; Zhonghua Lin; Nancy Y. Chiang; Kellen Schneider; Aaron T. Wecksler; Elizabeth Skippington; Nakamura; Dhaya Seshasayee; James T. Koerber; Jian Payandeh; Peter A. Smith; Steven T. Rutherford
Education
- University of California, Berkeley, PhD – 2008
- University of Illinois, Urbana-Champaign, B.S. – 2003
Awards & Honors
- Roche Key Contributor – 2017
- Roche Key Contributor – 2016
- Life Sciences Research Foundational Postdoctoral Fellowship – 2009
- National Science Foundation Graduate Fellowship – 2003