Karen Gascoigne
Senior Principal Scientist, Discovery Oncology, Research Biology
Postdoc Mentor
"It is inspiring to go to work each day knowing there is an opportunity to change patients lives with our science."
11
Years at Genentech
13
Publications at Genentech
4
Awards & Honors
I completed my postdoctoral research at the Whitehead Institute - MIT investigating the molecular determinates of aneuploidy in cancer. In 2013 I joined Genentech as a scientist in the Discovery Oncology department. Our goal is to use a deep molecular understanding of cancer to identify targetable vulnerabilities & contribute to the drug discovery effort.
Postdoctoral Mentor
Genentech’s postdoctoral research program offers a wonderful opportunity to carry out cutting edge cross-disciplinary research in a highly collaborative environment. By leveraging the outstanding research & technology infrastructure at Genentech, postdocs can take on big scientific questions and have a significant impact on their chosen field.
Featured Publication
Therapeutic Targeting of the CBP/p300 Bromodomain Blocks the Growth of Castration-Resistant Prostate Cancer.
Cancer Res. 2017 Oct 15;77(20):5564-5575.
Jin L, Garcia J, Chan E, de la Cruz C, Segal E, Merchant M, Kharbanda S, Raisner R, Haverty PM, Modrusan Z, Ly J, Choo E, Kaufman S, Beresini MH, Romero FA, Magnuson S, Gascoigne KE.
My Focus
I’m passionate about unraveling the complexities of cancer to identify new therapeutic strategies for the disease. My lab aims to identify targetable vulnerabilities, with a focus on understanding transcriptional and epigenetic dysregulation in cancer cells.
Genentech Publications
Cell Reports, ISSN: 22111247
Chad Liu; Takamasa Kudo; Xin Ye; Karen Gascoigne
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Peter Dragovich; Thomas H. Pillow; Robert A. Blake; Jack D. Sadowsky; Emel Adaligil; Pragya Adhikari; Sunil Bhakta; Nicole Blaquiere; Jinhua Chen; Josefa Dela Cruz Chuh; Karen Gascoigne; Steven J. Hartman; Mingtao He; Susan Kaufman; Tracy L. Kleinheinz; Katherine R. Kozak; Liang Liu; Liling Liu; Qi Liu; Ying Lu; Fanwei Meng; Melinda M. Mulvihill; Aimee O'Donohue; Rebecca K. Rowntree; Leanna Staben; Steven T. Staben; John Wai; Jian Wang; Binqing Wei; Catherine Wilson; Jianfeng Xin; Zijin Xu; Hui Yao; Donglu Zhang; Hongyan Zhang; Hao Zhou; Xiaoyu Zhu
PLoS ONE, ISSN: 19326203
Ryan Raisner; Russell Bainer; Peter M. Haverty; Kelli L. Benedetti; Karen Gascoigne
ChemMedChem, ISSN: 18607187 18607179
Thomas H. Pillow; Pragya Adhikari; Robert A. Blake; Jinhua Chen; Geoffrey Del Rosario; Gauri Deshmukh; Isabel Figueroa; Karen Gascoigne; Amrita Kamath; Susan Kaufman; Tracy L. Kleinheinz; Katherine R. Kozak; Brandon Latifi; Douglas Leipold; Chun Sing Li; Ruina Li; Melinda M. Mulvihill; Aimee O'Donohue; Rebecca K. Rowntree; Jack D. Sadowsky; John Wai; Xinxin Wang; Cong Wu; Zijin Xu; Hui Yao; Shang-Fan Yu; Donglu Zhang; Richard Zang; Hongyan Zhang; Hao Zhou; Xiaoyu Zhu; Peter Dragovich
Cell Reports, ISSN: 22111247
Denise De Almeida Nagata; Eugene Y. Chiang; Suchit Jhunjhunwala; Patrick Caplazi; Vidhyalakshmi Arumugam; Zora Modrusan; Emily Chan; Mark Merchant; Lingyan Jin; David Arnott; F. Anthony Romero; Steven Magnuson; Karen Gascoigne; Jane L. Grogan
Genome Biology, ISSN: 1474760X 14747596
Jean-Philippe Fortin; Jenille Tan; Karen Gascoigne; Peter M. Haverty; William F. Forrest; Michael Costa; Scott E. Martin
Cell Reports, ISSN: 22111247
Ryan Raisner; Samir Kharbanda; Lingyan Jin; Edwin Jeng; Emily Chan; Mark Merchant; Matthias Peter; Russell Bainer; Tommy K. Cheung; David Arnott; E. Megan Flynn; F. Anthony Romero; Steven Magnuson; Karen Gascoigne
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
F. Anthony Romero; Jeremy Murray; Kwong Wah Lai; Vickie Tsui; Brian K Albrecht; Le An; Beresini; Gladys De Leon Boenig; Sarah M. Bronner; Emily Chan; Kevin Chen; Zhongguo Chen; Edna F. Choo; Kyle Clagg; Clark; Terry Crawford; Patrick Cyr; Denise De Almeida Nagata; Karen Gascoigne; Jane L. Grogan; Georgia Hatzivassiliou; Wei Huang; Thomas Hunsaker; Susan Kaufman; Stefan G. Koenig; Ruina Li; Yingjie Li; Xiaorong Liang; Jiangpeng Liao; Wenfeng Liu; Justin Ly; Jonathan M. Maher; Colin Masui; Mark Merchant; Yingqing Ran; Alexander M. Taylor; John Wai; Fei Wang; Xiaocang Wei; Dong Yu; Bing-Yan Zhu; Xiaoyu Zhu; Steven Magnuson
Cancer Research, ISSN: 15387445 00085472
Lingyan Jin; Jesse Garcia; Emily Chan; Cecile C. de la Cruz; Ehud Segal; Mark Merchant; Samir Kharbanda; Ryan Raisner; Matthias Peter; Zora Modrusan; Justin Ly; Edna F. Choo; Susan Kaufman; Beresini; F. Anthony Romero; Steven Magnuson; Karen Gascoigne
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Terry Crawford; F. Anthony Romero; Kwong Wah Lai; Vickie Tsui; Alexander M. Taylor; Gladys De Leon Boenig; Cameron Noland; Jeremy Murray; Justin Ly; Edna F. Choo; Thomas Hunsaker; Emily Chan; Mark Merchant; Samir Kharbanda; Karen Gascoigne; Susan Kaufman; Beresini; Jiangpeng Liao; Wenfeng Liu; Kevin Chen; Zhongguo Chen; Andrew R. Conery; Alexandre Côté; Hariharan Jayaram; Ying Jiang; James R. Kiefer; Tracy L. Kleinheinz; Yingjie Li; Jonathan M. Maher; Eneida Pardo; Florence Poy; Kerry L. Spillane; Fei Wang; Jian Wang; Xiaocang Wei; Zhaowu Xu; Zhongya Xu; Ivana Yen; Laura E. Zawadzke; Xiaoyu Zhu; Steve Bellon; Richard T Cummings; Andrea G Cochran; Brian K Albrecht; Steven Magnuson
eLife, ISSN: 2050084X
Andrew R. Conery; Richard C. Centore; Adrianne Neiss; Patricia J. Keller; Shivangi Joshi; Kerry L. Spillane; Peter Sandy; Charlie Hatton; Eneida Pardo; Laura E. Zawadzke; Archana Bommi-Reddy; Karen Gascoigne; Barbara M. Bryant; Jennifer A. Mertz; Robert J. Sims
Clinical Cancer Research, ISSN: 15573265 10780432
Jyoti Asundi; Lisa Crocker; Jarrod Tremayne; Peter Chang; Sakanaka; Josh Tanguay; Spencer; Sreedevi Chalasani; Luis; Karen Gascoigne; Rupal Desai; Rajiv Raja; Brad A. Friedman; Matthias Peter; Paul G. Polakis; Ron Firestein
Current Biology, ISSN: 18790445 09609822
Florencia Rago; Karen Gascoigne; Iain M. Cheeseman
Education
- Whitehead Institute - MIT, Postdoctoral Fellow – 2009-2013
- University of Manchester, Ph.D – 2004-2009
- University of Manchester, B.Sc. – 1999-2003
Awards & Honors
- US Leukemia and Lymphoma Society Special Fellow – 2012
- Manchester University Postgraduate student of the year – 2009
- EMBO long-term Fellow – 2009
- Manchester University Novartis research Prize – 2003