Kim Newton
Principal Scientist, Physiological Chemistry
19
Years at Genentech
49
Publications
2
Awards & Honors
I joined Genentech in 2001 as a postdoc after completing my PhD in the cell death lab of Andreas Strasser at the Walter & Eliza Hall Institute in Australia. As a postdoc with Vishva Dixit, I worked on several projects including the role of the adaptor protein CARMA1/CARD11 in lymphocyte development and activation, the effect of TNF family ligands EDA-A1 and EDA-A2 on hair, sweat gland and muscle homeostasis, and the characterization of a kinase called RIPK3, which turned out to be a key effector of a regulated form of necrotic cell death termed necroptosis. These diverse projects were developed in collaboration with several departments and I saw first hand how much can be achieved when experts across disciplines pull together. Enthusiastic, talented colleagues combined with exciting, medically relevant science made staying on as a scientist an easy decision.
The current mission of my group is to decipher the signaling mechanisms unleashing proinflammatory cell death programs that may exacerbate a range of inflammatory diseases. Our goal is to unveil novel therapeutics targets with the potential to benefit patients.
Featured Publication
RIPK1 inhibits ZBP1-driven necroptosis during development.
Nature. 2016 Dec 1;540(7631):129-133.
Newton K, Wickliffe KE, Maltzman A, Dugger DL, Strasser A, Pham VC, Lill JR, Roose-Girma M, Warming S, Solon M, Ngu H, Webster JD, Dixit VM.
My Focus
Inflammation is a driving factor in many chronic diseases. My group studies the contribution of cell death to inflammation because dying cells can release molecules that activate innate immune cells to produce an inflammatory response. Recent work has focused on the kinases RIPK1 and RIPK3 because of their contribution to proinflammatory cell death. We are using genetic and biochemical approaches to understand how, when and where these kinases get activated, as well as the signaling mechanisms that normally hold these kinases in check.
Publications
Nature, ISSN: 14764687 00280836
Kim Newton; Kate Wickliffe; Maltzman; Debbie Dugger; Rohit Reja; Yue Zhang; Meron Roose-Girma; Zora Modrusan; Meredith Sagolla; Webster; Vishva Dixit
Nature, ISSN: 14764687 00280836
Kim Newton; Kate Wickliffe; Debbie Dugger; Maltzman; Meron Roose-Girma; Monika Dohse; László Kömüves; Webster; Vishva Dixit
The RIPK4–IRF6 signalling axis safeguards epidermal differentiation and barrier function
Nature, ISSN: 00280836
Nina Oberbeck; Victoria Pham; Webster; Rohit Reja; Christine S. Huang; Yue Zhang; Meron Roose-Girma; Soren Warming; Qingling Li; Andrew Birnberg; Weng Wong; Wendy Sandoval; László Kömüves; Kebing Yu; Debbie Dugger; Maltzman; Kim Newton; Vishva Dixit
eLife, ISSN: 2050084X
Junghyun Lim; Hyunjoo Park; Jason Heisler; Timurs Maculins; Meron Roose-Girma; Min Xu; Brent McKenzie; Menno van Lookeren Campagne; Kim Newton; Aditya Murthy
Cell Reports, ISSN: 22111247
Jieqiong Zhang; Webster; Debbie Dugger; Tanya Goncharov; Meron Roose-Girma; Jeffrey Hung; Youngsu Kwon; Domagoj Vucic; Kim Newton; Vishva Dixit
PLoS ONE, ISSN: 19326203
Mona Abed; Erik Verschueren; Hanna G. Budayeva; Peter Liu; Don Kirkpatrick; Rohit Reja; Sarah Kummerfeld; Webster; Sarah Gierke; Mike Reichelt; Keith R. Anderson; Robert J (Research) Newman; Meron Roose-Girma; Zora Modrusan; Hazal Pektas; Emin Maltepe; Kim Newton; Vishva Dixit
Science, ISSN: 10959203 00368075
Meng He; Mira S. Chaurushiya; Webster; Sarah Kummerfeld; Rohit Reja; Subhra Chaudhuri; Jasmine Chen; Zora Modrusan; Benjamin Haley; Debbie Dugger; Jeff Eastham; Shari Lau; Anwesha Dey; Roger Caothien; Meron Roose-Girma; Kim Newton; Vishva Dixit
RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases
Cell Death and Differentiation, ISSN: 13509047
Snahel Patel; Webster; Eugene Varfolomeev; Youngsu Kwon; Jason Cheng; Juan Zhang; Debbie Dugger; Kate Wickliffe; Maltzman; Swathi Sujatha-Bhaskar; Pawan Bir Kohli; Sreema Ramaswamy; Gauri Deshmukh; Bianca Liederer; Rina Fong; Gregory L. Hamilton; Patrick Lupardus; Patrick Caplazi; Wyne P. Lee; Menno van Lookeren Campagne; Adam Johnson; Brent McKenzie; Melissa Junttila; Kim Newton; Domagoj Vucic
Ubiquitin ligase COP1 coordinates transcriptional programs that control cell type specification in the developing mouse brain
Proceedings of the National Academy of Sciences of the United States of America,
Kim Newton; Debbie Dugger; Arundhati Sengupta Ghosh; Ronald E. Ferrando; Felix Chu; Janet Tao; Wendy Lam; Susan Haller; Sara Chan; Susan Sa; Debra Dunlap; Jeff Eastham; Hai Ngu; Jeffrey Hung; Dorothy French; Webster; Brad Bolon; Jinfeng Liu; Rohit Reja; Sarah Kummerfeld; Ying-Jiun Chen; Zora Modrusan; Joe Lewcock; Vishva Dixit
Kinase domain dimerization drives RIPK3-dependent necroptosis
Science Signaling, ISSN: 19450877
Saravanan Raju; Dan Whalen; Meron Mengistu; Carter J. Swanson; John G. Quinn; Susan Taylor; Webster; Kim Newton; Andrey Shaw
Nature, ISSN: 14764687 00280836
Klaus Heger; Kate Wickliffe; Ada Ndoja; Juan Zhang; Aditya Murthy; Debbie Dugger; Maltzman; Felipe de Sousa e Melo; Jeffrey Hung; Yi Zeng; Erik Verschueren; Don Kirkpatrick; Domagoj Vucic; Wyne Lee; Meron Roose-Girma; Robert J (Research) Newman; Soren Warming; Yi-Chun Hsiao; László Kömüves; Webster; Kim Newton; Vishva Dixit
Cell Death and Disease, ISSN: 20414889
Marinella Callow; Colin Watanabe; Kate Wickliffe; Russell Bainer; Sarah Kummerfield; Julie Weng; Trinna Cuellar; Vasant Janakiraman; Honglin Chen; Ben Chih; Yuxin Liang; Benjamin Haley; Kim Newton; Mike Costa
Detection of necroptosis by phospho-RIPK3 immunohistochemical labeling
Methods in Molecular Biology, ISSN: 10643745
Webster; Margaret Solon; Susan Haller; Kim Newton
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Zhen Zhang; Kim Newton; Sarah Kummerfeld; Webster; Don Kirkpatrick; Lilian Phu; Jeff Eastham Anderson; Jinfeng Liu; Wyne Lee; Jiansheng Wu; Hong Li; Melissa Junttila; Vishva Dixit
Cell Death and Differentiation, ISSN: 14765403
Maria Cristina De Almagro; Tanya Goncharov; Anita Izrael-Tomasevic; Stefanie Duttler; Matthias Kist; Eugene Varfolomeev; Xiumin Wu; Wyne Lee; Jeremy Murray; Joshua Webster; Kebing Yu; Don Kirkpatrick; Kim Newton; Domagoj Vucic
Nature, ISSN: 14764687
Kim Newton; Kate Wickliffe; Maltzman; Debbie Dugger; Andreas Strasser; Victoria Pham; Jennie Lill; Meron Roose-Girma; Soren Warming; Margaret Solon; Hai Ngu; Webster; Vishva Dixit
Cell Death and Differentiation, ISSN: 14765403
Kim Newton; Debbie Dugger; Maltzman; Joan Greve; Maj Hedehus; Baby Martin-Mcnulty; Rick Carano; Cao; Nick Van Bruggen; Bernstein; Wyne Lee; Xiumin Wu; Jason DeVoss; Zhang; Surinder Jeet; Peng; Brent McKenzie; Meron Roose-Girma; Patrick Caplazi; Lauri Diehl; Webster; Vucic
Annual Review of Biochemistry, ISSN: 15454509
Kim Newton; Gerard Manning
Journal of Experimental Medicine, ISSN: 15409538
Yan Qu; Shahram Misaghi; Kim Newton; Maltzman; Anita Izrael-Tomasevic; David Arnott; Vishva Dixit
Nature, ISSN: 14764687
Ingrid Wertz; Kim Newton; Dhaya Seshasayee; Saritha Kusam; Cynthia Lam; Juan Zhang; Nataliya Popovych; Elizabeth Helgason; Allyn Schoeffler; Surinder Jeet; Nandhini Ramamoorthi; Kategaya; Robert J (Research) Newman; Keisuke Horikawa; Debbie Dugger; Wendy Sandoval; Susmith Mukund; Anuradha Zindal; Flavius Martin; Clifford Quan; Jeffrey Tom; Wayne Fairbrother; Michael Townsend; Soren Warming; Jason DeVoss; Jinfeng Liu; Erin Dueber; Patrick Caplazi; Wyne Lee; Christopher C. Goodnow; Mercedesz Balazs; Kebing Yu; Ganesh Kolumam; Vishva Dixit
Cell, ISSN: 10974172
Rowena Suriben; Kelly A. Kaihara; Magdalena Paolino; Mike Reichelt; Sarah Kummerfeld; Zora Modrusan; Debbie Dugger; Kim Newton; Meredith Sagolla; Webster; Jinfeng Liu; Matthias Hebrok; Vishva Dixit
Structure, ISSN: 18784186
Peter Yin; Allyn Schoeffler; Kate Wickliffe; Kim Newton; Melissa Starovasnik; Erin Dueber; Seth Harris
Cell Death and Disease, ISSN: 20414889
Maria Cristina De Almagro; Tanya Goncharov; Kim Newton; Domagoj Vucic
Journal of Histochemistry and Cytochemistry, ISSN: 15515044
Ronald Ferrando; Kim Newton; Felix Chu; Joshua Webster; Dorothy French
Nature, ISSN: 14764687
Sascha Rutz; Nobuhiko Kayagaki; Qui Phung; Celine Eidenschenk; Raj Noubade; Xiaoting Wang; Justin Lesch; Rongze Lu; Kim Newton; Oscar Huang; Andrea Cochran; Mark Vasser; Benjamin Fauber; Jason DeVoss; Webster; Lauri Diehl; Zora Modrusan; Don Kirkpatrick; Jennie Lill; Wenjun Ouyang; Vishva Dixit
Trends in Cell Biology, ISSN: 18793088
Kim Newton
Nature, ISSN: 00280836
Kim Newton; Joanne M. Hildebrand; Zhirong Shen; Diego Rodriguez; Silvia Alvarez-Diaz; Sean Petersen; Saumil Shah; Debbie Dugger; Chunzi Huang; Johan Auwerx; Vandenabeele; Douglas R. Green; Avi Ashkenazi; Vishva Dixit; William J. Kaiser; Andreas Strasser; Alexei Degterev; John Silke
Science, ISSN: 10959203
Kim Newton; Debbie Dugger; Kate Wickliffe; Neeraj Kapoor; Maria Cristina De Almagro; Domagoj Vucic; László Kömüves; Ronald Ferrando; Dorothy French; Webster; Meron Roose-Girma; Soren Warming; Vishva Dixit
Journal of Cell Biology, ISSN: 00219525
Sarah Huntwork-Rodriguez; Bei Wang; Trent Watkins; Arundhati Sengupta Ghosh; Christine Pozniak; Daisy Bustos; Kim Newton; Don Kirkpatrick; Joe Lewcock
Science, ISSN: 10959203
Andy Huang; James C. McGann; Bob Liu; Rami Hannoush; Jennie Lill; Victoria Pham; Kim Newton; Mike Kakunda; Jinfeng Liu; Christine Yu; Sarah Hymowitz; Jo-Anne Hongo; Anthony Wynshaw-Boris; Paul Polakis; Richard M. Harland; Vishva Dixit
Biochemical Journal, ISSN: 02646021
Eugene Varfolomeev; Elham Moradi; Jasmin Dynek; Jiping Zha; Anna Fedorova; Kurt Deshayes; Wayne Fairbrother; Kim Newton; Jenn Le Couter; Domagoj Vucic
Nature, ISSN: 00280836
Yan Qu; Shahram Misaghi; Anita Izrael-Tomasevic; Kim Newton; Laurie Appling; Mohamed Lamkanfi; Salina Louie; Nobuhiko Kayagaki; Jinfeng Liu; László Kömüves; Jim Cupp; David Arnott; Denise M. Monack; Vishva Dixit
Science, ISSN: 10959203
Anwesha Dey; Dhaya Seshasayee; Raj Noubade; Dorothy French; Jinfeng Liu; Mira S. Chaurushiya; Don Kirkpatrick; Victoria Pham; Jennie Lill; Corey Bakalarski; Jiansheng Wu; Lilian Phu; Paula Katavolos; Lindsay M. LaFave; Omar Abdel-Wahab; Zora Modrusan; Somasekar Seshagiri; Ken Dong; Zhonghua Lin; Mercedesz Balazs; Rowena Suriben; Kim Newton; Sarah Hymowitz; Guillermo Garcia-Manero; Flavius Martin; Ross L. Levine; Vishva Dixit
Methods in Molecular Biology, ISSN: 10643745
Kim Newton; Marissa Matsumoto; Ronald Ferrando; Kate Wickliffe; Michael Rape; Robert Kelley; Vishva Dixit
Cold Spring Harbor Perspectives in Biology, ISSN: 19430264
Kim Newton; Vishva Dixit
Nature, ISSN: 00280836
Nobuhiko Kayagaki; Soren Warming; Mohamed Lamkanfi; Lieselotte Vande Walle; Salina Louie; Jennifer Dong; Kim Newton; Yan Qu; Jinfeng Liu; Sherry Heldens; Juan Zhang; Wyne Lee; Meron Roose-Girma; Vishva Dixit
Nature, ISSN: 00280836
Alberto C. Vitari; Kevin Leong; Kim Newton; Cindy Yee; Karen O'Rourke; Jinfeng Liu; Lilian Phu; Rajesh Vij; Ronald Ferrando; Suzana Couto; Sankar Mohan; Ajay Pandita; Jo-Anne Hongo; David Arnott; Ingrid Wertz; Wei-Qiang Gao; Dorothy French; Vishva Dixit
Journal of Immunology, ISSN: 00221767
Yan Qu; Shahram Misaghi; Kim Newton; Laurie Appling; Salina Louie; Jim Cupp; George R. Dubyak; David Hackos; Vishva Dixit
Journal of Experimental Medicine, ISSN: 15409538
Petr Broz; Kim Newton; Mohamed Lamkanfi; Sanjeev Mariathasan; Vishva Dixit; Denise M. Monack
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424
Jonathan W. Jones; Nobuhiko Kayagaki; Petr Broz; Thomas Henry; Kim Newton; Karen O'Rourke; Salina Chan; Jennifer Dong; Yan Qu; Meron Roose-Girma; Vishva Dixit; Denise M. Monack
Cell, ISSN: 00928674
Kim Newton; Marissa Matsumoto; Ingrid Wertz; Don Kirkpatrick; Jennie Lill; Jenille Tan; Debbie Dugger; Nathaniel Gordon; Sachdev Sidhu; Frederic A. Fellouse; László Kömüves; Dorothy French; Ronald Ferrando; Cynthia Lam; Deanne Compaan; Christine Yu; Ivan Bosanac; Sarah Hymowitz; Robert Kelley; Vishva Dixit
Cancer Investigation, ISSN: 07357907
Kim Newton; Domagoj Vucic
Nature, ISSN: 14764687
Sanjeev Mariathasan; David S. Weiss; Kim Newton; Jacqueline McBride; Karen O'Rourke; Meron Roose-Girma; Wyne Lee; Yvette Weinrauch; Denise M. Monack; Vishva Dixit
Cancer Research, ISSN: 00085472
David Dornan; Sheila Bheddah; Kim Newton; William Inice; Gretchen Frantz; Patrick Dowd; Hartmut Koeppen; Vishva Dixit; Dorothy French
Cell Death and Differentiation, ISSN: 13509047
O'Reilly; Divisekera; Kim Newton; Scalzo; Kataoka; Puthalakath; Ito; David C.S. Huang; Andreas Strasser
Molecular and Cellular Biology, ISSN: 02707306
Kim Newton; Xiaoqing Sun; Vishva Dixit
Molecular and Cellular Biology, ISSN: 02707306
Kim Newton; Dorothy French; Minhong Yan; Gretchen Frantz; Vishva Dixit
Current Biology, ISSN: 09609822
Kim Newton; Vishva Dixit
Caspases signal not only apoptosis but also antigen-induced activation in cells of the immune system
Genes and Development, ISSN: 08909369
Kim Newton; Andreas Strasser
Education
- University of Melbourne, Australia, PhD in Medical Biology – 2000
- University of Auckland, New Zealand, MSc in Cellular and Molecular Biology – 1996
- University of Auckland, New Zealand, BSc in Biochemistry – 1994
Awards & Honors
- Premier’s Commendation for Medical Research, Victoria, Australia – 2000
- University of Auckland R E F Matthews Prize in Cellular and Molecular Biology – 1997