Kim Newton
Distinguished Scientist, Physiological Chemistry, Research Biology
24
Years at Genentech
68
Publications at Genentech
2
Awards & Honors
I joined Genentech in 2001 as a postdoc after completing my PhD in the cell death lab of Andreas Strasser at the Walter & Eliza Hall Institute in Australia. As a postdoc with Vishva Dixit, I worked on several projects including the role of the adaptor protein CARMA1/CARD11 in lymphocyte development and activation, the effect of TNF family ligands EDA-A1 and EDA-A2 on hair, sweat gland and muscle homeostasis, and the characterization of a kinase called RIPK3, which turned out to be a key effector of a regulated form of necrotic cell death termed necroptosis. These diverse projects were developed in collaboration with several departments and I saw first hand how much can be achieved when experts across disciplines pull together. Enthusiastic, talented colleagues combined with exciting, medically relevant science made staying on as a scientist an easy decision.
The current mission of my group is to decipher the signaling mechanisms unleashing proinflammatory cell death programs that may exacerbate a range of inflammatory diseases. Our goal is to unveil novel therapeutics targets with the potential to benefit patients.
Featured Publication
RIPK1 inhibits ZBP1-driven necroptosis during development.
Nature. 2016 Dec 1;540(7631):129-133.
Newton K, Wickliffe KE, Maltzman A, Dugger DL, Strasser A, Pham VC, Lill JR, Roose-Girma M, Warming S, Solon M, Ngu H, Webster JD, Dixit VM.
My Focus
Inflammation is a driving factor in many chronic diseases. My group studies the contribution of cell death to inflammation because dying cells can release molecules that activate innate immune cells to produce an inflammatory response. Recent work has focused on the kinases RIPK1 and RIPK3 because of their contribution to proinflammatory cell death. We are using genetic and biochemical approaches to understand how, when and where these kinases get activated, as well as the signaling mechanisms that normally hold these kinases in check.
Genentech Publications
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Özge Karayel; Allison L. Soung; Hem R. Gurung; Alexander F Schubert; Susan Klaeger; Marc Kschonsak; Aljazi Al-Maraghi; Ajaz A. Bhat; Ammira S. Alshabeeb Akil; Dugger; Webster; French; Dhullipala Anand; Naharmal Soni; Khalid Fakhro; Christopher M. Rose; Seth F. Harris; Ada Ndoja; Kim Newton; Vishva M. Dixit
Immunity, ISSN: 10747613
Alexander D. Gitlin; Maltzman; Yuzuka Kanno; Klaus D. Heger; Rohit Reja; Alexander F Schubert; Linsey J. Wierciszewski; Homer Pantua; Sharookh B. Kapadia; Seth F. Harris; Webster; Kim Newton; Vishva M. Dixit
Annual Review of Pathology: Mechanisms of Disease,
Nobuhiko Kayagaki; Webster; Kim Newton
Cell, ISSN: 00928674
Kim Newton; Andreas Strasser; Nobuhiko Kayagaki; Vishva M. Dixit
Nature, ISSN: 14764687 00280836
Sergei Pourmal; Melissa E. Truong; Matthew C. Johnson; Ying Yang; Lijuan Zhou; Kamela Alegre; Irma B. Stowe; Shalini Gupta; Phoebe A. Chen; Yingnan Zhang; Alexis Rohou; Kim Newton; Nobuhiko Kayagaki; Vishva M. Dixit; Ishan Deshpande
Cell Death and Differentiation, ISSN: 13509047
Margaret Solon; Nianfeng Ge; Shannon Hambro; Susan Haller; Jian Jiang; Miriam Baca; Jessica Preston; Maltzman; Katherine E. Wickliffe; Yuxin Liang; Rohit Reja; Dorothee Nickles; Kim Newton; Webster
Cell Death and Differentiation, ISSN: 13509047
Kim Newton; Katherine E. Wickliffe; Maltzman; Dugger; Joshua D. Webster; Hongyan Guo; Vishva M. Dixit
Cell, ISSN: 00928674
Ahmad N. Nabhan; Webster; Jarret J. Adams; Levi Blazer; Christine Everrett; Celine Eidenschenk; Alexander Arlantico; Isabel Fleming; Hans D. Brightbill; Paul J. Wolters; Zora Modrusan; Somasekar Seshagiri; Stephane Angers; Sachdev S. Sidhu; Kim Newton; Joseph R. Arron; Vishva M. Dixit
Nature, ISSN: 00280836
Nobuhiko Kayagaki; Irma B. Stowe; Kamela Alegre; Ishan Deshpande; Shuang Wu; Zhonghua Lin; Opher S. Kornfeld; Bettina L. Lee; Juan Zhang; John Liu; Eric Suto; Wyne P. Lee; Kellen Schneider; Wei Yu Lin; Dhaya Seshasayee; Tushar Bhangale; Cecile Chalouni; Matthew C. Johnson; Prajakta Joshi; Jan Mossemann; Sarah Zhao; Danish Ali; Neil M. Goldenberg; Blayne A. Sayed; Benjamin E. Steinberg; Kim Newton; Webster; Ryan Kelly; Vishva M. Dixit
Cell Death and Disease, ISSN: 20414889
Axel Witt; Tatiana Goncharov; Yujung Michelle Lee; Matthias Kist; Monika Dohse; Jeffrey Eastham; Dugger; Kim Newton; Joshua D Webster; Domagoj Vucic
Biochemical Journal, ISSN: 14708728 02646021
Kim Newton; Alexander D. Gitlin
Science, ISSN: 10959203 00368075
Kim Newton; Vishva M. Dixit; Nobuhiko Kayagaki
Cell Host and Microbe, ISSN: 19346069 19313128
Giovanni Luchetti; Justin L. Roncaioli; Roberto A. Chavez; Alexander F Schubert; Eric M. Kofoed; Rohit Reja; Tommy K. Cheung; Yuxin Liang; Webster; Isabelle Lehoux; Elizabeth Skippington; Janina Reeder; Benjamin Haley; Man-Wah Tan; Christopher M. Rose; Kim Newton; Nobuhiko Kayagaki; Russell E. Vance; Vishva M. Dixit
Cell, ISSN: 10974172 00928674
Neri Amara; Madison P. Cooper; Maria A. Voronkova; Bradley A. Webb; Eric M. Lynch; Justin Kollman; Taylur P. Ma; Kebing Yu; Zijuan Lai; Dewakar Sangaraju; Nobuhiko Kayagaki; Kim Newton; Matthew Bogyo; Steven T. Staben; Vishva M. Dixit
Cell, ISSN: 10974172 00928674
Neri Amara; Madison P. Cooper; Maria A. Voronkova; Bradley A. Webb; Eric M. Lynch; Justin Kollman; Taylur Ma; Kebing Yu; Zijuan Lai; Dewakar Sangaraju; Nobuhiko Kayagaki; Kim Newton; Matthew Bogyo; Steven T. Staben; Vishva M. Dixit
Cell Death and Differentiation, ISSN: 14765403 13509047
Matthias Kist; László Kömüves; Tatiana Goncharov; Dugger; Charles Yu; Merone Roose-Girma; Kim Newton; Webster; Domagoj Vucic
Nature, ISSN: 14764687 00280836
Alexander D. Gitlin; Klaus D. Heger; Alexander F Schubert; Rohit Reja; Donghong Yan; Victoria Pham; Eric Suto; Juan Zhang; Youngsu C. Kwon; Emily C. Freund; Jing Kang; Anna Pham; Roger Caothien; Natasha Bacarro; Trent Hinkle; Min Xu; Brent Mckenzie; Benjamin Haley; Wyne P. Lee; Jennie R. Lill; Merone Roose-Girma; Monika Dohse; Webster; Kim Newton; Vishva M. Dixit
Cell, ISSN: 10974172 00928674
Ada Ndoja; Rohit Reja; Seung-Hye Lee; Webster; Hai Ngu; Christopher M. Rose; Donald S. Kirkpatrick; Zora Modrusan; Ying-Jiun J. Chen; Dugger; Vineela D. Gandham; Luke Xie; Kim Newton; Vishva M. Dixit
Cold Spring Harbor Perspectives in Medicine, ISSN: 21571422
Kim Newton
Cell Death and Differentiation, ISSN: 14765403 13509047
Snahel Patel; Webster; Eugene Varfolomeev; Youngsu C. Kwon; Jason H. Cheng; Juan Zhang; Dugger; Katherine E. Wickliffe; Maltzman; Swathi Sujatha-Bhaskar; Pawan Bir Kohli; Sreemathy Ramaswamy; Gauri Deshmukh; Bianca M. Liederer; Rina Fong; Gregory L. Hamilton; Patrick J. Lupardus; Patrick Caplazi; Wyne P. Lee; Menno Van Lookeren Campagne; Adam R. Johnson; Brent Mckenzie; Melissa Junttila; Kim Newton; Domagoj Vucic
Nature, ISSN: 14764687 00280836
Kim Newton; Katherine E. Wickliffe; Maltzman; Dugger; Rohit Reja; Yue Zhang; Merone Roose-Girma; Zora Modrusan; Meredith Sagolla; Webster; Vishva M. Dixit
Nature, ISSN: 14764687 00280836
Kim Newton; Katherine E. Wickliffe; Dugger; Maltzman; Merone Roose-Girma; Monika Dohse; László Kömüves; Webster; Vishva M. Dixit
Nature, ISSN: 14764687 00280836
Nina Oberbeck; Victoria Pham; Webster; Rohit Reja; Christine S. Huang; Yue Zhang; Merone Roose-Girma; Søren Warming; Qingling Li; Andrew Birnberg; Weng Wong; Wendy N. Sandoval; László Kömüves; Kebing Yu; Dugger; Maltzman; Kim Newton; Vishva M. Dixit
eLife, ISSN: 2050084X
Junghyun Lim; Hyunjoo Park; Jason Heisler; Timurs Maculins; Merone Roose-Girma; Min Xu; Brent Mckenzie; Menno Van Lookeren Campagne; Kim Newton; Aditya Murthy
Cell Reports, ISSN: 22111247
Jieqiong Zhang; Webster; Dugger; Tatiana Goncharov; Merone Roose-Girma; Jeffrey Hung; Youngsu C. Kwon; Domagoj Vucic; Kim Newton; Vishva M. Dixit
PLoS ONE, ISSN: 19326203
Mona Abed; Erik Verschueren; Hanna G. Budayeva; Peter S. Liu; Donald S. Kirkpatrick; Rohit Reja; Sarah K. Kummerfeld; Webster; Sarah Gierke; Mike Reichelt; Keith R. Anderson; Robert J. Newman; Merone Roose-Girma; Zora Modrusan; Hazal Pektas; Emin Maltepe; Kim Newton; Vishva M. Dixit
Science, ISSN: 10959203 00368075
Meng He; Mira S. Chaurushiya; Webster; Sarah K. Kummerfeld; Rohit Reja; Subhra Chaudhuri; Ying-Jiun Chen; Zora Modrusan; Benjamin Haley; Dugger; Jeffrey Eastham-Anderson; Shari Lau; Anwesha Dey; Roger Caothien; Merone Roose-Girma; Kim Newton; Vishva M. Dixit
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Kim Newton; Dugger; Arundhati Sengupta Ghosh; Ron Ferrando; Felix Chu; Janet Tao; Wendy Lam; Susan Haller; Sara M. Chan; Susan Sa; Debra Dunlap; Jeffrey Eastham-Anderson; Hai Ngu; Jeffrey Hung; French; Webster; Brad Bolon; Jinfeng Liu; Rohit Reja; Sarah K. Kummerfeld; Ying-Jiun Chen; Zora Modrusan; Joe Lewcock; Vishva M. Dixit
Science Signaling, ISSN: 19379145 19450877
Saravanan Raju; Daniel M. Whalen; Meron Mengistu; Carter J. Swanson; John Quinn; Taylor; Webster; Kim Newton; Andrey S. Shaw
Nature, ISSN: 14764687 00280836
Klaus D. Heger; Katherine E. Wickliffe; Ada Ndoja; Juan Zhang; Aditya Murthy; Dugger; Maltzman; Felipe de Sousa e Melo; Jeffrey Hung; Yi Zeng; Erik Verschueren; Donald S. Kirkpatrick; Domagoj Vucic; Wyne P. Lee; Merone Roose-Girma; Robert J. Newman; Søren Warming; Yi-Chun Hsiao; László Kömüves; Webster; Kim Newton; Vishva M. Dixit
Cell Death and Disease, ISSN: 20414889
Marinella G. Callow; Colin K. Watanabe; Katherine E. Wickliffe; Russell Bainer; Sarah Kummerfield; Julie Weng; Trinna L. Cuellar; Vasantharajan Janakiraman; Chen; Ben Chih; Yuxin Liang; Benjamin Haley; Kim Newton; Michael Costa
Methods in Molecular Biology, ISSN: 10643745
Webster; Margaret Solon; Susan Haller; Kim Newton
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Zhen Zhang; Kim Newton; Sarah K. Kummerfeld; Webster; Donald S. Kirkpatrick; Lilian Phu; Jeffrey Eastham-Anderson; Jinfeng Liu; Wyne P. Lee; Jiansheng Wu; Hong Li; Melissa Junttila; Vishva M. Dixit
Cell Death and Differentiation, ISSN: 14765403 13509047
Maria Cristina De Almagro; Tatiana Goncharov; Anita Izrael-Tomasevic; Stefanie Duttler; Matthias Kist; Eugene Varfolomeev; Xiumin Wu; Wyne P. Lee; Jeremy Murray; Webster; Kebing Yu; Donald S. Kirkpatrick; Kim Newton; Domagoj Vucic
Nature, ISSN: 14764687 00280836
Kim Newton; Katherine E. Wickliffe; Maltzman; Dugger; Andreas Strasser; Victoria Pham; Jennie R. Lill; Merone Roose-Girma; Søren Warming; Margaret Solon; Hai Ngu; Webster; Vishva M. Dixit
Cell Death and Differentiation, ISSN: 14765403 13509047
Kim Newton; Dugger; Maltzman; Joan M. Greve; Maj Hedehus; Baby Martin-McNulty; Richard A. D. Carano; Tim C. Cao; Nicholas Van Bruggen; Lisa J. Bernstein; Wyne P. Lee; Xiumin Wu; Jason Devoss; Juan Zhang; Surinc Er Jeet; Ivan Peng; Brent Mckenzie; Merone Roose-Girma; Patrick Caplazi; Laurie Diehl; Webster; Domagoj Vucic
Annual Review of Biochemistry, ISSN: 15454509 00664154
Kim Newton; Gerard Manning
Journal of Experimental Medicine, ISSN: 15409538 00221007
Yan Qu; Shahram Misaghi; Kim Newton; Maltzman; Anita Izrael-Tomasevic; David Arnott; Vishva M. Dixit
Nature, ISSN: 14764687 00280836
Ingrid E. Wertz; Kim Newton; Dhaya Seshasayee; Saritha Kusam; Cynthia Lam; Juan Zhang; Nataliya Popovych; Elizabeth Helgason; Allyn J. Schoeffler; Surinc Er Jeet; Nandhini Ramamoorthi; Kategaya; Robert J. Newman; Keisuke Horikawa; Dugger; Wendy N. Sandoval; Susmith Mukund; Anuradha Zindal; Flavius Martin; Quan; Jeffrey Tom; Wayne J. Fairbrother; Michael J. Townsend; Søren Warming; Jason Devoss; Jinfeng Liu; Erin C. Dueber; Patrick Caplazi; Wyne P. Lee; Christopher C. Goodnow; Mercedesz Balazs; Kebing Yu; Ganesh Kolumam; Vishva M. Dixit
Cell, ISSN: 10974172 00928674
Rowena Suriben; Kelly A. Kaihara; Magdalena Paolino; Mike Reichelt; Sarah K. Kummerfeld; Zora Modrusan; Dugger; Kim Newton; Meredith Sagolla; Webster; Jinfeng Liu; Matthias Hebrok; Vishva M. Dixit
Structure, ISSN: 18784186 09692126
Jianping Yin; Allyn J. Schoeffler; Katherine E. Wickliffe; Kim Newton; Melissa A. Starovasnik; Erin C. Dueber; Seth F. Harris
Cell Death and Disease, ISSN: 20414889
Maria Cristina De Almagro; Tatiana Goncharov; Kim Newton; Domagoj Vucic
Trends in Cell Biology, ISSN: 18793088 09628924
Kim Newton
Journal of Histochemistry and Cytochemistry, ISSN: 15515044 00221554
Ron Ferrando; Kim Newton; Felix Chu; Webster; French
Nature, ISSN: 14764687 00280836
Sascha Rutz; Nobuhiko Kayagaki; Qui Phung; Celine Eidenschenk; Rajkumar Noubade; Xiaoting Wang; Justin Lesch; Rongze Lu; Kim Newton; Oscar W Huang; Andrea G Cochran; Vasser; Benjamin P. Fauber; Jason Devoss; Webster; Laurie Diehl; Zora Modrusan; Donald S. Kirkpatrick; Jennie R. Lill; Wenjun Ouyang; Vishva M. Dixit
Nature, ISSN: 00280836 14764687
Kim Newton; Joanne M. Hildebrand; Zhirong Shen; Diego Rodriguez; Silvia Alvarez-Diaz; Sean Petersen; Saumil Shah; Dugger; Chunzi Huang; Johan Auwerx; Vandenabeele; Douglas R. Green; Avi Ashkenazi; Vishva M. Dixit; William J. Kaiser; Andreas Strasser; Alexei Degterev; John Silke
Science, ISSN: 10959203 00368075
Kim Newton; Dugger; Katherine E. Wickliffe; Neeraj Kapoor; Maria Cristina De Almagro; Domagoj Vucic; László Kömüves; Ron Ferrando; French; Webster; Merone Roose-Girma; Søren Warming; Vishva M. Dixit
Journal of Cell Biology, ISSN: 00219525 15408140
Sarah Huntwork-Rodriguez; Bei Wang; Trent A. Watkins; Arundhati Sengupta Ghosh; Christine D. Pozniak; Daisy J. Bustos; Kim Newton; Donald S. Kirkpatrick; Joe Lewcock
Science, ISSN: 10959203 00368075
Xiaodong Huang; James C. McGann; Bob Y. Liu; Rami N. Hannoush; Jennie R. Lill; Victoria Pham; Kim Newton; Michael Kakunda; Jinfeng Liu; Christine Yu; Sarah G. Hymowitz; Hongo; Anthony Wynshaw-Boris; Paul G. Polakis; Richard M. Harland; Vishva M. Dixit
Biochemical Journal, ISSN: 02646021 14708728
Eugene Varfolomeev; Elham Moradi; Jasmin N. Dynek; Jiping Zha; Anna V. Fedorova; Deshayes; Wayne J. Fairbrother; Kim Newton; Jennifer Le Couter; Domagoj Vucic
Nature, ISSN: 00280836 14764687
Yan Qu; Shahram Misaghi; Anita Izrael-Tomasevic; Kim Newton; Laurie L. Gilmour; Lamkanfi; Salina Louie; Nobuhiko Kayagaki; Jinfeng Liu; László Kömüves; James Cupp; David Arnott; Denise M. Monack; Vishva M. Dixit
Science, ISSN: 10959203 00368075
Anwesha Dey; Dhaya Seshasayee; Rajkumar Noubade; French; Jinfeng Liu; Mira S. Chaurushiya; Donald S. Kirkpatrick; Victoria Pham; Jennie R. Lill; Corey Bakalarski; Jiansheng Wu; Lilian Phu; Paula Katavolos; Lindsay M. LaFave; Omar Abdel-Wahab; Zora Modrusan; Somasekar Seshagiri; Ken Dong; Zhonghua Lin; Mercedesz Balazs; Rowena Suriben; Kim Newton; Sarah G. Hymowitz; Guillermo Garcia-Manero; Flavius Martin; Ross L. Levine; Vishva M. Dixit
Methods in Molecular Biology, ISSN: 10643745
Kim Newton; Marissa L. Matsumoto; Ron Ferrando; Katherine E. Wickliffe; Michael Rape; Robert F. Kelley; Vishva M. Dixit
Cold Spring Harbor Perspectives in Biology, ISSN: 19430264
Kim Newton; Vishva M. Dixit
Nature, ISSN: 00280836 14764687
Nobuhiko Kayagaki; Søren Warming; Lamkanfi; Lieselotte Vande Walle; Salina Louie; Jennifer Dong; Kim Newton; Yan Qu; Jinfeng Liu; Sherry Heldens; Juan Zhang; Wyne P. Lee; Merone Roose-Girma; Vishva M. Dixit
Nature, ISSN: 00280836 14764687
Alberto C. Vitari; Kevin G. Leong; Kim Newton; Cindy Yee; Karen M. O'Rourke; Jinfeng Liu; Lilian Phu; Rajesh Vij; Ron Ferrando; Suzana Couto; Sankar Mohan; Ajay Pandita; Hongo; David Arnott; Ingrid E. Wertz; Gao; French; Vishva M. Dixit
Journal of Immunology, ISSN: 00221767 15506606
Yan Qu; Shahram Misaghi; Kim Newton; Laurie L. Gilmour; Salina Louie; James Cupp; George R. Dubyak; David Hackos; Vishva M. Dixit
Journal of Experimental Medicine, ISSN: 15409538 00221007
Petr Broz; Kim Newton; Lamkanfi; Sanjeev Mariathasan; Vishva M. Dixit; Denise M. Monack
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Jonathan W. Jones; Nobuhiko Kayagaki; Petr Broz; Thomas Henry; Kim Newton; Karen M. O'Rourke; Salina Chan; Jennifer Dong; Yan Qu; Merone Roose-Girma; Vishva M. Dixit; Denise M. Monack
Cell, ISSN: 00928674
Kim Newton; Marissa L. Matsumoto; Ingrid E. Wertz; Donald S. Kirkpatrick; Jennie R. Lill; Jenille Tan; Dugger; Nathaniel C. Gordon; Sachdev S. Sidhu; Frederic A. Fellouse; László Kömüves; French; Ron Ferrando; Cynthia Lam; Deanne M. Compaan; Christine Yu; Ivan Bosanac; Sarah G. Hymowitz; Robert F. Kelley; Vishva M. Dixit
Cancer Investigation, ISSN: 07357907 15324192
Kim Newton; Domagoj Vucic
Nature, ISSN: 14764687 00280836
Sanjeev Mariathasan; David S. Weiss; Kim Newton; Jacqueline McBride; Karen M. O'Rourke; Merone Roose-Girma; Wyne P. Lee; Yvette Weinrauch; Denise M. Monack; Vishva M. Dixit
Cancer Research, ISSN: 00085472
David Dornan; Sheila Bheddah; Kim Newton; William Inice; Gretchen D. Frantz; Patrick Dowd; Koeppen; Vishva M. Dixit; French
Cell Death and Differentiation, ISSN: 13509047
O'Reilly; Divisekera; Kim Newton; Scalzo; Kataoka; Puthalakath; Ito; David C.S. Huang; Andreas Strasser
Molecular and Cellular Biology, ISSN: 02707306
Kim Newton; French; Minhong Yan; Gretchen D. Frantz; Vishva M. Dixit
Molecular and Cellular Biology, ISSN: 02707306
Kim Newton; Xiaoqing Sun; Vishva M. Dixit
Current Biology, ISSN: 09609822
Kim Newton; Vishva M. Dixit
Caspases signal not only apoptosis but also antigen-induced activation in cells of the immune system
Genes and Development, ISSN: 08909369
Kim Newton; Andreas Strasser
Education
- University of Melbourne, Australia, PhD in Medical Biology – 2000
- University of Auckland, New Zealand, MSc in Cellular and Molecular Biology – 1996
- University of Auckland, New Zealand, BSc in Biochemistry – 1994
Awards & Honors
- Premier’s Commendation for Medical Research, Victoria, Australia – 2000
- University of Auckland R E F Matthews Prize in Cellular and Molecular Biology – 1997