Lee Honigberg
Senior Director and Principal Scientist, OMNI Biomarker Development
"Genentech is a great place to do drug development – we test novel therapeutics for serious diseases and take an integrated approach to clinical development that is driven by a strong commitment to scientific integrity."
13
Years at Genentech
18
Publications at Genentech
I did my PhD in Neuroscience at UCSF and then started at a small company using C. elegans to discover new drug targets for neuropathic pain. That company was subsequently acquired by Celera Genomics where I continued to work in drug discovery across several therapeutic areas. After Celera, I moved further toward the clinic, leading the preclinical and biomarker development for a Btk inhibitor at Pharmacyclics. I joined Genentech in 2009 to return to Neuroscience and focus on biomarkers.
Featured Publication
Identification of longitudinally dynamic biomarkers in Alzheimer’s disease cerebrospinal fluid by targeted proteomics
Mol Neurodegener. 2014; 9: 22. Published online 2014 Jun 6.
Wildsmith KR, Schauer SP, Smith AM, Arnott D, Zhu Y, Haznedar J, Kaur S, Mathews WR, Honigberg LA.
My Focus
For me, biomarkers are at the sweet spot between research and the clinic. We use genetic, protein, and imaging biomarkers to better understand disease subsets, patterns of disease progression and the effects of novel therapeutics. My group focuses on Neuroscience (Alzheimer’s and other neurodegenerative diseases) and Ophthalmology (primarily advanced age-related macular degeneration). Part of the job is pure research – discovering new biomarkers and figuring out better ways to measure biomarkers in clinical trials. And part of the job can be very pragmatic – working with global teams to incorporate biomarkers into clinical trials to help us find the right patients and the right dose for a given therapeutic. The most exciting part of the job is when the biomarker data comes in from a clinical trial and we learn more about the disease and the drug and then apply that to the next clinical trial.
Genentech Publications
Annals of Clinical and Translational Neurology,
Jonathan S. Katz; Jeffrey D. Rothstein; Merit E. Cudkowicz; Angela Genge; Björn Oskarsson; Avis Hains; Chen Chen; Joshua Galanter; Braydon L. Burgess; William Cho; Geoffrey A. Kerchner; Felix L. Yeh; Arundhati Sengupta Ghosh; Sravanthi Cheeti; Logan Brooks; Lee Honigberg; Jessica A. Couch; Michael E. Rothenberg; Flavia Brunstein; Khema R. Sharma; Leonard van den Berg; James D. Berry; Jonathan D. Glass
Ophthalmologica, ISSN: 00303755
Steffen Schmitz-Valckenberg; Martina D. Braun; Sarah Thiele; Daniela Ferrara; Lee Honigberg; Simon S. Gao; Hao Chen; Verena Steffen; Frank G. Holz; Marlene Saßmannshausen
American Journal of Ophthalmology, ISSN: 18791891 00029394
Arshad M. Khanani; Vrinda S. Hershberger; Dante Joseph Pieramici; Rahul N. Khurana; Flavia Brunstein; Ling Ma; Katie F. Maass; Lee Honigberg; Irene Tom; Hao Chen; Erich C. Strauss; Phillip Lai
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Irene Tom; Victoria Pham; Kenneth J. Katschke Jr.; Wei Li; Wei-Ching Liang; Johnny Gutierrez; Andrew Ah Young; Isabel Figueroa; Shadi Toghi Eshghi; Ching Wei V. Lee; Jitendra Kanodia; Scott J. Snipas; Guy S. Salvesen; Phillip Lai; Lee Honigberg; Menno Van Lookeren Campagne; Daniel Kirchhofer; Amos Baruch; Jennie R. Lill
Alzheimer's Research and Therapy, ISSN: 17589193
Yoshida; Anita Moein; Tobias Bittner; Ostrowitzki; Helen Lin; Lee Honigberg; Jin Y. Jin; Angelica Quartino
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Heleen Scheerens; Ashley Smith; Olga Li; Lee Honigberg; Harris; Gabriële Holtappels; Claus Bachert
Alzheimer's Research and Therapy, ISSN: 17589193
Stephen P. Schauer; William R. Mylott; Moucun Yuan; Rand Jenkins; William Mathews; Lee Honigberg; Kristin R. Wildsmith
Alzheimer's Research and Therapy, ISSN: 17589193
Stephen Salloway; Lee Honigberg; William Cho; Michael Ward; Michel Friesenhahn; Flavia Brunstein; Angelica Quartino; David Clayton; Deborah L. Mortensen; Tobias Bittner; Carole Ho; Christina Rabe; Stephen P. Schauer; Kristin R. Wildsmith; Reina N. Fuji; Shehnaaz Suliman; Eric M. Reiman; Kewei Chen; Robert Paul
JAMA Ophthalmology, ISSN: 21686165
Frank G. Holz; Srinivas Sadda; Emily Y. Chew; Paul Mitchell; Adnan Tufail; Christopher Brittain; Daniela Ferrara; Sarah Gray; Lee Honigberg; Jillian Martin; Barbara Tong; Jason S. Ehrlich; Neil M. Bressler; Federico Furno Sola; Patricio G. Schlottmann; Alberto Zambrano; Carlos Zeolite; Jennifer Arnold; Mark Gillies; Alan Luckie; Paul Mitchell; Nicole Schneltzer; Julie de Zaeytijd; Shelley Boyd; Alan Cruess; Peter Kertes; Laurent Lalonde; David Maberley; Caroline Laugesen; Bahram Bodaghi; Salomon Yves Cohen; Catherine Francais; Eric H. Souied; Ramin Tadayoni; Lebriz Altay; Nicole Eter; Nicolas Feltgen; Carsten Framme; Salvatore Grisanti; Frank Holz; Daniel Pauleikhoff; András Seres; Attila Vajas; Francesco Boscia; Maria Cristina Parravano; Federico Ricci; Francesco Viola; David Lozano Rechy; Virgilio Morales; Dijkman; Reinier Schlingemann; Guillermo Reategui; Dorota Raczyńska; Bożena Romanowska-Dixon; Slawomir Teper; Marek Kacerík; Blandina Lipkova; Ocne Oddelenie; Hedviga Mikova; Javier Araiz; Luis Arias; Jorge Mataix; Jordi Monés; Javier A. Montero; Laura Sararols; Stephan Michels; Christopher Brand; Baljean Dhillon; Anita Agarwal; Virgil Alfaro; Brad Baker; Brian Berger; Robert B. Bhisitkul; Barbara A. Blodi; David S. Boyer; H. Logan Brooks; Stuart Burgess; Brandon G. Busbee; Miguel Busquets; David Callanan; Clement Chan; Jeffrey Chang; Sanford Chen; James Combs; Dilsher S. Dhoot; Pravin U. Dugel; Richard M. Feist; Philip J. Ferrone; Howard Fine; Jorge Fortun; Gregory A. Fox; Arthur Fu; Ronald C. Gentile; Ghassan Ghorayeb; Manjot Gill; Victor H. Gonzalez; Carmelina Gordon; Sunil Gupta; Robert Hampton; Jeffrey S. Heier; Vrinda S. Hershberger; Patrick Higgins; Darma Ie; Ricky Isernhagen; Randy Katz; Gregg T. Kokame; Robert Kwun; Paul Lee; Seong Lee; Sam Mansour; Dennis Marcus; Raj Maturi; Mark Michels; Jeffrey Moore; Jared Nielsen; George Novalis; Michael Ober; Karl Olsen; Sunil Patel; Dante Joseph Pieramici; Paul Raskauskas; Soraya Rofagha; Alan Ruby; Todd Schneiderman; Steven D. Schwartz; Rajiv Shah; Veeral Sheth; Lawrence Singerman; Rishi Singh; Glenn Stoller; Robert Stoltz; Ivan J. Suñer; Ali Tabassian; Ryan Tarantola; Allen B. Thach; Rafael Ufret-Vincenty; Robert Wirthlin; Andre Witkin; Robert Wong; Matthew Wood; Jeffrey Zheutlin; Arturo Alezzandrini; Mauricio Martinez Cartier; Devinder Chauhan; Fred Chen; Jagjit Gilhotra; Robyn H. Guymer; Anthony Kwan; Ursula Schmidt-Erfurth; Julie Jacob; Laurence Postelmans; Michael Larsen; Catherine Creuzot Garcher; Chu Bocage; Francois Devin; Laurent Kodjikian; Jean Francois Korobelnik; Saddek Mohand Said; Michel Weber; Hansjurgen Agostini; Gerd Auffarth; Ulrich Bartz-Schmidt; Katharina Bell; Andreea Gamulescu; Lars-Olof Hattenbach; Chris P. Lohmann; Armin Wolf; Janos Nemeth; Péter Vámosi; Balazs Varsanyi; Francesco Bandello; Chiara Eandi; Paolo Lanzetta; Massimo Nicolo; Giovanni Staurenghi; Gianni Virgili; Renata Garcia Franco; Juan Ramirez Estudillo; Carel Hoyng; Carlos Fernandez; Miguel Guzman; Silvio Lujan; Ewa Herba; Jozef Kaluzny; Marta Misiuk-Hojło; Jerzy Nawrocki; Angela Carneiro; Joao Figueira; Rufino Silva; Sara Vaz-Pereira; Elmira Abdulaeva; Valery Erichev; Andrey Zolotarev; Andrej Cernak; Marta Figueroa; Roberto Gallego-Pinazo; Alfredo Garcia-Layana; Francisco Gomez Ulla; Rafael Navarro; Jose Manuel Ortiz; Ramon Torres Imaz; Anders Kvanta; Katja Hatz; Sebastian Wolf; Bora Eldem; Nur Kir; Jale Mentes; Osman Saatci; Gursel Yilmaz; Clare C. Bailey; Sanjiv Banerjee; Andrew Browning; Simona Esposti; Richard Gale; Faruque Ghanchi; Timothy L. Jackson; Andrew Lotery; Sajjad Mahmood; Quresh Mohamed; Niro Narendran; Ian Pearce; Michael Williams; Prema Abraham; Gary Abrams; Sean D. Adrean; Virgil Alfaro; Andrew N. Antoszyk; Carl Baker; Richard Breazeale; William Z. Bridges; H. Logan Brooks; David M. Brown; Jorge Calzada; Peter A. Campochiaro; Nauman Chaudhry; Lloyd Clark; Brian Connolly; Karl G. Csaky; Diana V. Do; Richard F. Dreyer; William Durant; Alexander Eaton; David Eichenbaum; Leonard Feiner; Henry A. Ferreyra; Christina Flaxel; Scott Foxman; K. Bailey Freund; Christine R. Gonzales; Alan Gordon; Larry Halperin; Allen C. Ho; Nancy M. Holekamp; Deeba Husain; Nieraj Jain; Cameron Javid; Mark Johnson; Mark Johnson; Szilárd Kiss; Eleonora M. Lad; Theodore Leng; Mimi Liu; Nikolas J.S. London; Brian Madow; Daniel M. Miller; Lawrence S. Morse; Jared Nielsen; Matthew Ohr; Scott C. N. Oliver; Swati Patel; Joel Pearlman; Dante Pieramici; Subhransu K. Ray; Carl D. Regillo; Robert Rosa; Philip J. Rosenfeld; David Saperstein; David Sarraf; Yevgeniy Shildkrot; Raymond Sjaarda; Eric Suan; Paul Weishaar; Mark R. Wieland; David F. Williams; Jonathan Williams; Charles C. Wykoff
Alzheimer's and Dementia: Translational Research and Clinical Interventions, ISSN: 23528737
Pierre N. Tariot; Francisco Lopera; Jessica B. Langbaum; Ronald G. Thomas; Suzanne Hendrix; Lon S. Schneider; Silvia Rios-Romenets; Margarita Giraldo; Natalia Acosta; Carlos Tobon; Claudia Ramos; Alejandro Espinosa; William Cho; Michael Ward; David Clayton; Michel Friesenhahn; Howard M. Mackey; Lee Honigberg; Sandra M. Sanabria-Bohorquez; Kewei Chen; Trisha Walsh; Carolyn Langlois; Eric M. Reiman
Neurology, ISSN: 1526632X 00283878
Jeffrey L. Cummings; Sharon Cohen; Christopher H. Van Dyck; Mark Brody; Craig Curtis; William Cho; Michael Ward; Michel Friesenhahn; Flavia Brunstein; Angelica Quartino; Lee Honigberg; Reina N. Fuji; David Clayton; Deborah L. Mortensen; Carole Ho; Robert Paul; Christina Rabe
Science Translational Medicine, ISSN: 19466242 19466234
Brian L. Yaspan; David F. Williams; Frank G. Holz; Carl D. Regillo; Zhengrong Li; Amy Dressen; Menno Van Lookeren Campagne; Kha Le; Robert R. Graham; Tatiana Beres; Tushar Bhangale; Lee Honigberg; Ashley Smith; Erin C. Henry; Carole Ho; Erich C. Strauss
Proteomics - Clinical Applications, ISSN: 18628354 18628346
Spellman; Kristin R. Wildsmith; Lee Honigberg; Marianne Tuefferd; David Baker; Nandini Raghavan; Angus C. Nairn; Pascal Croteau; Michael Schirm; René Allard; Julie Lamontagne; Daniel Chelsky; Steven Hoffmann; William Z. Potter
Science Translational Medicine, ISSN: 19466242
Reina N. Fuji; Michael Flagella; Miriam Baca; Marco A. S Baptista; Jens Brodbeck; Bryan K. Chan; Brian K. Fiske; Lee Honigberg; Adrian M. Jubb; Paula Katavolos; Donna W. Lee; Sock-Cheng Lewin-Koh; Tori Lin; Xingrong Liu; Shannon Liu; Joseph P. Lyssikatos; Jennifer O'Mahony; Mike Reichelt; Merone Roose-Girma; Zejuan Sheng; Todd Sherer; Ashley Smith; Margaret Solon; Zachary K. Sweeney; Jacqueline M. Tarrant; Alison Urkowitz; Søren Warming; Murat Yaylaoglu; Shuo Zhang; Haitao Zhu; Anthony A. Estrada; Ryan J. Watts
Science Translational Medicine, ISSN: 19466242 19466234
Reina N. Fuji; Michael Flagella; Miriam Baca; Marco A. S Baptista; Jens Brodbeck; Bryan K. Chan; Brian K. Fiske; Lee Honigberg; Adrian M. Jubb; Paula Katavolos; Donna W. Lee; Sock-Cheng Lewin-Koh; Tori Lin; Xingrong Liu; Shannon Liu; Joseph P. Lyssikatos; Jennifer O'Mahony; Mike Reichelt; Merone Roose-Girma; Zejuan Sheng; Todd Sherer; Ashley Smith; Margaret Solon; Zachary K. Sweeney; Jacqueline M. Tarrant; Alison Urkowitz; Søren Warming; Murat Yaylaoglu; Shuo Zhang; Haitao Zhu; Anthony A. Estrada; Ryan J. Watts
Molecular Neurodegeneration, ISSN: 17501326
Kristin R. Wildsmith; Stephen P. Schauer; Ashley Smith; David Arnott; Yuda Zhu; Joshua Haznedar; Surinder Kaur; William Mathews; Lee Honigberg
PLoS ONE, ISSN: 19326203
Svetlana Pidasheva; Sara Trifari; Anne Phillips; Jason A. Hackney; Ma; Ashley Smith; Sue J. Sohn; Hergen Spits; Randall D. Little; Timothy W. Behrens; Lee Honigberg; Nico Ghilardi; Hilary F. Clark
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490
Lee Honigberg; Ashley Smith; Mint Sirisawad; Erik Verner; David Loury; Betty Chang; Shyr Li; Zhengying Pan; Douglas H. Thamm; Richard A. Miller; Joseph J. Buggy
Education
- UC San Francisco, PhD in Neuroscience – 1998
- Dartmouth College, AB in Computer Science – 1989