Genentech: Marcel Hop | Vice President, Drug Metabolism & Pharmacokinetics

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Scientists / Our Scientists

"Many of us have relatives affected by debilitating and sometimes terminal diseases. It is hard to top the personal satisfaction that comes from knowing that we are working to improve and extend the lives of patients."

Years at Genentech

Publications

I joined Genentech in 2007 as director of the small molecule Drug Metabolism & Pharmacokinetics department. The mission of the DMPK department is to enable the discovery, selection, development, and commercialization of medicines for significant unmet medical needs by elucidating the absorption, distribution, metabolism, elimination and pharmacokinetic/pharmacodynamic properties of small molecule drug candidates and antibody-drug conjugates. We accomplish this through application of state-of-the-art technologies, drug metabolism and disposition expertise, bioanalysis, innovative thinking, effective collaboration and teamwork.

Drug discovery and development continues to be extremely challenging and success is only achievable by integrating the contributions from excellent scientists here at Genentech. Having everyone on one campus is ideal, because you can simply walk over and discuss the latest data and next steps.

Genentech's strength lies in its deep knowledge of the biology as it relates to oncology, immunology, CNS disorders and bacterial infections. ADME in drug discovery and development is a rapidly evolving field and we have great opportunities to apply the latest science to identify molecules that are ideal candidates for clinical testing. It is critically important to emphasize continuous learning – talk to and listen to in house colleagues, read the literature diligently and attend relevant conferences. Keep your skills sharp, process everything and apply the best approaches to your projects.

Featured Publication

Rational Use of Plasma Protein and Tissue Binding Data in Drug Design

Journal of Medicinal Chemistry, 2014, ISSN: 0022-2623

Liu, Xingrong; Wright, Matthew; Hop, Cornelis E C A.

View Abstract on PubMed

Genentech's strength lies in its deep knowledge of the biology as it relates to oncology, immunology, CNS disorders and bacterial infections. Our goal is to contribute to small molecule and antibody-drug conjugate drug discovery and development to make it as successful as Genentech's many biological drugs. Indeed, our department has made critical contributions to the development and subsequent launch of vismodegib and cobimetinib in the last few years.

The ADME science related to small molecule drug discovery and development is a rapidly evolving field and we have great opportunities to apply the latest science to identify molecules that are ideal candidates for clinical testing.

It is critically important to emphasize continuous learning – talk to and listen to in house colleagues, read the literature diligently and attend relevant conferences. Keep your skills sharp, process everything and apply the best approaches to your projects.

Prediction of transporter-mediated rosuvastatin hepatic uptake clearance and drug interaction in humans using proteomics-informed REF approach

Drug Metabolism and Disposition, ISSN: 00909556

Vineet Kumar; Mengyue Yin; Kazuya Ishida; Laurent Salphati; Marcel Hop; Christopher Rowbottom; Guangqing Xiao; Yurong Lai; Anita Mathias; Xiaoyan Chu; W. Griffith Humphreys; Mingxiang Liao; Zsuzsanna Nerada; Nóra Szilvásy; Scott Heyward; Jashvant D. Unadkat

Characterization of Antineovascularization Activity and Ocular Pharmacokinetics of Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitor GNE-947

Drug Metabolism and Disposition, ISSN: 1521009X

Xingrong Liu; Xiaorong Liang; Jenninfer LeCouter; Savita Ubhayakar; Jacob Chen; Jay Cheng; Tom Lee; Joe Lubach; Jim Nonomiya; Sheerin Latham; Cristine Quiason-Huynh; Eric G. Solon; Matthew Wright; Marcel Hop; Tim Heffron

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Marcel Hop

Vice President, Drug Metabolism & Pharmacokinetics

Featured Publication

Rational Use of Plasma Protein and Tissue Binding Data in Drug Design