Ola Saad
Distinguished Scientist and Senior Director, BioAnalytical Sciences, Development Sciences
"Every day, I find inspiration working with teams passionate about the science and ultimately its translation into life-changing therapies for patients."
19
Years at Genentech
38
Publications at Genentech
5
Awards & Honors
As a chemistry graduate student I visited and aspired to come work at Genentech and contribute to the mission of developing innovative medicines to help address unmet medical needs. My background research was around utilization of mass spectrometry for the structural characterization and quantitation of complex biological macromolecules such as glycosoaminoglycans.
After earning my Ph.D. in Chemistry, I joined Genentech in 2005 as an Associate Scientist to support the bioanalysis of our antibody-drug conjugate (ADC) programs. It has been a great opportunity to be pioneering in our field, and within our group applying both small and large molecule bioanalytical mass spectrometry to a breadth of programs.
I am grateful to be working in an organization with access to cutting edge instrumentation, smart, committed colleagues, and a collaborative, science-driven culture. Every day, I find inspiration working with teams passionate about the science and ultimately its translation into life-changing therapies for patients. Certainly some of the most motivating and rewarding experiences for me working at Genentech are actually seeing and hearing from patients who have benefited from these efforts.
Featured Publication
Bioanalytical approaches for characterizing catabolism of antibody-drug conjugates.
Bioanalysis. 2015;7(13):1583-604.
Saad O.M., Shen B-Q., Xu K., Khojasteh C., Girish S., Kaur S.
My Focus
My group is interested in the design of LC-MS based bioanalytical strategies for the characterization of antibody-drug conjugates (ADCs) and other biotherapeutics. We focus on the development, evaluation, and implementation of bioanalytical LC-MS methods to characterize ADC biopharmaceuticals, quantify therapeutic antibody and drug levels, as well as characterize catabolites in a variety of biological matrices.
Genentech Publications
Nature Communications,
Gail D. Lewis; Guangmin Li; Jun Guo; Shang-Fan Yu; Carter Fields; Genee Lee; Donglu Zhang; Peter Dragovich; Thomas H. Pillow; Binqing Wei; Jack D. Sadowsky; Douglas Leipold; Wilson; Amrita Kamath; Michael Mamounas; M. Violet Lee; Ola M. Saad; Voleak Choeurng; Alexander Ungewickell; Sharareh Monemi; Lisa Crocker; Kevin Kalinsky; Shanu Modi; Kyung Hae Jung; Erika Hamilton; Patricia LoRusso; Ian E. Krop; Melissa Schutten; Renee Commerford; Mark X. Sliwkowski; Eunpi Cho
Bioanalysis,
Johanna Mora; Rachel Palmer; Leslie Wagner; Bonnie Wu; Michael A. Partridge; Meena; Ivo Sonderegger; John Smeraglia; Nicoletta Bivi; Naveen Dakappagari; Sandra Diebold; Fabio Garofolo; Grimaldi; Warren Kalina; John Kamerud; Sumit Kar; Jean-Claude Marshall; Christian Mayer; Andrew Melton; Keith D. Merdek; Katrina Nolan; Serge Picard; Weiping Shao; Jessica Seitzer; Yoichi Tanaka; Omar Tounekti; Adam Vigil; Karl Walravens; Joshua Xu; Weifeng Xu; Yuanxin Xu; Lin Yang; Liang Zhu; Verthelyi; Robert J Kubiak; Kelly Coble; Swati Gupta; Mohsen Rajabi Abhari; Susan Richards; Yuan Song; Martin Ullmann; Boris Calderon; Isabelle Cludts; George R. Gunn; Shalini Gupta; Akiko Ishii-Watabe; Mohanraj Manangeeswaran; Kimberly Maxfield; Fred McCush; Christine O'Day; Kate Peng; Johann Poetzl; Michele Rasamoelisolo; Ola M. Saad; Kara Scheibner; Sophie Shubow; Sam Song; Seth Thacker
Analytical and Bioanalytical Chemistry, ISSN: 16182642
Suk-Joon Hyung; Dongwei Li; Neelima Koppada; Surinder Kaur; Ola M. Saad
Xenobiotica, ISSN: 00498254
Victor Yip; Ola M. Saad; Douglas Leipold; Chunze Li; Amrita Kamath; Shen
Bioanalysis, ISSN: 17576180
Matthew Szapacs; Wenying Jian; Spellman; Jennifer Cunliffe; Elizabeth Verburg; Surinder Kaur; John Kellie; Wenkui Li; John T. Mehl; Mark Qian; Xiazi Qiu; Federico Riccardi Sirtori; Anton I Rosenbaum; Timothy Sikorski; Sekhar Surapaneni; Jian Wang; Amanda Wilson; Jinhui Zhang; Xue; Noah Post; Yue Huang; Dina Goykhman; Long Yuan; Kasie Fang; Ellen Casavant; Lin-Zhi Chen; Yunlin Fu; Ming Huang; Allena Ji; Jay Johnson; Michael Lassman; Jing Li; Ola M. Saad; Hetal Sarvaiya; Lin Tao; Yuting Wang; Naiyu Zheng; Arindam Dasgupta; Mohsen Rajabi Abhari; Akiko Ishii-Watabe; Yoshiro Saito; Dulcyane Neiva Mendes Fernandes; Joe Bower; Chris Burns; Kevin Carleton; Seongeun Julia Cho; Xiulian Du; Marianne Scheel Fjording; Fabio Garofolo; Sumit Kar; Olga Kavetska; Elham Kossary; Yang Lu; Andrew Mayer; Nisha Palackal; Danielle Salha; Eric Thomas; Tom Verhaeghe; Stephen Vinter; Katty Wan; Yow-Ming C. Wang; Kathi Williams; Eric Woolf; Li Yang; Eric Yang; Abbas Bandukwala; Shirley Hopper; Kevin Maher; Joshua Xu; Eric Brodsky; Isabelle Cludts; Chad Irwin; Julie Joseph; Susan Kirshner; Mohanraj Manangeeswaran; Kimberly Maxfield; Joao Pedras-Vasconcelos; Therese Solstad; Seth Thacker; Omar Tounekti; Verthelyi; Meenu Wadhwa; Leslie Wagner; Takenori Yamamoto; Lucia Zhang; Lin Zhou
Frontiers in Immunology,
M. Violet Lee; Ola M. Saad; Sylvia Wong; Jason LaMar; Lynn Kamen; Benjamin A. Ordonia; Rachel Melendez; Azadeh Hassanzadeh; Shan Chung; Surinder Kaur
Analytical Chemistry, ISSN: 15206882 00032700
Suk-Joon Hyung; Douglas Leipold; Donna W. Lee; Surinder Kaur; Ola M. Saad
Journal of Clinical Medicine, ISSN: 20770383
Victor Yip; M. Violet Lee; Ola M. Saad; Shuguang Ma; S. Cyrus Khojasteh; Shen
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Hao Cai; Victor Yip; M. Violet Lee; Sylvia Wong; Ola M. Saad; Shuguang Ma; Nina Ljumanovic; S. Cyrus Khojasteh; Amrita Kamath; Shen
Analytical Chemistry, ISSN: 15206882 00032700
M. Violet Lee; Surinder Kaur; Ola M. Saad
Molecular Cancer Research, ISSN: 15573125 15417786
Vineesh Indira Chandran; Ann-Sofie Mansson; Magdalena Barbachowska; Myriam Cerezo-Magana; Bjorn Nodin; Bharat Joshi; Neelima KoppaD.A.; Ola M. Saad; Oleg Gluz; Karolin Isaksson; Signe Borgquist; Karin Jirstrom; Ivan R. Nabi; Helena Jernstrom; Mattias Belting
mAbs, ISSN: 19420870 19420862
Rong Deng; Chenguang Zhou; Dongwei Li; Hao Cai; Siddharth Sukumaran; Montserrat Carrasco-Triguero; Ola M. Saad; Denise Nazzal; Christopher Lowe; Ramanujan; Amrita Kamath
Antimicrobial Agents and Chemotherapy, ISSN: 10986596 00664804
Melicent Peck; Michael E. Rothenberg; Rong Deng; Nicholas Lewin-Koh; Gaohong She; Amrita Kamath; Montserrat Carrasco-Triguero; Ola M. Saad; Aide Castro; Lisa Teufel; Daniel S. Dickerson; Marisa Leonardelli; Jorge A. Tavel
Analytical and Bioanalytical Chemistry, ISSN: 16182650 16182642
Suk-Joon Hyung; Dongwei Li; Neelima Koppada; Surinder Kaur; Ola M. Saad
Bioconjugate Chemistry, ISSN: 15204812 10431802
Dian Su; Jinhua Chen; Ely Cosino; Josefa Dela Cruz Chuh; Helen Davis; Geoffrey Del Rosario; Isabel Figueroa; Leanne Goon; Jintang He; Amrita Kamath; Surinder Kaur; Katherine R. Kozak; Jeffrey Lau; Donna W. Lee; M. Violet Lee; Douglas Leipold; Luna Liu; Peter S. Liu; Guo-Liang Lu; Nelson; Carl Ng; Thomas H. Pillow; Paul G. Polakis; Andrew G. Polson; Rebecca K. Rowntree; Ola M. Saad; Brian S. Safina; Nicola J. Stagg; Moana Tercel; Richard L. Vandlen; Breanna S. Vollmar; John Wai; Tao Wang; Binqing Wei; Keyang Xu; Juanjuan Xue; Zijin Xu; Gang Yan; Hui Yao; Shang-Fan Yu; Donglu Zhang; Fiona Zhong; Peter Dragovich
Bioanalysis, ISSN: 17576199 17576180
Montserrat Carrasco-Triguero; Randall Dere; Marija Milojic-Blair; Ola M. Saad; Denise Nazzal; Kyu Hong; Surinder Kaur
mAbs, ISSN: 19420870 19420862
Douglas Leipold; Isabel Figueroa; Shabkhaiz Masih; Brandon Latifi; Victor Yip; Shen; Randall Dere; Montserrat Carrasco-Triguero; M. Violet Lee; Ola M. Saad; Luna Liu; Jintang He; Dian Su; Keyang Xu; Brian R. Vuillemenot; Steven T. Laing; Melissa Schutten; Katherine R. Kozak; Bing Zheng; Andrew G. Polson; Amrita Kamath
mAbs, ISSN: 19420870 19420862
Shun xin Wang-Lin; Chenguang Zhou; Amrita Kamath; Kyu Hong; Neelima Koppada; Ola M. Saad; Montserrat Carrasco-Triguero; S. Cyrus Khojasteh; Rong Deng
Journal of Pharmacokinetics and Pharmacodynamics, ISSN: 15738744 1567567X
Kagedal; Leonid Gibiansky; Jian Xu; Xin Wang; Divya Samineni; Shang-Chiung Chen; Dan Lu; Priya Agarwal; Wang; Ola M. Saad; Neelima Koppada; Bernard M. Fine; Jin Y. Jin; Sandhya Girish; Chunze Li
Bioanalysis, ISSN: 17576199 17576180
Hendrik Neubert; An Song; Anita Lee; Cong Wei; Jeff Duggan; Keyang Xu; Eric Woolf; Christopher Evans; Joe Palandra; Omar Laterza; Shashi Amur; Isabella Berger; Mark Bustard; Mark T. Cancilla; Shang-Chiung Chen; Seongeun Julia Cho; Eugene Ciccimaro; Isabelle Cludts; Cocea; Celia D'Arienzo; Lieza Danan-Leon; Lorella Di Donato; Fabio Garofolo; Sam Haidar; Akiko Ishii-Watabe; Hao Jiang; John Kadavil; Sean Kassim; Pekka Kurki; Olivier Le Blaye; Kai Liu; Rod Mathews; Gustavo Mendes Lima Santos; Makoto Niwa; Joao Pedras-Vasconcelos; Mark Qian; Brian Rago; Ola M. Saad; Yoshiro Saito; Natasha Savoie; Dian Su; Matthew Szapacs; Nilufer Tampal; Stephen Vinter; Jian Wang; Jan Welink; Emma Whale; Amanda Wilson; Xue
AAPS Journal, ISSN: 15507416
Siddharth Sukumaran; Crystal Zhang; Douglas Leipold; Ola M. Saad; Keyang Xu; Kapil Gadkar; Divya Samineni; Wang; Marija Milojic-Blair; Montserrat Carrasco-Triguero; Bonnee Rubinfeld; Fielder; Kedan Lin; Ramanujan
mAbs, ISSN: 19420870 19420862
Chenguang Zhou; Sophie M. Lehar; Johnny Gutierrez; Carrie M. Rosenberger; Nina Ljumanovic; Jason Dinoso; Neelima Koppada; Kyu Hong; Amos Baruch; Montserrat Carrasco-Triguero; Ola M. Saad; Sanjeev Mariathasan; Amrita Kamath
Drug Metabolism Letters, ISSN: 18723128
Shen; Daniela Bumbaca; Qin Yue; Ola M. Saad; Jay Tibbitts; S. Cyrus Khojasteh; Sandhya Girish
Bioanalysis, ISSN: 17576199 17576180
Ola M. Saad; Shen; Keyang Xu; S. Cyrus Khojasteh; Sandhya Girish; Surinder Kaur
Pharmaceutical Research, ISSN: 1573904X 07248741
Dan Lu; Jin Y. Jin; Sandhya Girish; Priya Agarwal; Dongwei Li; Saileta Prabhu; Randall Dere; Ola M. Saad; Denise Nazzal; Neelima Koppada; Ramanujan; Chee Ng
Clinical Cancer Research, ISSN: 15573265 10780432
Hirdesh Uppal; Estelle Doudement; Kaushiki Mahapatra; Darbonne; Daniela Bumbaca; Shen; Xiaoyan Du; Ola M. Saad; Kristin Harden; Steve Olsen; Gail L. Phillips; Dylan P. Hartley; Mark X. Sliwkowski; Sandhya Girish; Donna M. Dambach; Vanitha Ramakrishnan
Toxicology and Applied Pharmacology, ISSN: 0041008X 10960333
Kirsten Achilles Poon; Kelly Flagella; Joseph Beyer; Jay Tibbitts; Surinder Kaur; Ola M. Saad; Joo-Hee Yi; Sandhya Girish; Noel Dybdal; Theresa Reynolds
Characterization of Protein Therapeutics using Mass Spectrometry,
Surinder Kaur; Keyang Xu; Ola M. Saad; Luna Liu; Tim Slattery; Randall Dere
Bioanalysis, ISSN: 17576180 17576199
Randall Dere; Joo-Hee Yi; Corinna Lei; Ola M. Saad; Catherine Huang; Yanhong Li; Jakub Baudys; Surinder Kaur
Clinical Pharmacology in Drug Development, ISSN: 2160763X 21607648
Manish Gupta; Wang; Timothy J. Carrothers; Patricia M. LoRusso; Yu-Waye Chu; Ted Shih; David Loecke; Amita Joshi; Ola M. Saad; Joo-Hee Yi; Sandhya Girish
Bioanalysis, ISSN: 17576180 17576199
Surinder Kaur; Keyang Xu; Ola M. Saad; Randall Dere; Montserrat Carrasco-Triguero
Current Drug Metabolism, ISSN: 13892002 18755453
Shen; Daniela Bumbaca; Ola M. Saad; Qin Yue; Cinthia V Pastuskovas; S. Cyrus Khojasteh; Jay Tibbitts; Surinder Kaur; Wang; Yu-Waye Chu; Patricia M. LoRusso; Sandhya Girish
Cancer Chemotherapy and Pharmacology, ISSN: 03445704 14320843
Sandhya Girish; Manish Gupta; Wang; Dan Lu; Ian E. Krop; Charles L. Vogel; Howard A. Burris; Patricia M. LoRusso; Joo-Hee Yi; Ola M. Saad; Barbara Tong; Yu-Waye Chu; Scott N. Holden; Amita Joshi
Nature Biotechnology, ISSN: 15461696 10870156
Shen; Keyang Xu; Luna Liu; Helga Raab; Sunil Bhakta; Margaret Kenrick; Kathryn Parsons; Janet Y. Tien; Shang-Fan Yu; Elaine Mai; Dongwei Li; Jay Tibbitts; Jakub Baudys; Ola M. Saad; Suzie J. Scales; Paul McDonald; Hass; Eigenbrot; Trung Nguyen; Willy A. Solis; Reina N. Fuji; Kelly Flagella; Darshana Patel; Spencer; Leslie A. Khawli; Allen Ebens; Wai Lee T. Wong; Richard L. Vandlen; Surinder Kaur; Mark X. Sliwkowski; Richard H. Scheller; Paul G. Polakis; Jagath R. Junutula
Bioconjugate Chemistry, ISSN: 15204812 10431802
C. Andrew Boswell; Eduardo E. Mundo; Crystal Zhang; Daniela Bumbaca; Nicole R. Valle; Katherine R. Kozak; Aimee Fourie-O'Donohue; Josefa Chuh; Neelima Koppada; Ola M. Saad; Herman S. Gill; Shen; Bonnee Rubinfeld; Jay Tibbitts; Surinder Kaur; Frank-Peter Theil; Fielder; Leslie A. Khawli; Kedan Lin
Analytical Biochemistry, ISSN: 10960309 00032697
Keyang Xu; Luna Liu; Ola M. Saad; Jakub Baudys; Lara Williams; Douglas Leipold; Shen; Helga Raab; Jagath R. Junutula; Amy H. Kim; Surinder Kaur
Bioconjugate Chemistry, ISSN: 10431802
Jean-Philippe Stephan; Pamela Chan; Chien C. Lee; Nelson; J. Michael Elliott; Charity Bechtel; Helga Raab; David Xie; Jon Akutagawa; Jakub Baudys; Ola M. Saad; Saileta Prabhu; Wai Lee T. Wong; Richard L. Vandlen; Fred Jacobson; Allen Ebens
Journal of the American Society for Mass Spectrometry, ISSN: 10440305
Yonghao Yu; Matthew D. Sweeney; Ola M. Saad; Julie A. Leary
Education
- University of California, Berkeley, Ph.D. Chemistry. Thesis title: “Mass Spectrometric Characterization of Glycosaminoglycans: Fundament – 2005
- Saint Mary’s College of California, Moraga, CA, B.S. Chemistry. (summa cum laude) Emphasis in Biochemistry, Minor in Philosophy – 2000
Awards & Honors
- Genentech Recognition Awards – 2006-2015
- American Society For Mass Spectrometry Conference Travel Award – 2002-2004
- Saint Mary’s Honors Scholarship – 1999-2000
- Science and Mathematics Award of Excellence from the American Association of University Women – 1995
- California Section American Chemical Society Chemistry Award – 1995