Paul J Fielder
VP PTPK OMNI Biomarker Dev, PTPK & ITGR/OMNI Biomarker Development
"Many Scientists aspire to help discover and develop a life changing therapeutic for a significant unmet medical need. At Genentech, we have had the privilege of helping to make this a reality for thousands of patients. To be a part of this mission is both humbling and inspiring."
28
Years at Genentech
58
Publications
3
Awards & Honors
After completing my Ph.D. at UCSC and Postdoctoral fellowship at Stanford, I joined Genentech in 1993 as a Scientist to help develop a new field studying the Pharmacokinetics and Pharmacodynamics of protein therapeutics. I was drawn to Genentech because of its great scientific reputation and it offered me the best opportunity to pursue great science in the mission of helping patients.
Over my career at Genentech, I have had the privilege of contributing to the discovery and development of multiple therapeutics, as well as, the training and development of our next generation of scientists and drug developers.
Featured Publication
Evidence for an asialoglycoprotein receptor on nonparenchymal cells for O-linked glycoproteins.
Journal of Pharmacology and Experimental Therapeutics. 2008 Nov;327(2):308-15.
Stefanich EG, Ren R, Danilenko DM, Lim A, Song A, Iyer S, Fielder PJ.
The pharmacokinetic and pharmacodynamic characteristics of a long-acting growth hormone (GH) preparation (nutropin depot) in GH-deficient adults.
Journal of Clinical Endocrinology & Metabolism. 87(10):4508-14, 2002 Oct.
Cook DM. Biller BM. Vance ML. Hoffman AR. Phillips LS. Ford KM. Benziger DP. Illeperuma A. Blethen SL. Attie KM. Dao LN. Reimann JD. Fielder PJ.
My Focus
I am currently leading 2 groups focused on Preclinical and Translational Pharmacology for all therapeutic areas and Biomarkers and Diagnostics for our non-oncology pipeline. These groups contribute to the preclinical and clinical development of molecules in multiple therapeutic areas, as well as, to the basic science of Pharmacokinetics, Systems Pharmacology and Biomarkers/Diagnostics.
Together our major goals are to develop state of the art “Translational Pharmacology” and “Biomarker” tools, data, and analyses to help enter the clinical development with both the knowledge and tools to maximize clinical success, to enable informed decision-making, and to enable our PHC mission. Ultimately our data helps ensure we give the right drug at the right dose to the right patients.
Publications
Pharmacology Research and Perspectives, ISSN: 20521707
Daniela Bumbaca Yadav; Art Reyes; Priyanka Gupta; Jean-Michel Vernes; Y Gloria Meng; Michelle Schweiger; Shannon Stainton; Germaine Fuh; Paul Fielder; Amrita Kamath; Ben-Quan Shen
AAPS Journal, ISSN: 15507416
Sid Sukumaran; Crystal Zhang; Douglas Leipold; Ola Saad; Keyang Xu; Kapil Gadkar; Divya Samineni; Wang; Marija Milojic Blair; Montse Carrasco-Triguero; Bonnee Rubinfeld; Fielder; Kedan Lin; Saroja Ramanujan
AAPS Journal, ISSN: 15507416
Chee Nam Ng; Paul Fielder; Jin Jin; Rong Deng
Pharmaceutical Biotechnology: Fundamentals and Applications, Third Edition,
Banmeet Anand; Rong Deng; Peter Theil; Jing Li; Shasha Jumbe; Tom Gelzleichter; Paul Fielder; Amita Joshi; Sara Kenkare-Mitra
Biopharmaceutics and Drug Disposition, ISSN: 1099081X
Jing Wang; Suhas Iyer; Paul Fielder; John Davis; Rong Deng
Molecular Pharmaceutics, ISSN: 15438392
Andy Boswell; Eduardo Emir Mundo; Sheila Ulufatu; Daniela Yadav; Hendry Cahaya; Nicholas Majidy; Marjie Van Hoy; Michelle Schweiger; Paul Fielder; Saileta Prabhu; Leslie Khawli
CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306
Kapil Gadkar; Nageshwar Budha; Baruch; John Davis; Fielder; Saroja Ramanujan
European Journal of Pharmaceutical Sciences, ISSN: 09280987
Chee Nam Ng; Kelly Loyet; Suhas Iyer; Paul Fielder; Rong Deng
mAbs, ISSN: 19420870
Victor Yip; Enzo Palma; Devin Tesar; Eduardo Emir Mundo; Daniela Yadav; Elizabeth Torres; Noe A. Reyes; Ben-Quan Shen; Paul Fielder; Saileta Prabhu; Leslie Khawli; Andy Boswell
Journal of Medicinal Chemistry, ISSN: 15204804
Andy Boswell; Jan Marik; Michael Elowson; Noe A. Reyes; Sheila Ulufatu; Daniela Yadav; Victor Yip; Eduardo Emir Mundo; Nicholas Majidy; Marjie Van Hoy; Saritha Goriparthi; Anthony Trias; Herman Gill; Simon Williams; Jagath Reddy Junutula; Paul Fielder; Leslie Khawli
Molecular Pharmaceutics, ISSN: 15438384
Andy Boswell; Eduardo Emir Mundo; Bernadette Johnstone; Sheila Ulufatu; Michelle Schweiger; Daniela Yadav; Paul Fielder; Saileta Prabhu; Leslie Khawli
Pharmaceutical Biotechnology: Fundamentals and Applications, Fourth Edition,
John Davis; Rong Deng; Andy Boswell; Yi Zhang; Jing Li; Paul Fielder; Amita Joshi; Sara Kenkare-Mitra
mAbs, ISSN: 19420862
Isidro Hotzel; Peter Theil; Lisa Bernstein; Saileta Prabhu; Rong Deng; Leah Quintana; Jeff Lutman; Renuka Sibia; Pamela Chan; Daniela Yadav; Paul Fielder; Paul Carter; Robert Kelley
mAbs, ISSN: 19420862
Deborah Mortensen; Saileta Prabhu; Eric Stefanich; Saloumeh Kadkhodayan Fischer; Tom Gelzleichter; Dana Baker; Jenny Jiang; Kristin Wallace; Suhas Iyer; Paul Fielder; Wendy Putnam
AAPS Journal, ISSN: 15507416
Andy Boswell; Daniela Yadav; Paul Fielder; Leslie Khawli
AAPS Journal, ISSN: 15507416
Daniela Yadav; Andy Boswell; Paul Fielder; Leslie Khawli
British Journal of Pharmacology, ISSN: 00071188
Daniela Yadav; Hong Xiang; Andy Boswell; Ruediger Port; Shannon Stainton; Eduardo Emir Mundo; Sheila Ulufatu; Anil Bagri; Peter Theil; Paul Fielder; Leslie Khawli; Ben-Quan Shen
Molecular Cancer Therapeutics, ISSN: 15357163
Cinthia Pastuskovas; Eduardo Emir Mundo; Simon Williams; Tapan K. Nayak; Jason Ho; Sheila Ulufatu; Suzy Clark; Sarajane Ross; Eric Cheng; Kathryn Parsons-Reponte; Gary Cain; Marjie Van Hoy; Nicholas Majidy; Sheila Bheddah; Josefa Chuh; Kathy Kozak; Nicholas Lewin-Koh; Peter Nauka; Daniela Yadav; Mark Sliwkowski; Jack (Jay) Tibbitts; Peter Theil; Paul Fielder; Leslie Khawli; Andy Boswell
Science, ISSN: 10959203
Chia-Lin Hsu; WeiYu Lin; Dhaya Seshasayee; John Chen; Xiao Ding; Zhonghua Lin; Eric Suto; Zhiyu Huang; Wyne Lee; Summer Park; Min Xu; Shao Mei Sun; Linda Rangell; Jeff Lutman; Sheila Ulufatu; Eric Stefanich; Cecile Chalouni; Meredith Sagolla; Lauri Diehl; Paul Fielder; Brian Dean; Mercedesz Balazs; Flavius Martin
mAbs, ISSN: 19420870
Yanan Zheng; Devin Tesar; Lisa Benincosa; Herbert Birnböck; Andy Boswell; Daniela Yadav; Kyra Cowan; Dimitry Danilenko; Ann Daugherty; Paul Fielder; Hans Peter Grimm; Amita Joshi; Nicole Justies; Gerry Kolaitis; Nicholas Lewin-Koh; Jing Li; Sami McVay; Jennifer O'Mahony; Michael Otteneder; Michael P. Pantze; Wendy Putnam; Julia Qiu; Jane Ruppel; Thomas Singer; Oliver Boris Stauch; Peter Theil; Jenn Visich; Jihong Yang; Yong Ying He; Leslie Khawli; Wolfgang F. Richter
mAbs, ISSN: 19420862
Rong Deng; Gloria Meng; Kwame Hoyte; Jeff Lutman; Yanmei Lu; Suhas Iyer; Laura DeForge; Peter Theil; Paul Fielder; Saileta Prabhu
Bioconjugate Chemistry, ISSN: 10431802
Andy Boswell; Eduardo Emir Mundo; Crystal Zhang; Daniela Yadav; Nicole Valle; Kathy Kozak; Aimee Fourie-O'Donohue; Josefa Chuh; Neelima Koppada; Ola Saad; Herman Gill; Ben-Quan Shen; Bonnee Rubinfeld; Jack (Jay) Tibbitts; Surinder Kaur; Peter Theil; Paul Fielder; Leslie Khawli; Kedan Lin
Science Translational Medicine, ISSN: 19466234
Kasia Owczarczyk; Preeti Lal; Alexander Abbas; Kristen Wolslegel; Cecile Holweg; Wolfgang Dummer; Ariella Kelman; Paul Brunetta; Nicholas Lewin-Koh; Marco Sorani; Diane Leong; Paul Fielder; David Yocum; Carole Ho; Ward Ortmann; Michael Townsend; Tim Behrens
PLoS ONE, ISSN: 19326203
Andy Boswell; Greg Ferl; Eduardo Emir Mundo; Daniela Yadav; Michelle Schweiger; Peter Theil; Paul Fielder; Leslie Khawli
Clinical Pharmacology and Therapeutics, ISSN: 00099236
Yanan Zheng; Heleen Scheerens; John C. Davis; Rong Deng; Sally Fischer; Woods; Paul Fielder; Eric Stefanich
mAbs, ISSN: 19420862
Rong Deng; Suhas Iyer; Peter Theil; Deborah Mortensen; Paul Fielder; Saileta Prabhu
Bioconjugate Chemistry, ISSN: 10431802
Andy Boswell; Devin Tesar; Kiran Mukhyala; Peter Theil; Paul Fielder; Leslie Khawli
Drug Metabolism and Disposition, ISSN: 00909556
Cinthia Pastuskovas; Bill Mallet; Suzy Clark; Margaret Kenrick; Nicholas Majidy; Michelle Schweiger; Marjie Van Hoy; Siao Ping Tsai; Greg Bennett; Ben-Quan Shen; Sarajane Ross; Paul Fielder; Leslie Khawli; Jack (Jay) Tibbitts
Molecular Pharmaceutics, ISSN: 15438384
Andy Boswell; Greg Ferl; Eduardo Emir Mundo; Michelle Schweiger; Jan Marik; Mike Reich; Peter Theil; Paul Fielder; Leslie Khawli
Journal of Pharmacokinetics and Pharmacodynamics, ISSN: 1567567X
Nelson Jumbe; Yan Xin; Douglas Leipold; Lisa Crocker; Debbie Dugger; Elaine Mai; Mark Sliwkowski; Paul Fielder; Jack (Jay) Tibbitts
Drug Metabolism and Disposition, ISSN: 00909556
Rong Deng; Kelly Loyet; Samantha Lien; Suhas Iyer; Laura DeForge; Peter Theil; Henry Lowman; Paul Fielder; Saileta Prabhu
Proteins and Peptides: Pharmacokinetic, Pharmacodynamic, and Metabolic Outcomes,
Andy Boswell; Rong Deng; Kedan Lin; Wendy Putnam; Cherry Lei; Peter Theil; Amita Joshi; Paul Fielder; Leslie Khawli
Molecular Cancer Therapeutics, ISSN: 15357163
Zachary Boyd; Jenny Wu; Carol O'Brien; Jill Spoerke; Heidi Savage; Paul Fielder; Lukas Amler; Yibing Yan; Mark Lackner
Journal of Pharmacology and Experimental Therapeutics, ISSN: 00223565
Eric Stefanich; Song Ren; Dimitry Danilenko; Amy Lim; An Song; Suhas Iyer; Paul Fielder
AAPS Journal, ISSN: 15507416
Wendy Putnam; Jing Li; Jonas Haggstrom; Chee Nam Ng; Saloumeh Kadkhodayan Fischer; Melissa Cheu; Yamo Deniz; Henry Lowman; Paul Fielder; Jenn Visich; Amita Joshi; Nelson Jumbe
Pharmaceutical Research, ISSN: 07248741
Chee Nam Ng; Eric Stefanich; Banmeet Anand; Paul Fielder; Louis Vaickus
Journal of Clinical Endocrinology and Metabolism, ISSN: 0021972X
Andrew R. Hoffman; Beverly M. K. Biller; David Cook; Joyce Baptista; Bernard L. Silverman; Le Dao; Kenneth Attie; Paul Fielder; Thomas Maneatis; Barbara Lippe
Journal of Immunotherapy, ISSN: 15249557
Yulia Vugmeyster; Joe Beyer; Kathy Howell; Daniel Combs; Paul Fielder; Jihong Yang; Ferhan Qureshi; Bryan Sandlund; Ly Kawaguchi; Wolfgang Dummer; Henry Lowman; Kathleen McKeever
Drug Metabolism and Disposition, ISSN: 00909556
Greg P. Coffey; Judith Fox; Susanne D. Pippig; Susan L. Palmieri; Barbara Leanne Reitz; Michelle Gonzales; Anahid Bakshi; Josette Padilla Eagar; Paul Fielder
Journal of Pharmacology and Experimental Therapeutics, ISSN: 00223565
Greg P. Coffey; Eric Stefanich; Susan L. Palmieri; Renee Eckert; Josette Padilla Eagar; Paul Fielder; Susanne D. Pippig
Journal of Clinical Endocrinology and Metabolism, ISSN: 0021972X
Stephen F. Kemp; Paul Fielder; Kenneth Attie; Sandra L. Blethen; Edward O. Reiter; Kathleen M. Ford; Melinda Marian; Le Dao; Lee; Saenger
Journal of Clinical Endocrinology and Metabolism, ISSN: 0021972X
David Cook; Beverly M. K. Biller; Mary Lee Vance; Andrew R. Hoffman; Lawrence S. Phillips; Kathleen M. Ford; Benziger; Illeperuma; Sandra L. Blethen; Kenneth Attie; Le Dao; James Reimann; Paul Fielder
Biomaterials, ISSN: 01429612
Franklin W. Okumu; Le Dao; Paul Fielder; Noel Dybdal; Dennis A. Brooks; Samir Sane; Jeffrey L. Cleland
Clinical Pharmacology and Therapeutics, ISSN: 00099236
Carla Washington; Kathy Howell; Linda A. Zuckerman; Phong T. Tran; John Lowe; Mortesen; Paul Fielder; Judith Fox; Clarke
Cancer Chemotherapy and Pharmacology, ISSN: 03445704
Eric Stefanich; Carlson-Zermeno; McEvoy; Mike Reich; Paul Fielder
Endocrinology, ISSN: 00137227
Yves J. Dubaquie; Deborah Mortensen; Anthony J. Intintoli; Deborah Hogue; Gerry Nakamura; Pat Rancatore; Philip Lester; Michael Sadick; Ellen Filvaroff; Paul Fielder; Henry Lowman
Stem Cells, ISSN: 10665099
Gerard Wagemaker; Karen J. Neelis; Simone C. C. Hartong; Albertus W. Wognum; Thomas; Paul Fielder; Dan Eaton
British Journal of Haematology, ISSN: 00071048
Takeyuki Sato; Akira Fuse; Hiroo Niimi; Paul Fielder; Hava Avraham
Endocrinology, ISSN: 00137227
Peter Bang; Paul Fielder
Blood, ISSN: 00064971
Eric Stefanich; Tauri Senn; Ramon Widmer; Christine Fratino; Gilbert-Andre Keller; Paul Fielder
Blood, ISSN: 00064971
Paul Fielder; Phil Hass; Mark Nagel; Eric Stefanich; Ramon Widmer; Greg Bennett; Gilbert-Andre Keller; Frederic De Sauvage; Dan Eaton
Endocrinology, ISSN: 00137227
Wenlu Li; Janet Fawcett; Widmer; Paul Fielder; Ralph Rabkin; Gilbert-Andre Keller
American Journal of Physiology - Endocrinology and Metabolism, ISSN: 01931849
Oster; Nancy Levin; Paul Fielder; Iain Robinson; Baxter; Cronin
Endocrinology, ISSN: 00137227
Paul Fielder; Deborah Mortensen; Phyllis Antoinette Mallett; Carlsson; Baxter; Ross Clark
Blood, ISSN: 00064971
Paul Fielder; Austin L. Gurney; Eric Stefanich; Melinda Marian; Mark Moore; Karen Elizabeth Carver-Moore; Frederic De Sauvage
Journal of Clinical Investigation, ISSN: 00219738
Oster; Paul Fielder; Nancy Levin; Cronin
Journal of Clinical Endocrinology and Metabolism, ISSN: 19457197
Paul Fielder; Jaime Guevara-Aguirret; Arlan L. Rosenbloom; Carlsson; Hintz; Rosenfeld
Endocrinology, ISSN: 19457170
G. Paolo Ceda; Paul Fielder; William J. Henzel; Louie; Sharon M. Donovan; Andrew R. Hoffman; Rosenfeld; Paul J. Fielder
Education
- University of California, Santa Cruz, Ph.D. in Biology – 1989
- University of California, Santa Cruz, B.A. in Psychobiology – 1984
Awards & Honors
- Stanford University National Research Service Award – 1990-'93
- University of California, Santa Cruz, Honors in Psychobiology – 1984
- University of California, Santa Cruz, Merrill College Honors – 1984
