Paul J Fielder
VP PTPK OMNI Biomarker Dev, PTPK & ITGR/OMNI Biomarker Development, Development Sciences
"Many Scientists aspire to help discover and develop a life changing therapeutic for a significant unmet medical need. At Genentech, we have had the privilege of helping to make this a reality for thousands of patients. To be a part of this mission is both humbling and inspiring."
31
Years at Genentech
58
Publications at Genentech
3
Awards & Honors
After completing my Ph.D. at UCSC and Postdoctoral fellowship at Stanford, I joined Genentech in 1993 as a Scientist to help develop a new field studying the Pharmacokinetics and Pharmacodynamics of protein therapeutics. I was drawn to Genentech because of its great scientific reputation and it offered me the best opportunity to pursue great science in the mission of helping patients.
Over my career at Genentech, I have had the privilege of contributing to the discovery and development of multiple therapeutics, as well as, the training and development of our next generation of scientists and drug developers.
Featured Publication
Evidence for an asialoglycoprotein receptor on nonparenchymal cells for O-linked glycoproteins.
Journal of Pharmacology and Experimental Therapeutics. 2008 Nov;327(2):308-15.
Stefanich EG, Ren R, Danilenko DM, Lim A, Song A, Iyer S, Fielder PJ.
The pharmacokinetic and pharmacodynamic characteristics of a long-acting growth hormone (GH) preparation (nutropin depot) in GH-deficient adults.
Journal of Clinical Endocrinology & Metabolism. 87(10):4508-14, 2002 Oct.
Cook DM. Biller BM. Vance ML. Hoffman AR. Phillips LS. Ford KM. Benziger DP. Illeperuma A. Blethen SL. Attie KM. Dao LN. Reimann JD. Fielder PJ.
My Focus
I am currently leading 2 groups focused on Preclinical and Translational Pharmacology for all therapeutic areas and Biomarkers and Diagnostics for our non-oncology pipeline. These groups contribute to the preclinical and clinical development of molecules in multiple therapeutic areas, as well as, to the basic science of Pharmacokinetics, Systems Pharmacology and Biomarkers/Diagnostics.
Together our major goals are to develop state of the art “Translational Pharmacology” and “Biomarker” tools, data, and analyses to help enter the clinical development with both the knowledge and tools to maximize clinical success, to enable informed decision-making, and to enable our PHC mission. Ultimately our data helps ensure we give the right drug at the right dose to the right patients.
Genentech Publications
Pharmacology Research and Perspectives, ISSN: 20521707
Daniela Bumbaca Yadav; Arthur Reyes; Priyanka Gupta; Jean-Michel Vernes; Y. Gloria Meng; Michelle G. Schweiger; Shannon Stainton; Fuh; Fielder; Amrita Kamath; Shen
AAPS Journal, ISSN: 15507416
Siddharth Sukumaran; Crystal Zhang; Douglas Leipold; Ola M. Saad; Keyang Xu; Kapil Gadkar; Divya Samineni; Wang; Marija Milojic-Blair; Montserrat Carrasco-Triguero; Bonnee Rubinfeld; Fielder; Kedan Lin; Ramanujan
AAPS Journal, ISSN: 15507416
Chee Ng; Fielder; Jin Y. Jin; Rong Deng
Pharmaceutical Biotechnology: Fundamentals and Applications, Third Edition,
Banmeet S. Anand; Rong Deng; Frank-Peter Theil; Jing Li; Shasha Jumbe; Thomas R. Gelzleichter; Fielder; Amita Joshi; Sara Kenkare-Mitra
Biopharmaceutics and Drug Disposition, ISSN: 1099081X 01422782
Jing Wang; Suhasini Iyer; Fielder; John Davis; Rong Deng
Molecular Pharmaceutics, ISSN: 15438392 15438384
C. Andrew Boswell; Eduardo E. Mundo; Sheila Ulufatu; Daniela Bumbaca; Hendry S. Cahaya; Nicholas Majidy; Marjie Van Hoy; Michelle G. Schweiger; Fielder; Saileta Prabhu; Leslie A. Khawli
European Journal of Pharmaceutical Sciences, ISSN: 09280987 18790720
Chee Ng; Kelly M. Loyet; Suhasini Iyer; Fielder; Rong Deng
CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306
Kapil Gadkar; Nageshwar Budha; Amos Baruch; John Davis; Fielder; Ramanujan
mAbs, ISSN: 19420870 19420862
Victor Yip; Enzo Palma; Devin B. Tesar; Eduardo E. Mundo; Daniela Bumbaca; Elizabeth K. Torres; Noe A. Reyes; Shen; Fielder; Saileta Prabhu; Leslie A. Khawli; C. Andrew Boswell
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
C. Andrew Boswell; Jan Marik; Michael J. Elowson; Noe A. Reyes; Sheila Ulufatu; Daniela Bumbaca; Victor Yip; Eduardo E. Mundo; Nicholas Majidy; Marjie Van Hoy; Saritha N. Goriparthi; Anthony Trias; Herman S. Gill; Simon P. Williams; Jagath R. Junutula; Fielder; Leslie A. Khawli
Molecular Pharmaceutics, ISSN: 15438384 15438392
C. Andrew Boswell; Eduardo E. Mundo; Bernadette Johnstone; Sheila Ulufatu; Michelle G. Schweiger; Daniela Bumbaca; Fielder; Saileta Prabhu; Leslie A. Khawli
Pharmaceutical Biotechnology: Fundamentals and Applications, Fourth Edition,
John Davis; Rong Deng; C. Andrew Boswell; Yi Zhang; Jing Li; Fielder; Amita Joshi; Sara Kenkare-Mitra
mAbs, ISSN: 19420862 19420870
Isidro Hötzel; Frank-Peter Theil; Lisa J. Bernstein; Saileta Prabhu; Rong Deng; Leah Quintana; Jeff Lutman; Renuka Sibia; Pamela Chan; Daniela Bumbaca; Fielder; Paul J. Carter; Robert F. Kelley
mAbs, ISSN: 19420862 19420870
Deborah L. Mortensen; Saileta Prabhu; Stefanich; Saloumeh Kadkhodayan Fischer; Thomas R. Gelzleichter; Baker; Jenny Jiang; Kristin Wallace; Suhasini Iyer; Fielder; Wendy Putnam
AAPS Journal, ISSN: 15507416
Daniela Bumbaca; C. Andrew Boswell; Fielder; Leslie A. Khawli
AAPS Journal, ISSN: 15507416
C. Andrew Boswell; Daniela Bumbaca; Fielder; Leslie A. Khawli
British Journal of Pharmacology, ISSN: 00071188 14765381
Daniela Bumbaca; Hong Xiang; C. Andrew Boswell; Ruediger E. Port; Shannon Stainton; Eduardo E. Mundo; Sheila Ulufatu; Anil Bagri; Frank-Peter Theil; Fielder; Leslie A. Khawli; Shen
Molecular Cancer Therapeutics, ISSN: 15357163 15388514
Cinthia V Pastuskovas; Eduardo E. Mundo; Simon P. Williams; Tapan K. Nayak; Jason Ho; Sheila Ulufatu; Suzanna Clark; Ross; Eric Cheng; Kathryn Parsons; Cain; Marjie Van Hoy; Nicholas Majidy; Sheila Bheddah; Josefa Chuh; Katherine R. Kozak; Nicholas Lewin-Koh; Peter Nauka; Daniela Bumbaca; Mark X. Sliwkowski; Jay Tibbitts; Frank-Peter Theil; Fielder; Leslie A. Khawli; C. Andrew Boswell
Science, ISSN: 10959203 00368075
Chia-Lin Hsu; Wei Yu Lin; Dhaya Seshasayee; Yunghsiang Chen; Xiao Ding; Zhonghua Lin; Eric Suto; Zhiyu Huang; Wyne P. Lee; Hyunjoo Park; Min Xu; Mei Sun; Linda Rangell; Jeff Lutman; Sheila Ulufatu; Stefanich; Cecile Chalouni; Meredith Sagolla; Laurie Diehl; Fielder; Brian J. Dean; Mercedesz Balazs; Flavius Martin
mAbs, ISSN: 19420870 19420862
Zheng; Devin B. Tesar; Lisa Benincosa; Herbert F. Birnböck; C. Andrew Boswell; Daniela Bumbaca; Kyra J. Cowan; Dimitry Danilenko; Daugherty; Fielder; Hans Peter Grimm; Amita Joshi; Nicole Justies; Gerry Kolaitis; Nicholas Lewin-Koh; Jing Li; Sami McVay; Jennifer O'Mahony; Michael Otteneder; Michael P. Pantze; Wendy Putnam; Zhihua Julia Qiu; Jane Ruppel; Thomas Singer; Oliver B. Stauch; Frank-Peter Theil; Jennifer Visich; Yang; Yong Ying; Leslie A. Khawli; Wolfgang F. Richter
mAbs, ISSN: 19420862 19420870
Rong Deng; Meng; Kwame Hoyte; Jeff Lutman; Yanmei Lu; Suhasini Iyer; Laura DeForge; Frank-Peter Theil; Fielder; Saileta Prabhu
Bioconjugate Chemistry, ISSN: 15204812 10431802
C. Andrew Boswell; Eduardo E. Mundo; Crystal Zhang; Daniela Bumbaca; Nicole R. Valle; Katherine R. Kozak; Aimee Fourie-O'Donohue; Josefa Chuh; Neelima Koppada; Ola M. Saad; Herman S. Gill; Shen; Bonnee Rubinfeld; Jay Tibbitts; Surinder Kaur; Frank-Peter Theil; Fielder; Leslie A. Khawli; Kedan Lin
Science Translational Medicine, ISSN: 19466234 19466242
Kasia Owczarczyk; Preeti Lal; Abbas Alexander; Kristen Wolslegel; Cécile T.J. Holweg; Wolfgang Dummer; Ariella Kelman; Paul Brunetta; Nicholas Lewin-Koh; Marco Sorani; Diane Leong; Fielder; David E. Yocum; Carole Ho; Ward Ortmann; Michael J. Townsend; Timothy W. Behrens
PLoS ONE, ISSN: 19326203
C. Andrew Boswell; Gregory Z. Ferl; Eduardo E. Mundo; Daniela Bumbaca; Michelle G. Schweiger; Frank-Peter Theil; Fielder; Leslie A. Khawli
Clinical Pharmacology and Therapeutics, ISSN: 00099236 15326535
Zheng; Heleen Scheerens; John C. Davis; Rong Deng; Saloumeh Kadkhodayan Fischer; Cynthia Woods; Fielder; Stefanich
mAbs, ISSN: 19420862 19420870
Rong Deng; Suhasini Iyer; Frank-Peter Theil; Deborah L. Mortensen; Fielder; Saileta Prabhu
Bioconjugate Chemistry, ISSN: 15204812 10431802
C. Andrew Boswell; Devin B. Tesar; Kiran Mukhyala; Frank-Peter Theil; Fielder; Leslie A. Khawli
Drug Metabolism and Disposition, ISSN: 00909556 1521009X
Cinthia V Pastuskovas; William Mallet; Suzanna Clark; Margaret Kenrick; Nicholas Majidy; Michelle G. Schweiger; Marjie Van Hoy; Siao Ping Tsai; Bennett; Shen; Ross; Fielder; Leslie A. Khawli; Jay Tibbitts
Molecular Pharmaceutics, ISSN: 15438384 15438392
C. Andrew Boswell; Gregory Z. Ferl; Eduardo E. Mundo; Michelle G. Schweiger; Jan Marik; Mike Reich; Frank-Peter Theil; Fielder; Leslie A. Khawli
Journal of Pharmacokinetics and Pharmacodynamics, ISSN: 1567567X
Nelson L'ntshotsholé Jumbe; Yan Xin; Douglas Leipold; Lisa Crocker; Dugger; Elaine Mai; Mark X. Sliwkowski; Fielder; Jay Tibbitts
Drug Metabolism and Disposition, ISSN: 00909556 1521009X
Rong Deng; Kelly M. Loyet; Samantha Lien; Suhasini Iyer; Laura DeForge; Frank-Peter Theil; Henry B. Lowman; Fielder; Saileta Prabhu
Proteins and Peptides: Pharmacokinetic, Pharmacodynamic, and Metabolic Outcomes,
C. Andrew Boswell; Rong Deng; Kedan Lin; Wendy Putnam; Cherry Lei; Frank-Peter Theil; Amita Joshi; Fielder; Leslie A. Khawli
Molecular Cancer Therapeutics, ISSN: 15357163
Zachary Boyd; Jenny Q. Wu; Carol O'Brien; Jill M. Spoerke; Heidi Savage; Fielder; Lukas Amler; Yibing Yan; Lackner
Journal of Pharmacology and Experimental Therapeutics, ISSN: 00223565 15210103
Stefanich; Song Ren; Dimitry Danilenko; Lim; An Song; Suhasini Iyer; Fielder
AAPS Journal, ISSN: 15507416
Wendy Putnam; Jing Li; Jonas Haggstrom; Chee Ng; Saloumeh Kadkhodayan Fischer; Melissa Cheu; Yamo Deniz; Henry B. Lowman; Fielder; Jennifer Visich; Amita Joshi; Nelson L'ntshotsholé Jumbe
Pharmaceutical Research, ISSN: 07248741
Chee Ng; Stefanich; Banmeet S. Anand; Fielder; Louis Vaickus
Journal of Clinical Endocrinology and Metabolism, ISSN: 0021972X 0021972X
Andrew R. Hoffman; Beverly M. K. Biller; David Cook; Joyce Baptista; Bernard L. Silverman; Dao; Kenneth M. Attie; Fielder; Thomas J. Maneatis; Barbara M. Lippe
Drug Metabolism and Disposition, ISSN: 00909556
Greg P. Coffey; Judy Fox; Susanne Pippig; Susan Palmieri; Barbara Reitz; Michelle Gonzales; Anahid Bakshi; Josette Padilla-Eagar; Fielder
Journal of Immunotherapy, ISSN: 15249557
Yulia Vugmeyster; Joseph Beyer; Howell; Dan Combs; Fielder; Yang; Ferhan Qureshi; Bryan Sandlund; Ly Kawaguchi; Wolfgang Dummer; Henry B. Lowman; Kathleen McKeever
Journal of Pharmacology and Experimental Therapeutics, ISSN: 00223565
Greg P. Coffey; Stefanich; Susan Palmieri; Eckert; Josette Padilla-Eagar; Fielder; Susanne Pippig
Journal of Clinical Endocrinology and Metabolism, ISSN: 0021972X
Stephen F. Kemp; Fielder; Kenneth M. Attie; Sandra L. Blethen; Edward O. Reiter; Kathleen M. Ford; Marian; Dao; Lee; Saenger
Journal of Clinical Endocrinology and Metabolism, ISSN: 0021972X
David Cook; Beverly M. K. Biller; Mary Lee Vance; Andrew R. Hoffman; Lawrence S. Phillips; Kathleen M. Ford; Benziger; Illeperuma; Sandra L. Blethen; Kenneth M. Attie; Dao; Reimann; Fielder
Biomaterials, ISSN: 01429612
Okumu; Dao; Fielder; Noel Dybdal; Brooks; Samir Sane; Cleland
Clinical Pharmacology and Therapeutics, ISSN: 00099236
Carla Washington; Howell; Zuckerman; Tran; John Lowe; Mortesen; Fielder; Judy Fox; Janet Clarke
Cancer Chemotherapy and Pharmacology, ISSN: 03445704
Stefanich; Carlson-Zermeno; McEvoy; Mike Reich; Fielder
Endocrinology, ISSN: 00137227
Yves Dubaquié; Deborah L. Mortensen; Anthony Intintoli; Deborah A. Hogue; Nakamura; Rancatore; Philip M. Lester; Michael D Sadick; Ellen H. Filvaroff; Fielder; Henry B. Lowman
British Journal of Haematology, ISSN: 00071048
Takeyuki Sato; Akira Fuse; Hiroo Niimi; Fielder; Hava Avraham
Stem Cells, ISSN: 10665099
Gerard Wagemaker; Karen J. Neelis; Simone C. C. Hartong; Albertus W. Wognum; G. Roger Thomas; Fielder; Dan L. Eaton
Blood, ISSN: 00064971
Stefanich; Tauri D. Senn; Ramon Widmer; Christine Fratino; Gilbert-Andre Keller; Fielder
Blood, ISSN: 00064971
Fielder; Hass; Nagel; Stefanich; Ramon Widmer; Bennett; Gilbert-Andre Keller; Frederic J. De Sauvage; Dan L. Eaton
Endocrinology, ISSN: 00137227
Wenlu Li; Janet Fawcett; Widmer; Fielder; Ralph Rabkin; Gilbert-Andre Keller
Endocrinology, ISSN: 00137227
Peter Bang; Fielder
Blood, ISSN: 00064971
Fielder; Austin L. Gurney; Stefanich; Marian; Mark Moore; Karen Carver-Moore; Frederic J. De Sauvage
American Journal of Physiology - Endocrinology and Metabolism, ISSN: 01931849
Oster; Nancy Levin; Fielder; Icaf Robinson; Baxter; Cronin
Endocrinology, ISSN: 00137227
Fielder; Deborah L. Mortensen; Phyllis Mallet; Carlsson; Baxter; Ross Clark
Journal of Clinical Investigation, ISSN: 00219738
Oster; Fielder; Nancy Levin; Cronin
Journal of Clinical Endocrinology and Metabolism, ISSN: 19457197 0021972X
Fielder; Jaime Guevara-Aguirret; Arlan L. Rosenbloom; Carlsson; Hintz; Rosenfeld
Endocrinology, ISSN: 19457170 00137227
G. Paolo Ceda; William J. Henzel; Louie; Sharon M. Donovan; Andrew R. Hoffman; Rosenfeld; Fielder
Education
- University of California, Santa Cruz, Ph.D. in Biology – 1989
- University of California, Santa Cruz, B.A. in Psychobiology – 1984
Awards & Honors
- Stanford University National Research Service Award – 1990-'93
- University of California, Santa Cruz, Honors in Psychobiology – 1984
- University of California, Santa Cruz, Merrill College Honors – 1984
