"Pathology – the science behind the medicine."
Over the past 20 years, my laboratory has successfully focused on gastrointestinal immune responses to both pathogenic (H. pylori) and commensal microbiota and the impact of these responses on systemic autoimmune diseases. In my clinical activities, I have been continuously involved in the Clinical Immunology Diagnostic Laboratories at both Washington University in St. Louis and UAB. I am board certified in Clinical Pathology and I have a longstanding involvement in the Academy of Clinical and Laboratory Physicians and Scientists (ACLPS), where I have helped to formulate their national curriculum for the teaching of clinical immunology. More recently, I was one of the leaders in the national dialogue on whether Pathology should form a research track for Pathology residents. This track was recently endorsed by the American Board of Pathology and is now available to Pathology residents who are training to become physician-scientists. In parallel with my research and clinical career, I have also been dedicated to physician-scientist education and training.
The opportunity to come to Genentech to help develop the talent within the department, as well as to drive innovation in drug discovery, was a perfect fit for my skills and expertise. In my short time here, I am already enthusiastic about the vision and future impact of the Research Pathology Department and I look forward to helping connecting scientists with creative solutions and collaborations.
Acad Pathol. 2016 Mar 2;3:2374289516632240.
Research Pathology supports lab scientists engaged in drug discovery within Genentech's Research organization. The Department also provides high quality pathology support to laboratory and clinical scientists engaged in biomarker strategy/development/deployment across the drug development pipeline. These activities can extend into "late stage" clinical development efforts (Phase III clinical trials). The Research Pathology department provides Research and Development personnel with intellectual and technical expertise concerning pathology-related study design, tissue selection, microscopic interpretation, analytical techniques, and support for regulatory and clinical queries. The Pathologists' collaborative support of R and D scientists include histopathology interpretive expertise informed by traditional diagnostic categories and by detailed and current understanding of molecular and cellular biology. These activities provide cutting edge technology platforms for analysis of fresh, frozen and formalin-fixed paraffin embedded tissues and cell lines used to assess (i) new therapeutic targets and pathways and (ii) biomarkers relevant to diagnosing and treating human disease. The Department also manages 6 core pathology laboratories that include necropsy, clinical pathology, histopathology, immunohistochemistry / in situ hybridization, a human tissue biorepository, and advanced light microscopy, electron microscopy and digital pathology.