Sascha Rutz
Principal Scientist, Cancer Immunology
"These are exciting times to be an immunologist! We are making rapid advances in our fundamental understanding of how anti-tumor immunity is regulated, and to see firsthand how these collective insights are transforming cancer therapy is deeply satisfying."
13
Years at Genentech
32
Publications at Genentech
I have been studying how T cells regulate and balance their production of pro-inflammatory and immunosuppressive cytokines, with a particular focus on the IL-17 and IL-10 families of cytokines. I joined Genentech as a Postdoc in 2009 and uncovered pathways for the transcriptional regulation of IL-22, a cytokine critical for host defense at mucosal surfaces and tissue repair. I quickly became interested in how the ubiquitin system controls various aspects of T cell biology at the post-translational level, examples of which are the role of the deubiquitinase DUBA as a cell-intrinsic suppressor of IL-17 production, and the essential function of BAP1 for thymic development and proliferation of T cells. In addition to uncovering new biology, I have always been eager to develop and adapt new technologies to study T cell immunity. Recently, the advent of single cell sequencing and CRISPR/Cas9 gene-editing has fundamentally changed our ability to monitor and manipulate immune responses.
In 2014, I started my own research program in the Department of Cancer Immunology applying cellular immunology, single cell sequencing, gene-editing, proteomics, and mouse models to study anti-tumor T cell immunity. My group currently focusses on regulatory T cell biology and T cell therapies. I also maintain a strong research interest in the regulation of T cell immunity by the ubiquitin system.
Featured Publication
Optimized RNP transfection for highly efficient CRISPR/Cas9-mediated gene knockout in primary T cells.
Journal of Experimental Medicine, ISSN: 15409538 00221007
Akiko Seki; Sascha Rutz
My Focus
Current areas of research in my group are aimed at:
- Understanding the role of regulatory T cells in anti-tumor immunity and discovering novel ways of targeting them therapeutically.
- Developing gene-editing tools for T cell engineering and target identification screens.
- Identifying novel mechanisms through which the ubiquitin pathway regulates T cell immunity.
Genentech Publications
Current Protocols,
Kate Senger; Ilseyar Akhmetzyanova; Benjamin Haley; Sascha Rutz; Soyoung A. Oh
Journal of Experimental Medicine, ISSN: 15409538 00221007
Soyoung A. Oh; Kate Senger; Shravan Madireddi; Ilseyar Akhmetzyanova; Isabel E. Ishizuka; Somayeh S. Tarighat; Jerry H. Lo; David Shaw; Benjamin Haley; Sascha Rutz
Journal of Experimental Medicine, ISSN: 15409538
Soyoung A. Oh; Kate Senger; Shravan Madireddi; Ilseyar Akhmetzyanova; Isabel E. Ishizuka; Somayeh S. Tarighat; Jerry H. Lo; David Shaw; Benjamin Haley; Sascha Rutz
Nature Immunology, ISSN: 15292916 15292908
Rosa Barreira da Silva; Ricardo M. Leitao; Ximo Pechuan-Jorge; Scott Werneke; Jason Oeh; Vincent Javinal; Yingyun Wang; Wilson Phung; Christine Everett; Jim Nonomiya; David Arnott; Cheng Lu; Yi-Chun Hsiao; James T. Koerber; Isidro Hötzel; James Ziai; Zora Modrusan; Thomas H. Pillow; Merone Roose-Girma; Jill Schartner; Mark Merchant; Sascha Rutz; Celine Eidenschenk; Ira Mellman; Matthew L. Albert
Nature Immunology, ISSN: 15292916 15292908
Barreira da Silva; Ricardo M. Leitao; Ximo Pechuan-Jorge; Scott Werneke; Jason Oeh; Vincent Javinal; Yingyun Wang; Wilson Phung; Christine Everett; Jim Nonomiya; David Arnott; Cheng Lu; Yi-Chun Hsiao; James T. Koerber; Isidro Hötzel; James Ziai; Zora Modrusan; Thomas H. Pillow; Merone Roose-Girma; Jill Schartner; Mark Merchant; Sascha Rutz; Celine Eidenschenk; Ira Mellman; Matthew L. Albert
Nature Immunology, ISSN: 15292908
Barreira da Silva; Ricardo M. Leitao; Ximo Pechuan-Jorge; Scott Werneke; Jason Oeh; Vincent Javinal; Yingyun Wang; Wilson Phung; Christine Everett; Jim Nonomiya; David Arnott; Cheng Lu; Yi-Chun Hsiao; James T. Koerber; Isidro Hötzel; James Ziai; Zora Modrusan; Thomas H. Pillow; Merone Roose-Girma; Jill Schartner; Mark Merchant; Sascha Rutz; Celine Eidenschenk; Ira Mellman; Matthew L. Albert
Nature Cancer, ISSN: 26621347
Soyoung A. Oh; Dai-Chen Wu; Jeanne Cheung; Armando Navarro; Huizhong Xiong; Rafael Cubas; Klara Totpal; Chiu; Yan Wu; Laetitia Comps-Agrar; Andrew Leader; Miriam Merad; Merone Roose-Germa; Søren Warming; Minhong Yan; Kim; Sascha Rutz; Ira Mellman
Nature Cancer,
Soyoung A. Oh; Dai-Chen Wu; Jeanne Cheung; Armando Navarro; Huizhong Xiong; Rafael Cubas; Klara Totpal; Chiu; Yan Wu; Laetitia Comps-Agrar; Andrew Leader; Miriam Merad; Merone Roose-Germa; Søren Warming; Minhong Yan; Kim; Sascha Rutz; Ira Mellman
Seminars in Immunology, ISSN: 10963618 10445323
Christian Neumann; Alexander Scheffold; Sascha Rutz
Cancer immunology research, ISSN: 23266074 23266066
Huizhong Xiong; Stephanie Mittman; Ryan Rodriguez; Patricia Pacheco-Sanchez; Marina Moskalenko; Yagai Yang; Justin Elstrott; Alex T. Ritter; Sören Müller; Dorothee Nickles; Teresita L. Arenzana; Aude-Hélène Capietto; Lélia Delamarre; Zora Modrusan; Sascha Rutz; Ira Mellman; Rafael Cubas
Nature Immunology, ISSN: 15292916 15292908
Christian Neumann; Jonas Blume; Urmi Roy; Peggy P. Teh; Ajithkumar Vasanthakumar; Alexander Beller; Yang Liao; Frederik Heinrich; Teresita L. Arenzana; Jason A. Hackney; Celine Eidenschenk; Eric J. C. Gálvez; Christina Stehle; Gitta A. Heinz; Patrick Maschmeyer; Tom Sidwell; Yifang Hu; Derk Amsen; Chiara Romagnani; Hyun-Dong Chang; Andrey Kruglov; Mir-Farzin Mashreghi; Wei Shi; Till Strowig; Sascha Rutz; Axel Kallies; Alexander Scheffold
Cold Spring Harbor Perspectives in Biology, ISSN: 19430264
Xiaoting Wang; Kit Wong; Wenjun Ouyang; Sascha Rutz
Current Protocols in Immunology, ISSN: 1934368X 19343671
Soyoung A. Oh; Akiko Seki; Sascha Rutz
Journal of Experimental Medicine, ISSN: 15409538 00221007
Akiko Seki; Sascha Rutz
Science immunology, ISSN: 24709468
Teresita L. Arenzana; Steve Lianoglou; Akiko Seki; Celine Eidenschenk; Tommy K. Cheung; Dhaya Seshasayee; Thijs Hagenbeek; Arivazhagan Sambandam; Rajkumar Noubade; Ivan Peng; Justin Lesch; Jason Devoss; Xiumin Wu; Wyne P. Lee; Patrick Caplazi; Webster; Jinfeng Liu; Victoria Pham; David Arnott; Jennie R. Lill; Zora Modrusan; Anwesha Dey; Sascha Rutz
Advances in Experimental Medicine and Biology, ISSN: 22148019 00652598
Sascha Rutz; Wenjun Ouyang
Cytokine and Growth Factor Reviews, ISSN: 18790305 13596101
Sascha Rutz; Celine Eidenschenk; James R. Kiefer; Wenjun Ouyang
Nature Immunology, ISSN: 15292916 15292908
Sascha Rutz; Wenjun Ouyang
Encyclopedia of Immunobiology,
Sascha Rutz; Xiaoting Wang; Celine Eidenschenk; Naruhisa Ota; Wenjun Ouyang
Nature, ISSN: 14764687 00280836
Sascha Rutz; Nobuhiko Kayagaki; Qui Phung; Celine Eidenschenk; Rajkumar Noubade; Xiaoting Wang; Justin Lesch; Rongze Lu; Kim Newton; Oscar W Huang; Andrea G Cochran; Vasser; Benjamin P. Fauber; Jason Devoss; Webster; Laurie Diehl; Zora Modrusan; Donald S. Kirkpatrick; Jennie R. Lill; Wenjun Ouyang; Vishva M. Dixit
Immunity, ISSN: 10974180 10747613
Melba Muñoz; Celine Eidenschenk; Naruhisa Ota; Kit Wong; Uwe Lohmann; Anja A. Kühl; Xiaoting Wang; Paolo Manzanillo; Yun Li; Sascha Rutz; Yan Zheng; Laurie Diehl; Nobuhiko Kayagaki; Menno Van Lookeren Campagne; Oliver Liesenfeld; Markus Heimesaat; Wenjun Ouyang
Nature Reviews Immunology, ISSN: 14741741 14741733
Sascha Rutz; Xiaoting Wang; Wenjun Ouyang
Current Topics in Microbiology and Immunology, ISSN: 21969965 0070217X
Celine Eidenschenk; Sascha Rutz; Oliver Liesenfeld; Wenjun Ouyang
Nature, ISSN: 14764687 00280836
Rajkumar Noubade; Kit Wong; Naruhisa Ota; Sascha Rutz; Celine Eidenschenk; Patricia A. Valdez; Jiabing Ding; Ivan Peng; Andrew Sebrell; Patrick Caplazi; Jason Devoss; Robert Soriano; Tao Sai; Rongze Lu; Zora Modrusan; Jason A. Hackney; Wenjun Ouyang
Immunological Reviews, ISSN: 01052896 1600065X
Sascha Rutz; Celine Eidenschenk; Wenjun Ouyang
Science, ISSN: 10959203 00368075
Elke Glasmacher; Smita Agrawal; Abraham B. Chang; Theresa L. Murphy; Wenwen Zeng; Bryan Vander Lugt; Aly A. Khan; Maria Ciofani; Chauncey J. Spooner; Sascha Rutz; Jason A. Hackney; Roza Nurieva; Carlos R. Escalante; Wenjun Ouyang; Dan R. Littman; Kenneth M. Murphy; Harinder Singh
Trends in Immunology, ISSN: 14714906 14714981
Rajita Pappu; Sascha Rutz; Wenjun Ouyang
Nature Immunology, ISSN: 15292908 15292916
Sascha Rutz; Rajkumar Noubade; Celine Eidenschenk; Naruhisa Ota; Wenwen Zeng; Yan Zheng; Jason A. Hackney; Jiabing Ding; Harinder Singh; Wenjun Ouyang
Current Opinion in Immunology, ISSN: 09527915 18790372
Sascha Rutz; Wenjun Ouyang
Annual Review of Immunology, ISSN: 07320582
Wenjun Ouyang; Sascha Rutz; Natasha K Crellin; Patricia A. Valdez; Sarah G. Hymowitz
European Journal of Immunology, ISSN: 15214141 00142980
Elisabeth Calderón-Gómez; Vicky Lampropoulou; Ping Shen; Patricia Neves; Toralf Roch; Ulrik Stervbo; Sascha Rutz; Anja A. Kühl; Frank L. Heppner; Christoph Loddenkemper; Stephen M. Anderton; Jean M. Kanellopoulos; Pierre Charneau; Simon Fillatreau
Journal of Immunology, ISSN: 00221767 15506606
Nadine Kassner; Manuela Krueger; Hideo Yagita; Andrzej Dzionek; Andreas Hutloff; Richard Kroczek; Alexander Scheffold; Sascha Rutz
Education
- Degrees Humboldt University, Berlin, Germany, Ph.D. in Biology / Immunology – 2008
- Free University, Berlin, Germany, M.Sc. in Biochemistry – 2002