Seth Harris - Director & Distinguished Scientist (Technology), Computational Structural Biology, Drug Discovery

Seth Harris

Director & Distinguished Scientist (Technology), Computational Structural Biology, Drug Discovery

Postdoc Mentor
"Scientific discoveries help drive progress, particularly towards sustainability. It is exciting to work where you can imagine each day might be the day where you help design or contribute to a new therapeutic that could have world-wide impact, or a new class of antibiotic that might be a first for the whole human race in over 50 years!"
Years at Genentech
Publications at Genentech
Awards & Honors

I study protein architecture and function as a window into fundamental and mechanistic understanding of biology and disease. My academic research focused on structural aspects of papillomavirus transcription and heat shock protein 90 (Hsp90). I continued with structure-based drug design at Roche Palo Alto, contributing to diverse discovery projects including hepatitis C virus (HCV) and human immunodeficiency virus (HIV) research. Since 2009 I have been in the Structural Biology group at Genentech, enjoying an unparalleled breadth of topics and collaborations, unified in the focus to aid patients with new therapeutics. To wit, I work on advanced small molecule and biologic discovery projects in neurodegeneration, oncology, angiogenesis, metabolism, cancer immunotherapy, and infectious diseases. In addition, we also explore fundamental research questions, exemplified by my group’s recent elucidation of a ternary complex structure of a deubiquitinase system.

To support these diverse directions I develop computational tools and infrastructure to innovate and facilitate our capabilities across all projects, both in producing and analyzing protein structures. These include technical aspects such as using acoustic liquid transfer to set up nanoliter-scale crystallization trials, as well as software tools and database interfaces to navigate our ever-expanding structural and functional datasets.

Postdoctoral Mentor

Genentech’s postdoctoral program provides an incredible platform of resources and collaborative scientific context to explore innovative research directions, truly bridging industry and academic foci. Our group is expanding involvement with highly engaged researchers who bring their own unique ideas and directions pertinent to our pipeline work, but with publication-oriented, broader implications and understanding of novel biology. We are aiming to combine structural biology, including state-of-the-art crystallography and electron microscopy techniques, with informatics and biochemical analyses to study larger multi-subunit protein complexes in the ubiquitin pathway. These structure:function discoveries will provide insight into regulation and prospective for therapeutic intervention. We are excited to initiate this project, motivated by the potential inherent in the available scientific resources and expertise at Genentech that creates fertile ground for inquisitive research to support and aid in the development of new careers and discovery in these areas.

Featured Publication

Structural Insights into WD-Repeat 48 Activation of Ubiquitin-Specific Protease 46

Structure (London, England : 1993), 2015, ISSN: 0969-2126

Yin J, Schoeffler AJ, Wickliffe K, Newton K, Starovasnik MA, Dueber EC, Harris SF.