"Proficiency in both the dry- and wet-lab skills is the key to success in modern biology research."
I was trained as a wet-lab scientist during graduate school, investigating the innate immune response during virus infection. And then I was fascinated by the latest genomic technologies and joined Gary Hon’s lab in UT Southwestern, Dallas for my postdoc trainings. During which I learned the construction of NGS libraries as well as building computational tools for large-scale data analysis. I developed a highly multiplexed functional screen assay for enhancers in which the CRISPR-based enhancer perturbation is combined with the single-cell RNA-seq readout. I joined Genentech in 2020 and lead a team in to perform the large-scale single-cell functional genomics assays. I strongly believe that the combination of both the wet and dry lab is the key to success in the modern biology researches and my lab is actively working on both aspects.
Molecular cell, 2017
My lab is focused on understanding the impact of genes, regulator elements and genomic variations on genome function and phenotypes. We leverage the latest single-cell genomics assays to acquire rich phenotypic readout coupled with systematic perturbations. The lab has three general research goals: 1) understanding of drug response in complex model systems; 2) evaluation of diseases-associated mutations to identify new therapeutic targets and 3) identification of key genes for cell fate engineering.