"Using the ever-expanding genome engineering toolbox to facilitate drug discovery."
I came to Genentech in 2006 after completing a postdoctoral fellowship in mouse cancer genetics and genome engineering in the joint laboratory of Drs. Neal Copeland and Nancy Jenkins at the National Cancer Institute, Frederick, Maryland.
Trained in classic and molecular mouse genetics, I was attracted to Genentech by the opportunity to be able to apply genetic tools and genetically engineered murine models to facilitate drug discovery.
Genentech is an exciting and very collaborative place, striking that perfect balance between basic scientific discovery and drug development.
The postdoctoral program at Genentech provides a unique and exciting training opportunity where the postdoc can take advantage of a wide range of in-house resources, expertise and core facilities. Specifically, a postdoc in my laboratory can take advantage of in-house expertise in mouse genome engineering, animal model generation and advanced cell line engineering and apply this to facilitate scientific and drug discovery. In addition he/she can explore the power of genetics in model systems using innovative combinations of genetic tools and latest genome engineering technology.
Nature (2011) 479:117-21.
My lab uses and develops state-of-the-art genome engineering tools to facilitate the design and generation of animal models for basic research purposes and to facilitate and accelerate drug discovery. New genome engineering tools such as nucleases allow us to not only develop these models faster than before, but also enable us to make more sophisticated models.
With the constant development of more powerful next-gen sequencing technology and with the cost of whole genome sequencing going down, we have recently started to also explore the use of more classic mouse genetics for scientific and target discovery.