Søren Warming
Associate Director, Molecular Biology
Postdoc Mentor
"Using the ever-expanding genome engineering toolbox to facilitate drug discovery."
13
Years at Genentech
39
Publications
3
Awards & Honors
I came to Genentech in 2006 after completing a postdoctoral fellowship in mouse cancer genetics and genome engineering in the joint laboratory of Drs. Neal Copeland and Nancy Jenkins at the National Cancer Institute, Frederick, Maryland.
Trained in classic and molecular mouse genetics, I was attracted to Genentech by the opportunity to be able to apply genetic tools and genetically engineered murine models to facilitate drug discovery.
Genentech is an exciting and very collaborative place, striking that perfect balance between basic scientific discovery and drug development.
Postdoctoral Mentor
The postdoctoral program at Genentech provides a unique and exciting training opportunity where the postdoc can take advantage of a wide range of in-house resources, expertise and core facilities. Specifically, a postdoc in my laboratory can take advantage of in-house expertise in mouse genome engineering, animal model generation and advanced cell line engineering and apply this to facilitate scientific and drug discovery. In addition he/she can explore the power of genetics in model systems using innovative combinations of genetic tools and latest genome engineering technology.
Featured Publication
My Focus
My lab uses and develops state-of-the-art genome engineering tools to facilitate the design and generation of animal models for basic research purposes and to facilitate and accelerate drug discovery. New genome engineering tools such as nucleases allow us to not only develop these models faster than before, but also enable us to make more sophisticated models.
With the constant development of more powerful next-gen sequencing technology and with the cost of whole genome sequencing going down, we have recently started to also explore the use of more classic mouse genetics for scientific and target discovery.
Publications
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Xiangnan Du; Patricia de Almeida; Nicholas A. Manieri; Denise De Almeida Nagata; Thomas D. Wu; Kristin Harden Bowles; Vidhyalakshmi Arumugam; Jill Schartner; Rafael Cubas; Stephanie Mittman; Vincent Javinal; Keith R. Anderson; Soren Warming; Jane Grogan; Eugene Y. Chiang
Zinc finger protein 521 regulates early hematopoiesis through cell-extrinsic mechanisms in the bone marrow microenvironment
Molecular and Cellular Biology, ISSN: 02707306
Courtney J. Fleenor; Tessa Arends; Hong Lei; Josefine Ahsberg; Kazuki Okuyama; Jacob Kuruvilla; Susana Cristobal; Jennifer L. Rabe; Ahwan Pandey; Thomas Danhorn; Desiree Straign; Joaquin M. Espinosa; Soren Warming; Eric Pietras; Mikael Sigvardsson; James R. Hagman
Nature, ISSN: 14764687 00280836
Klaus Heger; Kate Wickliffe; Ada Ndoja; Juan Zhang; Aditya Murthy; Debbie Dugger; Maltzman; Felipe de Sousa e Melo; Jeffrey Hung; Yi Zeng; Erik Verschueren; Don Kirkpatrick; Domagoj Vucic; Wyne Lee; Meron Roose-Girma; Robert J (Research) Newman; Soren Warming; Yi-Chun Hsiao; László Kömüves; Webster; Kim Newton; Vishva Dixit
Nature Methods, ISSN: 15487105 15487091
Keith R. Anderson; Maximilian Haeussler; Colin Watanabe; Vasant Janakiraman; Jessica Lund; Zora Modrusan; Jeremy Stinson; Qixin Bei; Andrew Buechler; Charles Yu; Sobha R. Thamminana; Lucinda Tam; Michael-Anne Sowick; Tuija Alcantar; Natasha O'Neil; Jinjie Li; Linda Ta; Lisa Lima; Meron Roose-Girma; Xin Rairdan; Steffen Durinck; Soren Warming
The Kinase Activity of Hematopoietic Progenitor Kinase 1 Is Essential for the Regulation of T Cell Function
Cell Reports,
Sairy Hernandez; Jing Qing; Rebecca Hong Thibodeau; Xiangnan Du; Summer Park; Hyang-Mi Lee; Min Xu; Soyoung Oh; Armando Navarro; Meron Roose-Girma; Robert J (Research) Newman; Soren Warming; Michelle Nannini; Deepak Sampath; Jeong Kim; Jane Grogan; Ira Mellman
Journal of Experimental Medicine, ISSN: 15409538 00221007
Bettina L. Lee; Irma Stowe; Aaron Gupta; Opher S. Kornfeld; Meron Roose-Girma; Keith R. Anderson; Soren Warming; Juan Zhang; Wyne Lee; Nobuhiko Kayagaki
The kinase TPL2 activates ERK and p38 signaling to promote neutrophilic inflammation
Science Signaling, ISSN: 19450877
Kate Senger; Victoria Pham; Eugene Varfolomeev; Jason Hackney; Alex Corzo; Jenna Collier; Vivian W. C. Lau; Zhiyu Huang; Kajal Hamidzhadeh; Patrick Caplazi; Ivan Peng; Francesca Setiadi; Ross Francis; Andres Paler Martinez; Youngsu Kwon; Vladimir Ramirez Carrozzi; Yonglian Sun; Patricia Grigg; Meron Roose-Girma; Surinder Jeet; Kai Barck; Anna Pham; Ota; Connie Ha; Jeremy Stinson; Joe Guillory; Lucinda Tam; Zora Modrusan; Claire Emson; Brent McKenzie; Michael Townsend; Rick Carano; Soren Warming; Domagoj Vucic; Jason De Voss; Wyne Lee; Jennie Lill; Ali Zarrin
Science Signaling, ISSN: 19379145
Kate Senger; Victoria Pham; Eugene Varfolomeev; Jason Hackney; Alex Corzo; Jenna Collier; Vivian W. C. Lau; Zhiyu Huang; Kajal Hamidzhadeh; Patrick Caplazi; Ivan Peng; Francesca Setiadi; Ross Francis; Andres Paler Martinez; Youngsu Kwon; Vladimir Ramirez Carrozzi; Yonglian Sun; Patricia Grigg; Meron Roose-Girma; Surinder Jeet; Kai Barck; Anna Pham; Neko Ota; Connie Ha; Jeremy Stinson; Joe Guillory; Lucinda Tam; Zora Modrusan; Claire Emson; Brent McKenzie; Michael Townsend; Rick Carano; Soren Warming; Domagoj Vucic; Jason De Voss; Wyne Lee; Jennie Lill; Ali Zarrin
Scientific Reports, ISSN: 20452322
Martin Weber; Tiffany Wu; Bill Meilandt; Sara Dominguez; Hilda Solanoy; Janice Maloney; Hai Ngu; Miriam Baca; Chung Kung; Lisa Lima; Timothy K. Earr; Daniel Fleck; Shannon Shields; Bill Forrest; Oded Foreman; Soren Warming; Ryan Watts; Kimberly Scearce-Levie
Nature Communications, ISSN: 20411723
Eugene Chiang; Tianbo Li; Surinder Jeet; Peng; Juan Zhang; Wyne Lee; Jason DeVoss; Patrick Caplazi; Jun Chen; Soren Warming; David Hackos; Susmith Mukund; Chris Koth; Jane Grogan
FGF21 mimetic antibody stimulates UCP1-independent brown fat thermogenesis via FGFR1/βKlotho complex in non-adipocytes
Molecular Metabolism,
Mark Chen; Joshua C. Chang; Jose Zavala-Solorio; Lance Kates; Minh Thai; Annie Ogasawara; Xiaobo Bai; Sean Flanagan; Victor Nunez; Khanhky Phamluong; James Ziai; Robert J (Research) Newman; Soren Warming; Ganesh Kolumam; Jun Sonoda
Nucleic Acids Research, ISSN: 13624962
Carol Cain-Hom; Erik Splinter; Max Van Min; Marieke Simonis; Monique Van De Heijning; Maria Martinez; Vida Asghari; J. Colin Cox; Soren Warming
Nature, ISSN: 14764687
Kim Newton; Kate Wickliffe; Maltzman; Debbie Dugger; Andreas Strasser; Victoria Pham; Jennie Lill; Meron Roose-Girma; Soren Warming; Margaret Solon; Hai Ngu; Webster; Vishva Dixit
Nature, ISSN: 14764687
Ingrid Wertz; Kim Newton; Dhaya Seshasayee; Saritha Kusam; Cynthia Lam; Juan Zhang; Nataliya Popovych; Elizabeth Helgason; Allyn Schoeffler; Surinder Jeet; Nandhini Ramamoorthi; Kategaya; Robert J (Research) Newman; Keisuke Horikawa; Debbie Dugger; Wendy Sandoval; Susmith Mukund; Anuradha Zindal; Flavius Martin; Clifford Quan; Jeffrey Tom; Wayne Fairbrother; Michael Townsend; Soren Warming; Jason DeVoss; Jinfeng Liu; Erin Dueber; Patrick Caplazi; Wyne Lee; Christopher C. Goodnow; Mercedesz Balazs; Kebing Yu; Ganesh Kolumam; Vishva Dixit
Nature, ISSN: 14764687
Daniel Lafkas; Amy Shelton; Cecilia Chiu; Gladys Boenig; Yongmei Chen; Scott Stawicki; Christian Siltanen; Mike Reichelt; Meijuan Zhou; Xiumin Wu; Jeff Eastham Anderson; Heather Moore; Meron Roose-Girma; Yvonne Chinn; Julie Q. Hang; Soren Warming; Jackson Egen; Wyne Lee; Cary Austin; Yan Wu; Jian Payandeh; John B. Lowe (Path); Chris Siebel
Journal of Pathology, ISSN: 10969896
Mark McCleland; Tim Soukup; Scot Liu; Jonathan H. Esensten; Felipe de Sousa e Melo; Murat Yaylaoglu; Soren Warming; Meron Roose-Girma; Ron Firestein
Nucleic Acids Research, ISSN: 13624962
Robert J (Research) Newman; Meron Roose-Girma; Soren Warming
Nature, ISSN: 14764687
Nobuhiko Kayagaki; Irma Stowe; Bettina Lee; Karen O'Rourke; Keith Anderson; Soren Warming; Trinna Cuellar; Benjamin Haley; Meron Roose-Girma; Qui Phung; Peter Liu; Jennie Lill; Hong Li; Jiansheng Wu; Sarah Kummerfeld; Juan Zhang; Wyne Lee; Scott J. Snipas; Guy S. Salvesen; Lucy X. Morris; Linda Fitzgerald; Yafei Zhang; Edward M. Bertram; Christopher C. Goodnow; Vishva Dixit
EBioMedicine, ISSN: 23523964
Ganesh Kolumam; Mark Chen; Raymond K. Tong; Jose Zavala-Solorio; Lance Kates; Nick Van Bruggen; Jed Ross; Shelby Wyatt; Vineela Gandham; Rick Carano; Diana Ronai Dunshee; Ai-Luen Wu; Benjamin Haley; Keith Anderson; Soren Warming; Xin Rairdan; Nicholas Lewin-Koh; Yingnan Zhang; Johnny Gutierrez; Amos Baruch; Tom Gelzleichter; Dale Stevens; Sharmila Rajan; Travis Bainbridge; Jean-Michel Vernes; Gloria Meng; James Ziai; Robert Soriano; Matt Brauer; Yongmei Chen; Scott Stawicki; Hok Seon Kim; Laetitia Comps-Agrar Fraisse; Elizabeth Luis; Christoph Spiess; Yan Wu; James Ernst; Owen P. McGuinness; Andy Peterson; Jun Sonoda
Mucosal Immunology, ISSN: 19353456
Bates; Ken Flanagan; Lian Mo; Ota; Ding; Ho; Liu; Meron Roose-Girma; Soren Warming; Lauri Diehl
Science Translational Medicine, ISSN: 19466242
Reina Fuji; Mike Flagella; Miriam Baca; Marco A. S Baptista; Jens Brodbeck; Bryan Chan; Brian K. Fiske; Lee Honigberg; Adrian Jubb; Paula Katavolos; Donna Lee; Sock-Cheng Lewin-Koh; Tori Lin; Xingrong Liu; Shannon Liu; Joe Lyssikatos; Jennifer O'Mahony; Mike Reichelt; Meron Roose-Girma; Zejuan Sheng; Todd Sherer; Ashley Smith; Margaret Solon; Zach Sweeney; Jacqueline Tarrant; Alison Urkowitz; Soren Warming; Murat Yaylaoglu; Shuo Zhang; Haitao Zhu; Tony Estrada; Ryan Watts
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490
Ashley Fouts; Laetitia Comps-Agrar Fraisse; Katharina Stengel; Diego Ellerman; Allyn Schoeffler; Soren Warming; Dan Eaton; Becket Feierbach
Science, ISSN: 10959203
Kim Newton; Debbie Dugger; Kate Wickliffe; Neeraj Kapoor; Maria Cristina De Almagro; Domagoj Vucic; László Kömüves; Ronald Ferrando; Dorothy French; Webster; Meron Roose-Girma; Soren Warming; Vishva Dixit
Nature, ISSN: 14764687
Etienne Meunier; Mathias S. Dick; Roland F. Dreier; Nura Schürmann; Daniela Kenzelmann Broz; Soren Warming; Meron Roose-Girma; Dirk Bumann; Nobuhiko Kayagaki; Kiyoshi Takeda; Masahiro Yamamoto; Petr Broz
Developmental Biology, ISSN: 1095564X 00121606
Idella F. Yamben; Rivka A. Rachel; Shalini Shatadal; Neal G. Copeland; Nancy A. Jenkins; Soren Warming; Anne E. Griep
Blood, ISSN: 00064971
Christopher Wilson; Leon Parker IV; Christopher J. Hall; Tanya Smyczek; Judy Mak; Ailey Crow; George Posthuma; Ann De Mazière; Meredith Sagolla; Cecile Chalouni; Philip Vitorino; Meron Roose-Girma; Soren Warming; Judith Klumperman; Philip S. Crosier; Weilan Ye
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424
Shahram Misaghi; Kate Senger; Tao Sai; Yan Qu; Yonglian Sun; Kajal Hamidzadeh; Allen Nguyen; Zhaoyu Jin; Meijuan Zhou; Donghong Yan; WeiYu Lin; Zhonghua Lin; Maria Lorenzo; Andrew Sebrell; Jiabing Ding; Min Xu; Patrick Caplazi; Cary Austin; Mercedesz Balazs; Meron Roose-Girma; Laura DeForge; Soren Warming; Wyne Lee; Vishva Dixit; Ali Zarrin
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424
Hao Chen; John Brady; Tao Sai; Joyce Lai; Soren Warming; Hanying Chen; Meron Roose-Girma; Gu Zhang; Weinian Shou; Minhong Yan
Journal of Experimental Medicine, ISSN: 00221007
Riku Kiviranta; Kei Yamana; Hiroaki Saito; Daniel K. Ho; Julius Laine; Kati Tarkkonen; Vappu Nieminen-Pihala; Eric Hesse; Diego Correa; Jorma Määttä; Lino Tessarollo; Evan D. Rosen; William C. Horne; Nancy A. Jenkins; Neal G. Copeland; Soren Warming; Roland Baron
Autoimmunity, ISSN: 08916934
Yonglian Sun; Ivan Peng; Kate Senger; Kajal Hamidzadeh; Mike Reichelt; Miriam Baca; Ronald Yeh; Maria Lorenzo; Andrew Sebrell; Chris Dela Cruz; Lucinda Tam; Racquel Corpuz; Jiansheng Wu; Tao Sai; Meron Roose-Girma; Soren Warming; Mercedesz Balazs; Lino Gonzalez; Patrick Caplazi; Flavius Martin; Jason DeVoss; Ali Zarrin
Nature, ISSN: 00280836
Nobuhiko Kayagaki; Soren Warming; Mohamed Lamkanfi; Lieselotte Vande Walle; Salina Louie; Jennifer Dong; Kim Newton; Yan Qu; Jinfeng Liu; Sherry Heldens; Juan Zhang; Wyne Lee; Meron Roose-Girma; Vishva Dixit
Nature, ISSN: 00280836
Hua Tian; Brian Biehs; Soren Warming; Kevin Leong; Linda Rangell; Ophir D. Klein; Frederic De Sauvage
Science Signaling, ISSN: 19450877
Susanna Stinson; Mark Lackner; Alex T. Adai; Nancy Yu; Hyo-jin Kim; Carol O'Brien; Jill Spoerke; Suchit Jhunjhunwala; Zachary Boyd; Tom Januario; Robert J (Research) Newman; Peng Yue; Richard Bourgon; Zora Modrusan; Howard Stern; Soren Warming; Frederic De Sauvage; Lukas Amler; Ru-Fang Yeh; David Dornan
Science Signaling, ISSN: 19450877
Susanna Stinson; Mark Lackner; Alex T. Adai; Nancy Yu; Hyo-jin Kim; Carol O'Brien; Jill Spoerke; Suchit Jhunjhunwala; Zachary Boyd; Tom Januario; Robert J (Research) Newman; Peng Yue; Richard Bourgon; Zora Modrusan; Howard Stern; Soren Warming; Frederic De Sauvage; Lukas Amler; Ru-Fang Yeh; David Dornan
Developmental Cell, ISSN: 15345807
Diego Correa; Eric Hesse; Dutmanee Seriwatanachai; Riku Kiviranta; Hiroaki Saito; Kei Yamana; Lynn Neff; Azeddine Atfi; Lucie Coillard; Despina Sitara; Yukiko Maeda; Soren Warming; Nancy A. Jenkins; Neal G. Copeland; William C. Horne; Beate Lanske; Roland Baron
Genetics, ISSN: 00166731
Georg L. Bauer; Christian Praetorius; Kristín Bergsteinsdóttir; Jón H. Hallsson; Bryndís K. Gísladóttir; Alexander Schepsky; Deborah A. Swing; T. Norene O'Sullivan; Heinz Arnheiter; Keren Bismuth; Julien Debbache; Colin Fletcher; Soren Warming; Neal G. Copeland; Nancy A. Jenkins; Eiríkur Steingrímsson
Blood, ISSN: 00064971
Kazuko Miyazaki; Norimasa Yamasaki; Hideaki Oda; Takeshi Kuwata; Yohei Kanno; Masaki Miyazaki; Yukiko Komeno; Jiro Kitaura; Zen-Ichiro Honda; Soren Warming; Nancy A. Jenkins; Neal G. Copeland; Toshio Kitamura; Takuro Nakamura; Hiroaki Honda
PLoS ONE, ISSN: 19326203
Renata I. Mazzucchelli; Soren Warming; Scott M. Lawrence; Masaru Ishii; Mehrnoosh Abshari; A. Vallance Washington; Lionel Feigenbaum; Andrew C. Warner; Davis J. Sims; Wen Qing Li; Julie A. Hixon; Daniel H.D. Gray; Benjamin E. Rich; Matthew Morrow; Miriam R. Anver; J. Michael Cherry; Dieter Naf; Lawrence R. Sternberg; Daniel W. McVicar; Andrew G. Farr; Ronald N. Germain; Keith Rogers; Nancy A. Jenkins; Neal G. Copeland; Scott K. Durum
The RNA-binding motif protein 15B (RBM15B/OTT3) acts as cofactor of the nuclear export receptor NXF1
Journal of Biological Chemistry, ISSN: 00219258
Hiroaki Uranishi; Andrei S. Zolotukhin; Susan Lindtner; Soren Warming; Gen-Mu Zhang; Jenifer Bear; Neal G. Copeland; Nancy A. Jenkins; George N. Pavlakis; Barbara K. Felber
Education
- National Cancer Institute, in the lab of Dr. Neal G. Copeland, Postdoctoral scholar – 2002-2006
- Aarhus University, Denmark, Ph.D. Molecular Biology – 2000
- Aarhus University, Denmark, M.Sc. Molecular Biology – 1997
- Aarhus University, Denmark, B.Sc. Biology – 1995
Awards & Honors
- DHHS, NIH, NCI, Visiting Fellowship – 2002-2006
- Danish Natural Science Research and Medical Research Councils Relocation Grants – 2002
- Danish Cancer Society Scholarship – 2000