Genentech: Søren Warming | Associate Director, Molecular Biology

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Scientists / Our Scientists

"Using the ever-expanding genome engineering toolbox to facilitate drug discovery."

Years at Genentech

Publications

Awards & Honors

I came to Genentech in 2006 after completing a postdoctoral fellowship in mouse cancer genetics and genome engineering in the joint laboratory of Drs. Neal Copeland and Nancy Jenkins at the National Cancer Institute, Frederick, Maryland.

Trained in classic and molecular mouse genetics, I was attracted to Genentech by the opportunity to be able to apply genetic tools and genetically engineered murine models to facilitate drug discovery.

Genentech is an exciting and very collaborative place, striking that perfect balance between basic scientific discovery and drug development.

Postdoctoral Mentor

The postdoctoral program at Genentech provides a unique and exciting training opportunity where the postdoc can take advantage of a wide range of in-house resources, expertise and core facilities. Specifically, a postdoc in my laboratory can take advantage of in-house expertise in mouse genome engineering, animal model generation and advanced cell line engineering and apply this to facilitate scientific and drug discovery. In addition he/she can explore the power of genetics in model systems using innovative combinations of genetic tools and latest genome engineering technology.

Featured Publication

CRISPR off-target analysis in genetically engineered rats and mice

Nature Methods, ISSN: 15487105 15487091

Keith R. Anderson; Maximilian Haeussler; Colin Watanabe; Vasant Janakiraman; Jessica Lund; Zora Modrusan; Jeremy Stinson; Qixin Bei; Andrew Buechler; Charles Yu; Sobha R. Thamminana; Lucinda Tam; Michael-Anne Sowick; Tuija Alcantar; Natasha O0Neil; Jinjie Li; Linda Ta; Lisa Lima; Meron Roose-Girma; Xin Rairdan; Steffen Durinck; Soren Warming

View Abstract

My lab uses and develops state-of-the-art genome engineering tools to facilitate the design and generation of animal models for basic research purposes and to facilitate and accelerate drug discovery. New genome engineering tools such as nucleases allow us to not only develop these models faster than before, but also enable us to make more sophisticated models.

With the constant development of more powerful next-gen sequencing technology and with the cost of whole genome sequencing going down, we have recently started to also explore the use of more classic mouse genetics for scientific and target discovery.

The RIPK4–IRF6 signalling axis safeguards epidermal differentiation and barrier function

Nature, ISSN: 00280836

Nina Oberbeck; Victoria Pham; Webster; Rohit Reja; Christine S. Huang; Yue Zhang; Meron Roose-Girma; Soren Warming; Qingling Li; Andrew Birnberg; Weng Wong; Wendy Sandoval; László Kömüves; Kebing Yu; Debbie Dugger; Maltzman; Kim Newton; Vishva Dixit

CD226 regulates natural killer cell antitumor responses via phosphorylation-mediated inactivation of transcription factor FOXO1

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424

Xiangnan Du; Patricia de Almeida; Nicholas A. Manieri; Denise De Almeida Nagata; Thomas D. Wu; Kristin Harden Bowles; Vidhyalakshmi Arumugam; Jill Schartner; Rafael Cubas; Stephanie Mittman; Vincent Javinal; Keith R. Anderson; Soren Warming; Jane Grogan; Eugene Y. Chiang

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Søren Warming

Associate Director, Molecular Biology

Featured Publication

CRISPR off-target analysis in genetically engineered rats and mice