Genentech: Soyoung Oh | Principal Scientist, Cancer Immunology, Research Biology

Scientists / Our Scientists

"The creativity, rigor, and collaborative nature of the science at Genentech make this a very special place. It’s inspiring to be part of a community that puts science and patients first."

Years at Genentech

Publications at Genentech

I joined Genentech in 2016 as a Senior Scientific Researcher in the Cancer Immunology department, and in 2020, started my own group as a Scientist in the department. During my time at Genentech, I have continued to explore my long-standing interest in T cell biology by studying how key regulatory pathways and T cell-intrinsic properties influence the outcome of a T cell response. From identifying the critical role dendritic cells play in the PD-1/PD-L1 regulatory axis, to employing novel CRISPR-engineering technologies in the development of T cell therapies, Genentech has provided a dynamic, creative, and collaborative environment to pursue incredible science with the goal of bringing new therapeutics to patients in need.

Featured Publication

PD-L1 expression by dendritic cells is a key regulator of T-cell immunity in cancer

Nature Cancer, 2020

Oh, S.A., Wu, DC., Cheung, J. et al.

View Abstract

Productive T cell responses are critical for the effective control of tumors and infections. However, fundamental questions remain about the factors that drive the development of such T cell responses, particularly in settings of chronic stimulation, such as tumors. My group is interested in better understanding how both T cell-intrinsic and -extrinsic factors influence the outcome of a T cell response. By using a combination of cellular immunology, CRISPR-engineering, and next generation sequencing approaches, we are studying how the specific properties of T cell receptors, T cell differentiation status, and the context of antigen exposure affects T cell responses against tumors.

Loss of the autoimmune risk gene TREX1 reveals a convergence of mechanisms promoting immune tolerance loss and antitumor immunity

Science Advances,

Junghyun Lim; Katherine Williams; Stephanie Mittman; Patricia Pacheco Sanchez; Ryan Rodriguez; Annie K. Ogasawara; Grace Barnett; Mayra Cruz Tleugabulova; Barzin Y. Nabet; Jefferey C. Hung; Kevin A. Marroquin; Shari Lau; Serena Y. Lee; Paul Tyler; Elizabeth T. Carbone; Bridget Hough; Janice Corpuz; Haruka Murota; Edward Dere; Smadar Shiffman; Leah K. Schutt; Herman S. Gill; Julia Lau; Marco de Simone; Lucinda W. Tam; Merone Roose-Girma; Søren Warming; Soyoung A. Oh; Sascha Rutz; Mengxiao He; Sören Muller; Nathan R. West; Thomas Francis Brewer; Prashant V. Desai; Simon Peter Williams; James M. Ziai; Yan Qu; Klaus D. Heger

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IL-27 elicits a cytotoxic CD8+ T cell program to enforce tumour control

Nature, ISSN: 14764687 00280836

Beatrice Breart; Katherine Williams; Stellanie Krimm; Tiffany Wong; Brandon D. Kayser; Lifen Wang; Eric Cheng; Mayra Cruz Tleugabulova; Romain Bouziat; Tianshi Lu; Kobe Yuen; Natalie S. Firmino; Daniel D. Bravo; Juliette Roels; Atish Bhakta; Jack Bevers; Isabelle Lehoux; Alan G. Gutierrez; Yajun Chestnut; Joanna E. Klementowicz; Teresita L. Arenzana; Ilseyar Akhmetzyanova; Elizabeth Dixon; Min Chen; Kazi Tasneem; Rajbharan Yadav; Koeppen; Soyoung A. Oh; Lélia Delamarre; Haochu Huang; Shion A. Lim; Nakamura; Jianyong Wang; Chan Gao; Corpuz; Sören Müller; Nathaniel West

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Pseudokinase STK40 limits T cell exhaustion through COP1-dependent degradation of AP1-family transcription factors

Nature Immunology, ISSN: 15292908

Svetlana Altshuler-Keylin; Nicole Caduff; Isabel E. Ishizuka; Rohit Reja; Katherine M. Nutsch; Chan Gao; Joy Wang; Ulrike Kaufmann; Mayra Cruz Tleugabulova; Elizabeth Dixon; Hannah Little-Hooy; Rachana N. Pradhan; Rosa Barreira da Silva; Teresita L. Arenzana; Min Xu; Mark S. Wilson; Jill M. Schartner; Soyoung A. Oh; Kim P. Newton; Vishva M. Dixit; Sascha Rutz

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Systematic discovery of neoepitope–HLA pairs for neoantigens shared among patients and tumor types

Nature Biotechnology, ISSN: 10870156

Hem R. Gurung; Amy Heidersbach; Martine Darwish; Pamela Pui Fung Chan; Jenny Li; Beresini; Oliver A. Zill; Andrew Wallace; Ann-Jay Tong; Daniel Hascall; Eric Torres; Andy Chang; Kenny ‘Hei-Wai’ Lou; Yassan Abdolazimi; Christian Hammer; Ana Xavier-Magalhães; Ana Marcu; Samir Vaidya; Daniel D. Le; Ilseyar Akhmetzyanova; Soyoung A. Oh; Amanda J. Moore; Uzodinma N. Uche; Melanie B. Laur; Richard J. Notturno; Peter J. R. Ebert; Craig D. Blanchette; Benjamin Haley; Christopher M. Rose

View on Scopus

Plasmid-Based Donor Templates for Nonviral CRISPR/Cas9-Mediated Gene Knock-In in Human T Cells

Current Protocols,

Kate Senger; Ilseyar Akhmetzyanova; Benjamin Haley; Sascha Rutz; Soyoung A. Oh

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High-efficiency nonviral CRISPR/Cas9-mediated gene editing of human T cells using plasmid donor DNA

Journal of Experimental Medicine, ISSN: 15409538 00221007

Soyoung A. Oh; Kate Senger; Shravan Madireddi; Ilseyar Akhmetzyanova; Isabel E. Ishizuka; Somayeh S. Tarighat; Jerry H. Lo; David Shaw; Benjamin Haley; Sascha Rutz

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PD-L1 expression by dendritic cells is a key regulator of T-cell immunity in cancer

Nature Cancer,

Soyoung A. Oh; Dai-Chen Wu; Jeanne Cheung; Armando Navarro; Huizhong Xiong; Rafael Cubas; Klara Totpal; Chiu; Yan Wu; Laetitia Comps-Agrar; Andrew Leader; Miriam Merad; Merone Roose-Germa; Søren Warming; Minhong Yan; Kim; Sascha Rutz; Ira Mellman

View on Scopus

Ribonucleoprotein Transfection for CRISPR/Cas9-Mediated Gene Knockout in Primary T Cells

Current Protocols in Immunology, ISSN: 1934368X 19343671

Soyoung A. Oh; Akiko Seki; Sascha Rutz

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The Kinase Activity of Hematopoietic Progenitor Kinase 1 Is Essential for the Regulation of T Cell Function

Cell Reports, ISSN: 22111247

Sairy Hernandez; Jing Qing; Rebecca Hong Thibodeau; Xiangnan Du; Summer Park; Hyang-Mi Lee; Min Xu; Soyoung Oh; Armando Navarro; Merone Roose-Girma; Robert J. Newman; Søren Warming; Michelle Nannini; Deepak Sampath; Kim; Jane L. Grogan; Ira Mellman

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University of Pennsylvania, Ph.D. in Immunology – 2010
Princeton University, A.B. in Molecular Biology – 2003

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Soyoung Oh

Principal Scientist, Cancer Immunology, Research Biology

Featured Publication

PD-L1 expression by dendritic cells is a key regulator of T-cell immunity in cancer