Stefan Koenig
Distinguished Scientist (Chemistry), Synthetic Molecule Pharmaceutical Sciences within Drug Discovery
"Let’s do this!"
16
Years at Genentech
58
Publications at Genentech
9
Awards & Honors
I arrived at Genentech in 2010 to join a nascent Process Chemistry team. Though the group was initially tasked with delivering traditional small molecule pharmaceuticals focused on oncology, we have grown to impact a larger swath of the pipeline. This has included collaborative efforts to assemble new molecular constructs, explore novel formulations, etc., in therapeutic areas such as immunology, ocular, respiratory, infectious diseases and also oncology.
What I like about the approach to doing science at Genentech is that we intrepidly pursue medicines to treat unmet needs. Though it may take great effort, we are dedicated to finding the best treatment and consider what patients will require once our products reach them. Purposefully, the organization provides support to bring this vision to reality and encourages pushing the limits of chemistry to achieve our goals. We are also charged with publishing our findings so that the scientific community can benefit.
Featured Publication
Development of a Broadly Applicable Enzymatic Ligation Process for the Production of Single Guide RNAs
J. Org. Chem. + Org. Process Res. Dev. 2025 Apr 18;29(8):1228–1236.
Bigatti M, Moser A, Dierssen B, Frrokaj S, Covato E, Pfleger C, Lill J, Leiser Y, Zuber J, Staempfli A, Sladojevich F, Koenig SG.
My Focus
At Genentech, I lead teams to deliver the full Chemistry, Manufacturing, and Controls (CMC) package in support of development compounds. We 2 to 3 paragraphs about your implement phase-appropriate solutions to enable entry into the clinic and beyond. I have been involved with advancing projects ranging from small molecules and antibody conjugates to oligonucleotides, peptides, and novel formulation approaches.
My independent research has been guided by practical problem-solving to benefit the greater scientific community and facilitate more sustainable research & development in the pharma industry. Publications from my team include work in novel technologies, C-H functionalization, base metal catalysis, and biocatalytic approaches to synthesis.
Genentech Publications
Journal of the American Chemical Society,
Tianyi Zhang; William G. Whitehurst; Matthew V. Pecoraro; Junho Kim; Stefan G. Koenig; Paul J. Chírik
ACS Sustainable Chemistry and Engineering,
Juan Colberg; John L. Tucker; Isamir Martinez; J. Daniel Bailey; Christiana Briddell; Stefan G. Koenig; Michael E. Kopach; Sharon Michalak; Astrid Parsons; Paul Richardson; Frank Roschangar; Eva Vestergaard; Adelina Voutchkova-Kostal
Organic Process Research and Development, ISSN: 10836160
Martina Bigatti; André Moser; Bas Dierssen; Shtjefen Frrokaj; Elena Covato; Christophe Pfleger; Joerg Lill; Yael Leiser; Joël Zuber; Andreas Staempfli; Filippo Sladojevich; Stefan G. Koenig
Journal of Controlled Release, ISSN: 01683659
Yuchen Fan; Diamanda Rigas; Lee Joon Kim; Feng-Peng Chang; Nanzhi Zang; Kristina McKee; Christopher C. Kemball; Zhixin Yu; Pascal Winkler; Wan-Chih Su; Pierce Jessen; Greg L. Hura; Tao Chen; Stefan G. Koenig; Karthik Nagapudi; Dennis H. Leung; Chun-Wan Yen
Rsc Mechanochemistry,
James D. Thorpe; Julian Marlyn; Stefan G. Koenig; Masad José Damha
Journal of the American Chemical Society, ISSN: 00027863
Tianyi Zhang; William G. Whitehurst; Matthew V. Pecoraro; Junho Kim; Stefan G. Koenig; Paul J. Chirik
Journal of Chromatography A, ISSN: 00219673
Alexandre Goyon; Molly S. Blevins; José G. Napolitano; Daniel Nguyen; Meenakshi Goel; Brandon Scott; Jennifer Wang; Stefan G. Koenig; Tao Chen; Kelly Zhang
Molecular Pharmaceutics, ISSN: 15438384
Matthew N. O’Brien Laramy; Antonio P. Costa; Yareli Maciel Cebrero; Johnson Joseph; Apoorva Sarode; Nanzhi Zang; Lee Joon Kim; Kate Hofmann; Shirley Wang; Alexandre Goyon; Stefan G. Koenig; Michal Hammel; Greg L. Hura
Organic Process Research and Development, ISSN: 10836160
Nicholas Wong; Eileen X. Zhao; Jiangyin Bao; Stefan G. Koenig; Carmela Molinaro; Jacob C. Timmerman; Haiming Zhang; C. Gregory Sowell; Francis Gosselin
ACS Catalysis,
William G. Whitehurst; Junho Kim; Stefan G. Koenig; Paul J. Chirik
Chemical Science, ISSN: 20416520
Cameron B. Lennox; Tristan H. Borchers; Lori Gonnet; Christopher J. Barrett; Stefan G. Koenig; Karthik Nagapudi; Tomislav Friščić
Journal of Medicinal Chemistry, ISSN: 00222623
Michael Berlin; Jennifer Cantley; Mark Bookbinder; Elizabeth Bortolon; Broccatelli; Greg Cadelina; Emily Chan; Huifen Chen; Xin Chen; Yun-Xing Cheng; Tommy K. Cheung; Kim Davenport; Dean DiNicola; Debbie Gordon; Brian D. Hamman; Alicia Harbin; Roy Haskell; Mingtao He; Alison J. Hole; Thomas Januario; Philip S. Kerry; Stefan G. Koenig; Limei Li; Mark Merchant; Inmaculada Pérez-Dorado; Jennifer Pizzano; Connor Quinn; Christopher M. Rose; Emma Rousseau; Leofal Soto; Leanna Staben; Hongming Sun; Qingping Tian; Jing Wang; Weifeng Wang; Crystal S. Ye; Ye; Penghong Zhang; Yuhui Zhou; Robert Yauch; Peter Dragovich
Journal of Organic Chemistry, ISSN: 00223263
Ivy Kekessie; Katarzyna Wegner; Isamir Martinez; Michael E. Kopach; Timothy White; Janine K. Tom; Martin N. Kenworthy; Fabrice Gallou; John Lopez; Stefan G. Koenig; Philippa R. Payne; Stefan Eissler; Balasubramanian Arumugam; Changfeng Li; Subha Mukherjee; Albert Isidro-Llobet; Olivier Ludemann-Hombourger; Paul Richardson; Jörg Kittelmann; Daniel Sejer Pedersen; Leendert J. van den Bos
Resonant acoustic mixing (RAM) for efficient mechanoredox catalysis without grinding or impact media
Chemical Communications, ISSN: 1364548X 13597345
Farshid Effaty; Lori Gonnet; Stefan G. Koenig; Karthik Nagapudi; Xavier Ottenwaelder; Tomislav Friščić
Journal of the American Chemical Society, ISSN: 15205126 00027863
William G. Whitehurst; Junho Kim; Stefan G. Koenig; Paul J. Chirik
Organic Process Research and Development, ISSN: 1520586X 10836160
Stefan G. Koenig; Remy Angelaud; Christopher M. Crittenden; Kenji Kurita; David J. Russell; Jean-Francois Marcoux; Thomas Matt; Francis Gosselin
Organic Process Research and Development, ISSN: 1520586X 10836160
Juan Colberg; King Kuok Hii; Stefan G. Koenig
Faraday Discussions, ISSN: 13645498 13596640
Lori Gonnet; Tristan H. Borchers; Cameron B. Lennox; Jogirdas Vainauskas; Yong Teoh; Hatem M. Titi; Christopher J. Barrett; Stefan G. Koenig; Karthik Nagapudi; Tomislav Friščić
Challenges in the structure determination of a dimeric impurity found during development of GDC-0326
Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085
Nathaniel Segraves; Stefan G. Koenig; Jeffrey Stults; Shengli Ma; Antonio G. DiPasquale; Sarah J. Robinson; David J. Russell
Challenges in the structure determination of a dimeric impurity found during development of GDC-0326
Journal of Pharmaceutical and Biomedical Analysis, ISSN: 07317085
Nathaniel Segraves; Stefan G. Koenig; Jeffrey Stults; Shengli Ma; Antonio G. DiPasquale; Sarah J. Robinson; David J. Russell
ACS Sustainable Chemistry and Engineering, ISSN: 21680485
Frank Roschangar; Jun Li; Yanyan Zhou; Wim Aelterman; Alina Borovika; Juan Colberg; David P. Dickson; Fabrice Gallou; John Hayler; Stefan G. Koenig; Michael E. Kopach; Birgit Kosjek; David Leahy; Erin O'Brien; Austin G. Smith; Manuel Henry; Jutta Cook; Roger A. Sheldon
Angewandte Chemie - International Edition, ISSN: 15213773 14337851
Lori Gonnet; Cameron B. Lennox; Jean-Louis Do; Ivani Malvestiti; Stefan G. Koenig; Karthik Nagapudi; Tomislav Friščić
Journal of the American Chemical Society, ISSN: 15205126 00027863
William G. Whitehurst; Junho Kim; Stefan G. Koenig; Paul J. Chirik
Nanoscale Advances, ISSN: 25160230
Apoorva Sarode; Yuchen Fan; Amy E. Byrnes; Michal Hammel; Greg L. Hura; Yige Fu; Ponien Kou; Chloe Hu; Flora I. Hinz; Jasmine Roberts; Stefan G. Koenig; Karthik Nagapudi; Casper C Hoogenraad; Tao Chen; Dennis H. Leung; Chun-Wan Yen
Current Research in Green and Sustainable Chemistry, ISSN: 26660865
Kristi L. Budzinski; Stefan G. Koenig
Journal of the American Chemical Society, ISSN: 15205126 00027863
William G. Whitehurst; Junho Kim; Stefan G. Koenig; Paul J. Chirik
Organic Process Research and Development, ISSN: 10836160
Stefan G. Koenig; Remy Angelaud; Christopher M. Crittenden; Kenji Kurita; David J. Russell; Jean-Francois Marcoux; Thomas Matt; Francis Gosselin
Organic Process Research and Development, ISSN: 1520586X 10836160
Juan Colberg; King Kuok Hii; Stefan G. Koenig
Nanoscale Advances, ISSN: 25160230
Apoorva Sarode; Yuchen Fan; Amy E. Byrnes; Michal Hammel; Greg L. Hura; Yige Fu; Ponien Kou; Chloe Hu; Flora I. Hinz; Jasmine Roberts; Stefan G. Koenig; Karthik Nagapudi; Casper C Hoogenraad; Tao Chen; Dennis H. Leung; Chun-Wan Yen
Organic Process Research and Development, ISSN: 1520586X 10836160
Daniel Zell; Michael E. Dalziel; Diane Carrera; Andreas Stumpf; Stephan Bachmann; Eduardo V. Mercado-Marin; Stefan G. Koenig; Haiming Zhang; Francis Gosselin
International Journal of Pharmaceutics, ISSN: 18733476 03785173
Yuchen Fan; Chun-Wan Yen; Hsiu-Chao Lin; Weijia Hou; Alberto Estevez; Apoorva Sarode; Alexandre Goyon; Juan Bian; Jessica Lin; Stefan G. Koenig; Dennis H. Leung; Karthik Nagapudi; Kelly Zhang
Tetrahedron, ISSN: 14645416 00404020
Stefan G. Koenig; Keena L. Green; Barbara Müller; C. Gregory Sowell; David Askin; Francis Gosselin
Journal of Organic Chemistry, ISSN: 15206904 00223263
Benjamin I. Andrews; Firoz D. Antia; Shawn B. Brueggemeier; Louis Diorazio; Stefan G. Koenig; Michael E. Kopach; Heewon Lee; Martin Olbrich; Anna L. Watson
ACS Sustainable Chemistry and Engineering, ISSN: 21680485
Frank Roschangar; Jun Li; Yanyan Zhou; Wim Aelterman; Alina Borovika; Juan Colberg; David P. Dickson; Fabrice Gallou; John Hayler; Stefan G. Koenig; Michael E. Kopach; Birgit Kosjek; David Leahy; Erin O'Brien; Austin G. Smith; Manuel Henry; Jutta Cook; Roger A. Sheldon
Journal of the American Chemical Society, ISSN: 15205126 00027863
William G. Whitehurst; Junho Kim; Stefan G. Koenig; Paul J. Chirik
Nature Sustainability, ISSN: 23989629
Alina Borovika; Jacob Albrecht; Jun Li; Andrew S. Wells; Christiana Briddell; Barry Dillon; Louis Diorazio; James R. Gage; Fabrice Gallou; Stefan G. Koenig; Michael E. Kopach; David Leahy; Isamir Martinez; Martin Olbrich; Jared L. Piper; Frank Roschangar; Edward C. Sherer; Martin D. Eastgate
ACS Sustainable Chemistry and Engineering, ISSN: 21680485
Stefan G. Koenig; Cisco Bee; Alina Borovika; Christiana Briddell; Juan Colberg; Guy R. Humphrey; Michael E. Kopach; Isamir Martinez; Sudhir Nambiar; Scott Plummer; Seth D. Ribe; Frank Roschangar; Jeremy P. Scott; Helen F. Sneddon
New Biotechnology, ISSN: 18764347 18716784
Kristi L. Budzinski; Megan Blewis; Philip Dahlin; Daniel D'Aquila; Julia Esparza; Jack Gavin; Sa V. Ho; Clarice Hutchens; David Kahn; Stefan G. Koenig; Robert E. Kottmeier; Jeff Millard; Matt Snyder; Stanard; Lixin Sun
Tetrahedron Letters, ISSN: 18733581 00404039
Kyle Clagg; Sara Hold; Archana Kumar; Stefan G. Koenig; Remy Angelaud
ACS Symposium Series, ISSN: 19475918 00976156
Stefan G. Koenig; Thomas H. Pillow
Organic Process Research and Development, ISSN: 1520586X 10836160
Stefan G. Koenig; David Leahy; Andrew S. Wells
Chemistry - A European Journal, ISSN: 15213765 09476539
Xin Linghu; Nathaniel Segraves; Ifat Abramovich; Nicholas Wong; Barbara Müller; Nadja Neubauer; Serena M. Fantasia; Sebastian Rieth; Stephan Bachmann; Michael Jansen; C. Gregory Sowell; David Askin; Stefan G. Koenig; Francis Gosselin
Green Chemistry, ISSN: 14639270 14639262
Marian C. Bryan; Peter Dunn; David Entwistle; Fabrice Gallou; Stefan G. Koenig; John Hayler; Matthew Hickey; Shaun Hughes; Michael E. Kopach; Gerard Moine; Paul Richardson; Frank Roschangar; Alan Steven; Franz J. Weiberth
Green Chemistry, ISSN: 14639270 14639262
Frank Roschangar; Yanyan Zhou; David J. C. Constable; Juan Colberg; David P. Dickson; Peter Dunn; Martin D. Eastgate; Fabrice Gallou; John Hayler; Stefan G. Koenig; Michael E. Kopach; David Leahy; Ingrid Mergelsberg; Ulrich Scholz; Austin G. Smith; Manuel Henry; Jason Mulder; Jörg Brandenburg; Juan R. Dehli; Daniel R. Fandrick; Keith R. Fandrick; Frieder Gnad-Badouin; Georg Zerban; Klaus Groll; Paul T. Anastas; Roger A. Sheldon; Chris H. Senanayake
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
F. Anthony Romero; Jeremy Murray; Kwong Wah Lai; Vickie Tsui; Brian K Albrecht; Le An; Beresini; Gladys De Leon Boenig; Sarah M. Bronner; Emily Chan; Kevin Chen; Zhongguo Chen; Edna F. Choo; Kyle Clagg; Clark; Terry Crawford; Patrick Cyr; Denise De Almeida Nagata; Karen Gascoigne; Jane L. Grogan; Georgia Hatzivassiliou; Wei Huang; Thomas Hunsaker; Susan Kaufman; Stefan G. Koenig; Ruina Li; Yingjie Li; Xiaorong Liang; Jiangpeng Liao; Wenfeng Liu; Justin Ly; Jonathan M. Maher; Colin Masui; Mark Merchant; Yingqing Ran; Alexander M. Taylor; John Wai; Fei Wang; Xiaocang Wei; Dong Yu; Bing-Yan Zhu; Xiaoyu Zhu; Steven Magnuson
Organic Process Research and Development, ISSN: 1520586X 10836160
Xin Linghu; Nicholas Wong; Hans Iding; Vera Jost; Haiming Zhang; Stefan G. Koenig; C. Gregory Sowell; Francis Gosselin
Green Chemistry, ISSN: 14639270 14639262
Frank Roschangar; Juan Colberg; Peter Dunn; Fabrice Gallou; John Hayler; Stefan G. Koenig; Michael E. Kopach; David Leahy; Ingrid Mergelsberg; John L. Tucker; Roger A. Sheldon; Chris H. Senanayake
Nature Chemistry, ISSN: 17554349 17554330
Leanna Staben; Stefan G. Koenig; Sophie M. Lehar; Richard L. Vandlen; Donglu Zhang; Josefa Chuh; Shang-Fan Yu; Carl Ng; Jun Guo; Yanzhou Liu; Aimee Fourie-O'Donohue; MaryAnn Go; Xin Linghu; Nathaniel Segraves; Tao Wang; Jinhua Chen; Binqing Wei; Gail L. Phillips; Keyang Xu; Katherine R. Kozak; Sanjeev Mariathasan; Flygare; Thomas H. Pillow
Organic Letters, ISSN: 15237052 15237060
Kyle Clagg; Haiyun Hou; Adam B. Weinstein; David J. Russell; Shannon S. Stahl; Stefan G. Koenig
Nature Biotechnology, ISSN: 15461696 10870156
Kristi L. Budzinski; Stefan G. Koenig; Deborah O'Connor; Tse-Sung Wu
Organic Process Research and Development, ISSN: 1520586X 10836160
Hang Zhao; Stefan G. Koenig; John W. Dankwardt; Surendra P. Singh
Green Chemistry, ISSN: 14639270 14639262
Florence M. Chardon; Nicole Blaquiere; Georgette M. Castanedo; Stefan G. Koenig
Organic Process Research and Development, ISSN: 10836160 1520586X
Peter Poechlauer; Juan Colberg; Elizabeth Fisher; Michael Jansen; Martin D. Johnson; Stefan G. Koenig; Michael Lawler; Thomas Laporte; Julie Manley; Benjamin Martin; Anne O'Kearney-Mcmullan
Innovations in Pharmaceutical Technology, ISSN: 14717204
Juan Colberg; Stefan G. Koenig; David Leahy; Peter Poechlauer
Scalable Green Chemistry: Case Studies from the Pharmaceutical Industry,
Stefan G. Koenig
Scalable Green Chemistry: Case Studies from the Pharmaceutical Industry,
Stefan G. Koenig
Scalable Green Chemistry: Case Studies from the Pharmaceutical Industry,
Stefan G. Koenig
Organic Letters, ISSN: 15237060 15237052
Sushant Malhotra; Pamela S. Seng; Stefan G. Koenig; Alan Deese; Kevin A. Ford
Education
- Isenberg School of Management, University of Massachusetts, Amherst, MBA – 2013
- ETH Zurich (Swiss Federal Institute of Technology), Postdoctoral Fellow – 2003
- Yale University, Ph.D. Chemistry – 2002
- Providence College, B.S. Chemistry, summa cum laude – 1997
Awards & Honors
- Charles Yang Collaboration Award – 2024
- ACS Award for Affordable Green Chemistry – 2024
- Roche Environmental Awareness in Chemical Technology (REACT) Award – 2024
- ACS Innovative Project Grant (IPG) – 2023
- ACS Fellow selection – 2022
- Executive Committee Member, National ACS Organic Division – 2019-2021
- Co-Chair, ACS Green Chemistry Institute Pharmaceutical Roundtable – 2015-2017
- ACS Younger Chemists Committee (YCC) Leadership Development Award – 2010
- ACS Young Industrial Investigator Award – 2009