Steven Magnuson
Principal Scientist and Director, Discovery Chemistry
"The challenges of drug discovery, the opportunity to work with amazing colleagues, and the rewards of helping patients – what a great job!"
12
Years at Genentech
34
Publications
I got my PhD in organic chemistry from the University of Alberta and after a postdoctoral fellowship at Columbia University, I started my industrial career at Bayer. In 2007, I got the opportunity to work in the Discovery Chemistry Department at Genentech and help build a lead identification group as the small molecule effort expanded here. I was attracted to the company’s focus on science and helping patients. Since that time I’ve been able to work on projects throughout the drug discovery process from inception to clinical testing in different therapeutic areas. Every project is unique and the daily challenges of finding that ideal molecule means no two days are ever the same.
Featured Publication
My Focus
Early in my time at Genentech, my focus was on lead identification finding promising chemical series for new biological targets. It’s a fast pace area with lots of different chemistry, assays, and biology where we worked on a number of different collaborations focused on new technologies and novel research areas. I’ve also had the opportunity to lead project teams in the lead optimization space for both immunology and oncology targets as well as leading a project in Early Development on its path through advanced safety testing towards Phase 1 testing in people. I’ve learned a great deal in each of these different areas working alongside great scientists.
Publications
CBP/p300 drives the differentiation of regulatory T cells through transcriptional and non-transcriptional mechanisms
Cancer Research, ISSN: 00085472
Joseph Castillo; Esther Wu; Christopher Lowe; Shrividhya Srinivasan; Mccord; Marie-Claire Wagle; Sangeeta Jayakar; Melissa Gonzalez Edick; Jeff Eastham; Bonnie Liu; Katherine E. Hutchinson; Wendell Jones; Matthew P. Stokes; Somayeh S. Tarighat; Tom Holcomb; Andrew Glibicky; Anthony Romero; Steven Magnuson; Shih-Min A. Huang; Vicki Plaks; Jennifer Giltnane; Mark Lackner; Zineb Mounir
Cell Reports, ISSN: 22111247
Denise De Almeida Nagata; Eugene Chiang; Suchit Jhunjhunwala; Patrick Caplazi; Vidhyalakshmi Arumugam; Zora Modrusan; Emily Chan; Mark Merchant; Lingyan Jin; David Arnott; Anthony Romero; Steven Magnuson; Karen Gascoigne; Jane Grogan
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Shumei Wang; Vickie Tsui; Terry Crawford; James E. Audia; Dan Burdick; Maureen Beresini; Alexandre Côté; Richard T Cummings; Martin Duplessis; Megan Flynn; Michael C. Hewitt; Hon-Ren Huang; Hariharan Jayaram; Ying Jiang; Shivangi Joshi; Jeremy Murray; Christopher G. Nasveschuk; Eneida Pardo; Florence Poy; Anthony Romero; Yong Tang; Alexander M. Taylor; Jian Wang; Zhaowu Xu; Laura E. Zawadzke; Xiaoyu Zhu; Brian K Albrecht; Steven Magnuson; Steve Bellon; Andrea Cochran
Cell Reports, ISSN: 22111247
Ryan Raisner; Samir Kharbanda; Lingyan Jin; Edwin Jeng; Emily Chan; Mark Merchant; Matthias Peter; Russell Bainer; Tommy K Cheung; David Arnott; Megan Flynn; Anthony Romero; Steven Magnuson; Karen Gascoigne
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Kwong Wah Lai; Anthony Romero; Vickie Tsui; Maureen Beresini; Gladys Boenig; Sarah M. Bronner; Kevin Chen; Zhongguo Chen; Edna Choo; Terry Crawford; Patrick Cyr; Susan Kaufman; Yingjie Li; Jiangpeng Liao; Wenfeng Liu; Justin Ly; Jeremy Murray; Weichao Shen; John Wai; Fei Wang; Caicai Zhu; Xiaoyu Zhu; Steven Magnuson
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Sarah M. Bronner; Jeremy Murray; Anthony Romero; Kwong Wah Lai; Vickie Tsui; Patrick Cyr; Maureen Beresini; Gladys Boenig; Zhongguo Chen; Edna Choo; Kevin Clark; Terry Crawford; Hariharan Jayaram; Susan Kaufman; Ruina Li; Yingjie Li; Jiangpeng Liao; Xiaorong Liang; Wenfeng Liu; Justin Ly; Jonathan M. Maher; John Wai; Fei Wang; Aijun Zheng; Xiaoyu Zhu; Steven Magnuson
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Anthony Romero; Jeremy Murray; Kwong Wah Lai; Vickie Tsui; Brian K Albrecht; Le An; Maureen Beresini; Gladys Boenig; Sarah M. Bronner; Emily Chan; Kevin Chen; Zhongguo Chen; Edna Choo; Kyle Clagg; Kevin Clark; Terry Crawford; Patrick Cyr; Denise De Almeida Nagata; Karen Gascoigne; Jane Grogan; Georgia Hatzivassiliou; Wei Huang; Thomas Hunsaker; Susan Kaufman; Stefan G. Koenig; Ruina Li; Yingjie Li; Xiaorong Liang; Jiangpeng Liao; Wenfeng Liu; Justin Ly; Jonathan M. Maher; Colin Masui; Mark Merchant; Yingqing Ran; Alexander M. Taylor; John Wai; Fei Wang; Xiaocang Wei; Dong Yu; Bing-Yan Zhu; Xiaoyu Zhu; Steven Magnuson
Cancer Research, ISSN: 15387445 00085472
Lingyan Jin; Jesse Garcia; Emily Chan; Cecile de la Cruz; Ehud Segal; Mark Merchant; Samir Kharbanda; Ryan Raisner; Pete Haverty; Zora Modrusan; Justin Ly; Edna Choo; Sue Kaufman; Maureen Beresini; Anthony Romero; Steven Magnuson; Karen Gascoigne
ACS Medicinal Chemistry Letters, ISSN: 19485875
Terry Crawford; James E. Audia; Steve Bellon; Dan Burdick; Archana Bommi-Reddy; Alexandre Côté; Richard T Cummings; Martin Duplessis; Megan Flynn; Michael C. Hewitt; Hon-Ren Huang; Hariharan Jayaram; Ying Jiang; Shivangi Joshi; James Kiefer; Jeremy Murray; Christopher G. Nasveschuk; Adrianne Neiss; Eneida Pardo; Anthony Romero; Peter Sandy; Robert J. Sims; Yong Tang; Alexander M. Taylor; Vickie Tsui; Jian Wang; Shumei Wang; Yongyun Wang; Zhaowu Xu; Laura E. Zawadzke; Xiaoqin Zhu; Brian K Albrecht; Steven Magnuson; Andrea Cochran
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405
Terry Crawford; Steffan Vartanian; Alexandre Côté; Steve Bellon; Martin Duplessis; Megan Flynn; Michael C. Hewitt; Hon-Ren Huang; James Kiefer; Jeremy Murray; Christopher G. Nasveschuk; Eneida Pardo; Anthony Romero; Peter Sandy; Yong Tang; Alexander M. Taylor; Vickie Tsui; Jian Wang; Shumei Wang; Laura E. Zawadzke; Brian K Albrecht; Steven Magnuson; Andrea Cochran; David Stokoe
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Jun Liang; Anne Van Abbema; Mercedesz Balazs; Kathy Barrett; Leo Berezhkovsky; Wade Blair; Christine Chang; Donnie Delarosa; Jason DeVoss; James Driscoll; Charles Eigenbrot; Simon Goodacre; Nico Ghilardi; Calum Macleod; Adam Johnson; Pawan Bir Kohli; Yingjie Lai; Zhonghua Lin; Priscilla Mantik; Kapil Menghrajani; Hieu Nguyen; Ivan Peng; Amy Sambrone; Steven Shia; Jan Smith; Sue Sohn; Vickie Tsui; Mark Ultsch; Karen Williams; Lawren Wu; Wenqian Yang; Birong Zhang; Steven Magnuson
Journal of Medicinal Chemistry, ISSN: 15204804
Terry Crawford; Anthony Romero; Kwong Wah Lai; Vickie Tsui; Alexander M. Taylor; Gladys Boenig; Cameron Noland; Jeremy Murray; Justin Ly; Edna Choo; Thomas Hunsaker; Emily W. Chan; Mark Merchant; Samir Kharbanda; Karen Gascoigne; Sue Kaufman; Maureen Beresini; Jiangpeng Liao; Wenfeng Liu; Kevin Chen; Zhongguo Chen; Andrew R. Conery; Alexandre Côté; Hariharan Jayaram; Ying Jiang; James Kiefer; Tracy Kleinheinz; Yingjie Li; Jonathan Maher; Eneida Pardo; Florence Poy; Kerry L. Spillane; Fei Wang; Jian Wang; Xiaocang Wei; Zhaowu Xu; Zhongya Xu; Ivana Yen; Laura E. Zawadzke; Xiaoyu Zhu; Steve Bellon; Richard T Cummings; Andrea Cochran; Brian K Albrecht; Steven Magnuson
Journal of Biological Chemistry, ISSN: 1083351X
Srimoyee Ghosh; Alexander M. Taylor; Melissa Chin; Hon-Ren Huang; Andrew R. Conery; Jennifer A. Mertz; Andres Salmeron; Pranal J. Dakle; Deanna Mele; Alexandre Côté; Hari Jayaram; Jeremy Setser; Florence Poy; Georgia Hatzivassiliou; Denise de Almeida Nagata; Peter Sandy; Charlie Hatton; Anthony Romero; Eugene Chiang; Thornik Reimer; Terry Crawford; Eneida Pardo; Venita G. Watson; Vickie Tsui; Andrea Cochran; Laura E. Zawadzke; Jean-Christophe Harmange; James E. Audia; Barbara M. Bryant; Richard T Cummings; Steven Magnuson; Jane Grogan; Steve Bellon; Brian K Albrecht; Robert J. Sims; Jose M. Lora
Journal of Medicinal Chemistry, ISSN: 15204804
Terry Crawford; Vickie Tsui; Megan Flynn; Shumei Wang; Alexander M. Taylor; Alexandre Côté; James E. Audia; Maureen Beresini; Dan Burdick; Richard T Cummings; Leslie A. Dakin; Martin Duplessis; Andrew C. Good; Michael C. Hewitt; Hon-Ren Huang; Hariharan Jayaram; James Kiefer; Ying Jiang; Jeremy Murray; Christopher G. Nasveschuk; Eneida Pardo; Florence Poy; Anthony Romero; Yong Tang; Jian Wang; Zhaowu Xu; Laura E. Zawadzke; Xiaoyu Zhu; Brian K Albrecht; Steven Magnuson; Steve Bellon; Andrea Cochran
ACS Medicinal Chemistry Letters, ISSN: 19485875
Alexander M. Taylor; Alexandre Côté; Michael C. Hewitt; Rich Pastor; Yves Leblanc; Christopher G. Nasveschuk; Anthony Romero; Terry Crawford; Nico Cantone; Hariharan Jayaram; Jeremy Setser; Jeremy Murray; Maureen Beresini; Gladys Boenig; Zhongguo Chen; Andrew R. Conery; Richard T Cummings; Leslie A. Dakin; Megan Flynn; Oscar Huang; Sue Kaufman; Patricia J. Keller; James Kiefer; Tommy Lai; Yingjie Li; Jiangpeng Liao; Wenfeng Liu; Henry Lu; Eneida Pardo; Vickie Tsui; Jian Wang; Yongyun Wang; Zhaowu Xu; Fen Yan; Dong Yu; Laura E. Zawadzke; Xiaoqin Zhu; Xiaoyu Zhu; Robert J. Sims; Andrea Cochran; Steve Bellon; James E. Audia; Steven Magnuson; Brian K Albrecht
Cancer Research, ISSN: 15387445
John P. McGrath; Kaylyn E Williamson; Srividya Balasubramanian; Shobu Odate; Shilpi Arora; Charlie Hatton; Thomas M. Edwards; Thomas O'Brien; Steven Magnuson; David Stokoe; Danette L. Daniels; Barbara M. Bryant; Patrick Trojer
Journal of Medicinal Chemistry, ISSN: 15204804
Anthony Romero; Alexander M. Taylor; Terry Crawford; Vickie Tsui; Alexandre Côté; Steven Magnuson
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405
Dan Burdick; Shumei Wang; Chris Heise; Borlan Pan; Jake Drummond; Peter Yin; Lauren Goeser; Steven Magnuson; Jeff Blaney; John Moffat; Weiru Wang; Huifen Chen
Journal of Medicinal Chemistry, ISSN: 15204804
Giovanni Cervi; Paola Magnaghi; Daniela Asa; Nilla Avanzi; Alessandra Badari; Daniela Borghi; Michele Caruso; Alessandra Cirla; Liviana Cozzi; Eduard Felder; Arturo Galvani; Fabio Gasparri; Antonio Lomolino; Steven Magnuson; Beatrice Malgesini; Ilaria Motto; Maurizio Pasi; Simona Rizzi; Barbara Salom; Graziella Sorrentino; Sonia Troiani; Barbara Valsasina; Thomas O'Brien; Antonella Isacchi; Daniele Donati; Roberto D'Alessio
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405
Lan Wang; Mark Stanley; Jason Boggs; Terry Crawford; Brandon Bravo; Tony Giannetti; Seth Harris; Steven Magnuson; Jim Nonomiya; Steve Schmidt; Ping Wu; Weilan Ye; Stephen Gould; Lesley Murray; Chudi Ndubaku; Huifen Chen
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405
Rich Pastor; Jason Burch; Steven Magnuson; Dan Ortwine; Yuan Chen; Michael De La Torre; Xiao Ding; Charles Eigenbrot; Adam Johnson; Marya Liimatta; Yichin Liu; Steven Shia; Xiaolu Wang; Lawren Wu; Zhonghua Pei
Journal of Medicinal Chemistry, ISSN: 15204804
Terry Crawford; Chudi Ndubaku; Huifen Chen; Jason Boggs; Brandon Bravo; Kelly Delatorre; Tony Giannetti; Stephen Gould; Seth Harris; Steven Magnuson; Erin McNamara; Lesley Murray; Jim Nonomiya; Amy Sambrone; Steve Schmidt; Tanya Smyczek; Mark Stanley; Philip Vitorino; Lan Wang; Kristina West; Ping Wu; Weilan Ye
Journal of Medicinal Chemistry, ISSN: 15204804
Benjamin Fauber; Steven Magnuson
Journal of Heterocyclic Chemistry, ISSN: 19435193
Jun Liang; Valerie Dorman Soucy; Vickie Tusi; Yanzhou Liu; Birong Zhang; Yingjie Lai; Steven Magnuson; Bing-Yan Zhu; Fangdao Wang; Jinghao Gu; Qingfen Zhang; Yuan Wu; Wei Deng; Wenqian Yang
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Mike Siu; Rich Pastor; Wendy Liu; Kathy Barrett; Megan Berry Swadell; Wade Blair; Christine Chang; Jacob Chen; Charles Eigenbrot; Nico Ghilardi; Paul Gibbons; Haiying He; Christopher A. Hurley; Jane Kenny; Cyrus Khojasteh; Hoa Le; Leslie Lee; Joe Lyssikatos; Steven Magnuson; Rebecca Pulk; Vickie Tsui; Mark Ultsch; Yisong Xiao; Bing-Yan Zhu; Deepak Sampath
Journal of Immunology, ISSN: 00221767
Sue Sohn; Kathy Barrett; Anne Van Abbema; Christine Chang; Pawan Bir Kohli; Hidenobu Kanda; Janice Smith; Yingjie Lai; Aihe Zhou; Birong Zhang; Wenqian Yang; Karen Williams; Calum Macleod; Christopher A. Hurley; Janusz J. Kulagowski; Nicholas Lewin-Koh; Hart S. Dengler; Adam Johnson; Nico Ghilardi; Mark Zak; Jun Liang; Wade Blair; Steven Magnuson; Lawren Wu
European Journal of Medicinal Chemistry, ISSN: 02235234
Jun Liang; Vickie Tsui; Anne Van Abbema; Liang Bao; Kathy Barrett; Maureen Beresini; Leo Berezhkovskiy; Wade Blair; Christine Chang; James Driscoll; Charles Eigenbrot; Nico Ghilardi; Paul Gibbons; Jason Halladay; Adam Johnson; Pawan Bir Kohli; Yingjie Lai; Marya Liimatta; Priscilla Mantik; Kapil Menghrajani; Jeremy Murray; Amy Sambrone; Yisong Xiao; Steven Shia; Young Shin; Jan Smith; Sue Sohn; Mark Stanley; Mark Ultsch; Birong Zhang; Lawren Wu; Steven Magnuson
Journal of Medicinal Chemistry, ISSN: 00222623
Jun Liang; Anne Van Abbema; Mercedesz Balazs; Kathy Barrett; Leo Berezhkovsky; Wade Blair; Christine Chang; Donnie Delarosa; Jason DeVoss; James Driscoll; Charles Eigenbrot; Nico Ghilardi; Paul Gibbons; Jason Halladay; Adam Johnson; Pawan Bir Kohli; Yingjie Lai; Yanzhou Liu; Joe Lyssikatos; Priscilla Mantik; Kapil Menghrajani; Jeremy Murray; Ivan Peng; Amy Sambrone; Steven Shia; Young Shin; Jan Smith; Sue Sohn; Vickie Tsui; Mark Ultsch; Lawren Wu; Yisong Xiao; Wenqian Yang; Judy Young; Birong Zhang; Bing-Yan Zhu; Steven Magnuson
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Gina Wang; Steven Magnuson; Rich Pastor; Eric Fan; Huiyong Hu; Vickie Tsui; Wei Deng; Jeremy Murray; Micah Steffek; Heidi Ackerly Wallweber; John Moffat; Jake Drummond; Grace Chan; Eric Harstad; Allen Ebens
Cancer Research, ISSN: 00085472
Ted Lau; Emily Chan; Marinella Callow; Jo Waaler; Jason Boggs; Robert A. Blake; Steven Magnuson; Amy Sambrone; Melissa Schutten; Ron Firestein; Ondrej Machon; Vladimir Korinek; Edna Choo; Dolo Diaz; Mark Merchant; Paul Polakis; Daniel D. Holsworth; Stefan Krauss; Mike Costa
Tetrahedron Letters, ISSN: 00404039
Olivier Rene; Alexandra Souverneva; Steven Magnuson; Benjamin Fauber
Journal of Medicinal Chemistry, ISSN: 15204804
Paolo Polucci; Paola Magnaghi; Mauro Angiolini; Daniela Asa; Nilla Avanzi; Alessandra Badari; Jay Bertrand; Elena Casale; Silvia Cauteruccio; Alessandra Cirla; Liviana Cozzi; Arturo Galvani; Peter Jackson; Yichin Liu; Steven Magnuson; Beatrice Malgesini; Stefano Nuvoloni; Christian Orrenius; Federico Riccardi Sirtori; Laura Riceputi; Simona Rizzi; Beatrice Trucchi; Thomas O'Brien; Antonella Isacchi; Daniele Donati; Roberto D'Alessio
Journal of Medicinal Chemistry, ISSN: 00222623
Emily Hanan; Anne Van Abbema; Kathy Barrett; Wade Blair; Jeff Blaney; Christine Chang; Charles Eigenbrot; Sean Flynn; Paul Gibbons; Christopher A. Hurley; Jane Kenny; Janusz J. Kulagowski; Leslie Lee; Steven Magnuson; Claire Morris; Jeremy Murray; Rich Pastor; Thomas Rawson; Mike Siu; Mark Ultsch; Aihe Zhou; Deepak Sampath; Joe Lyssikatos
Proteins: Structure, Function and Bioinformatics, ISSN: 08873585
Vickie Tsui; Paul Gibbons; Mark Ultsch; Kyle Mortara; Christine Chang; Wade Blair; Rebecca Pulk; Mark Stanley; Melissa Starovasnik; David Williams; Maria Lamers; Phillip Leonard; Steven Magnuson; Jun Liang; Charles Eigenbrot
Education
- Columbia University, Postdoctoral Fellowship – 1998
- University of Alberta, Ph.D in Organic Chemistry – 1996
- University of British Columbia, B.Sc in Honours Chemistry – 1991