Steven Rutherford
Principal Scientist - SS, Infectious Diseases
"Every day we aim to address difficult but critical research questions and I am constantly inspired by the innovative, rigorous, and collaborative scientific approaches employed by Genentech scientists to seek out answers."
9
Years at Genentech
12
Publications at Genentech
5
Awards & Honors
I joined the Department of Infectious Diseases at Genentech as a Scientist in 2013. My background is in bacterial physiology and genetics and my group focusses on discovering and validating novel antibiotic targets in Gram-negative bacteria. I was attracted to Genentech because it offered me the opportunity to investigate difficult scientific questions that are critical for human health and allowed me to work with the most creative, innovative, and collaborative scientists in the world.
Featured Publication
Monoclonal antibody targeting the β-barrel assembly machine of Escherichia coli is bactericidal.
Proc Natl Acad Sci USA 115:3692-3697.
Storek KM, Auerbach MR, Shi H, Garcia NK, Sun D, Nickerson NN, Vij R, Chiang N, Schneider K, Wecksler AT, Skippington E, Nakamura G, Seshasayee D, Koerber JT, Payandeh J, Smith PA, Rutherford ST.
My Focus
Infections by bacteria resistant to all available antibiotics are on the rise and new treatment options are needed. This is especially true for Gram-negative bacterial pathogens for which the last new class of antibiotics was introduced to the clinic over 50 years ago. My group aims to discover and validate new potential antibiotic targets in Gram-negative bacteria and test novel inhibitory modalities.
We have focused on the outer membrane, a defining feature of Gram-negative bacteria that serves as a permeability barrier to prevent penetrance of antibiotics and other toxic molecules. Working closely with colleagues in Structural Biology, Antibody Engineering, Biochemical and Cellular Pharmacology, Chemistry, Translational Immunology, and Early Discovery Biochemistry, we have explored multiple essential pathways involved in constructing and mainlining the outer membrane and used antibodies and other molecules to dissect and target these processes.
Genentech Publications
Nature Communications, ISSN: 20411723
Paul White; Samuel F. Haysom; Matthew G. Iadanza; Anna J. Higgins; Jonathan M. Machin; James M. Whitehouse; Jim E. Horne; Bob Schiffrin; Charlotte Carpenter-Platt; Antonio N. Calabrese; Kelly M. Storek; Steven T. Rutherford; David J. Brockwell; Neil A. Ranson; Sheena E. Radford
Journal of Bacteriology, ISSN: 10985530 00219193
Jingyu Diao; Rie Komura; Tatsuya Sano; Homer Pantua; Kelly M. Storek; Hiroko Inaba; Haruhiko Ogawa; Cameron Noland; Yutian Peng; Susan L. Gloor; Donghong Yan; Jing Kang; Anand K. Katakam; Michael Volny; Peter S. Liu; Nicholas N. Nickerson; Wendy N. Sandoval; Cary D. Austin; Jeremy Murray; Steven T. Rutherford; Mike Reichelt; Yiming Xu; Min Xu; Hayato Yanagida; Junichi Nishikawa; Patrick C. Reid; Christian N. Cunningham; Sharookh B. Kapadia
Trends in Microbiology, ISSN: 18784380 0966842X
Randi L. Guest; Steven T. Rutherford; Thomas J. Silhavy
Nature Reviews Microbiology, ISSN: 17401534 17401526
Jiawei Sun; Steven T. Rutherford; Thomas J. Silhavy; Kerwyn Casey Huang
Nature, ISSN: 14764687 00280836
Thomas Clairfeuille; Kerry R. Buchholz; Qingling Li; Erik Verschueren; Peter S. Liu; Dewakar Sangaraju; Summer Park; Cameron Noland; Kelly M. Storek; Nicholas N. Nickerson; Lynn Martin; Trisha Dela Vega; Anh Miu; Janina Reeder; Maria Ruiz-Gonzalez; Danielle L. Swem; Guanghui Han; Daniel P. DePonte; Mark S. Hunter; Cornelius Gati; Sheerin Shahidi-Latham; Min Xu; Nicholas J. Skelton; Benjamin D. Sellers; Elizabeth Skippington; Wendy N. Sandoval; Emily J. Hanan; Jian Payandeh; Steven T. Rutherford
eLife, ISSN: 2050084X
Kelly M. Storek; Joyce Chan; Rajesh Vij; Nancy Y. Chiang; Zhonghua Lin; Jack Bevers; Christopher M. Koth; Jean-Michel Vernes; Y. Gloria Meng; Jianping Yin; Heidi J. A. Wallweber; Olivier Dalmas; Stephanie K. Shriver; Christine Tam; Kellen Schneider; Dhaya Seshasayee; Nakamura; Peter A. Smith; Jian Payandeh; James T. Koerber; Laetitia Comps-Agrar; Steven T. Rutherford
Journal of Bacteriology, ISSN: 10985530 00219193
Kelly M. Storek; Rajesh Vij; Dawei Sun; Peter A. Smith; James T. Koerber; Steven T. Rutherford
Scientific Reports, ISSN: 20452322
Rajesh Vij; Zhonghua Lin; Nancy Y. Chiang; Jean-Michel Vernes; Kelly M. Storek; Summer Park; Joyce Chan; Y. Gloria Meng; Laetitia Comps-Agrar; Patricia Luhn; Sophia Lee; Kellen Schneider; Jack Bevers; Inna Zilberleyb; Christine Tam; Christopher M. Koth; Min Xu; Avinash Gill; Marcy Auerbach; Peter A. Smith; Steven T. Rutherford; Nakamura; Dhaya Seshasayee; Jian Payandeh; James T. Koerber
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Kelly M. Storek; Marcy Auerbach; Handuo Shi; Natalie K. Garcia; Dawei Sun; Nicholas N. Nickerson; Rajesh Vij; Zhonghua Lin; Nancy Y. Chiang; Kellen Schneider; Aaron T. Wecksler; Elizabeth Skippington; Nakamura; Dhaya Seshasayee; James T. Koerber; Jian Payandeh; Peter A. Smith; Steven T. Rutherford
Antimicrobial Agents and Chemotherapy, ISSN: 10986596 00664804
Nicholas N. Nickerson; Christine C. Jao; Yiming Xu; John Quinn; Elizabeth Skippington; Mary Kate Alexander; Anh Miu; Nicholas J. Skelton; Jessica V. Hankins; Michael S. Lopez; Christopher M. Koth; Steven T. Rutherford; Mireille Nishiyama
A Qrr noncoding RNA deploys four different regulatory mechanisms to optimize quorum-sensing dynamics
Cell, ISSN: 10974172 00928674
Lihui Feng; Steven T. Rutherford; Kai Papenfort; John D. Bagert; Julia C. Van Kessel; David A. Tirrell; Ned S. Wingreen; Bonnie L. Bassler
Journal of Bacteriology, ISSN: 10985530 00219193
Julia C. Van Kessel; Steven T. Rutherford; Jian-Ping Cong; Sofia Quinodoz; James Healy; Bonnie L. Bassler
Education
- Princeton University, Postdoctoral Fellow – 2008-2013
- University of Wisconsin-Madison, Ph.D. in Microbiology – 2008
- Miami University, B.A. in Microbiology – 2002
Awards & Honors
- Genentech Scientific Mentorship Award Finalist – 2019
- Genentech Research Innovation Fund Award – 2016, 2019
- NIH Kirschstein National Research Service Award – 2010
- Thomsen Distinguished Graduate Fellowship – 2007
- Wisconsin Alumni Research Foundation Fellowship – 2004