Genentech: Tim Heffron | Senior Director and Senior Principal Scientist, Discovery Chemistry

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Scientists / Our Scientists

"Each day we work to extend and improve lives."

Years at Genentech

Publications

I joined the Discovery Chemistry department at Genentech as a Medicinal Chemist in 2005 after completing my PhD in organic chemistry at MIT. I now lead interdisciplinary teams focused on the discovery of new drugs to extend and improve people’s lives.

Featured Publication

Discovery of Clinical Development Candidate GDC-0084, a Brain Penetrant Inhibitor of PI3K and mTOR.

ACS Med Chem Lett. 2016 Feb 16;7(4):351-6.

Heffron TP, Ndubaku CO, Salphati L, Alicke B, Cheong J, Drobnick J, Edgar K, Gould SE, Lee LB, Lesnick JD, Lewis C, Nonomiya J, Pang J, Plise EG, Sideris S, Wallin J, Wang L, Zhang X, Olivero AG.

View Abstract

As a chemist, my work can focus on designing drugs directed to whatever target is most compelling from a biological point of view without being confined to a particular therapeutic area. In my time at Genentech I have contributed to programs directed toward the discovery of new therapeutics for oncology (including cancer immunotherapy), neuro-oncology, neurology, and ophthalmology indications. Each program brings unique scientific challenges and a need to innovate to discover new medicines.

Characterization of Antineovascularization Activity and Ocular Pharmacokinetics of Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitor GNE-947

Drug Metabolism and Disposition, ISSN: 1521009X

Xingrong Liu; Xiaorong Liang; Jenninfer LeCouter; Savita Ubhayakar; Jacob Chen; Jay Cheng; Tom Lee; Joe Lubach; Jim Nonomiya; Sheerin Latham; Cristine Quiason-Huynh; Eric G. Solon; Matthew Wright; Marcel Hop; Tim Heffron

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Tim Heffron

Senior Director and Senior Principal Scientist, Discovery Chemistry

Featured Publication

Discovery of Clinical Development Candidate GDC-0084, a Brain Penetrant Inhibitor of PI3K and mTOR.