Tim Heffron
Associate Director, Principal Scientist, Discovery Chemistry
"Each day we work to extend and improve lives."
14
Years at Genentech
33
Publications
I joined the Discovery Chemistry department at Genentech as a Medicinal Chemist in 2005 after completing my PhD in organic chemistry at MIT. I now lead interdisciplinary teams focused on the discovery of new drugs to extend and improve people’s lives.
Featured Publication
Discovery of Clinical Development Candidate GDC-0084, a Brain Penetrant Inhibitor of PI3K and mTOR.
ACS Med Chem Lett. 2016 Feb 16;7(4):351-6.
Heffron TP, Ndubaku CO, Salphati L, Alicke B, Cheong J, Drobnick J, Edgar K, Gould SE, Lee LB, Lesnick JD, Lewis C, Nonomiya J, Pang J, Plise EG, Sideris S, Wallin J, Wang L, Zhang X, Olivero AG.
My Focus
As a chemist, my work can focus on designing drugs directed to whatever target is most compelling from a biological point of view without being confined to a particular therapeutic area. In my time at Genentech I have contributed to programs directed toward the discovery of new therapeutics for oncology (including cancer immunotherapy), neuro-oncology, neurology, and ophthalmology indications. Each program brings unique scientific challenges and a need to innovate to discover new medicines.
Publications
Hematopoietic Progenitor Kinase-1 Structure in a Domain-Swapped Dimer
Structure,
Ping Wu; Christopher J. Sneeringer; Keith E. Pitts; Eric S. Day; Bryan Chan; Binqing Wei; Isabelle Lehoux; Kyle Mortara; Hong Li; Jiansheng Wu; Yvonne Franke; John Moffat; Jane Grogan; Tim Heffron; Weiru Wang
Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Sarah M. Bronner; Karl A. Merrick; Jeremy Murray; Laurent Salphati; John Moffat; Jodie Pang; Christopher Sneeringer; Nick Dompe; Patrick Cyr; Hans Purkey; Gladys de Leon Boenig; Jun Li; Aleksandr Kolesnikov; Larouche-Gauthier; Kwong Wah Lai; Xiaoli Shen; Samuel Aubert-Nicol; Yi-Chen Chen; Jonathan Cheong; James Crawford; Marc Hafner; Pouyan Haghshenas; Araz Jakalian; Jean-Philippe Leclerc; Ngiap-Kie Lim; Thomas O'Brien; Emile Plise; Shalan; Claudio Sturino; John Wai; Yang Xiao; Peter Yin; Zhao; Stephen Gould; Alan Olivero; Tim Heffron
ACS Symposium Series, ISSN: 19475918 00976156
Remy Angelaud; Steven Staben; Tim Heffron; Andreas M. Schuster; Frederic St-Jean
Neuro-Oncology, ISSN: 15235866 15228517
Tim Heffron
Drug Metabolism and Disposition, ISSN: 1521009X
Laurent Salphati; Bruno Alicke; Tim Heffron; Sheerin Latham; Merry Nishimura; Cao; Rick Carano; Jonathan Cheong; Joan Greve; Hartmut Koeppen; Shari Lau; Leslie Lee; Michelle Nannini; Jodie Pang; Emile Plise; Cristine Quiason; Linda Rangell; Xiaolin Zhang; Stephen Gould; Heidi Phillips; Alan Olivero
Journal of Medicinal Chemistry, ISSN: 15204804
Bryan Chan; Emily Hanan; Krista Bowman; Callie Bryan; Dan Burdick; Emily Chan; Yuan Chen; Saundra Clausen; Trisha Dela Vega; Jenna Dotson; Charles Eigenbrot; Richard Elliott; Robert Heald; Philip Jackson; Jamie D. Knight; Hank La; Michael Lainchbury; Shiva Malek; Hans Purkey; Gabriele Schaefer; Steve Schmidt; Eileen M. Seward; Steve Sideris; Lily Shao; Shumei Wang; Siew Kuen Yeap; Ivana Yen; Christine Yu; Tim Heffron
ACS Medicinal Chemistry Letters, ISSN: 19485875
Tim Heffron; Chudi Ndubaku; Laurent Salphati; Bruno Alicke; Jonathan Cheong; Joy Drobnick; Kyle Edgar; Stephen Gould; Leslie Lee; John Lesnick; Cris Lewis; Jim Nonomiya; Jodie Pang; Emile Plise; Steve Sideris; Jeffrey Wallin; Lan Wang; Xiaolin Zhang; Alan Olivero
Journal of Medicinal Chemistry, ISSN: 15204804
Tim Heffron; Robert Heald; Chudi Ndubaku; Binqing Wei; Martin Augistin; Steven Do; Kyle Edgar; Charles Eigenbrot; Lori Friedman; Emanuela Gancia; Philip Jackson; Graham Jones; Aleksandr Kolesnikov; Leslie B. Lee; John Lesnick; Cris Lewis; Neville J. McLean; Mario Mörtl; Jim Nonomiya; Jodie Pang; Steve Price; Wei Wei Prior; Laurent Salphati; Steve Sideris; Steven Staben; Stefan Steinbacher; Vickie Tsui; Jeffrey Wallin; Deepak Sampath; Alan Olivero
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405
Emily Hanan; Matt Baumgardner; Callie Bryan; Yuan Chen; Charles Eigenbrot; Peter Fan; Xiao-Hui Gu; Hank La; Shiva Malek; Hans Purkey; Gabriele Schaefer; Steve Schmidt; Steve Sideris; Ivana Yen; Christine Yu; Tim Heffron
ACS Medicinal Chemistry Letters, ISSN: 19485875
Callie Bryan; Dan Burdick; Bryan Chan; Yuan Chen; Saundra Clausen; Jenna Dotson; Charles Eigenbrot; Richard Elliott; Emily Hanan; Robert Heald; Philip Jackson; Hank La; Michael Lainchbury; Shiva Malek; Sam E. Mann; Hans Purkey; Gabriele Schaefer; Steve Schmidt; Eileen Seward; Steve Sideris; Shumei Wang; Ivana Yen; Christine Yu; Tim Heffron
ACS Symposium Series, ISSN: 19475918
Tim Heffron; Andrew McClory; Andy Stumpf
Journal of Medicinal Chemistry, ISSN: 15204804
Robert Heald; Krista Bowman; Callie Bryan; Dan Burdick; Bryan Chan; Emily Chan; Yuan Chen; Saundra Clausen; Belen Dominguez-Fernandez; Charles Eigenbrot; Richard Elliott; Emily Hanan; Philip Jackson; Jamie Knight; Hank La; Michael Lainchbury; Shiva Malek; Sam E. Mann; Mark Merchant; Kyle Mortara; Hans Purkey; Gabriele Schaefer; Stephen Schmidt; Eileen Seward; Steve Sideris; Lily Shao; Shumei Wang; Kuen Yeap; Ivana Yen; Christine Yu; Tim Heffron
Journal of Computer-Aided Molecular Design, ISSN: 15734951
Ignacio Aliagas; Alberto Gobbi; Tim Heffron; Man Ling Lee; Dan Ortwine; Mark Zak; Cyrus Khojasteh
Neuro-Oncology, ISSN: 15235866
Victor A. Levin; Peter J. Tonge; James M. Gallo; Marc R. Birtwistle; Arvin C. Dar; Antonio Iavarone; Patrick J. Paddison; Tim Heffron; William F. Elmquist; Jean E. Lachowicz; Ted W. Johnson; Forest M. White; Joohee Sul; Smith; Wang Shen; Jann N. Sarkaria; Ramakrishna Samala; Patrick Y. Wen; Donald A. Berry; Russell C. Petter
Journal of Medicinal Chemistry, ISSN: 15204804
Emily Hanan; Charles Eigenbrot; Callie Bryan; Dan Burdick; Bryan Chan; Yuan Chen; Jenna Dotson; Robert Heald; Philip Jackson; Hank La; Michael Lainchbury; Shiva Malek; Hans Purkey; Gabriele Schaefer; Steve Schmidt; Eileen M. Seward; Steve Sideris; Christine Tam; Shumei Wang; Siew Kuen Yeap; Ivana Yen; Peter Yin; Christine Yu; Inna Zilberleyb; Tim Heffron
Journal of Medicinal Chemistry, ISSN: 15204804
Tony Estrada; Bryan Chan; Charles Baker-Glenn; Alan Beresford; Dan Burdick; Mark Chambers; Huifen Chen; Sara Dominguez; Jenna Dotson; Jake Drummond; Mike Flagella; Reina Fuji; Andrew Gill; Jason Halladay; Seth Harris; Tim Heffron; Tracy Kleinheinz; Donna Lee; Claire Le Pichon; Xingrong Liu; Joe Lyssikatos; Andrew D. Medhurst; John Moffat; Kevin Nash; Kimberly Scearce-Levie; Zejuan Sheng; Daniel Shore; Susan Wong; Shuo Zhang; Xiaolin Zhang; Haitao Zhu; Zach Sweeney
Molecular Pharmaceutics, ISSN: 15438384
Gillian S. Smelick; Tim Heffron; Laura Chu; Brian Dean; David West; Scott L. Duvall; Bert Lum; Nageshwar Budha; Scott Holden; Leslie Z. Benet; Adam Frymoyer; Mark Dresser; Joseph Ware
Journal of Medicinal Chemistry, ISSN: 00222623
Chudi Ndubaku; Tim Heffron; Steven Staben; Matt Baumgardner; Nicole Blaquiere; Erin Bradley; Richard J. Bull; Steven Do; Jenna Dotson; Danette Dudley; Kyle Edgar; Lori Friedman; Rich Goldsmith; Robert Heald; Aleksandr Kolesnikov; Leslie Lee; Cris Lewis; Michelle Nannini; Jim Nonomiya; Jodie Pang; Steve Price; Wei Wei Prior; Laurent Salphati; Steve Sideris; Jeffrey Wallin; Lan Wang; Binqing Wei; Deepak Sampath; Alan Olivero
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Steven Staben; Chudi Ndubaku; Nicole Blaquiere; Marcia Belvin; Richard J. Bull; Danette Dudley; Kyle Edgar; Daniel Gray; Robert Heald; Tim Heffron; Graham E. Jones; Mark Jones; Aleksandr Kolesnikov; Leslie Lee; John Lesnick; Cris Lewis; Jeremy Murray; Neville J. McLean; Jim Nonomiya; Alan Olivero; Rachel Ord; Jodie Pang; Stephen Price; Wei Wei Prior; Lionel Rouge; Laurent Salphati; Deepak Sampath; Jeffrey Wallin; Lan Wang; Binqing Wei; Christian Weismann; Ping Wu
Cancer Discovery, ISSN: 21598274
Ho-June Lee; Gabriele Schaefer; Tim Heffron; Lily Shao; Xiaofen Ye; Steve Sideris; Shiva Malek; Emily Chan; Mark Merchant; Hank La; Savita Ubhayakar; Bob Yauch; Valentina Pirazzoli; Katerina Politi; Jeffrey Settleman
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Steven Staben; Nicole Blaquiere; Vickie Tsui; Aleksandr Kolesnikov; Steven Do; Erin Bradley; Jenna Dotson; Rich Goldsmith; Tim Heffron; John Lesnick; Cris Lewis; Jeremy Murray; Jim Nonomiya; Alan Olivero; Jodie Pang; Lionel Rouge; Laurent Salphati; Binqing Wei; Christian Wiesmann; Ping Wu
Journal of Medicinal Chemistry, ISSN: 00222623
Tony Estrada; Xingrong Liu; Charles Baker-Glenn; Alan Beresford; Dan Burdick; Mark Chambers; Bryan Chan; Huifen Chen; Xiao Ding; Antonio DiPasquale; Sara Dominguez; Jenna Dotson; Jake Drummond; Mike Flagella; Sean Flynn; Reina Fuji; Andrew Gill; Janet Gunzner-Toste; Seth Harris; Tim Heffron; Tracy Kleinheinz; Donna Lee; Claire Le Pichon; Joe Lyssikatos; Andrew D. Medhurst; John Moffat; Susmith Mukund; Kevin Nash; Kimberly Scearce-Levie; Zejuan Sheng; Daniel Shore; Thuy Tran; Naimisha Trivedi; Shumei Wang; Shuo Zhang; Xiaolin Zhang; Guiling Zhao; Haitao Zhu; Zach Sweeney
Clinical Cancer Research, ISSN: 10780432
Laurent Salphati; Tim Heffron; Bruno Alicke; Merry Nishimura; Kai Barck; Rick Carano; Jonathan Cheong; Kyle Edgar; Joan Greve; Samir Kharbanda; Hartmut Koeppen; Shari Lau; Leslie Lee; Jodie Pang; Emile Plise; Jenny L. Pokorny; Hani Bou-Reslan; Jann N. Sarkaria; Jeffrey Wallin; Xiaolin Zhang; Stephen Gould; Alan Olivero; Heidi Phillips
Journal of Medicinal Chemistry, ISSN: 00222623
Tim Heffron; Laurent Salphati; Bruno Alicke; Jonathan Cheong; Jenna Dotson; Kyle Edgar; Rich Goldsmith; Stephen Gould; Leslie Lee; John Lesnick; Cris Lewis; Chudi Ndubaku; Jim Nonomiya; Alan Olivero; Jodie Pang; Emile Plise; Steve Sideris; Sean Trapp; Jeffrey Wallin; Lan Wang; Xiaolin Zhang
Journal of Chemical Information and Modeling, ISSN: 15205142
Man Ling Lee; Ignacio Aliagas; Jenna Dotson; JW Feng; Alberto Gobbi; Tim Heffron
Journal of Medicinal Chemistry, ISSN: 00222623
Tim Heffron; Binqing Wei; Alan Olivero; Steven Staben; Vickie Tsui; Steven Do; Jenna Dotson; Adrian J. Folkes; Paul Goldsmith; Rich Goldsmith; Janet Gunzner-Toste; John Lesnick; Cris Lewis; Simon Mathieu; Jim Nonomiya; Stephen Shuttleworth; Dan Sutherlin; Nan Chi Wan; Shumei Wang; Christian Wiesmann; Bing-Yan Zhu
Journal of Medicinal Chemistry, ISSN: 00222623
Dan Sutherlin; Linda Bao; Megan Berry Swadell; Georgette Castanedo; Irina Chuckowree; Jenna Dotson; Adrian Folks; Lori Friedman; Rich Goldsmith; Janet Gunzner-Toste; Tim Heffron; John Lesnick; Cris Lewis; Simon Mathieu; Jeremy Murray; Jim Nonomiya; Jodie Pang; Neil Pegg; Wei Wei Prior; Lionel Rouge; Laurent Salphati; Deepak Sampath; Qingping Tian; Vickie Tsui; Nan Chi Wan; Shumei Wang; Binqing Wei; Christian Wiesmann; Ping Wu; Bing-Yan Zhu; Alan Olivero
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Steven Staben; Mike Siu; Rich Goldsmith; Alan Olivero; Steven Do; Dan Burdick; Tim Heffron; Jenna Dotson; Dan Sutherlin; Bing-Yan Zhu; Vickie Tsui; Hoa Le; Leslie Lee; John Lesnick; Cris Lewis; Jeremy Murray; Jim Nonomiya; Jodie Pang; Wei Wei Prior; Laurent Salphati; Lionel Rouge; Deepak Sampath; Steve Sideris; Christian Wiesmann; Ping Wu
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Steven Staben; Tim Heffron; Dan Sutherlin; Seema Bhat; Georgette Castanedo; Irina Chuckowree; Jenna Dotson; Adrian J. Folkes; Lori Friedman; Leslie Lee; John Lesnick; Cris Lewis; Jeremy Murray; Jim Nonomiya; Alan Olivero; Emile Plise; Jodie Pang; Wei Wei Prior; Laurent Salphati; Lionel Rouge; Deepak Sampath; Vickie Tsui; Nan Chi Wan; Shumei Wang; Christian Weismann; Ping Wu; Bing-Yan Zhu
Journal of Organic Chemistry, ISSN: 00223263
Tim Heffron; Graham L. Simpson; Estibaliz Merino; Timothy F. Jamison
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Tim Heffron; Megan Berry Swadell; Georgette Castanedo; Christine Chang; Irina Chuckowree; Jenna Dotson; Adrian J. Folkes; Janet Gunzner-Toste; John Lesnick; Cris Lewis; Simon Mathieu; Jim Nonomiya; Alan Olivero; Jodie Pang; David Peterson; Laurent Salphati; Deepak Sampath; Steve Sideris; Dan Sutherlin; Vickie Tsui; Nan Chi Wan; Shumei Wang; Susan Wong; Bing-Yan Zhu
Journal of Medicinal Chemistry, ISSN: 00222623
Dan Sutherlin; Deepak Sampath; Megan Berry Swadell; Georgette Castanedo; Zhigang Chang; Irina Chuckowree; Jenna Dotson; Adrian J. Folkes; Lori Friedman; Rich Goldsmith; Tim Heffron; Leslie Lee; John Lesnick; Cris Lewis; Simon Mathieu; Jim Nonomiya; Alan Olivero; Jodie Pang; Wei Wei Prior; Laurent Salphati; Steve Sideris; Qingping Tian; Vickie Tsui; Nan Chi Wan; Shumei Wang; Christian Wiesmann; Susan Wong; Bing-Yan Zhu
Synlett, ISSN: 09365214
Tim Heffron; Timothy F. Jamison
Education
- Massachusetts Institute of Technology, Organic Chemistry, Ph. D. – 2005
- Yale University, Chemistry, B.S. – 2000