Tim Heffron
Senior Director and Senior Principal Scientist, Discovery Chemistry
"Each day we work to extend and improve lives."
17
Years at Genentech
36
Publications at Genentech
I joined the Discovery Chemistry department at Genentech as a Medicinal Chemist in 2005 after completing my PhD in organic chemistry at MIT. I now lead interdisciplinary teams focused on the discovery of new drugs to extend and improve people’s lives.
Featured Publication
Discovery of Clinical Development Candidate GDC-0084, a Brain Penetrant Inhibitor of PI3K and mTOR.
ACS Med Chem Lett. 2016 Feb 16;7(4):351-6.
Heffron TP, Ndubaku CO, Salphati L, Alicke B, Cheong J, Drobnick J, Edgar K, Gould SE, Lee LB, Lesnick JD, Lewis C, Nonomiya J, Pang J, Plise EG, Sideris S, Wallin J, Wang L, Zhang X, Olivero AG.
My Focus
As a chemist, my work can focus on designing drugs directed to whatever target is most compelling from a biological point of view without being confined to a particular therapeutic area. In my time at Genentech I have contributed to programs directed toward the discovery of new therapeutics for oncology (including cancer immunotherapy), neuro-oncology, neurology, and ophthalmology indications. Each program brings unique scientific challenges and a need to innovate to discover new medicines.
Genentech Publications
ACS Medicinal Chemistry Letters, ISSN: 19485875
Bryan K. Chan; Eileen Seward; Michael Lainchbury; Thomas F. Brewer; Le An; Toby Blench; Matthew W. Cartwright; Grace Chan; Edna F. Choo; Jason H. Drummond; Richard Elliott; Emanuela Gancia; Lewis Gazzard; Baihua Hu; Graham Jones; Xifeng Luo; Andrew Madin; Sushant Malhotra; John Moffat; Jodie Pang; Laurent Salphati; Chris J. Sneeringer; Craig E. Stivala; Binqing Wei; Weiru Wang; Ping Wu; Timothy P. Heffron
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Xingrong Liu; Xiaorong Liang; Jennifer Lecouter; Savita Ubhayakar; Jacob Z. Chen; Jay Cheng; Tom Lee; Joseph W. Lubach; Jim Nonomiya; Sheerin Shahidi-Latham; Cristine Quiason; Eric G. Solon; Matthew Wright; Cornelis E. Hop; Timothy P. Heffron
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Sarah M. Bronner; Karl A. Merrick; Jeremy Murray; Laurent Salphati; John Moffat; Jodie Pang; Chris J. Sneeringer; Nicholas A. Dompe; Patrick Cyr; Hans E. Purkey; Gladys de Leon Boenig; Jun Li; Aleksandr Kolesnikov; Larouche-Gauthier; Kwong Wah Lai; Xiaoli Shen; Samuel Aubert-Nicol; Yi-Chen Chen; Jonathan Cheong; James J. Crawford; Marc Hafner; Pouyan Haghshenas; Araz Jakalian; Jean-Philippe Leclerc; Ngiap-Kie Lim; Thomas O'Brien; Emile G. Plise; Shalan; Claudio Sturino; John Wai; Yang Xiao; Jianping Yin; Zhao; Stephen Gould; Alan G. Olivero; Timothy P. Heffron
Structure, ISSN: 18784186 09692126
Ping Wu; Chris J. Sneeringer; Keith Pitts; Eric S. Day; Bryan K. Chan; Binqing Wei; Isabelle Lehoux; Kyle Mortara; Hong Li; Jiansheng Wu; Yvonne Franke; John Moffat; Jane L. Grogan; Timothy P. Heffron; Weiru Wang
ACS Symposium Series, ISSN: 19475918 00976156
Remy Angelaud; Steven T. Staben; Timothy P. Heffron; Andreas M. Schuster; Frederic St-Jean
Neuro-Oncology, ISSN: 15235866 15228517
Timothy P. Heffron
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Laurent Salphati; Bruno Alicke; Timothy P. Heffron; Sheerin Shahidi-Latham; Merry C. Nishimura; Tim C. Cao; Richard A. D. Carano; Jonathan Cheong; Joan M. Greve; Koeppen; Shari Lau; Leslie Lee; Michelle Nannini; Jodie Pang; Emile G. Plise; Cristine Quiason; Linda Rangell; Xiaolin Zhang; Stephen Gould; Phillips; Alan G. Olivero
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Timothy P. Heffron
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Bryan K. Chan; Emily J. Hanan; Krista K. Bowman; Marian C. Bryan; Burdick; Emily Chan; Yuan Chen; Saundra Clausen; Trisha Dela Vega; Jennafer Dotson; Eigenbrot; Richard Elliott; Robert Heald; Philip Jackson; Jamie Knight; Hank La; Michael Lainchbury; Shiva Malek; Hans E. Purkey; Gabriele Schaefer; Stephen Schmidt; Eileen Seward; Steve Sideris; Lily Shao; Shumei Wang; Siew Kuen Yeap; Ivana Yen; Christine Yu; Timothy P. Heffron
ACS Medicinal Chemistry Letters, ISSN: 19485875
Timothy P. Heffron; Chudi O. Ndubaku; Laurent Salphati; Bruno Alicke; Jonathan Cheong; Joy Drobnick; Kyle A. Edgar; Stephen Gould; Leslie Lee; John Lesnick; Lewis; Jim Nonomiya; Jodie Pang; Emile G. Plise; Steve Sideris; Jeffery J. Wallin; Lan Wang; Xiaolin Zhang; Alan G. Olivero
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Timothy P. Heffron; Robert Heald; Chudi O. Ndubaku; Binqing Wei; Martin Augistin; Steven Do; Kyle A. Edgar; Eigenbrot; Lori S. Friedman; Emanuela Gancia; Philip Jackson; Graham Jones; Aleksandr Kolesnikov; Leslie Lee; John Lesnick; Lewis; Neville J. McLean; Mario Mörtl; Jim Nonomiya; Jodie Pang; Steve Price; Wei Wei Prior; Laurent Salphati; Steve Sideris; Steven T. Staben; Stefan Steinbacher; Vickie Tsui; Jeffery J. Wallin; Deepak Sampath; Alan G. Olivero
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Emily J. Hanan; Matthew Baumgardner; Marian C. Bryan; Yuan Chen; Eigenbrot; Peter W. Fan; Xiao-Hui Gu; Hank La; Shiva Malek; Hans E. Purkey; Gabriele Schaefer; Stephen Schmidt; Steve Sideris; Ivana Yen; Christine Yu; Timothy P. Heffron
ACS Medicinal Chemistry Letters, ISSN: 19485875
Marian C. Bryan; Burdick; Bryan K. Chan; Yuan Chen; Saundra Clausen; Jennafer Dotson; Eigenbrot; Richard Elliott; Emily J. Hanan; Robert Heald; Philip Jackson; Hank La; Michael Lainchbury; Shiva Malek; Sam E. Mann; Hans E. Purkey; Gabriele Schaefer; Stephen Schmidt; Eileen Seward; Steve Sideris; Shumei Wang; Ivana Yen; Christine Yu; Timothy P. Heffron
ACS Symposium Series, ISSN: 19475918 00976156
Timothy P. Heffron; Andrew McClory; Andreas Stumpf
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Robert Heald; Krista K. Bowman; Marian C. Bryan; Burdick; Bryan K. Chan; Emily Chan; Yuan Chen; Saundra Clausen; Belen Dominguez-Fernandez; Eigenbrot; Richard Elliott; Emily J. Hanan; Philip Jackson; Jamie Knight; Hank La; Michael Lainchbury; Shiva Malek; Sam E. Mann; Mark Merchant; Kyle Mortara; Hans E. Purkey; Gabriele Schaefer; Stephen Schmidt; Eileen Seward; Steve Sideris; Lily Shao; Shumei Wang; Kuen Yeap; Ivana Yen; Christine Yu; Timothy P. Heffron
Neuro-Oncology, ISSN: 15235866 15228517
Victor A. Levin; Peter J. Tonge; James M. Gallo; Marc R. Birtwistle; Arvin C. Dar; Antonio Iavarone; Patrick J. Paddison; Timothy P. Heffron; William F. Elmquist; Jean E. Lachowicz; Ted W. Johnson; Forest M. White; Joohee Sul; Smith; Wang Shen; Jann N. Sarkaria; Ramakrishna Samala; Patrick Y. Wen; Donald A. Berry; Russell C. Petter
Journal of Computer-Aided Molecular Design, ISSN: 15734951 0920654X
Ignacio Aliagas; Alberto Gobbi; Timothy P. Heffron; Man-Ling Lee; Daniel F. Ortwine; Mark Zak; S. Cyrus Khojasteh
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Emily J. Hanan; Eigenbrot; Marian C. Bryan; Burdick; Bryan K. Chan; Yuan Chen; Jennafer Dotson; Robert Heald; Philip Jackson; Hank La; Michael Lainchbury; Shiva Malek; Hans E. Purkey; Gabriele Schaefer; Stephen Schmidt; Eileen Seward; Steve Sideris; Christine Tam; Shumei Wang; Siew Kuen Yeap; Ivana Yen; Jianping Yin; Christine Yu; Inna Zilberleyb; Timothy P. Heffron
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Anthony A. Estrada; Bryan K. Chan; Charles Baker-Glenn; Alan Beresford; Burdick; Mark Chambers; Huifen Chen; Sara L. Dominguez; Jennafer Dotson; Jason H. Drummond; Michael Flagella; Reina N. Fuji; Andrew Gill; Jason S Halladay; Seth F. Harris; Timothy P. Heffron; Tracy L. Kleinheinz; Donna W. Lee; Claire E. Le Pichon; Xingrong Liu; Joseph P. Lyssikatos; Andrew D. Medhurst; John Moffat; Kevin Nash; Kimberly Scearce-Levie; Zejuan Sheng; Daniel G. Shore; Susan C. Wong; Shuo Zhang; Xiaolin Zhang; Haitao Zhu; Zachary K. Sweeney
Molecular Pharmaceutics, ISSN: 15438384 15438392
Gillian S. Smelick; Timothy P. Heffron; Laura Chu; Brian J. Dean; David A. West; Scott L. Duvall; Bert L. Lum; Nageshwar Budha; Scott N. Holden; Leslie Z. Benet; Adam Frymoyer; Mark J. Dresser; Joseph A. Ware
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Chudi O. Ndubaku; Timothy P. Heffron; Steven T. Staben; Matthew Baumgardner; Nicole Blaquiere; Erin K. Bradley; Richard J. Bull; Steven Do; Jennafer Dotson; Danette Dudley; Kyle A. Edgar; Lori S. Friedman; Richard Goldsmith; Robert Heald; Aleksandr Kolesnikov; Leslie Lee; Lewis; Michelle Nannini; Jim Nonomiya; Jodie Pang; Steve Price; Wei Wei Prior; Laurent Salphati; Steve Sideris; Jeffery J. Wallin; Lan Wang; Binqing Wei; Deepak Sampath; Alan G. Olivero
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Steven T. Staben; Chudi O. Ndubaku; Nicole Blaquiere; Marcia Belvin; Richard J. Bull; Danette Dudley; Kyle A. Edgar; Daniel C. Gray; Robert Heald; Timothy P. Heffron; Graham Jones; Mark Jones; Aleksandr Kolesnikov; Leslie Lee; John Lesnick; Lewis; Jeremy Murray; Neville J. McLean; Jim Nonomiya; Alan G. Olivero; Rachel Ord; Jodie Pang; Stephen Price; Wei Wei Prior; Lionel Rouge; Laurent Salphati; Deepak Sampath; Jeffery J. Wallin; Lan Wang; Binqing Wei; Christian Weismann; Ping Wu
Cancer Discovery, ISSN: 21598274 21598290
Ho-June Lee; Gabriele Schaefer; Timothy P. Heffron; Lily Shao; Ye; Steve Sideris; Shiva Malek; Emily Chan; Mark Merchant; Hank La; Savita Ubhayakar; Robert Yauch; Valentina Pirazzoli; Katerina Politi; Jeffrey Settleman
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Steven T. Staben; Nicole Blaquiere; Vickie Tsui; Aleksandr Kolesnikov; Steven Do; Erin K. Bradley; Jennafer Dotson; Richard Goldsmith; Timothy P. Heffron; John Lesnick; Lewis; Jeremy Murray; Jim Nonomiya; Alan G. Olivero; Jodie Pang; Lionel Rouge; Laurent Salphati; Binqing Wei; Wiesmann; Ping Wu
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Anthony A. Estrada; Xingrong Liu; Charles Baker-Glenn; Alan Beresford; Burdick; Mark Chambers; Bryan K. Chan; Huifen Chen; Xiao Ding; Antonio G. DiPasquale; Sara L. Dominguez; Jennafer Dotson; Jason H. Drummond; Michael Flagella; Sean Flynn; Reina N. Fuji; Andrew Gill; Janet Gunzner; Seth F. Harris; Timothy P. Heffron; Tracy L. Kleinheinz; Donna W. Lee; Claire E. Le Pichon; Joseph P. Lyssikatos; Andrew D. Medhurst; John Moffat; Susmith Mukund; Kevin Nash; Kimberly Scearce-Levie; Zejuan Sheng; Daniel G. Shore; Thuy Tran; Naimisha Trivedi; Shumei Wang; Shuo Zhang; Xiaolin Zhang; Guiling Zhao; Haitao Zhu; Zachary K. Sweeney
Clinical Cancer Research, ISSN: 10780432 15573265
Laurent Salphati; Timothy P. Heffron; Bruno Alicke; Merry C. Nishimura; Kai H. Barck; Richard A. D. Carano; Jonathan Cheong; Kyle A. Edgar; Joan M. Greve; Samir Kharbanda; Koeppen; Shari Lau; Leslie Lee; Jodie Pang; Emile G. Plise; Jenny L. Pokorny; Hani Bou-Reslan; Jann N. Sarkaria; Jeffery J. Wallin; Xiaolin Zhang; Stephen Gould; Alan G. Olivero; Phillips
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Timothy P. Heffron; Laurent Salphati; Bruno Alicke; Jonathan Cheong; Jennafer Dotson; Kyle A. Edgar; Richard Goldsmith; Stephen Gould; Leslie Lee; John Lesnick; Lewis; Chudi O. Ndubaku; Jim Nonomiya; Alan G. Olivero; Jodie Pang; Emile G. Plise; Steve Sideris; Sean Trapp; Jeffery J. Wallin; Lan Wang; Xiaolin Zhang
Journal of Chemical Information and Modeling, ISSN: 15205142 15499596
Man-Ling Lee; Ignacio Aliagas; Jennafer Dotson; Jianwen A. Feng; Alberto Gobbi; Timothy P. Heffron
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Timothy P. Heffron; Binqing Wei; Alan G. Olivero; Steven T. Staben; Vickie Tsui; Steven Do; Jennafer Dotson; Adrian J. Folkes; Paul Goldsmith; Richard Goldsmith; Janet Gunzner; John Lesnick; Lewis; Simon Mathieu; Jim Nonomiya; Stephen Shuttleworth; Daniel P. Sutherlin; Nan Chi Wan; Shumei Wang; Wiesmann; Bing-Yan Zhu
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Daniel P. Sutherlin; Linda Bao; Megan Berry; Georgette M. Castanedo; Irina Chuckowree; Jennafer Dotson; Adrian Folks; Lori S. Friedman; Richard Goldsmith; Janet Gunzner; Timothy P. Heffron; John Lesnick; Lewis; Simon Mathieu; Jeremy Murray; Jim Nonomiya; Jodie Pang; Neil Pegg; Wei Wei Prior; Lionel Rouge; Laurent Salphati; Deepak Sampath; Qingping Tian; Vickie Tsui; Nan Chi Wan; Shumei Wang; Binqing Wei; Wiesmann; Ping Wu; Bing-Yan Zhu; Alan G. Olivero
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405
Steven T. Staben; Michael Siu; Richard Goldsmith; Alan G. Olivero; Steven Do; Burdick; Timothy P. Heffron; Jennafer Dotson; Daniel P. Sutherlin; Bing-Yan Zhu; Vickie Tsui; Hoa Le; Leslie Lee; John Lesnick; Lewis; Jeremy Murray; Jim Nonomiya; Jodie Pang; Wei Wei Prior; Laurent Salphati; Lionel Rouge; Deepak Sampath; Steve Sideris; Wiesmann; Ping Wu
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Steven T. Staben; Timothy P. Heffron; Daniel P. Sutherlin; Seema R. Bhat; Georgette M. Castanedo; Irina Chuckowree; Jennafer Dotson; Adrian J. Folkes; Lori S. Friedman; Leslie Lee; John Lesnick; Lewis; Jeremy Murray; Jim Nonomiya; Alan G. Olivero; Emile G. Plise; Jodie Pang; Wei Wei Prior; Laurent Salphati; Lionel Rouge; Deepak Sampath; Vickie Tsui; Nan Chi Wan; Shumei Wang; Christian Weismann; Ping Wu; Bing-Yan Zhu
Journal of Organic Chemistry, ISSN: 00223263 15206904
Timothy P. Heffron; Graham L. Simpson; Estibaliz Merino; Timothy F. Jamison
Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X
Timothy P. Heffron; Megan Berry; Georgette M. Castanedo; Christine Chang; Irina Chuckowree; Jennafer Dotson; Adrian J. Folkes; Janet Gunzner; John Lesnick; Lewis; Simon Mathieu; Jim Nonomiya; Alan G. Olivero; Jodie Pang; David Peterson; Laurent Salphati; Deepak Sampath; Steve Sideris; Daniel P. Sutherlin; Vickie Tsui; Nan Chi Wan; Shumei Wang; Susan C. Wong; Bing-Yan Zhu
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Daniel P. Sutherlin; Deepak Sampath; Megan Berry; Georgette M. Castanedo; Zhigang Chang; Irina Chuckowree; Jennafer Dotson; Adrian J. Folkes; Lori S. Friedman; Richard Goldsmith; Timothy P. Heffron; Leslie Lee; John Lesnick; Lewis; Simon Mathieu; Jim Nonomiya; Alan G. Olivero; Jodie Pang; Wei Wei Prior; Laurent Salphati; Steve Sideris; Qingping Tian; Vickie Tsui; Nan Chi Wan; Shumei Wang; Wiesmann; Susan C. Wong; Bing-Yan Zhu
Synlett, ISSN: 09365214
Timothy P. Heffron; Timothy F. Jamison
Education
- Massachusetts Institute of Technology, Organic Chemistry, Ph. D. – 2005
- Yale University, Chemistry, B.S. – 2000