Tim Wilson
Senior Scientist, Oncology Biomarker Development
"It is very exciting to be a contributor to cross-functional, multifaceted teams with the same goal in mind – to bring the best anti-cancer medicines to patients that need them the most."
11
Years at Genentech
31
Publications
I joined the Oncology Biomarker Development group at Genentech in 2011, following my postdoctoral research at Massachusetts General Hospital / Harvard Medical School. I was attracted to Genentech as I had a passion to translate pre-clinical research into therapies for biomarker-defined patient populations.
Predictive biomarkers are critical to the vision of precision medicine. My role at Genentech is to develop and test biomarker hypotheses to enable clinical development of experimental medicines in the most appropriate patient populations.
Featured Publication
The Molecular Landscape of High-Risk Early Breast Cancer: Comprehensive Biomarker Analysis of a Phase III Adjuvant Population
npj Breast Cancer 2, Article number: 16022 (2016), doi:10.1038/npjbcancer.2016.22
Timothy R. Wilson, Jianjun Yu, Xuyang Lu, Jill M. Spoerke, Yuanyuan Xiao, Carol O’Brien, Heidi Savage, Ling-Yuh Huw, Wei Zou, Hartmut Koeppen, William F. Forrest, Jane Fridlyand, Ling Fu, Rachel Tam, Erica B. Schleifman, Teiko Sumiyoshi, Luciana Molinero, Garret M. Hampton, Joyce A. O’Shaughnessy and Mark R. Lackner
My Focus
My group focuses on two main areas: (1) to develop and implement robust biomarker strategies that enable clinical development of experimental therapeutics; and (2) to decipher the biomarker landscape of breast cancer to study biomarker prevalence and overlap, as well as to determine any prognostic implications associated with key patient subsets.
Publications
Updated Integrated Analysis of the Efficacy and Safety of Entrectinib in Locally Advanced or Metastatic ROS1 Fusion-Positive Non-Small-Cell Lung Cancer
Journal of Clinical Oncology,
Rafal Dziadziuszko; Matthew G Krebs; Filippo De Braud; Siena; Alexander Drilon; Robert C Doebele; Manish R. Patel; Byoung Chul Cho; Stephen V. Liu; Ahn; Chao-Hua Chiu; Anna F Farago; Chia-Chi Lin; Karapetis; Yu-Chung Li; Bann-Mo Day; David Chen; Tim Wilson; Fabrice Barlesi
Phase I basket study of taselisib, an isoform-selective PI3K inhibitor, in patients with PIK3CA-mutant cancers
Clinical Cancer Research, ISSN: 10780432
Komal Jhaveri; Matthew T. Chang; Dejan Juric; Saura; Valentina Gambardella; Anton Melnyk; Manish R. Patel; Vincent Ribrag; Cynthia X. Ma; Raid Aljumaily; Philippe L. Bedard; Jasgit C. Sachdev; Lara Dunn; Helen Won; John Bond; Surai Jones; Heidi Savage; Maurizio Scaltriti; Tim Wilson; Michael C. Wei; David M. Hyman
Clinical Cancer Research, ISSN: 15573265 10780432
Patrick Y. Wen; Timothy Cloughesy; Alan Olivero; Kari M. Morrissey; Tim Wilson; Xuyang Lu; Lars Mueller; Alexandre F. Coimbra; Benjamin M. Ellingson; Elizabeth Gerstner; Eudocia Q. Lee; Jordi Rodon
Entrectinib in patients with advanced or metastatic NTRK fusion-positive solid tumours: integrated analysis of three phase 1–2 trials
The Lancet Oncology, ISSN: 14702045
Robert C Doebele; Alexander Drilon; Luis Paz-Ares; Siena; Alice T. Shaw; Anna F Farago; Collin M Blakely; Takashi Seto; Byung Chul Cho; Diego Tosi; Benjamin Besse; Sant P Chawla; Lyudmila Bazhenova; John C Krauss; Young K Chae; Minal Barve; Ignacio Garrido-Laguna; Stephen V. Liu; Paul Conkling; Thomas John; Marwan Fakih; Darren Sigal; Herbert H Loong; Gary L Buchschacher; Pilar Garrido; Jorge Nieva; Conor Steuer; Tobias R Overbeck; Daniel W. Bowles; Elizabeth Fox; Todd Riehl; Edna Chow-Maneval; Brian Simmons; Na Cui; Ann Johnson; Susan Eng; Tim Wilson; George Demetri
Entrectinib in ROS1 fusion-positive non-small-cell lung cancer: integrated analysis of three phase 1–2 trials
The Lancet Oncology, ISSN: 14702045
Alexander Drilon; Siena; Rafal Dziadziuszko; Fabrice Barlesi; Matthew G Krebs; Alice T. Shaw; Filippo de Braud; Christian Rolfo; Myung-Ju Ahn; Jurgen Wolf; Takashi Seto; Byoung Chul Cho; Manish R. Patel; Chao-Hua Chiu; Tom John; Koichi Goto; Karapetis; Hendrick-Tobias Arkenau; Sang-We Kim; Yuichiro Ohe; Yu-Chung Li; Young K Chae; Christine H Chung; Gregory A Otterson; Haruyasu Murakami; Chia-Chi Lin; Daniel S W Tan; Hans Prenen; Todd Riehl; Edna Chow-Maneval; Brian Simmons; Na Cui; Ann Johnson; Susan Eng; Tim Wilson; Robert C Doebele
Molecular Cancer Therapeutics, ISSN: 15388514 15357163
Heather M. Moore; Heidi Savage; Carol O'Brien; Wei Zhou; Ethan S. Sokol; Michael E. Goldberg; Ciara Metcalfe; Lori Friedman; Mark Lackner; Tim Wilson
Phase III randomized study of taselisib or placebo with fulvestrant in estrogen receptor-positive, PIK3CA-mutant, HER2-negative, advanced breast cancer: the SANDPIPER trial
Annals of Oncology, ISSN: 09237534
Susan Dent; Javier Cortés; Im; Diéras; Nadia Harbeck; Ian E. Krop; Tim Wilson; Na Cui; Frauke Schimmoller; Jerry Hsu; Jing He; De Laurentiis; Sousa; Drullinsky; William Jacot
Science, ISSN: 10959203 00368075
Neil Vasan; Pedram Razavi; Jared L. Johnson; Hong Shao; Hardik Shah; Alesia Antoine; Erik Ladewig; Alexander Gorelick; Ting-Yu Lin; Eneda Toska; Guotai Xu; Abiha Kazmi; Matthew T. Chang; Barry S. Taylor; Maura N. Dickler; Komal Jhaveri; Sarat Chandarlapaty; Raul Rabadan; Ed Reznik; Melissa L. Smith; Robert Sebra; Frauke Schimmoller; Tim Wilson; Lori Friedman; Lewis C. Cantley; Maurizio Scaltriti; Baselga
Genomic alterations associated with recurrence and TNBC subtype in high-risk early breast cancers
Molecular Cancer Research, ISSN: 15417786
Tim Wilson; Akshata R. Udyavar; Ching-Wei Chang; Jill Spoerke; Junko Aimi; Heidi Savage; Anneleen Daemen; O'Shaughnessy; Richard Bourgon; Mark Lackner
The Lancet Oncology, ISSN: 14745488 14702045
Saura; Dominik Hlauschek; Oliveira; Zardavas; Jallitsch-Halper; Lorena de la Peña; Nuciforo; Alberto Ballestrero; Dubsky; Janine M Lombard; Peter Vuylsteke; Carlos A Castaneda; Colleoni; Giuliano Santos Borges; Eva Ciruelos; Monica Fornier; Katalin Boer; Aditya Bardia; Tim Wilson; Thomas J. Stout; Jerry Hsu; Yi Shi; Martine Piccart; Michael Gnant; José Baselga; Evandro de Azambuja
Tumor-Infiltrating Lymphocytes in Patients Receiving Trastuzumab/Pertuzumab-Based Chemotherapy: A TRYPHAENA Substudy
Journal of the National Cancer Institute,
Michail Ignatiadis; Gert G.G.M. Van Den Eynden; Salgado Roberto; Marco Fornili; Yacine Bareche; Christine Desmedt; Rothé; Maetens; David Venet; Esther Holgado; Virginia McNally; Astrid Kiermaier; Heidi Savage; Tim Wilson; Javier Cortes; Andreas Schneeweiss; Karen Willard-Gallo; Elia Biganzoli; Christos Sotiriou
Clinical Cancer Research, ISSN: 15573265 10780432
Maura N. Dickler; Saura; Donald A. Richards; Ian E. Krop; Andrés Cervantes; Philippe L. Bedard; Manish R. Patel; Pusztai; Oliveira; Alison Cardenas; Na Cui; Tim Wilson; Thomas J. Stout; Michael C. Wei; Jerry Hsu; Baselga
Cancer Discovery, ISSN: 21598290
Dejan Juric; Ian E. Krop; Ramesh K. Ramanathan; Tim Wilson; Joseph Ware; Sandra Sanabria; Heidi M. Savage; Deepak Sampath; Laurent Salphati; Ray Lin; Huan Jin; Hema Parmar; Jerry Y. Hsu; Daniel D. Von Hoff; Baselga
npj Breast Cancer, ISSN: 23744677
Tim Wilson; Yu; Xuyang Lu; Jill Spoerke; Yuanyuan Xiao; Carol O’brien; Heidi Savage; Ling-Yuh Huw; Wei Zou; Hartmut Koeppen; Bill Forrest; Jane (Zhenya) Fridlyand; Ling Fu; Nga Wan Rachel Tam; Erica Schleifman; Teiko Sumiyoshi; Luciana Molinero; Garret M. Hampton; Joyce A. O’shaughnessy; Mark Lackner
SANDPIPER: Phase III study of the PI3-kinase (PI3K) inhibitor taselisib (GDC-0032) plus fulvestrant in patients (pts) with oestrogen receptor (ER)-positive, HER2-negative locally advanced or metastatic breast cancer (BC) enriched for pts with PIK3CA-mutant tumours
Annals of Oncology, ISSN: 09237534
Baselga; Cortes Castan; De Laurentiis; Diéras; Nadia Harbeck; Jerry Hsu; Huan Jin; Frauke Schimmoller; Tim Wilson; Im; William Jacot; Ian E. Krop; Sunil Verma
Annals of Oncology, ISSN: 15698041
Fumagalli; Tim Wilson; Roberto Salgado; Lu; Yu; Carol O'Brien; Kimberly Walter; Ling-Yuh Huw; Carmen Criscitiello; Laios; Jose; Brown; Rothé; Maetens; Zardavas; Peter Savas; Denis Larsimont; Piccart-Gebhart; Stefan Michiels; Mark Lackner; Christos Sotiriou; Sherene Loi
Annals of Oncology, ISSN: 15698041 09237534
Baselga; Cortes Castan; De Laurentiis; Diéras; Nadia Harbeck; Jerry Hsu; Jin; Frauke Schimmoller; Tim Wilson; Im; William Jacot; Ian E. Krop; Sunil Verma
Journal of Clinical Oncology, ISSN: 15277755
Peter Schmid; Sarah Pinder; Duncan Wheatley; Jane Macaskill; Charles Zammit; Jennifer Hu; Robert Price; Nigel Bundred; Sirwan Hadad; Alice Shia; Shah-Jalal Sarker; Louise Lim; Patrycja Gazinska; Natalie Woodman; Darren Korbie; Matt Trau; Paul Mainwaring; Steven Gendreau; Mark Lackner; Mika Derynck; Tim Wilson; Hannah Butler; Gemma Earl; Parker; Arnie Purushotham; Alastair Thompson
Heterogeneity and clinical significance of ESR1 mutations in ER-positive metastatic breast cancer patients receiving fulvestrant
Nature Communications,
Jill Spoerke; Steven Gendreau; Walter; Jiaheng Qiu; Tim Wilson; Heidi Savage; Junko Aimi; Mika Derynck; Meng Chen; Iris Chan; Lukas Amler; Garret Hampton; Stephen Johnston; Ian E. Krop; Schmid; Mark Lackner
Annals of Oncology, ISSN: 15698041
Diéras; Campone; Denise A. Yardley; Romieu; Vicente Valero; Isakoff; Hartmut Koeppen; Tim Wilson; Xiao; David Shames; Simonetta Mocci; Chen; Schmid
Breast Cancer Research and Treatment, ISSN: 15737217
Tim Wilson; Yuanyuan Xiao; Jill Spoerke; Jane (Zhenya) Fridlyand; Hartmut Koeppen; Eloisa Fuentes; Ling-Yuh Huw; Ilma Abbas; Arjan Gower; Erica Schleifman; Rupal Desai; Ling Fu; Teiko Sumiyoshi; Joyce A. O’Shaughnessy; Garret Hampton; Mark Lackner
Cancer Research, ISSN: 15387445
Debasish Raha; Tim Wilson; Jing Peng; David Peterson; Peng Yue; Marie Evangelista; Catherine Wilson; Mark Merchant; Jeffrey Settleman
Cancer Research, ISSN: 15387445 00085472
Debasish Raha; Tim Wilson; Jing Peng; David Peterson; Peng Yue; Marie Evangelista; Catherine Wilson; Mark Merchant; Jeffrey E. Settleman
PLoS ONE, ISSN: 19326203
Erica Schleifman; Rupal Desai; Jill Spoerke; Yuanyuan Xiao; Cheryl Wong; Ilma Abbas; Carol O'Brien; Rajesh Patel; Teiko Sumiyoshi; Ling Fu; Nga Wan Rachel Tam; Hartmut Koeppen; Tim Wilson; Rajiv Raja; Garret Hampton; Mark Lackner
Genes and Cancer, ISSN: 19476027
Kyle Edgar; Lisa Crocker; Eric Cheng; Marie-Claire Wagle; Matthew Wongchenko; Yibing Yan; Tim Wilson; Nick Dompe; Rich Neve; Marcia Belvin; Deepak Sampath; Lori Friedman; Jeffrey Wallin
Breast Cancer Research and Treatment, ISSN: 15737217
Arthur; Turnbull; Renshaw; Keys; Thomas; Tim Wilson; Mark Lackner; Sims; Dixon
PLoS ONE, ISSN: 19326203
David Shames; Juliet Carbon; Kimberly Walter; Adrian Jubb; Cleopatra Kozlowski; Tom Januario; An Do; Ling Fu; Yuanyuan Xiao; Rajiv Raja; Brittany Jiang; Ashi Malekafzali; Howard Stern; Jeffrey Settleman; Tim Wilson; Garret Hampton; Bob Yauch; Andrea Pirzkall; Lukas Amler
Nature, ISSN: 00280836
Tim Wilson; Jane (Zhenya) Fridlyand; Yibing Yan; Elicia Penuel; Luciana Burton; Emily Chan; Jing Peng; Eva Lin; Yulei Wang; Jeffrey A. Sosman; Antoni Ribas; Jiang Li; John Moffat; Dan Sutherlin; Hartmut Koeppen; Mark Merchant; Rich Neve; Jeffrey Settleman
Growth Factors, ISSN: 08977194
Kristy J. Wilson; Christopher Mill; Sydney Lambert; Jennifer Buchman; Tim Wilson; Victor Hernandez-Gordillo; Richard M. Gallo; Laura M.C. Ades; Jeffrey Settleman; David J. Riese II
Future Oncology, ISSN: 17448301
Mark Lackner; Tim Wilson; Jeffrey Settleman
Cancer Cell, ISSN: 15356108
Tim Wilson; Diana Y. Lee; Leanne Ross; David Shames; Jeffrey Settleman
Education
- Genentech, Postdoctoral Fellow – 2011
- Massachusetts General Hospital/Harvard Medical School, Postdoctoral Fellow – 2010
- Queen’s University, Belfast, Postdoctoral Fellow – 2008
- Queen’s University, Belfast, Ph.D. in Cancer Biology – 2005
- University of Ulster, B.Sc. in Applied Biochemical Sciences – 2002