After completing my PhD and postdoctoral work in the area of Human Statistical Genetics, I joined Genentech in 2009 due to its unique environment of extraordinary basic science research coupled with outstanding translational expertise. Here I use my technical background to analyze the wealth of in-house and external genetic datasets to discover new targets and biomarkers for neurodegenerative and neuroinflammatory diseases.
Nature Genetics, ISSN: 15461718 10614036
My main focus is on leveraging Human Genetics for target and biomarker discovery in Neuroscience. To this end we analyze data from our clinical trials, in-house experiments, Genomewide association studies, and large biobanks (e.g. UK Biobank). We work closely with the experimental scientists for functional follow-up of new discoveries from genetic studies and evaluation/development of targets.
My group also works on developing the analysis infrastructure used by Human Genetics Department where we implement the latest technics for analysis of large-scale sequencing data, genetic association analysis, and integration of results with other types of data e.g. eQTL, functional genomics experiments, gene networks.