Vishal Verma
Senior Principal Scientist, Discovery Chemistry, Drug Discovery
"I’m motivated by working with a highly talented, multi-disciplinary group of scientists extremely focused on taking on the toughest challenges in the discovery for transformational therapies."
12
Years at Genentech
13
Publications at Genentech
I joined Genentech in 2012 after spending 4 years at Schering-Plough/Merck working on multiple virology programs. I received my PhD in 2008 from Stanford working with Paul Wender on natural product analog design and synthesis. During my PhD, it was extremely satisfying taking complex compounds I had synthesized myself and running biochemical and cellular assays to evaluate their activity. This training prepared me extremely well for a career in medicinal chemistry.
Featured Publication
Discovery of Inhibitors of the LPS transporter MsbA: From a Screening Hit to Potent Wild-Type Gram-negative Activity.
J. Med. Chem., 2022, 65, 4085-4120.
Verma, V.; Wang L.; Labadie, S.; Liang, J.; Sellers, B.; Wang, J.; Dong, L.; Qiuyue, W.; Zhang, S.; Xu, Z.; Zhang, Y.; Niu, Y.; Wang, X.; Wai, J.; Koehler, M. F. T.; Hu, H.; Alexander, M. K.; Nishiyama, M.; Niu, A.; Xu, Y.; Pangg, J.; Katakam, A. K.; Reichelt, M.; Austin, C. A.; Ho, H.; Payandeh, J.; Koth, C. M.
"Curse or Cure? A Perspective on the Developability of Aldehydes as Active Pharmaceutical Ingredients"
J. Med. Chem., 2020, 63, 14357–14381.
Gampe, C. M.; Verma. V. A.
My Focus
I lead teams focused on advancing novel chemical matter against tough-to-drug targets across a range of therapeutic areas including oncology, immunology and infectious disease. In this role, I have led teams taking on challenges including Genentech’s first foray into novel reversible covalent modalities that are increasingly being utilized across the industry as well as advancing hits to compounds that are active against multiple wild-type Gram-negative bacteria, including multi-drug resistant strains. I have also contributed to teams that have delivered both traditional small molecule therapeutics as well as antibody-drug conjugates into the clinic.
Genentech Publications
iScience,
Shawna Zhu; Mary Kate Alexander; Telmo O. Paiva; Kenneth Rachwalski; Anh Miu; Yiming Xu; Vishal A. Verma; Mike Reichelt; Yves F. Dufrêne; Eric D. Brown; Georgina Cox
ACS Medicinal Chemistry Letters,
Mingshuo Zeng; Jessica M. Grandner; Marian C. Bryan; Vishal A. Verma; Larouche-Gauthier; Jean-Philippe Leclerc; Zhao; Pouyan Haghshenas; Samuel Aubert-Nicol; Arun Yadav; Melissa Ashley; Jacob Z. Chen; Matthew Durk; Karen E. Samy; Marika Nespi; Elizabeth S. Levy; Karl A. Merrick; John Moffat; Jeremy Murray; Angela Oh; Christine Orr; Ehud Segal; Jessica Sims; Chris J. Sneeringer; Madeleine S. Prangley; Steffan Vartanian; Steven Magnuson; Brendan T. Parr
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Vishal A. Verma; Lan Wang; Sharada Labadie; Jun Liang; Benjamin D. Sellers; Jian Wang; Liting Dong; Qiuyue Wang; Shuang Zhang; Zhongya Xu; Yexia Zhang; Yanan Niu; Xinxin Wang; John Wai; Michael F. T. Koehler; Huiyong Hu; Mary Kate Alexander; Mireille Nishiyama; Anh Miu; Yiming Xu; Jodie Pang; Anand K. Katakam; Mike Reichelt; Cary D. Austin; Hoangdung Ho; Jian Payandeh; Christopher M. Koth
Journal of Experimental Medicine, ISSN: 15409538 00221007
Alessia Balestrini; Victory Joseph; Michelle Dourado; Rebecca M. Reese; Shannon D. Shields; Lionel Rouge; Daniel D. Bravo; Tania Chernov-Rogan; Cary D. Austin; Huifen Chen; Lan Wang; Elisia Villemure; Daniel G. Shore; Vishal A. Verma; Baihua Hu; Yong Chen; Laurie Leong; Chris Bjornson; Kathy Hötzel; Alvin Gogineni; Wyne P. Lee; Eric Suto; Xiumin Wu; John Liu; Juan Zhang; Vineela D. Gandham; Jianyong Wang; Jian Payandeh; Claudio Ciferri; Alberto Estevez; Christopher P. Arthur; Jens Kortmann; Ryan L. Wong; Jose Heredia; Jonas Martin Doerr; Min Jung; Jason A. Vander Heiden; Merone Roose-Girma; Lucinda Tam; Kai H. Barck; Richard A. D. Carano; Han Ting Ding; Bobby Brillantes; Christine Tam; Xiaoying Yang; Simon S. Gao; Justin Ly; Liling Liu; Liuxi Chen; Bianca M. Liederer; Joseph Lin; Steven Magnuson; Jun Chen; David Hackos; Justin Elstrott; Alexis Rohou; Brian S. Safina; Matthew Volgraf; Rebecca N. Bauer; Lorena Riol-Blanco
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Vishal A. Verma; Lan Wang; Sharada Labadie; Jun Liang; Benjamin D. Sellers; Jian Wang; Liting Dong; Qiuyue Wang; Shuang Zhang; Zhongya Xu; Yexia Zhang; Yanan Niu; Xinxin Wang; John Wai; Michael F. T. Koehler; Huiyong Hu; Mary Kate Alexander; Mireille Nishiyama; Anh Miu; Yiming Xu; Jodie Pang; Anand K. Katakam; Mike Reichelt; Cary D. Austin; Hoangdung Ho; Jian Payandeh; Christopher M. Koth
Curse or Cure? A Perspective on the Developability of Aldehydes as Active Pharmaceutical Ingredients
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Christian Gampe; Vishal A. Verma
Antimicrobial Agents and Chemotherapy, ISSN: 10986596 00664804
Mary Kate Alexander; Anh Miu; Angela Oh; Mike Reichelt; Hoangdung Ho; Cecile Chalouni; Sharada Labadie; Lan Wang; Jun Liang; Nicholas N. Nickerson; Huiyong Hu; Lan Yu; Miaofen Du; Donghong Yan; Summer Park; Janice Kim; Min Xu; Benjamin D. Sellers; Hans E. Purkey; Nicholas J. Skelton; Michael F. T. Koehler; Jian Payandeh; Vishal A. Verma; Yiming Xu; Christopher M. Koth; Mireille Nishiyama
Molecular Pharmaceutics, ISSN: 15438392 15438384
Zhonghua Pei; Chunjiao Chen; Jinhua Chen; Josefa Dela Cruz-Chuh; Reginald Delarosa; Yuzhong Deng; Aimee Fourie-O'Donohue; Isabel Figueroa; Jun Guo; Weiwei Jin; S. Cyrus Khojasteh; Katherine R. Kozak; Brandon Latifi; James Lee; Guangmin Li; Eva Lin; Liling Liu; Jiawei Lu; Scott E. Martin; Carl Ng; Trung Nguyen; Rachana Ohri; Gail L. Phillips; Thomas H. Pillow; Rebecca K. Rowntree; Nicola J. Stagg; David Stokoe; Sheila Ulufatu; Vishal A. Verma; John Wai; Jing Wang; Keyang Xu; Zijin Xu; Hui Yao; Shang-Fan Yu; Donglu Zhang; Peter Dragovich
Nature, ISSN: 14764687 00280836
Hoangdung Ho; Anh Miu; Mary Kate Alexander; Natalie K. Garcia; Angela Oh; Inna Zilberleyb; Mike Reichelt; Cary D. Austin; Christine Tam; Stephanie K. Shriver; Huiyong Hu; Sharada Labadie; Jun Liang; Lan Wang; Jian Wang; Yan Lu; Hans E. Purkey; John Quinn; Yvonne Franke; Clark; Beresini; Man-Wah Tan; Benjamin D. Sellers; Till Maurer; Michael F. T. Koehler; Aaron T. Wecksler; James R. Kiefer; Vishal A. Verma; Yiming Xu; Mireille Nishiyama; Jian Payandeh; Christopher M. Koth
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Huifen Chen; Matthew Volgraf; Steven Do; Aleksandr Kolesnikov; Daniel G. Shore; Vishal A. Verma; Elisia Villemure; Lan Wang; Yong Chen; Baihua Hu; Aijun Lu; Guosheng Wu; Xiaofeng Xu; Po-Wai Yuen; Yamin Zhang; Shawn D. Erickson; Martin Dahl; Christine Brotherton-Pleiss; Suzanne Tay; Justin Ly; Lesley J. Murray; Jun Chen; Desiree Amm; Wienke Lange; David Hackos; Rebecca M. Reese; Shannon D. Shields; Joseph P. Lyssikatos; Brian S. Safina; Anthony A. Estrada
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Binqing Wei; Janet Gunzner; Hui Yao; Tao Wang; Jing Wang; Zijin Xu; Jinhua Chen; John Wai; Jim Nonomiya; Siao Ping Tsai; Josefa Chuh; Katherine R. Kozak; Yichin Liu; Shang-Fan Yu; Jeffrey Lau; Guangmin Li; Gail L. Phillips; Douglas Leipold; Amrita Kamath; Dian Su; Keyang Xu; Eigenbrot; Stefan Steinbacher; Rachana Ohri; Helga Raab; Leanna Staben; Guiling Zhao; Flygare; Thomas H. Pillow; Vishal A. Verma; Luke Masterson; Philip W. Howard; Brian S. Safina
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Vishal A. Verma; Daniel G. Shore; Huifen Chen; Jun Chen; Steven Do; David Hackos; Aleksandr Kolesnikov; Joseph P. Lyssikatos; Suzanne Tay; Lan Wang; Anthony A. Estrada
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Vishal A. Verma; Thomas H. Pillow; Laura DePalatis; Guangmin Li; Gail L. Phillips; Andrew G. Polson; Helga Raab; Spencer; Bing Zheng
Education
- Stanford University, PhD in Chemistry – 2008
- Northwestern University, BA in Chemistry, BA in Integrated Science – 2003