Genentech takes the health and safety of our patients, customers, employees and local communities very seriously, and we are actively responding to the global COVID-19 pandemic. For more, please visit our COVID-19 response page or call 1-877-436-3683.

Vishal Verma - Principal Scientist, Discovery Chemistry

Vishal Verma

Principal Scientist, Discovery Chemistry

"I’m motivated by working with a highly talented, multi-disciplinary group of scientists extremely focused on taking on the toughest challenges in the discovery for transformational therapies."
9
Years at Genentech

I joined Genentech in 2012 after spending 4 years at Schering-Plough/Merck working on multiple virology programs. I received my PhD in 2008 from Stanford working with Paul Wender on natural product analog design and synthesis. During my PhD, it was extremely satisfying taking complex compounds I had synthesized myself and running biochemical and cellular assays to evaluate their activity.  This training prepared me extremely well for a career in medicinal chemistry.

Featured Publication

"Curse or Cure? A Perspective on the Developability of Aldehydes as Active Pharmaceutical Ingredients"

J. Med. Chem., 2020, 63, 14357–14381.

Gampe, C. M.; Verma. V. A.

"Structural basis for dual-mode inhibition of the ABC transporter MsbA"

Nature 2018, 557, 196-201.

Ho, H.; Miu, A.; Alexander, M. K.; Garcia, N. K.; Oh, A.; Zilberleyb, I.; Reichelt, M.; Austin, C. D.; Tam, C.; Shriver, S.; Hu, H.; Labadie, S. S.; Liang, J.; Wang, L.; Wang, J.; Lu, Y.; Purkey, H. E.; Quinn, J.; Franke, Y.; Clark, K.; Beresini, M. H.; Tan, M. W.; Sellers, B. D.; Maurer, T.; Koehler, M. F. T.; Wecksler, A. T.; Kiefer, J. R.; Verma, V.; Xu, Y.; Nishiyama, M.; Payandeh, J.; Koth, C. M.

"2'-Modified Guanosine Analogs for the Treatment of HCV"

Nucleosides, Nucleotides and Nucleic Acids 2016, 35, 277–294.

Girijavallabhan, V.; Arasappan, A.; Bennett, F.; Chen, K.; Dang, Q.; Huang, Y.; Kerekes, A.; Nair, L.; Pissarnitski, D.; Verma, V.; Alvarez, C.; Chen, P.; Cole, D.; Esposite, S.; Huang, Y.; Hong, Q.; Liu, Z.; Pan, W.; Pu, H.; Rossman, R.; Truong, Q.; Vibulbhan, B.; Wang, J.; Zhao, Z.; Olsen, D.; Stamford, A.; Bogen, S.; Njoroge, F. G.

"Synthesis and SAR of Geminal Substitutions at the C5' Carbosugar Position of Pyrimidine-Derived HCV Inhibitors"

Biorg. Med. Chem. Lett. 2012, 22, 6967-6973.

Verma, V. A.; Rossman, R.; Bennett, F.; Chen, L.; Gavalas, S.; Girijavallabhan, V.; Huang, Y.; Kim, S.-H.; Kosinski, A.; Pinto, P.; Rizvi, R.; Shankar, B.; Tong, L.; Velazquez, F.; Venkatraman, S.; Kozlowski, J.; MacCoss, M.; Kwong, C. D.; Bansal, N.; Kezar III, H. S.; Reynolds, R. C.; Maddry, J. A.; Ananthan, S.; Secrist III, J. A.; Li, C.; Chase, R.; Curry, S.; Huang, H.-C.; Tong, X.; Njoroge, F. G.; Arasappan, A.

"Synthesis and SAR of Pyridothiazole Substituted Pyrimidine Derived HCV Replicase Inhibitors"

Bioorg. Med. Chem. Lett. 2012, 22, 5652-5657.

Girijavallabhan, V.; Alvarez, C.; Bennett, F.; Chen, L.; Gavalas, S.; Huang, Y.; Kim, S.-H.; Kosinski, A.; Pinto, P.; Rizvi, R.; Rossman, R.; Shankar, B.; Tong, L.; Velazquez, F.; Venkatraman, S.; Verma, V. A.; Kozlowski, J.; Shih, N.-Y.; Piwinski, J. J.; MacCoss, M.; Kwong, C. D.; Bansal, N.; Clark, J.; Fowler, A. T.; Kezar III, H. S.; Valiyaveettil, J.; Reynolds, R. C.; Maddry, J. A.; Ananthan, S.; Secrist III, J. A.; Li, C.; Chase, R.; Curry, S.; Huang, H.-C.; Tong, X.; Njoroge, F. G.; Arasappan, A.

"A notable conversion of a thiolacetate to its corresponding sulfonyl chloride"

Tetrahedron Lett. 2012, 53, 3203-3205.

Huang, Y.; Bennett, F.; Verma, V.; Njoroge, F. G.; MacCoss, M

"5-Benzothiazole Substituted Pyrimidine Derivatives as HCV Replication (Replicase) Inhibitors"

Bioorg. Med. Chem. Lett. 2012, 22, 3229-3234.

Arasappan, A.; Bennett, F; Girijavallabhan, V.; Huang, Y.; Huelgas, R.; Alvarez, C.; Chen, L.; Gavalas, S.; Kim, S.-H.; Kosinski, A.; Pinto, P.; Rizvi, R.; Rossman, R.; Shankar, B.; Tong, L.; Velazquez, F.; Venkatraman, S.; Verma, V. A.; Kozlowski, J.; Shih, N.-Y.; Piwinski, J. J.; MacCoss, M.; Kwong, C. D.; Clark, J. L.; Fowler, A. T.; Geng, F.; Kezar III, H. S.; Roychowdhury, A.; Reynolds, R. C.; Maddry, J. A.; Ananthan, S.; Secrist III, J. A; Li, C.; Chase, R.; Curry, S.; Huang, H.-C.; Tong, X.; Njoroge, F. G.

"The Double Addition Reaction of Alkoxymethyl Nucleophiles to Esters to Generate Novel Polyoxygenated Species"

Tetrahedron Lett. 2010, 51, 4284-4286.

Verma, V. A.; Arasappan, A.; Njoroge, F. G.