"At Genentech I am surrounded by many dedicated scientists and technicians with the common goal of discovering and developing novel therapeutics to treat important human diseases."
I joined Genentech in 1992 and, together with Nick Skelton, established a Protein Nuclear Magnetic Resonance (NMR) group that focused primarily on the application of techniques for studying the solution structures of proteins and protein-protein or protein-ligand complexes of therapeutic interest. I was originally attracted to Genentech by the highly collaborative research environment, in general, and the scientists, in particular, who are dedicated to investigating important problems in biology and human disease.
I maintain an active interest in structural biology and protein NMR through interactions with the postdocs in my lab. The Postdoc Program emphasizes basic and fundamental discovery research, which allows us to continue working at the cutting edge of science. It also provides the postdoctoral fellows with a highly collaborative research environment and access to resources that are seldom available in academia.
Nat Rev Drug Discov. 2017 Apr;16(4):273-284.
In the past I have contributed structural biology support to a number of projects aimed at characterizing important protein-peptide interactions. I have also had leadership roles in multi-disciplinary projects in which structure-based design was used to identifying small-molecule antagonists of protein-protein interactions. Small molecules resulting from these efforts are being tested in clinical trials.
I now lead a department whose focus is exploring novel protein targets through the use of biophysical, biochemical, chemical and structural-biology methods; developing tools to pharmacologically validate novel targets; and the development of technologies to target challenging proteins.