Scientists / Our Scientists

Wayne Fairbrother

Distinguished Fellow and Vice President, Early Discovery Biochemistry, Drug Discovery

Postdoc Mentor

"At Genentech I am surrounded by many dedicated scientists and technicians with the common goal of discovering and developing novel therapeutics to treat important human diseases."

33

Years at Genentech

123

Publications at Genentech

4

Awards & Honors

I joined Genentech in 1992 and, together with Nick Skelton, established a Protein Nuclear Magnetic Resonance (NMR) group that focused primarily on the application of techniques for studying the solution structures of proteins and protein-protein or protein-ligand complexes of therapeutic interest. I was originally attracted to Genentech by the highly collaborative research environment, in general, and the scientists, in particular, who are dedicated to investigating important problems in biology and human disease.

Postdoctoral Mentor

I maintain an active interest in structural biology and protein NMR through interactions with the postdocs in my lab. The Postdoc Program emphasizes basic and fundamental discovery research, which allows us to continue working at the cutting edge of science. It also provides the postdoctoral fellows with a highly collaborative research environment and access to resources that are seldom available in academia.

Featured Publication

From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors.

Nat Rev Drug Discov. 2017 Apr;16(4):273-284.

Ashkenazi A, Fairbrother WJ, Leverson JD, Souers AJ.

 

In the past I have contributed structural biology support to a number of projects aimed at characterizing important protein-peptide interactions. I have also had leadership roles in multi-disciplinary projects in which structure-based design was used to identifying small-molecule antagonists of protein-protein interactions. Small molecules resulting from these efforts are being tested in clinical trials.

I now lead a department whose focus is exploring novel protein targets through the use of biophysical, biochemical, chemical and structural-biology methods; developing tools to pharmacologically validate novel targets; and the development of technologies to target challenging proteins.

Engineering ERα degraders with pleiotropic ubiquitin ligase ligands maximizes therapeutic efficacy by co-opting distinct effector ligases

Cell Chemical Biology, ISSN: 24519456

Anna Shemorry; Willem Den Besten; Melinda M. Mulvihill; Curt J. Essenburg; Nicole Blaquiere; Tracy L. Kleinheinz; Elisia Villemure; Franklin V. Peale Jr.; Gauri Deshmukh; Danilo Maddalo; Elizabeth S. Levy; Kebing Yu; Matthew R. Steensma; Elizabeth A. Tovar; Emily Wolfrum; Karthik Nagapudi; Robert A. Blake; William F. Forrest; Steven T. Staben; Carrie R. Graveel; Wayne J. Fairbrother; Ingrid E. Wertz

The discovery and structural basis of two distinct state-dependent inhibitors of BamA

Nature Communications,

Dawei Sun; Kelly M. Storek; Dimitry Tegunov; Ying Yang; Christopher P. Arthur; Matthew C. Johnson; John Quinn; Weijing Liu; Guanghui Han; Hany S. Girgis; Mary Kate Alexander; Austin K. Murchison; Stephanie K. Shriver; Christine Tam; Hiroshi Ijiri; Hiroko Inaba; Tatsuya Sano; Hayato Yanagida; Junichi Nishikawa; Christopher E. Heise; Wayne J. Fairbrother; Man-Wah Tan; Nicholas J. Skelton; Wendy N. Sandoval; Benjamin D. Sellers; Claudio Ciferri; Peter A. Smith; Patrick C. Reid; Christian N. Cunningham; Steven T. Rutherford; Jian Payandeh

Potency-Enhanced Peptidomimetic VHL Ligands with Improved Oral Bioavailability

Journal of Medicinal Chemistry, ISSN: 00222623

Hao Wu; Jeremy Murray; Noriko Ishisoko; Alexandra Frommlet; Gauri Deshmukh; Antonio G. DiPasquale; Melinda M. Mulvihill; Donglu Zhang; John Quinn; Robert A. Blake; Wayne J. Fairbrother; Jakob Fuhrmann

Targeted degradation via direct 26S proteasome recruitment

Nature Chemical Biology, ISSN: 15524469 15524450

Charlene Bashore; Sumit Prakash; Matthew C. Johnson; Ryan J. Conrad; Ivy Kekessie; Suzie J. Scales; Noriko Ishisoko; Tracy L. Kleinheinz; Peter S. Liu; Nataliya Popovych; Aaron T. Wecksler; Lijuan Zhou; Christine Tam; Inna Zilberleyb; Rajini Srinivasan; Robert A. Blake; Aimin Song; Steven T. Staben; Yingnan Zhang; David Arnott; Wayne J. Fairbrother; Scott A. Foster; Ingrid E. Wertz; Claudio Ciferri; Erin C. Dueber

IAP antagonist GDC-0917 is more potent than Debio1143 in promoting cell death, c-IAP1 degradation and tumor growth inhibition

Cell Death and Disease,

Bruno Alicke; Eugene Varfolomeev; Shi Hui Kaylee Lee; Alexandra Frommlet; Savita Ubhayakar; John G. Quinn; Wayne J. Fairbrother; Robert Jones; Stephen Gould; Domagoj Vucic

IAP antagonist GDC-0917 is more potent than Debio1143 in promoting cell death, c-IAP1 degradation and tumor growth inhibition

Cell Death and Disease, ISSN: 20414889

Bruno Alicke; Eugene Varfolomeev; Shi Hui Kaylee Lee; Alexandra Frommlet; Savita Ubhayakar; John G. Quinn; Wayne J. Fairbrother; Robert Jones; Stephen Gould; Domagoj Vucic

NMR Spectroscopy for Studying Peptide Conformations and Cell Permeability

ACS Symposium Series, ISSN: 00976156

Kaustav Biswas; Andrei A. Golosov; Emel Adaligil; Wayne J. Fairbrother

NMR Spectroscopy for Studying Peptide Conformations and Cell Permeability

ACS Symposium Series, ISSN: 19475918 00976156

Kaustav Biswas; Andrei A. Golosov; Emel Adaligil; Wayne J. Fairbrother

Structures of the ApoL1 and ApoL2 N-terminal domains reveal a non-classical four-helix bundle motif

Communications Biology, ISSN: 23993642

Ultsch; Michael J. Holliday; Gerhardy; Paul Moran; Suzie J. Scales; Nidhi Gupta; Francesca Oltrabella; Cecilia Chiu; Wayne J. Fairbrother; Eigenbrot; Daniel Kirchhofer

Ribosomal Synthesis of Macrocyclic Peptides with Linear γ4- And β-Hydroxy-γ4-amino Acids

ACS Chemical Biology, ISSN: 15548937 15548929

Emel Adaligil; Aimin Song; Christian N. Cunningham; Wayne J. Fairbrother

Primary Amine Tethered Small Molecules Promote the Degradation of X-Linked Inhibitor of Apoptosis Protein

Journal of the American Chemical Society, ISSN: 15205126 00027863

Willem Den Besten; Kshitij Verma; Sayumi Yamazoe; Nicole Blaquiere; Wilson Phung; Anita Izrael-Tomasevic; Melinda M. Mulvihill; Elizabeth Helgason; Sumit Prakash; Tatiana Goncharov; Domagoj Vucic; Erin C. Dueber; Wayne J. Fairbrother; Ingrid E. Wertz; Kebing Yu; Steven T. Staben

Ribosomal Synthesis of Macrocyclic Peptides with β2- And β2,3-Homo-Amino Acids for the Development of Natural Product-Like Combinatorial Libraries

ACS Chemical Biology, ISSN: 15548937 15548929

Emel Adaligil; Aimin Song; Kenneth K. Hallenbeck; Christian N. Cunningham; Wayne J. Fairbrother

Discovery of A-1331852, a First-in-Class, Potent, and Orally-Bioavailable BCL-XLInhibitor

ACS Medicinal Chemistry Letters, ISSN: 19485875

Le Wang; George A. Doherty; Andrew S. Judd; Zhi-Fu Tao; T. Matthew Hansen; Robin R. Frey; Xiaohong Song; Bruncko; Aaron R. Kunzer; Xilu Wang; Michael D. Wendt; Flygare; Nathaniel D. Catron; Russell A. Judge; Chang H. Park; Shashank Shekhar; Darren C. Phillips; Paul M. Nimmer; Morey L. Smith; Stephen K. Tahir; Yu Xiao; John Xue; Haichao Zhang; Phuong N. Le; Michael J. Mitten; Erwin R. Boghaert; Wenqing Gao; Peter J. Kovar; Edna F. Choo; Dolores Diaz; Wayne J. Fairbrother; Steven W. Elmore; Deepak Sampath; Joel D. Leverson; Andrew J. Souers

Heterobifunctional Molecules Induce Dephosphorylation of Kinases-A Proof of Concept Study

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Sayumi Yamazoe; Jeffrey Tom; Yue Fu; Wenqiong Wu; Liang Zeng; Changlei Sun; Qi Liu; Jie Lin; Kui Lin; Wayne J. Fairbrother; Steven T. Staben

Structures of autoinhibited and polymerized forms of CARD9 reveal mechanisms of CARD9 and CARD11 activation

Nature Communications, ISSN: 20411723

Michael J. Holliday; Axel Witt; Alejandro Rodríguez Gama; Benjamin T. Walters; Christopher P. Arthur; Randal Halfmann; Alexis Rohou; Erin C. Dueber; Wayne J. Fairbrother

Picomolar zinc binding modulates formation of Bcl10-nucleating assemblies of the caspase recruitment domain (CARD) of CARD9

Journal of Biological Chemistry, ISSN: 1083351X 00219258

Michael J. Holliday; Ryan Ferrao; Gladys De Leon Boenig; Alberto Estevez; Elizabeth Helgason; Alexis Rohou; Erin C. Dueber; Wayne J. Fairbrother

Discovery and development of venetoclax, a selective antagonist of BCL-2

Successful Drug Discovery,

Wayne J. Fairbrother; Joel D. Leverson; Deepak Sampath; Andrew J. Souers

Cyclodextrin Reduces Intravenous Toxicity of a Model Compound

Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549

Priscilla Mantik; Minli Xie; Harvey Wong; Hank La; Ronald Steigerwalt; Uday Devanaboyina; Geoffrey Ganem; Danny Shih; Flygare; Wayne J. Fairbrother; Paroma Chakravarty; David J. Russell; Gilberto E. Fernandez; Ajit S. Narang

Erratum to: A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells (Nature Chemical Biology, (2018), 14, 6, (582-590), 10.1038/s41589-018-0035-2)

Nature Chemical Biology, ISSN: 15524469 15524450

Aaron H Nile; Felipe de Sousa e Melo; Susmith Mukund; Robert Piskol; Simon Hansen; Lijuan Zhou; Yingnan Zhang; Yue Fu; Emily Gogol; László Kömüves; Zora Modrusan; Stephane Angers; Yvonne Franke; Christopher M. Koth; Wayne J. Fairbrother; Weiru Wang; Frederic J. De Sauvage; Rami N. Hannoush

A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells article

Nature Chemical Biology, ISSN: 15524469 15524450

Aaron H Nile; Felipe de Sousa e Melo; Susmith Mukund; Robert Piskol; Simon Hansen; Lijuan Zhou; Yingnan Zhang; Yue Fu; Emily Gogol; László Kömüves; Zora Modrusan; Stephane Angers; Yvonne Franke; Christopher M. Koth; Wayne J. Fairbrother; Weiru Wang; Frederic J. De Sauvage; Rami N. Hannoush

Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling

Molecular Cell, ISSN: 10974164 10972765

Tatiana Goncharov; Stefanie Hedayati; Melinda M. Mulvihill; Anita Izrael-Tomasevic; Zobel; Surinc Er Jeet; Anna V. Fedorova; Celine Eidenschenk; Jason Devoss; Kebing Yu; Andrey S. Shaw; Donald S. Kirkpatrick; Wayne J. Fairbrother; Deshayes; Domagoj Vucic

Found in translation: How preclinical research is guiding the clinical development of the BCL2-selective inhibitor venetoclax

Cancer Discovery, ISSN: 21598290 21598274

Joel D. Leverson; Deepak Sampath; Andrew J. Souers; Saul H. Rosenberg; Wayne J. Fairbrother; Amiot; Marina Konopleva; Anthony Letai

BCL2 mutations do not confer adverse prognosis in follicular lymphoma patients treated with rituximab

American Journal of Hematology, ISSN: 10968652 03618609

Sarah Huet; Edith Szafer-Glusman; Bruno Tesson; Luc Xerri; Wayne J. Fairbrother; Kiran Mukhyala; Christopher R. Bolen; Elizabeth A. Punnoose; Laurie Tonon; Catherine Chassagne-Clément; Pierre Feugier; Alain Viari; Fabrice Jardin; Gilles Salles; Pierre Sujobert

From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors

Nature Reviews Drug Discovery, ISSN: 14741784 14741776

Avi Ashkenazi; Wayne J. Fairbrother; Joel D. Leverson; Andrew J. Souers

A phase i dose-escalation study evaluating the safety tolerability and pharmacokinetics of CUDC-427, a potent, oral, monovalent IAP antagonist, in patients with refractory solid tumors

Clinical Cancer Research, ISSN: 15573265 10780432

Anthony W. Tolcher; Bendell; Kyriakos P. Papadopoulos; Howard A. Burris; Amita Patnaik; Wayne J. Fairbrother; Harvey Wong; Nageshwar Budha; Darbonne; Franklin V. Peale Jr.; Michael Mamounas; Stephanie Royer-Joo; Ron Yu; Chia C. Portera; Jeffery R. Infante

Expression profile of BCL-2, BCL-XL, and MCL-1 predicts pharmacological response to the BCL-2 selective antagonist venetoclax in multiple myeloma models

Molecular Cancer Therapeutics, ISSN: 15388514 15357163

Elizabeth A. Punnoose; Joel D. Leverson; Franklin V. Peale Jr.; Erwin R. Boghaert; Lisa D. Belmont; Nguyen Tan; Amy Young; Michael J. Mitten; Ellen Ingalla; Darbonne; Anatol Oleksijew; Paul Tapang; Peng Yue; Jason Oeh; Leslie Lee; Maïga; Wayne J. Fairbrother; Amiot; Andrew J. Souers; Deepak Sampath

Palmitoylation of TEAD Transcription Factors Is Required for Their Stability and Function in Hippo Pathway Signaling

Structure, ISSN: 18784186 09692126

Cameron Noland; Sarah Gierke; Paul D. Schnier; Jeremy Murray; Wendy N. Sandoval; Meredith Sagolla; Anwesha Dey; Rami N. Hannoush; Wayne J. Fairbrother; Christian N. Cunningham

Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation

Nature, ISSN: 14764687 00280836

Ingrid E. Wertz; Kim Newton; Dhaya Seshasayee; Saritha Kusam; Cynthia Lam; Juan Zhang; Nataliya Popovych; Elizabeth Helgason; Allyn J. Schoeffler; Surinc Er Jeet; Nandhini Ramamoorthi; Kategaya; Robert J. Newman; Keisuke Horikawa; Dugger; Wendy N. Sandoval; Susmith Mukund; Anuradha Zindal; Flavius Martin; Quan; Jeffrey Tom; Wayne J. Fairbrother; Michael J. Townsend; Søren Warming; Jason Devoss; Jinfeng Liu; Erin C. Dueber; Patrick Caplazi; Wyne P. Lee; Christopher C. Goodnow; Mercedesz Balazs; Kebing Yu; Ganesh Kolumam; Vishva M. Dixit

Therapeutic targeting of Bcl-2 family for treatment of B-cell malignancies

Expert Review of Hematology, ISSN: 17474094 17474086

Jane Huang; Wayne J. Fairbrother; John C. Reed

Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy

Science Translational Medicine, ISSN: 19466242 19466234

Joel D. Leverson; Darren C. Phillips; Michael J. Mitten; Erwin R. Boghaert; Dolores Diaz; Stephen K. Tahir; Lisa D. Belmont; Paul M. Nimmer; Yu Xiao; Xiaoju Max Ma; Kym N Lowes; Peter J. Kovar; Jun Chen; Sha Jin; Morey L. Smith; John Xue; Haichao Zhang; Anatol Oleksijew; Terrance J. Magoc; Kedar S. Vaidya; Daniel H. Albert; Jacqueline M. Tarrant; Nghi La; Le Wang; Zhi-Fu Tao; Michael D. Wendt; Deepak Sampath; Saul H. Rosenberg; Chris Tse; David C.S. Huang; Wayne J. Fairbrother; Steven W. Elmore; Andrew J. Souers

Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)

Cell Death and Disease, ISSN: 20414889

Joel D. Leverson; Haichao Zhang; Jun Chen; Stephen K. Tahir; Darren C. Phillips; John Xue; Paul M. Nimmer; Sha Jin; Morey L. Smith; Yu Xiao; Peter J. Kovar; Tanaka; Bruncko; Sheppard; Le Wang; Sarah Gierke; Kategaya; Daniel J Anderson; Wong; Jeffrey Eastham-Anderson; Ludlam; Deepak Sampath; Wayne J. Fairbrother; Ingrid E. Wertz; Saul H. Rosenberg; Chris Tse; Steven W. Elmore; Andrew J. Souers

Internal motions prime cIAP1 for rapid activation

Nature Structural and Molecular Biology, ISSN: 15459985 15459993

Aaron H. Phillips; Allyn J. Schoeffler; Tsutomu Matsui; Thomas M. Weiss; John W. Blankenship; Zobel; Anthony M. Giannetti; Erin C. Dueber; Wayne J. Fairbrother

Discovery of a potent and selective BCL-XLinhibitor with in vivo activity

ACS Medicinal Chemistry Letters, ISSN: 19485875

Zhi-Fu Tao; Lisa Hasvold; Le Wang; Xilu Wang; Andrew M. Petros; Chang H. Park; Erwin R. Boghaert; Nathaniel D. Catron; Jun Chen; Colman; Czabotar; Deshayes; Wayne J. Fairbrother; Flygare; Sarah G. Hymowitz; Sha Jin; Russell A. Judge; Michael F. T. Koehler; Peter J. Kovar; Guillaume Lessene; Michael J. Mitten; Chudi O. Ndubaku; Paul M. Nimmer; Hans E. Purkey; Anatol Oleksijew; Darren C. Phillips; Brad E Sleebs; Brian J. Smith; Morey L. Smith; Stephen K. Tahir; Keith G Watson; Yu Xiao; John Xue; Haichao Zhang; Zobel; Saul H. Rosenberg; Chris Tse; Joel D. Leverson; Steven W. Elmore; Andrew J. Souers

Designer proteins to trigger cell death

Cell, ISSN: 10974172 00928674

Wayne J. Fairbrother; Avi Ashkenazi

Structure-guided rescaffolding of selective antagonists of BCL-X L

ACS Medicinal Chemistry Letters, ISSN: 19485875

Michael F. T. Koehler; Philippe Bergeron; Edna F. Choo; Kevin Lau; Chudi O. Ndubaku; Danette Dudley; Paul Gibbons; Brad E Sleebs; Carl S. Rye; George Nikolakopoulos; Chinh Bui; Sanji Kulasegaram; Wilhelmus J A Kersten; Brian J. Smith; Czabotar; Colman; David C.S. Huang; Jonathan B Baell; Keith G Watson; Lisa Hasvold; Zhi-Fu Tao; Le Wang; Andrew J. Souers; Steven W. Elmore; Flygare; Wayne J. Fairbrother; Guillaume Lessene

Further insights into the effects of pre-organizing the BimBH3 Helix

ACS Chemical Biology, ISSN: 15548937 15548929

Toru Okamoto; David Segal; Zobel; Anna V. Fedorova; Hong Yang; Wayne J. Fairbrother; David C.S. Huang; Brian J. Smith; Deshayes; Czabotar

Learning and confirming with preclinical studies: Modeling and simulation in the discovery of GDC-0917, an inhibitor of apoptosis proteins antagonist

Drug Metabolism and Disposition, ISSN: 00909556 1521009X

Harvey Wong; Stephen Gould; Nageshwar Budha; Darbonne; Edward E. Kadel III; Hank La; Bruno Alicke; Jason S Halladay; Rebecca Erickson; Chia C. Portera; Anthony W. Tolcher; Jeffery R. Infante; Michael Mamounas; Flygare; Cornelis E. Hop; Wayne J. Fairbrother

Conformational dynamics control ubiquitin-deubiquitinase interactions and influence in vivo signaling

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424 10916490

Aaron H. Phillips; Yingnan Zhang; Christian N. Cunningham; Lijuan Zhou; William F. Forrest; Peter S. Liu; Micah Steffek; James Lee; Christine Tam; Elizabeth Helgason; Jeremy Murray; Donald S. Kirkpatrick; Wayne J. Fairbrother; Jacob E. Corn

Bcl-2/Bcl-xL inhibition increases the efficacy of MEK inhibition alone and in combination with PI3 kinase inhibition in lung and pancreatic tumor models

Molecular Cancer Therapeutics, ISSN: 15357163 15388514

Nguyen Tan; Maureen Wong; Michelle Nannini; Rebecca Hong; Leslie Lee; Stephen Price; Karen Williams; Pierre Pascal Savy; Peng Yue; Deepak Sampath; Jeffrey Settleman; Wayne J. Fairbrother; Lisa D. Belmont

Structure-guided design of a selective BCL-XL inhibitor

Nature Chemical Biology, ISSN: 15524450 15524469

Guillaume Lessene; Czabotar; Brad E Sleebs; Zobel; Kym N Lowes; Jerry M Adams; Jonathan B Baell; Colman; Deshayes; Wayne J. Fairbrother; Flygare; Paul Gibbons; Wilhelmus J A Kersten; Sanji Kulasegaram; Rebecca M Moss; John P Parisot; Brian J. Smith; Ian P Street; Hong Yang; David C.S. Huang; Keith G Watson

Stabilizing the pro-apoptotic BimBH3 helix (BimSAHB) does not necessarily enhance affinity or biological activity

ACS Chemical Biology, ISSN: 15548937 15548929

Toru Okamoto; Zobel; Anna V. Fedorova; Quan; Hong Yang; Wayne J. Fairbrother; David C.S. Huang; Brian J. Smith; Deshayes; Czabotar

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

Nature Medicine, ISSN: 10788956 1546170X

Andrew J. Souers; Joel D. Leverson; Erwin R. Boghaert; Scott L. Ackler; Nathaniel D. Catron; Jun Chen; Brian D. Dayton; Hong Ding; Sari H. Enschede; Wayne J. Fairbrother; David C.S. Huang; Sarah G. Hymowitz; Sha Jin; Seong Lin Khaw; Peter J. Kovar; Lloyd T. Lam; Jackie Lee; Heather Maecker; Kennan C. Marsh; Kylie D. Mason; Michael J. Mitten; Paul M. Nimmer; Anatol Oleksijew; Chang H. Park; Cheol-Min Park; Darren C. Phillips; Andrew W. Roberts; Deepak Sampath; John F. Seymour; Morey L. Smith; Gerard M. Sullivan; Stephen K. Tahir; Chris Tse; Michael D. Wendt; Yu Xiao; John Xue; Haichao Zhang; Rod A. Humerickhouse; Saul H. Rosenberg; Steven W. Elmore

Toxicity profile of small-molecule IAP antagonist GDC-0152 is linked to TNF-α pharmacology

Toxicological Sciences, ISSN: 10966080 10960929

Rebecca Erickson; Jacqueline M. Tarrant; Cain; Sock-Cheng Lewin-Koh; Noel Dybdal; Harvey Wong; Elizabeth M. Blackwood; Kristina West; Ronald Steigerwalt; Michael Mamounas; Flygare; Kenjie Amemiya; Donna M. Dambach; Wayne J. Fairbrother; Dolores Diaz

Dogs are more sensitive to antagonists of inhibitor of apoptosis proteins than rats and humans: A translational toxicokinetic/toxicodynamic analysis

Toxicological Sciences, ISSN: 10966080 10960929

Harvey Wong; Nageshwar Budha; Kristina West; Elizabeth M. Blackwood; Joseph A. Ware; Ron Yu; Darbonne; Stephen Gould; Ronald Steigerwalt; Rebecca Erickson; Cornelis E. Hop; Patricia M. LoRusso; Gail Eckhardt; Andrew Wagner; Iris Chan; Michael Mamounas; Flygare; Wayne J. Fairbrother

Characterization of ML-IAP protein stability and physiological role in vivo

Biochemical Journal, ISSN: 02646021 14708728

Eugene Varfolomeev; Elham Moradi; Jasmin N. Dynek; Jiping Zha; Anna V. Fedorova; Deshayes; Wayne J. Fairbrother; Kim Newton; Jennifer Le Couter; Domagoj Vucic

Navitoclax (ABT-263) reduces Bcl-x L-mediated chemoresistance in ovarian cancer models

Molecular Cancer Therapeutics, ISSN: 15357163 15388514

Maureen Wong; Nguyen Tan; Jiping Zha; Franklin V. Peale Jr.; Peng Yue; Wayne J. Fairbrother; Lisa D. Belmont

Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152)

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Flygare; Beresini; Nageshwar Budha; Helen Chan; Iris Chan; Sravanthi Cheeti; Frederick Cohen; Deshayes; Karl Doerner; Gail Eckhardt; Linda O. Elliott; Bainian Feng; Matthew C Franklin; Stacy Frankovitz Reisner; Lewis Gazzard; Jason S Halladay; Sarah G. Hymowitz; Hank La; Patricia M. LoRusso; Brigitte Maurer; Lesley J. Murray; Emile G. Plise; Quan; Jean-Philippe Stephan; Young G. Shin; Jeffrey Tom; Vickie Tsui; Joanne Um; Eugene Varfolomeev; Domagoj Vucic; Andrew Wagner; Heidi J. A. Wallweber; Lan Wang; Joseph A. Ware; Zhaoyang Wen; Harvey Wong; Jonathan M. Wong; Melisa Wong; Susan C. Wong; Ron Yu; Zobel; Wayne J. Fairbrother

The structure of the extracellular domain of the jumping translocation breakpoint protein reveals a variation of the midkine fold

Journal of Molecular Biology, ISSN: 10898638 00222836

Francois Rousseau; Borlan Pan; Wayne J. Fairbrother; J.Fernando Bazan; Andreas Lingel

Erratum: Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres (Bioorganic and Medicinal Chemistry Letters (2010) 20 (2229-2233))

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X 14643405

Frederick Cohen; Michael F. T. Koehler; Philippe Bergeron; Linda O. Elliott; Flygare; Matthew C Franklin; Lewis Gazzard; Stephen F. Keteltas; Kevin Lau; Cuong Q. Ly; Vickie Tsui; Wayne J. Fairbrother

Antagonists induce a conformational change in cIAP1 that promotes autoubiquitination

Science, ISSN: 10959203 00368075

Erin C. Dueber; Allyn J. Schoeffler; Andreas Lingel; J. Michael Elliott; Anna V. Fedorova; Anthony M. Giannetti; Zobel; Brigitte Maurer; Eugene Varfolomeev; Ping Wu; Heidi J. A. Wallweber; Sarah G. Hymowitz; Deshayes; Domagoj Vucic; Wayne J. Fairbrother

Murine Insulin Growth Factor-like (IGFL) and human IGFL1 proteins are induced in inflammatory skin conditions and bind to a novel tumor necrosis factor receptor family member, IGFLR1

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Adrian A. Lobito; Sree R. Ramani; Irene Tom; J.Fernando Bazan; Luis; Wayne J. Fairbrother; Wenjun Ouyang; Lino C. Gonzalez Jr.

Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity

Journal of Medicinal Chemistry, ISSN: 00222623 15204804

Brad E Sleebs; Czabotar; Wayne J. Fairbrother; Fairlie; Flygare; David C.S. Huang; Wilhelmus J A Kersten; Michael F. T. Koehler; Guillaume Lessene; Kym N Lowes; John P Parisot; Brian J. Smith; Morey L. Smith; Andrew J. Souers; Ian P Street; Hong Yang; Jonathan B Baell

Navitoclax enhances the efficacy of taxanes in non-small cell lung cancer models

Clinical Cancer Research, ISSN: 10780432 15573265

Nguyen Tan; Mehnaz Malek; Jiping Zha; Peng Yue; Robert Kassees; Berry; Wayne J. Fairbrother; Deepak Sampath; Lisa D. Belmont

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7

Nature, ISSN: 00280836 14764687

Ingrid E. Wertz; Saritha Kusam; Cynthia Lam; Toru Okamoto; Wendy N. Sandoval; Daniel J Anderson; Elizabeth Helgason; James A. Ernst; Mike Eby; Jinfeng Liu; Lisa D. Belmont; Joshua S. Kaminker; Karen M. O'Rourke; Kanan Pujara; Pawan Bir Kohli; Adam R. Johnson; Mark L. Chiu; Jennie R. Lill; Peter K Jackson; Wayne J. Fairbrother; Somasekar Seshagiri; Mary J. C. Ludlam; Kevin G. Leong; Erin C. Dueber; Heather Maecker; David C.S. Huang; Vishva M. Dixit

C-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling

EMBO Journal, ISSN: 02614189 14602075

Jasmin N. Dynek; Tatiana Goncharov; Erin C. Dueber; Anna V. Fedorova; Anita Izrael-Tomasevic; Lilian Phu; Elizabeth Helgason; Wayne J. Fairbrother; Deshayes; Donald S. Kirkpatrick; Domagoj Vucic

Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres

Bioorganic and Medicinal Chemistry Letters, ISSN: 0960894X

Frederick Cohen; Michael F. T. Koehler; Philippe Bergeron; Linda O. Elliott; Flygare; Matthew C Franklin; Lewis Gazzard; Stephen F. Keteltas; Kevin Lau; Cuong Q. Ly; Vickie Tsui; Wayne J. Fairbrother

Small-molecule pan-IAP antagonists: A patent review

Expert Opinion on Therapeutic Patents, ISSN: 13543776

Flygare; Wayne J. Fairbrother

X chromosome-linked inhibitor of apoptosis regulates cell death induction by proapoptotic receptor agonists

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Eugene Varfolomeev; Bruno Alicke; J. Michael Elliott; Zobel; Kristina West; Harvey Wong; Justin M. Scheer; Avi Ashkenazi; Stephen Gould; Wayne J. Fairbrother; Domagoj Vucic

NMR assignments of the human cytokine interleukin-33

Biomolecular NMR Assignments, ISSN: 18742718 1874270X

Andreas Lingel; Wayne J. Fairbrother

Structure of IL-33 and Its Interaction with the ST2 and IL-1RAcP Receptors-Insight into Heterotrimeric IL-1 Signaling Complexes

Structure, ISSN: 09692126

Andreas Lingel; Thomas M. Weiss; Marc Niebuhr; Borlan Pan; Brent A. Appleton; Wiesmann; J.Fernando Bazan; Wayne J. Fairbrother

Phosphorylation of a borealin dimerization domain is required for proper chromosome segregation

Biochemistry, ISSN: 00062960

Eric Bourhis; Andreas Lingel; Qui Phung; Wayne J. Fairbrother; Andrea G Cochran

Antagonism of c-IAP and XIAP proteins is required for efficient induction of cell death by small-molecule IAP antagonists

ACS Chemical Biology, ISSN: 15548929

Chudi O. Ndubaku; Eugene Varfolomeev; Lan Wang; Zobel; Kevin Lau; Linda O. Elliott; Brigitte Maurer; Anna V. Fedorova; Jasmin N. Dynek; Michael F. T. Koehler; Sarah G. Hymowitz; Vickie Tsui; Deshayes; Wayne J. Fairbrother; Flygare; Domagoj Vucic

Orally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffold

Journal of Medicinal Chemistry, ISSN: 00222623

Frederick Cohen; Bruno Alicke; Linda O. Elliott; Flygare; Tatiana Goncharov; Stephen F. Keteltas; Matthew C Franklin; Stacy Frankovitz; Jean-Philippe Stephan; Vickie Tsui; Domagoj Vucic; Harvey Wong; Wayne J. Fairbrother

Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP21

Biochemical Journal, ISSN: 02646021 14708728

John W. Blankenship; Eugene Varfolomeev; Tatiana Goncharov; Anna V. Fedorova; Donald S. Kirkpatrick; Anita Izrael-Tomasevic; Lilian Phu; David Arnott; Mariam Aghajan; Zobel; J.Fernando Bazan; Wayne J. Fairbrother; Deshayes; Domagoj Vucic

c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor α (TNFα)-induced NF-κB activation

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Eugene Varfolomeev; Tatiana Goncharov; Anna V. Fedorova; Jasmin N. Dynek; Zobel; Deshayes; Wayne J. Fairbrother; Domagoj Vucic

Microphthalmia-associated transcription factor is a critical transcriptional regulator of melanoma inhibitor of apoptosis in melanomas

Cancer Research, ISSN: 00085472

Jasmin N. Dynek; Sara M. Chan; Jinfeng Liu; Jiping Zha; Wayne J. Fairbrother; Domagoj Vucic

IAP Antagonists Induce Autoubiquitination of c-IAPs, NF-κB Activation, and TNFα-Dependent Apoptosis

Cell, ISSN: 00928674

Eugene Varfolomeev; John W. Blankenship; Sarah M. Wayson; Anna V. Fedorova; Nobuhiko Kayagaki; Parie Garg; Zobel; Jasmin N. Dynek; Linda O. Elliott; Heidi J. A. Wallweber; Flygare; Wayne J. Fairbrother; Deshayes; Vishva M. Dixit; Domagoj Vucic

The inhibitor of apoptosis proteins as therapeutic targets in cancer

Clinical Cancer Research, ISSN: 10780432

Domagoj Vucic; Wayne J. Fairbrother

Evaluation of assay technologies for the identification of protein-peptide interaction antagonists

Assay and Drug Development Technologies, ISSN: 1540658X

Saloumeh Kadkhodayan Fischer; Linda O. Elliott; Grace Mausisa; Heidi J. A. Wallweber; Deshayes; Bainian Feng; Wayne J. Fairbrother

Protein NMR Spectroscopy

Protein NMR Spectroscopy,

John Cavanagh; Wayne J. Fairbrother; Arthur G. Palmer III; Nicholas J. Skelton; Mark Rance

Protein NMR Spectroscopy: Principles and Practice

Protein NMR Spectroscopy: Principles and Practice,

John Cavanagh; Wayne J. Fairbrother; Arthur G. Palmer III; Mark Rance; Nicholas J. Skelton

Structure of C3b in complex with CRIg gives insights into regulation of complement activation

Nature, ISSN: 14764687 00280836

Wiesmann; Kenneth J. Katschke Jr.; Jianping Yin; Karim Y. Helmy; Micah Steffek; Wayne J. Fairbrother; Scott A. McCallum; Lizette Sturgeon; Laura DeForge; Hass; Menno Van Lookeren Campagne

Structure of SAP18: A ubiquitin fold in histone deacetylase complex assembly

Biochemistry, ISSN: 00062960

Scott A. McCallum; J.Fernando Bazan; Mark Merchant; Jianping Yin; Borlan Pan; Frederic J. De Sauvage; Wayne J. Fairbrother

The inhibitor of apoptosis protein fusion c-IAP2·MALT1 stimulates NF-κB activation independently of TRAF1 and TRAF2

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Eugene Varfolomeev; Sarah M. Wayson; Vishva M. Dixit; Wayne J. Fairbrother; Domagoj Vucic

Selective inhibition of fibroblast activation protein protease based on dipeptide substrate specificity

Journal of Biological Chemistry, ISSN: 00219258 1083351X

Conrad Yap Edosada; Quan; Wiesmann; Thuy Tran; Daniel P. Sutherlin; Mark E. Reynolds; J. Michael Elliott; Helga Raab; Wayne J. Fairbrother; Beni B. Wolf

Peptide substrate profiling defines fibroblast activation protein as an endopeptidase of strict Gly2-Pro1-cleaving specificity

FEBS Letters, ISSN: 00145793

Conrad Yap Edosada; Quan; Thuy Tran; Victoria Pham; Wiesmann; Wayne J. Fairbrother; Beni B. Wolf

Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs.

ACS Chemical Biology, ISSN: 15548937

Zobel; Lan Wang; Eugene Varfolomeev; Matthew C Franklin; Linda O. Elliott; Heidi J. A. Wallweber; David C Okawa; Flygare; Domagoj Vucic; Wayne J. Fairbrother; Deshayes

1H, 13C, and 15N resonance assignments of SAP18 [1]

Journal of Biomolecular NMR, ISSN: 09252738

Scott A. McCallum; Jianping Yin; Wayne J. Fairbrother

Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: Implications for Smac-dependent anti-apoptotic activity of ML-IAP

Biochemical Journal, ISSN: 02646021

Domagoj Vucic; Matthew C Franklin; Heidi J. A. Wallweber; Kanad Das; Brendan P. Eckelman; Hwain Shin; Linda O. Elliott; Saloumeh Kadkhodayan; Deshayes; Guy S. Salvesen; Wayne J. Fairbrother

Convergent recognition of the IgE binding site on the high-affinity IgE receptor

Structure, ISSN: 09692126

Jennifer Stamos; Eigenbrot; Nakamura; Mark E. Reynolds; Jianping Yin; Henry B. Lowman; Wayne J. Fairbrother; Melissa A. Starovasnik

Structure and function analysis of peptide antagonists of melanoma inhibitor of apoptosis (ML-IAP)

Biochemistry, ISSN: 00062960

Matthew C Franklin; Saloumeh Kadkhodayan; Heidi J. A. Wallweber; Daniela Alexandru; Mark D. Distefano; Linda O. Elliott; Flygare; Grace Mausisa; David C Okawa; Danny Ong; Domagoj Vucic; Deshayes; Wayne J. Fairbrother

BAFF/BLyS receptor 3 comprises a minimal TNF receptor-like module that encodes a highly focused ligand-binding site

Biochemistry, ISSN: 00062960

Nathaniel C. Gordon; Borlan Pan; Sarah G. Hymowitz; Jianping Yin; Robert F. Kelley; Andrea G Cochran; Minhong Yan; Vishva M. Dixit; Wayne J. Fairbrother; Melissa A. Starovasnik

Exploring protein-protein interactions with phage display

ChemBioChem, ISSN: 14394227

Sachdev S. Sidhu; Wayne J. Fairbrother; Deshayes

NMR structural analysis of vascular endothelial growth factor in complex with a phage-derived peptide antagonist

Spectroscopy, ISSN: 07124813

Borlan Pan; Wayne J. Fairbrother

Refinement of the solution structure of the heparin-binding domain of vascular endothelial growth factor using residual dipolar couplings

Journal of Biomolecular NMR, ISSN: 09252738

Melissa E. Stauffer; Nicholas J. Skelton; Wayne J. Fairbrother

SMAC negatively regulates the anti-apoptotic activity of melanoma inhibitor of apoptosis (ML-IAP)

Journal of Biological Chemistry, ISSN: 00219258

Domagoj Vucic; Deshayes; Heidi J. A. Wallweber; Pisabarro; Saloumeh Kadkhodayan; Wayne J. Fairbrother; Vishva M. Dixit

Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3

Journal of Biological Chemistry, ISSN: 00219258

Xiaoqing Sun; Jianping Yin; Melissa A. Starovasnik; Wayne J. Fairbrother; Vishva M. Dixit

1H, 13C, and 15N resonance assignment of the vascular endothelial growth factor receptor-binding domain in complex with a receptor-blocking peptide [5]

Journal of Biomolecular NMR, ISSN: 09252738

Borlan Pan; Wayne J. Fairbrother

Solution structure of a phage-derived peptide antagonist in complex with vascular endothelial growth factor

Journal of Molecular Biology, ISSN: 00222836

Borlan Pan; Bing Li; Russell; Jeffrey Tom; Andrea G Cochran; Wayne J. Fairbrother

Identification of a novel death domain-containing adaptor molecule for ectodysplasin-A receptor that is mutated in crinkled mice

Current Biology, ISSN: 09609822

Minhong Yan; Zemin Zhang; John B.B. Ridgway; Sarah Schilbach; Wayne J. Fairbrother; Vishva M. Dixit

The PYRIN domain: A member of the death domain-fold superfamily

Protein Science, ISSN: 09618368

Wayne J. Fairbrother; Nathaniel C. Gordon; Eric W. Humke; Karen M. O'Rourke; Melissa A. Starovasnik; Jianping Yin; Vishva M. Dixit

ICEBERG: A novel inhibitor of interleukin-1β generation

Cell, ISSN: 00928674

Eric W. Humke; Stephanie K. Shriver; Melissa A. Starovasnik; Wayne J. Fairbrother; Vishva M. Dixit

Characterization of the binding interface between the E-domain of Staphylococcal protein A and an antibody Fv-fragment

Biochemistry, ISSN: 00062960

David Meininger; Mark Rance; Melissa A. Starovasnik; Wayne J. Fairbrother; Nicholas J. Skelton

Antibody variable region binding by Staphylococcal protein A: Thermodynamic analysis and location of the Fv binding site on E-domain

Protein Science, ISSN: 09618368

Melissa A. Starovasnik; Mark P. O'Connell; Wayne J. Fairbrother; Robert F. Kelley

Novel peptides selected to bind vascular endothelial growth factor target the receptor-binding site

Biochemistry, ISSN: 00062960

Wayne J. Fairbrother; Hans W. Christinger; Andrea G Cochran; Fuh; Christopher J. Keenan; Quan; Stephanie K. Shriver; Jeffrey Tom; James A. Wells; Cunningham

Crystal structure of the complex between VEGF and a receptor-blocking peptide

Biochemistry, ISSN: 00062960

Wiesmann; Hans W. Christinger; Andrea G Cochran; Cunningham; Wayne J. Fairbrother; Christopher J. Keenan; Meng; De Vos

A His19 to Ala mutant of melanoma growth-stimulating activity is a partial antagonist of the CXCR2 receptor

Journal of Immunology, ISSN: 00221767

Deborah L. Baly; Richard Horuk; Yansura; Laura C. Simmons; Wayne J. Fairbrother; Claire Kotts; Wirth; Beth Gillece-Castro; Toy; Joseph Hesselgesser; David E. Allison

Backbone dynamics of the EGF-like domain of heregulin-α

Journal of Molecular Biology, ISSN: 00222836

Wayne J. Fairbrother; Jun Liu; Paul Pisacane; Mark X. Sliwkowski; Arthur G. Palmer III

Solution structure of the heparin-binding domain of vascular endothelial growth factor

Structure, ISSN: 09692126

Wayne J. Fairbrother; Mark Champe; Hans W. Christinger; Keyt; Melissa A. Starovasnik

Selection of heregulin variants having higher affinity for the ErbB3 receptor by monovalent phage display

Journal of Biological Chemistry, ISSN: 00219258

Ballinger; Jennifer T. Jones; Julie A. Lofgren; Wayne J. Fairbrother; Robert W. Akita; Mark X. Sliwkowski; James A. Wells

Binding interaction of the heregulinβ egf domain with ErbB3 and ErbB4 receptors assessed by alanine scanning mutagenesis

Journal of Biological Chemistry, ISSN: 00219258

Jennifer T. Jones; Ballinger; Paul Pisacane; Julie A. Lofgren; V. Danial Fitzpatrick; Wayne J. Fairbrother; James A. Wells; Mark X. Sliwkowski

Solution structure of the fourth metal-binding domain from the Menkes copper-transporting ATPase

Nature Structural Biology, ISSN: 10728368

Jane Gitschier; Moffat; Dorothea Reilly; William I. Wood; Wayne J. Fairbrother

Potent α4β1 peptide antagonists as potential anti-inflammatory agents

Journal of Medicinal Chemistry, ISSN: 00222623

Jackson; Quan; Dean R. Artis; Thomas E. Rawson; Brent Blackburn; Martin Struble; Geraldine Fitzgerald; Kathryn S. Chan; Sheldon Mullins; Burnier; Wayne J. Fairbrother; Clark; Maureen Berisini; Henry Chui; Renz; Susan Jones; Sherman Fong

Potent α4β1 peptide antagonists as potential anti-inflammatory agents

Journal of Medicinal Chemistry, ISSN: 00222623

Jackson; Quan; Dean R. Artis; Thomas E. Rawson; Brent Blackburn; Martin Struble; Geraldine Fitzgerald; Kathryn S. Chan; Sheldon Mullins; Burnier; Wayne J. Fairbrother; Clark; Maureen Berisini; Henry Chui; Renz; Susan Jones; Fong

1H, 13C, and 15N backbone assignment and secondary structure of the receptor-binding domain of vascular endothelial growth factor

Protein Science, ISSN: 09618368

Wayne J. Fairbrother; Mark Champe; Hans W. Christinger; Keyt; Melissa A. Starovasnik

Monomeric variants of IL-8: Effects of side chain substitutions and solution conditions upon dimer formation

Protein Science, ISSN: 09618368

Henry B. Lowman; Wayne J. Fairbrother; Paul H. Slagle; Rhona C. Kabakoff; Jun Liu; Steven J. Shire; Hébert

Solution structure of the E-domain of Staphylococcal protein A

Biochemistry, ISSN: 00062960

Melissa A. Starovasnik; Nicholas J. Skelton; Mark P. O'Connell; Robert F. Kelley; Dorothea Reilly; Wayne J. Fairbrother

Molecular recognition in protein complexes

FASEB Journal, ISSN: 08926638

James A. Wells; Brian C. Cunnmgham; Betty Li; Melissa A. Starovasnik; Wayne J. Fairbrother; Andrew Braisted

Exchanging interleukin-8 and melanoma growth-stimulating activity receptor binding specificities

Journal of Biological Chemistry, ISSN: 00219258

Henry B. Lowman; Paul H. Slagle; Laura DeForge; Wirth; Beth Gillece-Castro; James H. Bourell; Wayne J. Fairbrother

High-resolution solution structure of the EGF-like domain of heregulin-α

Biochemistry, ISSN: 00062960

Neil E. Jacobsen; Nasrin Abadi; Mark X. Sliwkowski; Dorothea Reilly; Nicholas J. Skelton; Wayne J. Fairbrother

Structure of the saponin adjuvant QS-21 and its base-catalyzed isomerization product by 1 H and natural abundance 13 C NMR spectroscopy

Carbohydrate Research, ISSN: 00086215

Neil E. Jacobsen; Wayne J. Fairbrother; Kensil; Lim; Deborah A. Wheeler; Powell

Minimization of a polypeptide hormone

Science, ISSN: 00368075

Bing Li; Jeffrey Tom; David A. Oare; Randy Yen; Wayne J. Fairbrother; James A. Wells; Cunningham

Growth hormone secretagogues: Characterization, efficacy, and minimal bioactive conformation

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

Robert S. McDowell; Kathleen A. Elias; Mark S. Stanley; Burdick; Burnier; Kathryn S. Chan; Wayne J. Fairbrother; R. Glenn Hammonds; Gladys S. Ingle; Neil E. Jacobsen; Deborah L. Mortensen; Thomas E. Rawson; Wesley B. Won; Ross Clark; Todd C. Somers

A mutant of melanoma growth stimulating activity does not activate neutrophils but blocks erythrocyte invasion by malaria

Journal of Biological Chemistry, ISSN: 00219258

Joseph Hesselgesser; Chitnis; Miller; Yansura; Laura C. Simmons; Wayne J. Fairbrother; Claire Kotts; Wirth; Beth Gillece-Castro; Richard Horuk

Solution Conformation of an Atrial Natriuretic Peptide Variant Selective for the Type A Receptor

Biochemistry, ISSN: 15204995 00062960

Wayne J. Fairbrother; Brian C. Cunningham; Robert S. McDowell

A reinvestigation of a synthetic peptide (TrPepz) designed to mimic trypsin

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424

James A. Wells; Wayne J. Fairbrother; Jacek Otlewski; Michael Laskowski Jr.; Burnier

A novel isotope labeling protocol for bacterially expressed proteins

Journal of Biomolecular NMR, ISSN: 09252738 15735001

Dorothea Reilly; Wayne J. Fairbrother

The solution structure of melanoma growth stimulating activity

Journal of Molecular Biology, ISSN: 00222836

Wayne J. Fairbrother; Dorothea Reilly; Timothy J. Colby; Joseph Hesselgesser; Richard Horuk

1H assignment and secondary structure determination of human melanoma growth stimulating activity (MGSA) by NMR spectroscopy

FEBS Letters, ISSN: 00145793

Wayne J. Fairbrother; Dorothea Reilly; Timothy J. Colby; Richard Horuk

Assignment of 1H, 15N, and 13C Resonances, Identification of Elements of Secondary Structure and Determination of the Global Fold of the DNA-Binding Domain of GAL4

Biochemistry, ISSN: 15204995 00062960

Masahiro Shirakawa; Yasuharu Serikawa; Yoshimasa Kyogoku; Wayne J. Fairbrother; Peter E. Wright; Tadayasu Ohkubo

Mapping of the Binding Interfaces of the Proteins of the Bacterial Phosphotransferase System, HPr and IIAglc

Biochemistry, ISSN: 15204995 00062960

Yuan Chen; Peter E. Wright; Jonathan Reizer; Milton H. Saier Jr.; Wayne J. Fairbrother

Backbone Dynamics of the Bacillus subtilis Glucose Permease IIA Domain Determined from 15N NMR Relaxation Measurements

Biochemistry, ISSN: 15204995 00062960

Martin J. Stone; Peter E. Wright; Wayne J. Fairbrother; Arthur G. Palmer III; Jonathan Reizer; Milton H. Saier Jr.

Assignment of the Aliphatic 1H and 13C Resonances of the Bacillus Subtilis Glucose Permease IIA Domain Using Double- and Triple-Resonance Heteronuclear Three-Dimensional NMR Spectroscopy

Biochemistry, ISSN: 15204995 00062960

Mark Ranee; Peter E. Wright; Wayne J. Fairbrother; Arthur G. Palmer III; Jonathan Reizer; Milton H. Saier Jr.

The Scripps Research Institute, Department of Molecular Biology, Postdoctoral Fellow – 1992
Oxford University, United Kingdom, Inorganic Chemistry Laboratory, D.Phil. – 1989
University of Otago, New Zealand, Department of Chemistry, B.Sc. – 1984

Ralph Schwall Memorial Award – 2013
Damon Runyon-Walter Winchell Cancer Research Fund Postdoctoral Fellowship – 1990-1992
Wolfson College Graduate Award – 1987-1989
Commonwealth Scholarship, Wolfson College, Oxford, U.K – 1986-1989