Weilan Ye
Senior Fellow, Molecular Oncology
Postdoc Mentor
Fellow
"Time and again, Genentech is proven to be the industry leader. This is a place where creative minds have a good chance to transform medicine."
28
Years at Genentech
46
Publications at Genentech
I came to Genentech as a postdoc in October 1995 to work on neural development and neural degenerative diseases. I enjoyed the dynamic and stimulating scientific environment so much that I decided to stay as a scientist. Beginning in November 1999, I started a small research lab focusing on vascular biology. Today, I am leading a multi-group program working on discovering potential treatments for a variety of diseases with vascular pathologies including exudative age related macular degeneration, diabetic retinopathy, hereditary vascular disorders, and cancer.
Postdoctoral Mentor
One of the most attractive and exciting features of being a scientist at Genentech is to mentor postdocs. Postdocs bring critical thinking, new ideas, and the youthful enthusiasm to our research programs. Mentoring postdocs energizes my mind and fuels my scientific curiosity. I truly enjoy helping them build their careers, and my group finds the postdocs an important part of our working “family”.
Featured Publication
MAP4K4 negatively regulates CD8 T cell–mediated antitumor and antiviral immunity
Science Immunology 27 Mar 2020:Vol. 5, Issue 45, eaay2245
Emel Esen, Ismail Sergin, Rajiv Jesudason, Patricia Himmels, Joshua D. Webster, Hua Zhang, Min Xu, Robert Piskol, Erin McNamara, Stephen Gould, Aude-Hélène Capietto, Lélia Delamarre, Kevin Walsh, and Weilan Ye
The Complexity of Translating Anti-angiogenesis Therapy from Basic Science to the Clinic.
Developmental Cell (April 2016)18;37(2):114-25. doi: 10.1016/j.devcel.2016.03.015.
Weilan Ye
My Focus
We are studying how vascular alteration contributes to human diseases. For example, increased vascular permeability is an important pathologic driver in the neovascular age-related macular degeneration and diabetic macular edema. Manipulating the molecular machineries that control vascular permeability may lead to the discovery of treatments for these diseases.
We are also exploring ways to modulate the vascular barrier function in order to increase or decrease leukocyte trafficking and drug distribution in disease tissues. Increasing lymphocyte trafficking into tumors, or decreasing leukocyte trafficking into inflamed tissues may be beneficial in managing these diseases.
Genentech Publications
Nature Immunology, ISSN: 15292916 15292908
Siri Tahtinen; Ann-Jay Tong; Patricia Himmels; Jaehak Oh; Andres Paler Martinez; Leesun Kim; Sara Wichner; Yoko Oei; Mark J. McCarron; Emily C. Freund; Zhainib Adel Amir; Cecile C. de la Cruz; Benjamin Haley; Craig D. Blanchette; Jill Schartner; Weilan Ye; Mahesh Yadav; Ugur Sahin; Lélia Delamarre; Ira Mellman
Development (Cambridge), ISSN: 14779129 09501991
Minkyoung Lee; Charles Betz; Jianmin Yin; Ilkka Paatero; Niels Schellinx; Adam N. Carte; Christopher W. Wilson; Weilan Ye; Markus Affolter; Heinz-Georg Belting
Science immunology, ISSN: 24709468
Emel Esen; Ismail Sergin; Rajiv Jesudason; Patricia Himmels; Webster; Hua Zhang; Min Xu; Robert Piskol; Erin McNamara; Stephen Gould; Aude-Hélène Capietto; Lélia Delamarre; Kevin B. Walsh; Weilan Ye
EMBO Molecular Medicine, ISSN: 17574684 17574676
Nevenka Dudvarski Stanković; Frank Bicker; Stefanie Keller; David T.W. Jones; Patrick N Harter; Arne Kienzle; Clarissa Gillmann; Philipp Arnold; Anna Golebiewska; Olivier Keunen; Alf Giese; von Deimling; Tobias Bäuerle; Simone P Niclou; Michel Mittelbronn; Weilan Ye; Stefan M. Pfister; Mirko HH Schmidt
Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704
Colin D. Weekes; Lee Rosen; Anna Capasso; Kit Man Wong; Weilan Ye; Maria Anderson; Bruce Mccall; Jill Fredrickson; Eric Wakshull; Stephen M. Eppler; Quyen Shon-Nguyen; Rupal Desai; Mahrukh Huseni; Priti Hegde; Tony Pourmohamad; Ina Rhee; Alberto Bessudo
Oncologist, ISSN: 1549490X 10837159
Joachim Von Pawel; David Spigel; Thomas J. Ervin; György Losonczy; Fabrice Barlesi; Erzsébet Juhász; Maria Anderson; Bruce Mccall; Eric Wakshull; Priti Hegde; Weilan Ye; Daniel S. Chen; Ilsung Chang; Ina Rhee; Martin Reck
Oncologist, ISSN: 1549490X 10837159
Rocío García-Carbonero; Eric Van Cutsem; Rivera; Jacek Jassem; Ira Gore; Niall C. Tebbutt; Fadi S. Braiteh; Guillem Argiles; Zev A. Wainberg; Roel Funke; Maria Anderson; Bruce Mccall; Mark Stroh; Eric Wakshull; Priti Hegde; Weilan Ye; Daniel S. Chen; Ilsung Chang; Ina Rhee; Herbert Hurwitz
ACS Medicinal Chemistry Letters, ISSN: 19485875
Chudi O. Ndubaku; Terry Crawford; Huifen Chen; Jason Boggs; Joy Drobnick; Seth F. Harris; Rajiv Jesudason; Erin McNamara; Jim Nonomiya; Amy Sambrone; Stephen Schmidt; Tanya Smyczek; Philip Vitorino; Lan Wang; Ping Wu; Stacey Yeung; Jinhua Chen; Kevin Chen; Charles Z. Ding; Tao Wang; Zijin Xu; Stephen Gould; Lesley J. Murray; Weilan Ye
Nature, ISSN: 14764687 00280836
Philip Vitorino; Stacey Yeung; Ailey Crow; Jesse Bakke; Tanya Smyczek; Kristina West; Erin McNamara; Jeffrey Eastham-Anderson; Stephen Gould; Seth F. Harris; Chudi O. Ndubaku; Weilan Ye
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Lan Wang; Mark S. Stanley; Jason Boggs; Terry Crawford; Brandon Bravo; Anthony M. Giannetti; Seth F. Harris; Steven Magnuson; Jim Nonomiya; Stephen Schmidt; Ping Wu; Weilan Ye; Stephen Gould; Lesley J. Murray; Chudi O. Ndubaku; Huifen Chen
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Terry Crawford; Chudi O. Ndubaku; Huifen Chen; Jason Boggs; Brandon Bravo; Kelly Delatorre; Anthony M. Giannetti; Stephen Gould; Seth F. Harris; Steven Magnuson; Erin McNamara; Lesley J. Murray; Jim Nonomiya; Amy Sambrone; Stephen Schmidt; Tanya Smyczek; Mark S. Stanley; Philip Vitorino; Lan Wang; Kristina West; Ping Wu; Weilan Ye
EMBO Journal, ISSN: 14602075 02614189
Weilan Ye
Journal of Pathology, ISSN: 00223417 10969896
Menno Van Lookeren Campagne; Jennifer Lecouter; Brian L. Yaspan; Weilan Ye
Cell Adhesion and Migration, ISSN: 19336926 19336918
Christopher W. Wilson; Weilan Ye
Blood, ISSN: 15280020 00064971
Christopher W. Wilson; Leon Parker; Christopher J. Hall; Tanya Smyczek; Judy Mak; Ailey Crow; George Posthuma; Ann De Mazière; Meredith Sagolla; Cecile Chalouni; Philip Vitorino; Merone Roose-Girma; Søren Warming; Judith Klumperman; Philip S. Crosier; Weilan Ye
Journal of Clinical Investigation, ISSN: 15588238 00219738
Leisa Johnson; Mahrukh Huseni; Tanya Smyczek; Anthony Lima; Stacey Yeung; Jason H. Cheng; Rafael Molina; David Kan; Ann De Mazière; Judith Klumperman; Ian Kasman; Yin Zhang; Dennis; Jeffrey Eastham-Anderson; Adrian M. Jubb; Olivia Hwang; Rupal Desai; Maike Schmidt; Michelle Nannini; Kai H. Barck; Richard A. D. Carano; William F. Forrest; Qinghua Song; Daniel S. Chen; Louie Naumovski; Mallika Singh; Weilan Ye; Priti Hegde
PLoS ONE, ISSN: 19326203
Alvin Gogineni; Maresa Caunt; Ailey Crow; Chingwei V. Lee; Fuh; Nicholas Van Bruggen; Weilan Ye; Robby M. Weimer
Neoplasia (United States), ISSN: 14765586 15228002
Deepak Sampath; Jason Oeh; Shelby K. Wyatt; Tim C. Cao; Koeppen; Jeffrey Eastham-Anderson; Liliane Robillard; Calvin Ho; Ross; Guanglei Zhuang; Hani Bou-Reslan; Philip Vitorino; Kai H. Barck; Sharon E. Ungersma; Jean-Michel Vernes; Maresa Caunt; Nicholas Van Bruggen; Weilan Ye; Ulka Vijapurkar; Yu-Ju Gloria Meng; Napoleone Ferrara; Lori S. Friedman; Richard A. D. Carano
Genome Research, ISSN: 10889051 15495469
Zhaoshi Jiang; Suchit Jhunjhunwala; Jinfeng Liu; Matthias Peter; Michael I. Kennemer; Yinghui Guan; William Lee; Paolo Carnevali; Stinson; Stephanie Johnson; Jingyu Diao; Stacey Yeung; Adrian M. Jubb; Weilan Ye; Thomas D Wu; Sharookh B. Kapadia; Frederic J. De Sauvage; Robert Gentleman; Howard M. Stern; Somasekar Seshagiri; Krishna P. Pant; Zora Modrusan; Dennis G. Ballinger; Zemin Zhang
Nature Biotechnology, ISSN: 15461696 10870156
Tracy Tzu-Ling Tang; Li Li; Zhijun Tang; Yun Li; Wei Yu Lin; Flavius Martin; Deanna Grant; Mark J. Solloway; Leon Parker; Weilan Ye; William F. Forrest; Nico Ghilardi; Tamás Oravecz; Kenneth A. Platt; Dennis S. Rice; Gwenn M. Hansen; Alejandro Abuin; Derek E. Eberhart; Godowski; Kathleen H. Holt; Andrew S. Peterson; Brian P. Zambrowicz; Frederic J. De Sauvage
Carcinogenesis, ISSN: 01433334 14602180
Cho S. Aung; Weilan Ye; Greg D. Plowman; Amelia A. Peters; Gregory R. Monteith; Sarah J. Roberts-Thomson
Cell, ISSN: 00928674
Harald Junge; Stacey Yang; Jeremy B. Burton; Kim Paes; Xiao Shu; French; Michael Costa; Dennis S. Rice; Weilan Ye
Science Signaling, ISSN: 19450877 19379145
Marie Evangelista; Tze Yang Lim; James Lee; Leon Parker; Amir M. Ashique; Andrew S. Peterson; Weilan Ye; David P. Davis; Frederic J. De Sauvage
Developmental Dynamics, ISSN: 10588388 10970177
Ann De Mazière; Leon Parker; Suzanne Van Dijk; Weilan Ye; Judith Klumperman
Investigative Ophthalmology and Visual Science, ISSN: 01460404 15525783
Claudio Campa; Ian Kasman; Weilan Ye; Wyne P. Lee; Fuh; Napoleone Ferrara
Novartis Foundation Symposium, ISSN: 15282511
Maike Schmidt; Ann De Mazière; Tanya Smyczek; Gray; Leon Parker; Ellen H. Filvaroff; French; Suzanne Van Dijk; Judith Klumperman; Weilan Ye
Novartis Foundation Symposium, ISSN: 15282511
Christiana Ruhrberg; Jonathan A. Epstein; Christopher J. Drake; Eckhard Lammert; Ralf H. Adams; Gary K. Owens; Frances High; Weilan Ye; Hellmut G. Augustin
Novartis Foundation Symposium, ISSN: 15282511
Eckhard Lammert; Christiana Ruhrberg; Christopher J. Drake; Brant M. Weinstein; Neil A. Vargesson; Weilan Ye
Novartis Foundation Symposium, ISSN: 15282511
Christopher J. Drake; Christer Betsholtz; Holger Gerhardt; Christiana Ruhrberg; Brant M. Weinstein; Eckhard Lammert; Weilan Ye; Elisabetta Dejana; Gary K. Owens; Masabumi Shibuya
Novartis Foundation Symposium, ISSN: 15282511
Ralf H. Adams; Hellmut G. Augustin; Christer Betsholtz; Elisabetta Dejana; Christopher J. Drake; Jonathan A. Epstein; Holger Gerhardt; Jan Kitajewski; Eckhard Lammert; Taija Mäkinen; Masabumi Shibuya; Claire L. Shovlin; Anne E. Uv; Brant M. Weinstein; Jörg Wilting; Yancopoulos; Weilan Ye
Novartis Foundation Symposium, ISSN: 15282511
Neil A. Vargesson; Brant M. Weinstein; Elisabetta Dejana; Eckhard Lammert; Weilan Ye; Christopher J. Drake; Anne E. Uv; Masabumi Shibuya
Novartis Foundation Symposium, ISSN: 15282511
Jamie A. Davies; Eckhard Lammert; Weilan Ye; Neil A. Vargesson; Keith E. Mostov; Adam Wilkins; Jörg Wilting; Christer Betsholtz; Anne Eichmann; Christopher J. Drake; Christiana Ruhrberg; Claire L. Shovlin; Elisabetta Dejana; Hellmut G. Augustin; Yancopoulos; Jan Kitajewski
Novartis Foundation Symposium, ISSN: 15282511
Hellmut G. Augustin; Yancopoulos; Brant M. Weinstein; Jan Kitajewski; Christiana Ruhrberg; Jonathan A. Epstein; Holger Gerhardt; Christopher J. Drake; Gary K. Owens; Claire L. Shovlin; Weilan Ye; Eckhard Lammert
Novartis Foundation Symposium, ISSN: 15282511
Christiana Ruhrberg; Christopher J. Drake; Jamie A. Davies; Eckhard Lammert; Weilan Ye; Yancopoulos; Gary K. Owens; Hellmut G. Augustin; Ralf H. Adams; Jörg Wilting; Adam Wilkins; Claire L. Shovlin
Novartis Foundation Symposium, ISSN: 15282511
Elisabetta Dejana; Weilan Ye; Christopher J. Drake; Ralf H. Adams; Hellmut G. Augustin; Masabumi Shibuya
Novartis Foundation Symposium, ISSN: 15282511
Jan Kitajewski; Deborah A. Freedman; Gary K. Owens; Christopher J. Drake; Jörg Wilting; Eckhard Lammert; Masabumi Shibuya; Holger Gerhardt; Weilan Ye; Brant M. Weinstein
Novartis Foundation Symposium, ISSN: 15282511
Weilan Ye; Anne E. Uv; Eckhard Lammert; Holger Gerhardt; Christer Betsholtz; Jörg Wilting
Development (Cambridge), ISSN: 09501991
Maike Schmidt; Kim Paes; Ann De Mazière; Tanya Smyczek; Stacey Yang; Gray; French; Ian Kasman; Judith Klumperman; Dennis S. Rice; Weilan Ye
Nature, ISSN: 00280836
Leon Parker; Maike Schmidt; Suk-Won Jin; Gray; Dimitris Beis; Thinh Q. Pham; Gretchen D. Frantz; Susan Palmieri; Kenneth J. Hillan; Didier Y. R. Stainier; Frederic J. De Sauvage; Weilan Ye
Development (Cambridge), ISSN: 09501991
Sarah E. Craven; Kim-Chew Lim; Weilan Ye; James Douglas Engel; Frederic J. De Sauvage; Arnon Rosental
Handbook of Cell Signaling,
Mark Merchant; Weilan Ye; Frederic J. De Sauvage
American Journal of Pathology, ISSN: 00029440
Fiona Oakley; Nathan Trim; Christothea M. Constandinou; Weilan Ye; Gray; Gretchen D. Frantz; Kenneth J. Hillan; Tim Kendall; R. Christopher Benyon; Derek A. Mann; John P. Iredale
Nature Neuroscience, ISSN: 10976256
Weilan Ye; Maxime Bouchard; Donna Stone; Xiaodong Liu; Francis Vella; James Lee; Harukazu Nakamura; Siew-Lan Ang; Meinrad Busslinger; Rosenthal
Nature Neuroscience, ISSN: 10976256
Mary Hynes; Weilan Ye; Kevin Wang; Donna Stone; Maximilien Murone; Frederic J. De Sauvage; Rosenthal
Journal of Cell Science, ISSN: 00219533
Donna Stone; Maximilien Murone; Shiuh-Ming Luoh; Weilan Ye; Armanini; Austin L. Gurney; Phillips; Brush; Goddard; Frederic J. De Sauvage; Rosenthal
Cell, ISSN: 00928674
Weilan Ye; Kenji Shimamura; John L. R. Rubenstein; Mary Hynes; Rosenthal
Education
- University of Pittsburgh, Department of Biological Sciences, Ph.D. Molecular, Cellular, Developmental Biology Program – 1995
- University of Science and Technology of China (USTC), Biophysics, B.S. – 1988