Weilan Ye
Senior Fellow, Molecular Oncology
Postdoc Mentor
Staff Scientist
"Time and again, Genentech is proven to be the industry leader. This is a place where creative minds have a good chance to transform medicine."
26
Years at Genentech
44
Publications
I came to Genentech as a postdoc in October 1995 to work on neural development and neural degenerative diseases. I enjoyed the dynamic and stimulating scientific environment so much that I decided to stay as a scientist. Beginning in November 1999, I started a small research lab focusing on vascular biology. Today, I am leading a multi-group program working on discovering potential treatments for a variety of diseases with vascular pathologies including exudative age related macular degeneration, diabetic retinopathy, hereditary vascular disorders, and cancer.
Postdoctoral Mentor
One of the most attractive and exciting features of being a scientist at Genentech is to mentor postdocs. Postdocs bring critical thinking, new ideas, and the youthful enthusiasm to our research programs. Mentoring postdocs energizes my mind and fuels my scientific curiosity. I truly enjoy helping them build their careers, and my group finds the postdocs an important part of our working “family”.
Featured Publication
MAP4K4 negatively regulates CD8 T cell–mediated antitumor and antiviral immunity
Science Immunology 27 Mar 2020:Vol. 5, Issue 45, eaay2245
Emel Esen, Ismail Sergin, Rajiv Jesudason, Patricia Himmels, Joshua D. Webster, Hua Zhang, Min Xu, Robert Piskol, Erin McNamara, Stephen Gould, Aude-Hélène Capietto, Lélia Delamarre, Kevin Walsh, and Weilan Ye
The Complexity of Translating Anti-angiogenesis Therapy from Basic Science to the Clinic.
Developmental Cell (April 2016)18;37(2):114-25. doi: 10.1016/j.devcel.2016.03.015.
Weilan Ye
My Focus
We are studying how vascular alteration contributes to human diseases. For example, increased vascular permeability is an important pathologic driver in the neovascular age-related macular degeneration and diabetic macular edema. Manipulating the molecular machineries that control vascular permeability may lead to the discovery of treatments for these diseases.
We are also exploring ways to modulate the vascular barrier function in order to increase or decrease leukocyte trafficking and drug distribution in disease tissues. Increasing lymphocyte trafficking into tumors, or decreasing leukocyte trafficking into inflamed tissues may be beneficial in managing these diseases.
Publications
Science immunology, ISSN: 24709468
Emel Esen; Ismail Sergin; Rajiv Jesudason; Patricia Himmels; Webster; Hua Zhang; Min Xu; Robert Piskol; Erin McNamara; Stephen Gould; Aude-Helene Capietto; Lelia Delamarre; Kevin B. Walsh; Weilan Ye
Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704
Colin D. Weekes; Lee Rosen; Anna Capasso; Kit Man Wong; Weilan Ye; Maria Anderson; Bruce McCall; Jill Fredrickson; Eric Wakshull; Stephen Eppler; Quyen Shon-Nguyen; Rupal Desai; Mahrukh Huseni; Priti Hegde; Tony Pourmohamad; Ina Rhee; Alberto Bessudo
EGFL7 enhances surface expression of integrin α5 β1 to promote angiogenesis in malignant brain tumors
EMBO Molecular Medicine, ISSN: 17574676
Nevenka Dudvarski Stanković; Frank Bicker; Stefanie Keller; David T.W. Jones; Patrick N Harter; Arne Kienzle; Clarissa Gillmann; Philipp Arnold; Anna Golebiewska; Olivier Keunen; Alf Giese; von Deimling; Tobias Bäuerle; Simone P Niclou; Michel Mittelbronn; Weilan Ye; Stefan M. Pfister; Mirko HH Schmidt
Randomized Phase II Trial of Parsatuzumab (Anti-EGFL7) or Placebo in Combination with Carboplatin, Paclitaxel, and Bevacizumab for First-Line Nonsquamous Non-Small Cell Lung Cancer
Oncologist, ISSN: 10837159
Joachim Von Pawel; David Spigel; Thomas J. Ervin; György Losonczy; Fabrice Barlesi; Erzsébet Juhász; Maria Anderson; Bruce McCall; Eric Wakshull; Priti Hegde; Weilan Ye; Daniel Chen; Ilsung Chang; Ina Rhee; Martin Reck
Oncologist, ISSN: 1549490X
Rocío García-Carbonero; Eric Van Cutsem; Rivera; Jacek Jassem; Ira Gore; Niall C. Tebbutt; Fadi S. Braiteh; Guillem Argiles; Zev A. Wainberg; Roel Funke; Maria Anderson; Bruce McCall; Mark Stroh; Eric Wakshull; Priti Hegde; Weilan Ye; Daniel Chen; Ilsung Chang; Ina Rhee; Herbert Hurwitz
ACS Medicinal Chemistry Letters, ISSN: 19485875
Chudi Ndubaku; Terry Crawford; Huifen Chen; Jason Boggs; Joy Drobnick; Seth Harris; Raj Jesudason; Erin McNamara; Jim Nonomiya; Amy Sambrone; Steve Schmidt; Tanya Smyczek; Philip Vitorino; Lan Wang; Ping Wu; Stacey Yeung; Jinhua Chen; Kevin Chen; Charles Z. Ding; Tao Wang; Zijin Xu; Stephen Gould; Lesley Murray; Weilan Ye
Nature, ISSN: 14764687
Philip Vitorino; Stacey Yeung; Ailey Crow; Jesse Bakke; Tanya Smyczek; Kristina West; Erin McNamara; Jeff Eastham Anderson; Stephen Gould; Seth Harris; Chudi Ndubaku; Weilan Ye
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405
Lan Wang; Mark Stanley; Jason Boggs; Terry Crawford; Brandon Bravo; Tony Giannetti; Seth Harris; Steven Magnuson; Jim Nonomiya; Steve Schmidt; Ping Wu; Weilan Ye; Stephen Gould; Lesley Murray; Chudi Ndubaku; Huifen Chen
Journal of Medicinal Chemistry, ISSN: 15204804
Terry Crawford; Chudi Ndubaku; Huifen Chen; Jason Boggs; Brandon Bravo; Kelly Delatorre; Tony Giannetti; Stephen Gould; Seth Harris; Steven Magnuson; Erin McNamara; Lesley Murray; Jim Nonomiya; Amy Sambrone; Steve Schmidt; Tanya Smyczek; Mark Stanley; Philip Vitorino; Lan Wang; Kristina West; Ping Wu; Weilan Ye
EMBO Journal, ISSN: 14602075
Weilan Ye
Cell Adhesion and Migration, ISSN: 19336926
Christopher Wilson; Weilan Ye
Journal of Pathology, ISSN: 00223417
Menno van Lookeren Campagne; Jennifer Lecouter; Brian Yaspan; Weilan Ye
Blood, ISSN: 00064971
Christopher Wilson; Leon Parker IV; Christopher J. Hall; Tanya Smyczek; Judy Mak; Ailey Crow; George Posthuma; Ann De Mazière; Meredith Sagolla; Cecile Chalouni; Philip Vitorino; Meron Roose-Girma; Soren Warming; Judith Klumperman; Philip S. Crosier; Weilan Ye
Journal of Clinical Investigation, ISSN: 15588238
Leisa Johnson; Mahrukh Huseni; Tanya Smyczek; Tony Lima; Stacey Yeung; Jason Cheng; Rafael Molina; David Kan; Ann De Mazière; Judith Klumperman; Ian Kasman; Yingnan Zhang; Mark Dennis; Jeff Eastham Anderson; Adrian Jubb; Olivia Hwang; Rupal Desai; Maike Schmidt; Michelle Nannini; Kai Barck; Rick Carano; Bill Forrest; Qinghua Song; Daniel Chen; Louie Naumovski; Mallika Singh; Weilan Ye; Priti Hegde
PLoS ONE, ISSN: 19326203
Alvin Gogineni; Maresa Caunt; Ailey Crow; Vivian Lee; Germaine Fuh; Nick Van Bruggen; Weilan Ye; Robby Weimer
Neoplasia (United States), ISSN: 15228002
Deepak Sampath; Jason Oeh; Shelby Wyatt; Tim Cao; Hartmut Koeppen; Jeff Eastham Anderson; Liliane Robillard; Calvin Ho; Jed Ross; Guanglei Zhuang; Hani Bou-Reslan; Philip Vitorino; Kai Barck; Sharon Ungersma; Jean-Michel Vernes; Maresa Caunt; Nick Van Bruggen; Weilan Ye; Ulka Vijapurkar; Yue Meng; Napoleone Ferrara; Lori Friedman; Rick Carano
Genome Research, ISSN: 10889051
Zhaoshi Jiang; Suchit Jhunjhunwala; Jinfeng Liu; Pete Haverty; Michael I. Kennemer; Ying Guan; William Lee; Paolo Carnevali; Jeremy Stinson; Stephanie Johnson; Jingyu Diao; Stacey Yeung; Adrian Jubb; Weilan Ye; Thomas Wu; Sharookh Kapadia; Frederic De Sauvage; Robert Gentleman; Howard Stern; Somasekar Seshagiri; Krishna P. Pant; Zora Modrusan; Dennis G. Ballinger; Zhen Zhang
Nature Biotechnology, ISSN: 15461696
Tracy Tang; Li Li; Jerry (Zhijun) Tang; Yun Li; WeiYu Lin; Flavius Martin; Deanna Grant; Mark Solloway; Leon Parker IV; Weilan Ye; Bill Forrest; Nico Ghilardi; Tamás Oravecz; Kenneth A. Platt; Dennis S. Rice; Gwenn M. Hansen; Alejandro Abuin; Derek E. Eberhart; Paul Godowski; Kathleen H. Holt; Andy Peterson; Brian P. Zambrowicz; Frederic De Sauvage
Carcinogenesis, ISSN: 01433334
Cho S. Aung; Weilan Ye; Greg Plowman; Amelia A. Peters; Gregory R. Monteith; Sarah J. Roberts-Thomson
Cell, ISSN: 00928674
Harald Junge; Stacey Yang; Jeremy Burton; Kim Paes; Xiao Shu; Dorothy French; Mike Costa; Dennis S. Rice; Weilan Ye
Science Signaling, ISSN: 19450877
Marie Evangelista; Tze Yang Lim; James Lee; Leon Parker IV; Amir Ashique; Andy Peterson; Weilan Ye; David Davis; Frederic De Sauvage
Developmental Dynamics, ISSN: 10588388
Ann De Mazière; Leon Parker IV; Suzanne Van Dijk; Weilan Ye; Judith Klumperman
Investigative Ophthalmology and Visual Science, ISSN: 01460404
Claudio Campa; Ian Kasman; Weilan Ye; Wyne Lee; Germaine Fuh; Napoleone Ferrara
Novartis Foundation Symposium, ISSN: 15282511
Maike Schmidt; Ann De Mazière; Tanya Smyczek; Alane Gray; Leon Parker IV; Ellen Filvaroff; Dorothy French; Suzanne Van Dijk; Judith Klumperman; Weilan Ye
Novartis Foundation Symposium, ISSN: 15282511
Christiana Ruhrberg; Jonathan A. Epstein; Christopher J. Drake; Eckhard Lammert; Ralf H. Adams; Gary K. Owens; Frances High; Weilan Ye; Hellmut G. Augustin
Novartis Foundation Symposium, ISSN: 15282511
Weilan Ye; Anne E. Uv; Eckhard Lammert; Holger Gerhardt; Christer Betsholtz; Jörg Wilting
Novartis Foundation Symposium, ISSN: 15282511
Christopher J. Drake; Christer Betsholtz; Holger Gerhardt; Christiana Ruhrberg; Brant M. Weinstein; Eckhard Lammert; Weilan Ye; Elisabetta Dejana; Gary K. Owens; Masabumi Shibuya
Novartis Foundation Symposium, ISSN: 15282511
Ralf H. Adams; Hellmut G. Augustin; Christer Betsholtz; Elisabetta Dejana; Christopher J. Drake; Jonathan A. Epstein; Holger Gerhardt; Jan Kitajewski; Eckhard Lammert; Taija Mäkinen; Masabumi Shibuya; Claire L. Shovlin; Anne E. Uv; Brant M. Weinstein; Jörg Wilting; Yancopoulos; Weilan Ye
Novartis Foundation Symposium, ISSN: 15282511
Jan Kitajewski; Deborah A. Freedman; Gary K. Owens; Christopher J. Drake; Jörg Wilting; Eckhard Lammert; Masabumi Shibuya; Holger Gerhardt; Weilan Ye; Brant M. Weinstein
Novartis Foundation Symposium, ISSN: 15282511
Elisabetta Dejana; Weilan Ye; Christopher J. Drake; Ralf H. Adams; Hellmut G. Augustin; Masabumi Shibuya
Novartis Foundation Symposium, ISSN: 15282511
Christiana Ruhrberg; Christopher J. Drake; Jamie Davies; Eckhard Lammert; Weilan Ye; Yancopoulos; Gary K. Owens; Hellmut G. Augustin; Ralf H. Adams; Jörg Wilting; Adam Wilkins; Claire L. Shovlin
Novartis Foundation Symposium, ISSN: 15282511
Hellmut G. Augustin; Yancopoulos; Brant M. Weinstein; Jan Kitajewski; Christiana Ruhrberg; Jonathan A. Epstein; Holger Gerhardt; Christopher J. Drake; Gary K. Owens; Claire L. Shovlin; Weilan Ye; Eckhard Lammert
Novartis Foundation Symposium, ISSN: 15282511
Jamie Davies; Eckhard Lammert; Weilan Ye; Neil A. Vargesson; Keith E. Mostov; Adam Wilkins; Jörg Wilting; Christer Betsholtz; Anne Eichmann; Christopher J. Drake; Christiana Ruhrberg; Claire L. Shovlin; Elisabetta Dejana; Hellmut G. Augustin; Yancopoulos; Jan Kitajewski
Novartis Foundation Symposium, ISSN: 15282511
Neil A. Vargesson; Brant M. Weinstein; Elisabetta Dejana; Eckhard Lammert; Weilan Ye; Christopher J. Drake; Anne E. Uv; Masabumi Shibuya
Novartis Foundation Symposium, ISSN: 15282511
Eckhard Lammert; Christiana Ruhrberg; Christopher J. Drake; Brant M. Weinstein; Neil A. Vargesson; Weilan Ye
Development (Cambridge), ISSN: 09501991
Maike Schmidt; Kim Paes; Ann De Mazière; Tanya Smyczek; Stacey Yang; Alane Gray; Dorothy French; Ian Kasman; Judith Klumperman; Dennis S. Rice; Weilan Ye
Nature, ISSN: 00280836
Leon Parker IV; Maike Schmidt; Suk-Won Jin; Alane Gray; Dimitris Beis; Thinh Pham; Gretchen Frantz; Susan L. Palmieri; Kenneth Hillan; Didier Y. R. Stainier; Frederic De Sauvage; Weilan Ye
Development (Cambridge), ISSN: 09501991
Sarah E. Craven; Kim-Chew Lim; Weilan Ye; James Douglas Engel; Frederic De Sauvage; Arnon Rosental
Handbook of Cell Signaling,
Mark Merchant; Weilan Ye; Frederic De Sauvage
American Journal of Pathology, ISSN: 00029440
Fiona Oakley; Nathan Trim; Christothea M. Constandinou; Weilan Ye; Alane Gray; Gretchen Frantz; Kenneth Hillan; Tim Kendall; R. Christopher Benyon; Derek A. Mann; John P. Iredale
Nature Neuroscience, ISSN: 10976256
Weilan Ye; Maxime Bouchard; Donna M. Stone; Xiaodong Liu; Francis Vella; James Lee; Harukazu Nakamura; Siew-Lan Ang; Meinrad Busslinger; Arnon Rosenthal
Nature Neuroscience, ISSN: 10976256
Mary A. Hynes; Weilan Ye; Kevin Wang; Donna M. Stone; Maximilien D. Murone; Frederic De Sauvage; Arnon Rosenthal
Journal of Cell Science, ISSN: 00219533
Donna M. Stone; Maximilien D. Murone; Shiuh Luoh; Weilan Ye; Mark P. Armanini; Austin L. Gurney; Heidi Phillips; Brush; Audrey Goddard; Frederic De Sauvage; Arnon Rosenthal
Cell, ISSN: 00928674
Weilan Ye; Kenji Shimamura; John L. R. Rubenstein; Mary A. Hynes; Arnon Rosenthal
Education
- University of Pittsburgh, Department of Biological Sciences, Ph.D. Molecular, Cellular, Developmental Biology Program – 1995
- University of Science and Technology of China (USTC), Biophysics, B.S. – 1988