Yulei Wang - Senior Scientist, Oncology Biomarker Development

Yulei Wang

Senior Scientist, Oncology Biomarker Development

Postdoc Mentor
6
Years at Genentech
9
Publications

I joined Genentech in 2011. As a Senior Scientist in the Department of Oncology Biomarker at Genentech, my group focuses on understanding the disease biology of ovarian cancer and developing biomarker strategies to enable targeted therapy (i.e. Antibody-Drug Conjugates, cancer immunotherapies) for this disease area. More recently, my group’s research interests also extend to understanding the tumor stroma biology and its interplay with anti-cancer immunity and response to immunotherapy. I am also passionate about technology development, leading efforts in developing and applying cancer genomics, next generation sequencing and single cell analysis for clinical biomarker development. Prior to joining Genentech in 2011, I led a R&D team to develop innovative genomic technologies and applications for cancer biomarker discovery and stem cell research at Applied Biosystems.

Postdoctoral Mentor

Becoming a postdoc mentor has been the most exciting and rewarding experience for me. The postdoc program provides us an excellent opportunity to explore uncharted area in drug development and dive in deeper into disease biology and mechanism studies.

Featured Publication

Upregulation of Periostin and Reactive Stroma Is Associated with Primary Chemoresistance and Predicts Clinical Outcomes in Epithelial Ovarian Cancer.

Clin Cancer Res. 2015 Jul 1;21(13):2941-51.

L. Ryner, Y. Guan, R. Firestein, Y. Xiao, Y. Choi, C. Rabe, S. Lu, E. Fuentes, L. Huw-Yuh, M. R. Lackner, L. Fu, L. C. Amler, C. Bais, Y. Wang.

High-throughput detection of clinically relevant mutations in archived tumor samples by multiplexed PCR and next-generation sequencing.

Clin Cancer Res. 2014 Apr 15;20(8):2080-91.

R. Bourgon, S. Lu, Y. Yan, M. R. Lackner, W. Wang, V. Weigman, D. Wang, Y. Guan, L. Ryner, H. Koeppen, R. Patel, G. M. Hampton, L. C. Amler, Y. Wang.