Antibodies are marvelous molecules. Over millions of years, evolution fine-tuned antibodies to bind single targets with incredible precision, playing a crucial role in the immune system’s defense against foreign invaders like bacteria and viruses. In recent decades, scientists have harnessed this power to help fight diseases such as cancer, rheumatoid arthritis, asthma, and multiple sclerosis. Now we can take therapeutic antibodies even further, beyond the capabilities that evolution has provided.
Thanks to recent advances in molecular engineering, including a technique we developed in our labs, it’s possible to make antibodies do something they never could before – bind two different targets simultaneously. These so called “bispecific” antibodies offer an unprecedented combination of precision, stability and diverse targeting ability that have the potential to revolutionize the way we treat serious diseases. See how in the video below.