Paul Carter
Genentech Fellow, Antibody Engineering
"My passion is the pursuit of breakthrough antibody-based therapeutics that transform the lives of patients."
I joined Genentech as a Postdoctoral Fellow in 1986 and left as a Senior Scientist and Head of the Postdoctoral Program in 2000. I had the good fortune to rejoin Genentech in 2010 as a Senior Director and Staff Scientist to lead the Antibody Engineering Department where I am now a Genentech Fellow.
I began research on antibodies many years ago when it was unclear if these complex proteins would ever provide meaningful benefit to patients. I co-initiated antibody humanization at Genentech with a novel and patentable method. This technology has utilized over many years for the discovery of 9 approved antibody products that have been used to treat millions of patients worldwide. We developed ‘knobs-into-holes’ technology that was incorporated into a one-armed antibody and 5+ bispecific antibodies that have reached clinical trials. We also developed a common light chain technology has used by several different companies for developing bispecific antibodies including 1 approved product. We invented technologies for high-level expression of antibody Fab fragments in E. coli used for 1 approved antibody product.
I have authored or co-authored 117+ scientific publications that together have been cited 19,800+ times. I am an inventor or co-inventor on 48+ granted US patents and 59+ published US patent applications. I have co-organized 18+ international conferences on antibody engineering and antibody therapeutics. I have delivered 119+ conference presentations and invited lectures including 12+ keynote presentations.
Featured Publication
Next generation antibody drugs: pursuit of the ‘high-hanging fruit’
Nature Reviews Drug Discovery (2018) 17, 197-223