Paul Carter - Senior Director and Staff Scientist, Antibody Engineering

Paul Carter

Senior Director and Staff Scientist, Antibody Engineering

Postdoc Mentor
Staff Scientist
"The long duration of drug development relative to the span of a career reminds me that, like the renown landscape gardener, Lancelot "Capability" Brown, one needs to plant for future generations."
21
Years at Genentech
62
Publications
6
Awards & Honors

I joined Genentech as a Postdoctoral Fellow in 1986 and left as a Senior Scientist and Head of the Postdoctoral Program in 2000. I then rejoined Genentech in 2010 as a Senior Director and Staff Scientist to lead the Antibody Engineering Department. My most significant contributions to drug development include initiating the antibody humanization program at Genentech. I am a co-inventor of five humanized or human antibodies that have reached clinical development, including one humanized antibody that later became a commercial product.

My lab developed technologies for high-level expression of antibody Fab fragments that were subsequently utilized for production of an antibody drug that is now marketed. We also developed "knobs-in-holes" technology for creating bispecific human IgG and other bifunctional molecules. This technology was enabling for a so-called one-armed antibody that was evaluated in phase III clinical trials and four bispecific antibodies that have reached at least phase I clinical trials. I have authored or co-authored about 110 scientific publications that together have been cited more than 15,700 times. I am an inventor or co-inventor on at least 43 issued US patents and 52 published US patent applications. I have co-organized 15 international conferences on antibody engineering and antibody therapeutics. I have delivered about 110 conference presentations and invited lectures including at least 10 keynote presentations.

Postdoctoral Mentor

I joined Genentech as a postdoc in 1986 in the laboratory of Dr James Wells. This was a dream come true and was a launching pad for my career. In the 1990s I became a mentor and tried to pass on what I had learned to my own postdocs. I have had the privilege to lead Genentech’s postdoctoral program (1998-2000) and postdoctoral programs at 2 other premiere biotechnology companies. One of my greatest sources of professional satisfaction is in mentoring a few of the next generation of scientists.

Featured Publication

Efficient production of bispecific IgG of different isotypes and species of origin in single mammalian cells.

MAbs. 2017 Feb/Mar;9(2):213-230.

Dillon M, Yin Y, Zhou J, McCarty L, Ellerman D, Slaga D, Junttila TT, Han G, Sandoval W, Ovacik MA, Lin K, Hu Z, Shen A, Corn JE, Spiess C, Carter PJ.