Genentech: Amy Guo | Senior Machine Learning Scientist, AI for Drug Discovery (Structure, Scoring, and Simulation), Prescient Design

Scientists / Our Scientists

Awards & Honors

I joined Prescient Design in 2025 as a part of the AI for Drug Discovery (Structure, Scoring, and Simulation) team. I have a B.S. in Chemistry, Materials Science and in Bioengineering from UCLA and then completed my Ph.D. in Bioengineering from the UC Berkeley-UCSF joint program. During my Ph.D., I focused on designing, tuning, and experimentally characterizing de novo ligand-responsive conformational dynamics in proteins.

Featured Publication

Deep learning–guided design of dynamic proteins

Science.org. May 2025

Amy B. Guo , Deniz Akpinaroglu, Christina A. Stephens, Michael Grabe, Colin A. Smith, Mark J. S. Kelly and Tanja Kortemme

View Abstract

I will be focused on generating biophysical data and metrics computationally to aid in developing machine learning models for molecular therapy design.

University of California, Berkeley & University of California, San Francisco, Ph.D. Bioengineering – 2024
University of California, Los Angeles, B.S. Chemistry, Materials Science & B.S. Bioengineering – 2019

UCSF Discovery Fellow – 2021
NSF GRFP – 2019

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Amy Guo

Senior Machine Learning Scientist, AI for Drug Discovery (Structure, Scoring, and Simulation), Prescient Design

Featured Publication

Deep learning–guided design of dynamic proteins