Andrew Chan
SVP Research Biology, Research Biology
Postdoc Mentor
"Innovation requires an open mind and continued challenging of current paradigms. Discovery requires action based on innovation."
24
Years at Genentech
49
Publications at Genentech
10
Awards & Honors
I joined Genentech in 2001 as senior director of immunology and antibody engineering, was named vice president and senior vice president of Research- Immunology in 2003 and 2007, respectively. In 2010, I was appointed senior vice president- Research Biology and oversee our research opportunities.
Genentech is one of the few places in the world where scientists have the ability to study basic biology, make new biological or technological discoveries, identify the pathogenic mechanisms driving human disease, discover new therapies and shepherd these therapies to launch and thereafter impact patients’ lives.
Postdoctoral Mentor
Postdoctoral training and mentorship is an essential part of a scientific career. It provides essential training and scientific experience for the mentee and an opportunity for the mentor to continue learning about new scientific paradigms and train the next generations of scientists.
Featured Publication
Autoimmunity linked protein phosphatase PTPN22 as a target for cancer immunotherapy.
J Immunotherapy of Cancer 2020; 8:”e001439.
Cubas, R, Khan, Z, Gong, Q, et al.
We are studying how autoimmunity-associated genes may be a source of targets to augment cancer immunotherapy. We had previously demonstrated that the protein tyrosine phosphatase PTPN22 is a negative regulator of T-cell antigen receptor (Hasegawa, Science 2004) and interferon-alpha receptor (Holmes, J Exp Med 2015) signaling. Here, we demonstrate that loss of PTPN22 phosphatase enzymatic activity augments both T-cell and interferon-alpha mediated functions leading to spontaneous remission of a number of syngeneic tumor models. In addition, individuals carrying the autoimmune-associated PTPN22(W620R) single-nucleotide polymorphism have lower risk of developing skin cancers and have more favorable responses to anti-PDL1 mAb treatment. These studies demonstrate the importance of host genetics in anti-tumor immunity.
My Focus
My research interests focus on regulation of immune cell functions. Our immune system is tightly regulated so that it has the ability to efficiently combat infectious pathogens without overexuberant immunity that can cause autoimmune or inflammatory diseases. My recent interests are focused on how modest alterations in lymphocyte signaling results in dysregulated immune cell functions in this tight balance of health and disease.
Genentech Publications
Nature Reviews Immunology, ISSN: 14741733
Andrew C. Chan; Gregory D. Martyn; Paul J. Carter
Journal for ImmunoTherapy of Cancer, ISSN: 20511426
Rafael Cubas; Zia Khan; Qian Gong; Marina Moskalenko; Huizhong Xiong; Qinglin Ou; Christine Pai; Ryan Rodriguez; Jeanne Cheung; Andrew A. Chan
Annual Review of Immunology, ISSN: 15453278 07320582
Nico Ghilardi; Rajita Pappu; Joseph R. Arron; Andrew A. Chan
Successful Drug Discovery,
Andrew A. Chan; Paul Brunetta; Peter Chin
Journal of Clinical Investigation, ISSN: 15588238 00219738
Jinbo Yu; Vu Huy Hoang Duong; Katrin Westphal; Andreas Westphal; Abdulhadi Suwandi; Guntram A. Grassl; Korbinian Brand; Andrew A. Chan; Niko Föger; Kyeong-Hee Lee
Biochemistry, ISSN: 15204995 00062960
Peter Chin; Andrew A. Chan
Autophagy, ISSN: 15548635 15548627
Marianne R. Spalinger; Silvia Lang; Claudia Gottier; Xuezhi Dai; David J. Rawlings; Andrew A. Chan; Gerhard Rogler; Michael Scharl
Journal of Clinical Investigation, ISSN: 15588238 00219738
Marianne R. Spalinger; Stephanie Kasper; Claudia Gottier; Silvia Lang; Kirstin Atrott; Stephan R. Vavricka; Sylvie Scharl; Petrus M. Gutte; Markus G. Grütter; Hans-Dietmar Beer; Emmanuel Contassot; Andrew A. Chan; Xuezhi Dai; David J. Rawlings; Florian Mair; Burkhard Becher; Werner Falk; Fried; Gerhard Rogler; Michael Scharl
Journal of Allergy and Clinical Immunology, ISSN: 10976825 00916749
Christina S. Yee; Michel J. Massaad; Wayne Bainter; Toshiro K. Ohsumi; Niko Föger; Andrew A. Chan; Nurten A. Akarsu; Caner Aytekin; Deniz Çagdas Ayvaz; Ilhan Tezcan; Özden Sanal; Raif S. Geha; Janet Chou
Cell, ISSN: 10974172 00928674
Chiao-Wen Yang; Caroline D Hojer; Meijuan Zhou; Xiumin Wu; Arthur Wuster; Wyne P. Lee; Brian L. Yaspan; Andrew A. Chan
Clinical Immunology, ISSN: 15217035 15216616
Joseph R. Arron; Michael J. Townsend; Mary E. Keir; Brian L. Yaspan; Andrew A. Chan
Journal of Experimental Medicine, ISSN: 15409538 00221007
Derek A. Holmes; Eric Suto; Wyne P. Lee; Qinglin Ou; Qian Gong; Hamish R.C. Smith; Patrick Caplazi; Andrew A. Chan
EMBO Journal, ISSN: 14602075 02614189
Derek A. Holmes; Jung-Hua Yeh; Donghong Yan; Min Xu; Andrew A. Chan
Blood, ISSN: 15280020 00064971
Catalina Lee-Chang; Monica Bodogai; Kanako Moritoh; Purevdorj Baljinnyam Olkhanud; Andrew C. Chan; Michael Croft; Julie A. Mattison; Peter Johannes Holst; Ronald E. Gress; Luigi G. Ferrucci; Frances T. Hakim; Arya Biragyn
Cell, ISSN: 10974172 00928674
John J. O'Shea; Yuka Kanno; Andrew A. Chan
Immunotherapy, ISSN: 1750743X 17507448
Andrew A. Chan; Albert Jan Schutte
Future Neurology, ISSN: 14796708 17486971
Andrew A. Chan; Albert Jan Schutte
Biology of Blood and Marrow Transplantation, ISSN: 15236536 10838791
Heather F. Johnston; Yajing Xu; Jeremy J. Racine; Kaniel Cassady; Xiong Ni; Tao Wu; Andrew A. Chan; Stephen Forman; Defu Zeng
Immunity, ISSN: 10747613 10974180
Yaya Wang; Iftach Shaked; Stephanie M. Stanford; Wenbo Zhou; JulieM. Curtsinger; Zbigniew Mikulski; ZacharyR. Shaheen; Genhong Cheng; Kristy Sawatzke; AmandaM. Campbell; JenniferL. Auger; Hatice Bilgic; FernandaM. Shoyama; DavidO. Schmeling; HenryH. Balfour; Kiminori Hasegawa; Andrew A. Chan; JohnA. Corbett; BryceA. Binstadt; MatthewF. Mescher; Klaus Ley; Nunzio Bottini; Erik J. Peterson
Cancer Research, ISSN: 00085472 15387445
Monica Bodogai; Catalina Lee-Chang; Katarzyna Wejksza; Jinping Lai; Maria Merino; Robert P. Wersto; Ronald E. Gress; Andrew A. Chan; Charles Hesdorffer; Arya Biragyn
PLoS ONE, ISSN: 19326203
Ghanashyam Sarikonda; Sowbarnika Sachithanantham; Yulia Manenkova; Tinalyn Kupfer; Amanda Posgai; Clive Wasserfall; Philip Bernstein; Laura Straub; Philippe P. Pagni; Darius Schneider; Teresa Rodriguez Calvo; Marilyne Coulombe; Kevan Herold; Ronald G. Gill; Mark Atkinson; Gerald Nepom; Mario Ehlers; Teodora Staeva; Hideki Garren; Lawrence Steinman; Andrew A. Chan; Matthias von Herrath
Nature Immunology, ISSN: 15292908 15292916
Andrew A. Chan; Timothy W. Behrens
Journal of Experimental Medicine, ISSN: 00221007 15409538
Niko Föger; André Jenckel; Zane Orinska; Kyeong-Hee Lee; Andrew A. Chan; Silvia Bulfone-Paus
Blood, ISSN: 15280020 00064971
Xuan-Hung Nguyen; Philipp A. Lang; Karl S. Lang; Dieter Adam; Gulnar Fattakhova; Niko Föger; Mohammad Azhar Kamal; Patricia Prilla; Sabine Mathieu; Christina Wagner; Tak W. Mak; Andrew A. Chan; Kyeong-Hee Lee
Science Translational Medicine, ISSN: 19466234 19466242
Andrew A. Chan
Molecular Immunology, ISSN: 01615890 18729142
Andrew A. Chan
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Stephanie M. Stanford; Divya Krishnamurthy; Matthew D. Falk; Rossella Messina; Bikash Debnath; Sheng Li; Tong Liu; Roza Kazemi; Russell Dahl; Yantao He; Xiao Yu; Andrew A. Chan; Zhong-Yin Zhang; Amy M. Barrios; Virgil L. Woods Jr.; Nouri Neamati; Nunzio Bottini
Immunological Reviews, ISSN: 01052896 1600065X
Michael J. Townsend; John G. Monroe; Andrew A. Chan
Journal of Biological Chemistry, ISSN: 00219258 1083351X
Edoardo Fiorillo; Valeria Orrú; Stephanie M. Stanford; Yingge Liu; Mogjiborahman Salek; Novella Rapini; Aaron D. Schenone; Patrizia Saccucci; Lucia G. Delogu; Federica Angelini; Maria Luisa Manca Bitti; Christian Schmedt; Andrew A. Chan; Oreste Acuto; Nunzio Bottini
Nature Reviews Immunology, ISSN: 14741733
Andrew A. Chan; Paul J. Carter
FEBS Journal, ISSN: 1742464X 17424658
Niko Föger; Silvia Bulfone-Paus; Andrew A. Chan; Kyeong-Hee Lee
Journal of Immunology, ISSN: 00221767 15506606
Julie Zikherman; Michelle Hermiston; David Steiner; Kiminori Hasegawa; Andrew A. Chan; Arthur Weiss
PLoS Biology, ISSN: 15449173 15457885
Raffi Tonikian; Yingnan Zhang; Stephen L. Sazinsky; Bridget Currell; Jung-Hua Yeh; Boris Reva; Heike A. Held; Brent A. Appleton; Marie Evangelista; Yan Wu; Xiaofeng Xin; Andrew A. Chan; Somasekar Seshagiri; Lasky; Chris Sander; Charles Boone; Gary D. Bader; Sachdev S. Sidhu
Immunological Reviews, ISSN: 01052896 1600065X
Andrew A. Chan
Cell, ISSN: 00928674
Jung-Hua Yeh; Sachdev S. Sidhu; Andrew A. Chan
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 00278424
Jie Liu; Lei Wang; Judith Harvey-White; Douglas Osei-Hyiaman; Raj Razdan; Qian Gong; Andrew A. Chan; Zhifeng Zhou; Bill X. Huang; Hee-Yong Kim; George Kunos
Science, ISSN: 00368075 10959203
Niko Föger; Linda Rangell; Dimitry Danilenko; Andrew A. Chan
Annual Review of Immunology, ISSN: 07320582
Flavius Martin; Andrew A. Chan
EMBO Journal, ISSN: 02614189 14602075
Kyeong-Hee Lee; Christine Feig; Vladimir Tchikov; Robert Schickel; Cora Hallas; Stefan Schütze; Marcus E. Peter; Andrew A. Chan
Genes and Immunity, ISSN: 14664879
Abbas Alexander; Daryl T. Baldwin; Yan Ma; Wenjun Ouyang; Austin L. Gurney; Flavius Martin; Fong; Menno Van Lookeren Campagne; Godowski; P. Mickey Williams; Andrew A. Chan; Hilary F. Clark
Journal of Pediatric Gastroenterology and Nutrition, ISSN: 02772116
Andrew A. Chan
Journal of Immunology, ISSN: 00221767
Qian Gong; Qinglin Ou; Shiming Ye; Wyne P. Lee; Jennine Cornelius; Laurie Diehl; Yu Lin Wei; Zhilan Hu; Yanmei Lu; Yongmei Chen; Yan Wu; Meng; Gribling; Zhonghua Lin; Kathy Nguyen; Thanhvien Tran; Yifan Zhang; Hugh Rosen; Flavius Martin; Andrew A. Chan
Immunity, ISSN: 10747613
Flavius Martin; Andrew A. Chan
Science, ISSN: 00368075
Kiminori Hasegawa; Flavius Martin; Guangming Huang; Daniel B. Tumas; Laurie Diehl; Andrew A. Chan
European Journal of Immunology, ISSN: 00142980
Judith Gerlach; Snigdha Ghosch; Hassan Jumaa; Michael Reth; Jürgen Wienands; Andrew A. Chan; Lars Nitschke
Handbook of Cell Signaling,
Kiminori Hasegawa; Shin W. Kang; Chris Chiu; Andrew A. Chan
Nature, ISSN: 00280836
Claudia Kemper; Andrew A. Chan; Jonathan M. Green; Kelly A. Brett; Kenneth M. Murphy; John P. Atkinson
Current Opinion in Immunology, ISSN: 09527915
Paul E. Love; Andrew A. Chan
EMBO Journal, ISSN: 02614189
Christopher Chiu; Mark Dalton; Masamichi Ishiai; Tomohiro Kurosaki; Andrew A. Chan
Education
- University of California, San Francisco Department of Medicine, Division of Rheumatology, Adjunct Associate Professor – 2019 - Present
- University of California, San Francisco Department of Medicine, Division of Rheumatology, Associate Clinical Professor – 2004–2012
- Washington University School of Medicine Howard Hughes Medical Institute, Associate Investigator – 2000-2001
- Washington University School of Medicine Departments of Internal Medicine and Pathology, Associate Professor – 1998-2001
- Washington University, Barnes Hospital Department of Internal Medicine, Attending Physician – 1994-2001
- Washington University School of Medicine Howard Hughes Medical Institute, Assistant Investigator – 1994-1999
- Washington University School of Medicine, Departments of Internal Medicine and Pathology, Assistant Professor – 1994-1998
- University of California, San Francisco Long-Moffitt Hospital, Department of Medicine, Attending Physician – 1992-1993
- University of California, San Francisco Department of Medicine, Division of Rheumatology, Assistant Adjunct Professor – 1992-1993
- University of California, San Francisco Department of Medicine, Division of Rheumatology, Clinical Fellow – 1989-1990
- Washington University School of Medicine Barnes Hospital, Department of Internal Medicine, Intern and Resident – 1986-1989
- Washington University School of Medicine, Department of Cellular and Developmental Biology, M.D., Ph.D. – 1986
- Northwestern University, Department of Chemistry, M.S., B.A. – 1980
Awards & Honors
- Northwestern University Alumni Medal – 2020
- Washington University School of Medicine Alumni Achievement Award – 2019
- American Federation for Aging Research, Chairman’s Award of Distinction – 2013
- Arthritis Foundation- Northern California, Guin Warnock Award – 2012
- American Association of Physicians – 2009
- Kunkel Society – 2005
- Special Recognition Award for Mentoring Graduate Students Washington University – 2000
- American College of Rheumatology Investigator Award – 1993
- American Foundation of Clinical Research Award – 1991
- American College of Rheumatology Senior Scholar Award – 1991
