Dan Lu
Senior Principal Scientist Development Modeling & Simulation, Development Sciences
"I aim to deliver the right dose to the right patient by applying modeling and simulation approaches"
12
Years at Genentech
37
Publications
I joined Genentech in March of 2009 after 2 years of work at Roche Palo Alto preclinical modeling and simulation group. Since joining Genentech, I have worked on both clinical pharmacology and modeling & simulation aspects to support drug development, mainly in the field of monoclonal antibodies and antibody drug conjugates for cancer treatment.
Featured Publication
Time-to-Event Analysis of Polatuzumab Vedotin-Induced Peripheral Neuropathy to Assist in the Comparison of Clinical Dosing Regimens.
CPT:PSP, CPT Pharmacometrics Syst Pharmacol. 2017 Jun;6(6):401-408.
Lu D, Gillespie WR, Girish S, Agarwal P, Li C, Hirata J, Chu YW, Kagedal M, Leon L, Maiya V, Jin JY.
My Focus
I am focusing on applying the advanced modeling and simulation approaches to support drug development.
Publications
Application of a Two-Analyte Integrated Population Pharmacokinetic Model to Evaluate the Impact of Intrinsic and Extrinsic Factors on the Pharmacokinetics of Polatuzumab Vedotin in Patients with Non-Hodgkin Lymphoma
Pharmaceutical Research, ISSN: 07248741
Dan Lu; Tong Lu; Rong Shi; Leonid Gibiansky; Priya Agarwal; Colby S. Shemesh; Randy Dere; Uzor Ogbu; Jamie Hirata; Pascal Chanu; Sandhya Girish; Jin Yan Jin; Chunze Li; Dale Miles
Journal of Clinical Pharmacology, ISSN: 15524604 00912700
Divya Samineni; Hao Ding; Fang Ma; Rong Shi; Dan Lu; Dale Miles; Jialin Mao; Chunze Li; Jin Jin; Matthew Wright; Sandhya Girish; Yuan Chen
Journal of Clinical Pharmacology, ISSN: 15524604 00912700
Chunze Li; Shang-Chiung Chen; Yuan Chen; Sandhya Girish; Matts Kaagedal; Dan Lu; Tong Lu; Divya Samineni; Jin Y. Jin
Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704
Colby S. Shemesh; Priya Agarwal; Tong Lu; Calvin Lee; Randy Dere; Xiaobin Li; Chunze Li; Jin Y. Jin; Sandhya Girish; Dale Miles; Dan Lu
Clinical pharmacology of vc-MMAE antibody–drug conjugates in cancer patients: learning from eight first-in-human Phase 1 studies
mAbs, ISSN: 19420862
Chunze Li; Cindy Zhang; Zao Li; Divya Samineni; Dan Lu; Wang; Shang-Chiung Chen; Rong Zhang; Priya Agarwal; Bernard Fine; Sandhya Girish
Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704
Rong Shi; Tong Lu; Grace Ku; Hao Ding; Tomohisa Saito; Leonid Gibiansky; Priya Agarwal; Xiaobin Li; Jin Yan Jin; Sandhya Girish; Dale Miles; Chunze Li; Dan Lu
Leukemia and Lymphoma, ISSN: 10292403 10428194
Tong Lu; Leonid Gibiansky; Xiaobin Li; Chunze Li; Rong Shi; Priya Agarwal; Jamie Hirata; Dale Miles; Pascal Chanu; Sandhya Girish; Jin Yan Jin; Dan Lu
The Lancet Oncology, ISSN: 14745488 14702045
Herve Tilly; Morschhauser; Nancy L. Bartlett; Amitkumar Mehta; Gilles Salles; Corinne Haioun; Javier Munoz; Andy I Chen; Kathryn S. Kolibaba; Dan Lu; Mark Yan; Elicia Penuel; Jamie Hirata; Calvin Lee; Jeff P. Sharman
Polatuzumab vedotin or pinatuzumab vedotin plus rituximab in patients with relapsed or refractory non-Hodgkin lymphoma: final results from a phase 2 randomised study (ROMULUS)
The Lancet Haematology,
Morschhauser; Ian W. Flinn; Ranjana H. Advani; Laurie H. Sehn; Catherine S. Diefenbach; Kathryn S. Kolibaba; Oliver W. Press; Gilles Salles; Herve Tilly; Andy I Chen; Sarit E. Assouline; Bruce D. Cheson; Dreyling; Anton Hagenbeek; Pier Luigi Zinzani; Surai Jones; Ji Cheng; Dan Lu; Elicia Penuel; Jamie Hirata; Michael Wenger; Yu-Waye Chu; Jeff P. Sharman
Time-to-Event Modeling of Peripheral Neuropathy: Platform Analysis of Eight Valine-Citrulline-Monomethylauristatin E Antibody–Drug Conjugates
CPT: Pharmacometrics and Systems Pharmacology,
Kagedal; Divya Samineni; Gillespie; Dan Lu; Bernard Fine; Sandhya Girish; Chunze Li; Jin Y. Jin
Clinical Pharmacokinetics, ISSN: 11791926 03125963
Rong Deng; Leonid Gibiansky; Tong Lu; Priya Agarwal; Hao Ding; Xiaobin Li; Smita Kshirsagar; Dan Lu; Chunze Li; Sandhya Girish; Jue Wang; Michelle Boyer; Kathryn Humphrey; Kevin J. Freise; Ahmed Hamed Salem; John F. Seymour; Kater; Dale Miles
Leukemia and Lymphoma, ISSN: 10292403 10428194
Rong Deng; Leonid Gibiansky; Tong Lu; Xiaobin Li; Dan Lu; Chunze Li; Sandhya Girish; Jue Wang; Michelle Boyer; Noopur Shankar; Kathryn Humphrey; Kevin J. Freise; Ahmed Hamed Salem; John F. Seymour; Kater; Dale Miles
Integrated Two-Analyte Population Pharmacokinetic Model of Polatuzumab Vedotin in Patients With Non-Hodgkin Lymphoma
CPT: Pharmacometrics and Systems Pharmacology,
Dan Lu; Tong Lu; Leonid Gibiansky; Xiaobin Li; Chunze Li; Priya Agarwal; Colby S. Shemesh; Rong Shi; Randy Dere; Jamie Hirata; Dale Miles; Pascal Chanu; Sandhya Girish; Jin Yan Jin
Pharmacokinetics of trastuzumab emtansine (T-DM1) as a single agent or in combination with pertuzumab in HER2-positive breast cancer patients with recurrent or locally advanced metastatic breast cancer
Cancer Chemotherapy and Pharmacology, ISSN: 03445704
Dan Lu; Chunze Li; Matthew Riggs; Daniel Polhamus; Jonathan French; Priya Agarwal; Shang-Chiung Chen; Shweta Vadhavkar; Patre; Alexander Strasak; Angelica Quartino; Jin Yan Jin; Sandhya Girish
Prediction of Human Pharmacokinetics of Antibody–Drug Conjugates From Nonclinical Data
Clinical and Translational Science, ISSN: 17528054
Chunze Li; Cindy Zhang; Rong Deng; Douglas Leipold; Dongwei Li; Brandon Latifi; Yuying Gao; Crystal Zhang; Zao Li; Dale Miles; Shang-Chiung Chen; Divya Samineni; Wang; Priya Agarwal; Dan Lu; Saileta Prabhu; Sandhya Girish; Amrita Kamath
Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704
Chunze Li; Bei Wang; Shang-Chiung Chen; Russell D. Wada; Dan Lu; Xin Wang; Daniel Polhamus; Jonathan French; Shweta Vadhavkar; Alexander Strasak; Melanie Smitt; Amita Joshi; Meghna Samant; Angelica Quartino; Jin Jin; Sandhya Girish
Platform model describing pharmacokinetic properties of vc-MMAE antibody–drug conjugates
Journal of Pharmacokinetics and Pharmacodynamics, ISSN: 1567567X
Kagedal; Leonid Gibiansky; Jian Xu; Xin Wang; Divya Samineni; Shang-Chiung Chen; Dan Lu; Priya Agarwal; Wang; Ola Saad; Neelima Koppada; Bernard Fine; Jin Y. Jin; Sandhya Girish; Chunze Li
CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306
Dan Lu; Gillespie; Sandhya Girish; Priya Agarwal; Chunze Li; Hirata; Wayne Chu; Kagedal; Leon; Maiya; Jin
Clinical Cancer Research, ISSN: 15573265
Ranjana H. Advani; Lebovic; Andy Chen; Mark Brunvand; Andre Goy; Julie E. Chang; Ephraim Hochberg; Sreeni Yalamanchili; Robert S. Kahn; Dan Lu; Priya Agarwal; Randy Dere; Hsin-Ju Hsieh; Surai Jones; Wayne Chu; Bruce D. Cheson
Assessment of Correlation Between Early and Late Efficacy Endpoints to Identify Potential Surrogacy Relationships in Non-Hodgkin Lymphoma: a Literature-Based Meta-analysis of 108 Phase II and Phase III Studies
AAPS Journal,
Rui Zhu; Lu; Wayne Chu; Akiko Chai; Michelle Green; Nancy Zhang; Jin Jin
CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306
Dan Lu; Leonid Gibiansky; Priya Agarwal; Randy Dere; Chunze Li; Wayne Chu; Hirata; Amita Joshi; Jin Jin; Sandhya Girish
Cancer Chemotherapy and Pharmacology, ISSN: 14320843
Chunze Li; Bei Wang; Dan Lu; Jin Jin; Yuying Gao; Kiyoshi Matsunaga; Yuriko Igawa; Ihsan Nijem; Michael Lu; Alexander Strasak; Nataliya Chernyukhin; Sandhya Girish
Breast Cancer Research, ISSN: 1465542X
Ian E. Krop; Shanu Modi; Patricia M. LoRusso; Pegram; Ellie Guardino; Betsy Althaus; Dan Lu; Alexander Strasak; Anthony Elias
Cancer Chemotherapy and Pharmacology, ISSN: 14320843
Dan Lu; Tong Lu; Mark Stroh; Rick Graham; Priya Agarwal; Luna Musib; Chi-Chung Li; Bert Lum; Amita Joshi
Pharmaceutical Research, ISSN: 1573904X
Dan Lu; Jin Y. Jin; Sandhya Girish; Priya Agarwal; Dongwei Li; Saileta Prabhu; Randy Dere; Ola Saad; Denise Nazzal; Neelima Koppada; Saroja Ramanujan; Chee Nam Ng
The Lancet Oncology, ISSN: 14745488
Palanca-Wessels; Myron S. Czuczman; Gilles Salles; Sarit E. Assouline; Laurie H. Sehn; Ian Flinn; Manish R. Patel; Randeep Sangha; Anton Hagenbeek; Ranjana H. Advani; Herve Tilly; Olivier Casasnovas; Oliver W. Press; Sreeni Yalamanchili; Robert S. Kahn; Randy Dere; Dan Lu; Surai Jones; Cheryl Jones; Wayne Chu; Morschhauser
Clinical Pharmacokinetics, ISSN: 11791926
Yuan Chen; Divya Samineni; Sophie Aurangabadwala; Harvey Wong; Ben-Quan Shen; Dan Lu; Sandhya Girish; Marcel Hop; Jin Y. Jin; Chunze Li
CPT: Pharmacometrics and Systems Pharmacology, ISSN: 21638306
Lu; Amita Joshi; Li; Zhang; Ren; Gao; Russ Wada; Jin Y. Jin
Cancer Chemotherapy and Pharmacology, ISSN: 14320843 03445704
Dan Lu; Sandhya Girish; Yuying Gao; Wang; Joo-Hee Yi; Ellie Guardino; Meghna Samant; Melody A. Cobleigh; Mothaffar F. Rimawi; Pier Franco Conte; Jin Y. Jin
Clinical Pharmacokinetics, ISSN: 03125963
Dan Lu; Amita Joshi; Bei Wang; Steven Olsen; Joo-Hee Yi; Ian E. Krop; Howard A. Burris; Sandhya Girish
Bioanalysis, ISSN: 17576180
Dan Lu; Srikumar Sahasranaman; Yingnan Zhang; Sandhya Girish
Current Drug Metabolism, ISSN: 13892002
Dan Lu; Howard A. Burris; Bei Wang; E. Claire Dees; Javier Cortés; Amita Joshi; Manish Gupta; Joo-Hee Yi; Wayne Chu; Ted Shih; Liang Fang; Sandhya Girish
Cancer Chemotherapy and Pharmacology, ISSN: 03445704
Sandhya Girish; Manish Gupta; Bei Wang; Dan Lu; Ian E. Krop; Charles L. Vogel; Howard A. Burris; Patricia M. LoRusso; Joo-Hee Yi; Ola Saad; Barbara Tong; Wayne Chu; Scott Holden; Amita Joshi
Cancer Chemotherapy and Pharmacology, ISSN: 03445704
Amrita Kamath; Dan Lu; Priyanka Gupta; Denise Jin; Hong Xiang; Anne Wong; Cecilia Leddy; Lisa Crocker; Gabriele Schaefer; Mark Sliwkowski; Lisa Damico-Beyer
Cancer Chemotherapy and Pharmacology, ISSN: 03445704
Amrita Kamath; Dan Lu; Priyanka Gupta; Denise Jin; Yan Xin; Ann Brady; Daniel Stephan; Hao Li; Janet Tien; Jing Qing; Lisa Damico-Beyer
Clinical Pharmacokinetics, ISSN: 03125963
Shuang Bai; Karin Jorga; Yan Xin; Denise Jin; Yanan Zheng; Lisa Damico-Beyer; Manish Gupta; Meina Tang; David Allison; Dan Lu; Yingnan Zhang; Amita Joshi; Mark Dresser
Therapeutic Delivery, ISSN: 20415990
Saileta Prabhu; Andy Boswell; Douglas Leipold; Leslie Khawli; Dongwei Li; Dan Lu; Peter Theil; Amita Joshi; Bert Lum
Education
- Ohio State University, Ph.D. – 2006