Edna Choo
Senior Director and Distinguished Scientist, Drug Metabolism & Pharmacokinetics, Drug Discovery
"It has been a highlight and humbling experience to work on projects that have advanced from discovery to market and see patients benefit from these therapies."
19
Years at Genentech
50
Publications at Genentech
I joined Genentech in 2005. I conducted my graduate work at Monash University (Australia), studying the effect of liver cirrhosis on drug metabolism. I undertook post-doctoral work at Vanderbilt University, investigating the role of drug transporters on drug disposition.
Featured Publication
Use of transgenic mouse models to understand the oral disposition and drug-drug interaction potential of cobimetinib, a MEK inhibitor.
Drug Metab Dispos. 2015 Jun;43(6):864-9.
Choo EF, Woolsey S, DeMent K, Ly J, Messick K, Qin A, Takahashi R.
My Focus
My research interests include investigating the pharmacokinetics and pharmacodynamics of drugs, and the application of preclinical in vivo models to understand ADME
Genentech Publications
Drug Metabolism and Disposition,
Chenghong Zhang; Dian Su; Edna F. Choo; Lichuan Liu; Sudheer Bobba; Jamie Jorski; Quynh Ho; Jing Wang; Jane R. Kenny; S Cyrus Khojasteh; Donglu Zhang
ACS Medicinal Chemistry Letters, ISSN: 19485875
Bryan K. Chan; Eileen Seward; Michael Lainchbury; Thomas F. Brewer; Le An; Toby Blench; Matthew W. Cartwright; Grace Chan; Edna F. Choo; Jason H. Drummond; Richard Elliott; Emanuela Gancia; Lewis Gazzard; Baihua Hu; Graham Jones; Xifeng Luo; Andrew Madin; Sushant Malhotra; John Moffat; Jodie Pang; Laurent Salphati; Chris J. Sneeringer; Craig E. Stivala; Binqing Wei; Weiru Wang; Ping Wu; Timothy P. Heffron
Haematologica, ISSN: 15928721 03906078
Raghuveer Singh Mali; Qi Zhang; Rosaanna Defilippis; Antonio Cavazos; Vinitha Mary Kuruvilla; Jayant Raman; Vidhi Mody; Edna F. Choo; Monique Dail; Neil P. Shah; Marina Konopleva; Deepak Sampath; Elisabeth A. Lasater
ACS Medicinal Chemistry Letters, ISSN: 19485875
Le Wang; George A. Doherty; Andrew S. Judd; Zhi-Fu Tao; T. Matthew Hansen; Robin R. Frey; Xiaohong Song; Bruncko; Aaron R. Kunzer; Xilu Wang; Michael D. Wendt; Flygare; Nathaniel D. Catron; Russell A. Judge; Chang H. Park; Shashank Shekhar; Darren C. Phillips; Paul M. Nimmer; Morey L. Smith; Stephen K. Tahir; Yu Xiao; John Xue; Haichao Zhang; Phuong N. Le; Michael J. Mitten; Erwin R. Boghaert; Wenqing Gao; Peter J. Kovar; Edna F. Choo; Dolores Diaz; Wayne J. Fairbrother; Steven W. Elmore; Deepak Sampath; Joel D. Leverson; Andrew J. Souers
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Teresa Mulder; Sudheer Bobba; Kevin Johnson; Jessica M. Grandner; Wei Wang; Chenghong Zhang; Jingwei Cai; Edna F. Choo; Cyrus Khojasteh; Donglu Zhang
Toxicologic Pathology, ISSN: 15331601 01926233
Paula Katavolos; Cain; Cindy A. Farman; F. Anthony Romero; Steven Magnuson; Justin Ly; Edna F. Choo; Anand K. Katakam; Roxanne Andaya; Jonathan M. Maher
ACS Medicinal Chemistry Letters, ISSN: 19485875
Naomi S. Rajapaksa; Alberto Gobbi; Joy Drobnick; Steven Do; Aleksandr Kolesnikov; Jun Liang; Yongsheng Chen; Swathi Sujatha-Bhaskar; Zhiyu Huang; Hans D. Brightbill; Ross Francis; Christine Yu; Edna F. Choo; Kevin Dement; Yingqing Ran; Le An; Claire Emson; Jonathan M. Maher; John Wai; Brent Mckenzie; Patrick J. Lupardus; Ali A. Zarrin; James R. Kiefer; Marian C. Bryan
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Marian C. Bryan; Joy Drobnick; Alberto Gobbi; Aleksandr Kolesnikov; Yongsheng Chen; Naomi S. Rajapaksa; Chudi O. Ndubaku; Jianwen A. Feng; Willy Chang; Ross Francis; Christine Yu; Edna F. Choo; Kevin Dement; Yingqing Ran; Le An; Claire Emson; Zhiyu Huang; Swathi Sujatha-Bhaskar; Hans D. Brightbill; Antonio G. DiPasquale; Jonathan M. Maher; John Wai; Brent Mckenzie; Patrick J. Lupardus; Ali A. Zarrin; James R. Kiefer
Biopharmaceutics and Drug Disposition, ISSN: 1099081X 01422782
Yuan Chen; Rui Zhu; Fang Ma; Jialin Mao; Eugene C. Chen; Edna F. Choo; Srikumar Sahasranaman; Lichuan Liu
Journal of Clinical Pharmacology, ISSN: 15524604 00912700
Lichuan Liu; Sravanthi Cheeti; Yoshida; Edna F. Choo; Eugene C. Chen; Buyun Chen; Mary Gates; Stina M. Singel; Roland Morley; Joseph A. Ware; Srikumar Sahasranaman
Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085
Buyun Chen; Pingping Lu; Dugan Freeman; Yang Gao; Edna F. Choo; Kevin Dement; Scott Savage; Kelly Zhang; Dennis Milanwoski; Lichuan Liu; Brian J. Dean; Yuzhong Deng
Clinical Pharmacology and Therapeutics, ISSN: 15326535 00099236
Edna F. Choo; Laurent Salphati
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Kwong Wah Lai; F. Anthony Romero; Vickie Tsui; Beresini; Gladys De Leon Boenig; Sarah M. Bronner; Kevin Chen; Zhongguo Chen; Edna F. Choo; Terry Crawford; Patrick Cyr; Susan Kaufman; Yingjie Li; Jiangpeng Liao; Wenfeng Liu; Justin Ly; Jeremy Murray; Weichao Shen; John Wai; Fei Wang; Caicai Zhu; Xiaoyu Zhu; Steven Magnuson
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Sarah M. Bronner; Jeremy Murray; F. Anthony Romero; Kwong Wah Lai; Vickie Tsui; Patrick Cyr; Beresini; Gladys De Leon Boenig; Zhongguo Chen; Edna F. Choo; Clark; Terry Crawford; Hariharan Jayaram; Susan Kaufman; Ruina Li; Yingjie Li; Jiangpeng Liao; Xiaorong Liang; Wenfeng Liu; Justin Ly; Jonathan M. Maher; John Wai; Fei Wang; Aijun Zheng; Xiaoyu Zhu; Steven Magnuson
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
F. Anthony Romero; Jeremy Murray; Kwong Wah Lai; Vickie Tsui; Brian K Albrecht; Le An; Beresini; Gladys De Leon Boenig; Sarah M. Bronner; Emily Chan; Kevin Chen; Zhongguo Chen; Edna F. Choo; Kyle Clagg; Clark; Terry Crawford; Patrick Cyr; Denise De Almeida Nagata; Karen Gascoigne; Jane L. Grogan; Georgia Hatzivassiliou; Wei Huang; Thomas Hunsaker; Susan Kaufman; Stefan G. Koenig; Ruina Li; Yingjie Li; Xiaorong Liang; Jiangpeng Liao; Wenfeng Liu; Justin Ly; Jonathan M. Maher; Colin Masui; Mark Merchant; Yingqing Ran; Alexander M. Taylor; John Wai; Fei Wang; Xiaocang Wei; Dong Yu; Bing-Yan Zhu; Xiaoyu Zhu; Steven Magnuson
Cancer Research, ISSN: 15387445 00085472
Lingyan Jin; Jesse Garcia; Emily Chan; Cecile C. de la Cruz; Ehud Segal; Mark Merchant; Samir Kharbanda; Ryan Raisner; Matthias Peter; Zora Modrusan; Justin Ly; Edna F. Choo; Susan Kaufman; Beresini; F. Anthony Romero; Steven Magnuson; Karen Gascoigne
Molecular Pharmaceutics, ISSN: 15438392 15438384
Justin Ly; Kirsten Messick; Ann R. Qin; Ryan Takahashi; Edna F. Choo
Xenobiotica, ISSN: 13665928 00498254
Ryan Takahashi; Shuguang Ma; Qin Yue; Heasook Kim-Kang; Yijun Yi; Justin Ly; Jason Boggs; Alec Fettes; Andrew McClory; Yuzhong Deng; Cornelis E. Hop; S. Cyrus Khojasteh; Edna F. Choo
Journal of Medicinal Chemistry, ISSN: 15204804 00222623
Terry Crawford; F. Anthony Romero; Kwong Wah Lai; Vickie Tsui; Alexander M. Taylor; Gladys De Leon Boenig; Cameron Noland; Jeremy Murray; Justin Ly; Edna F. Choo; Thomas Hunsaker; Emily Chan; Mark Merchant; Samir Kharbanda; Karen Gascoigne; Susan Kaufman; Beresini; Jiangpeng Liao; Wenfeng Liu; Kevin Chen; Zhongguo Chen; Andrew R. Conery; Alexandre Côté; Hariharan Jayaram; Ying Jiang; James R. Kiefer; Tracy L. Kleinheinz; Yingjie Li; Jonathan M. Maher; Eneida Pardo; Florence Poy; Kerry L. Spillane; Fei Wang; Jian Wang; Xiaocang Wei; Zhaowu Xu; Zhongya Xu; Ivana Yen; Laura E. Zawadzke; Xiaoyu Zhu; Steve Bellon; Richard T Cummings; Andrea G Cochran; Brian K Albrecht; Steven Magnuson
Toxicology and Applied Pharmacology, ISSN: 10960333 0041008X
Dong U. Lee; Paula Katavolos; Gopinath S. Palanisamy; Arna Katewa; Charly Sioson; Janice Corpuz; Jodie Pang; Kevin Dement; Edna F. Choo; Nico Ghilardi; Dolores Diaz; Dimitry Danilenko
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Ryan Takahashi; Edna F. Choo; Shuguang Ma; Susan C. Wong; Jason S Halladay; Yuzhong Deng; Isabelle Rooney; Mary Gates; Cornelis E. Hop; S. Cyrus Khojasteh; Mark J. Dresser; Luna Musib
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Ryan Takahashi; Shuguang Ma; Sarah J. Robinson; Qin Yue; Edna F. Choo; S. Cyrus Khojasteh
Drug Metabolism and Disposition, ISSN: 1521009X 00909556
Edna F. Choo; Sarah Woolsey; Kevin Dement; Justin Ly; Kirsten Messick; Ann R. Qin; Ryan Takahashi
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, ISSN: 1873376X 15700232
Yuzhong Deng; Luna Musib; Edna F. Choo; Matthew Chapple; Sarah Burke; James Johnson; Stephen M. Eppler; Brian J. Dean
Molecular Pharmaceutics, ISSN: 15438392 15438384
Edna F. Choo; Justin Ly; Jocelyn Chan; Sheerin Shahidi-Latham; Kirsten Messick; Emile G. Plise; Cristine Quiason; Lulu Yang
Bioorganic and Medicinal Chemistry Letters, ISSN: 14643405 0960894X
Kirk D. Robarge; Wendy Lee; Eigenbrot; Ultsch; Wiesmann; Robert Heald; Steve Price; Joanne F. M. Hewitt; Philip Jackson; Pascal P. A. Savy; Brenda Burton; Edna F. Choo; Jodie Pang; Jason Boggs; April Yang; Yang Xiao; Matthew Baumgardner
ACS Medicinal Chemistry Letters, ISSN: 19485875
Michael F. T. Koehler; Philippe Bergeron; Edna F. Choo; Kevin Lau; Chudi O. Ndubaku; Danette Dudley; Paul Gibbons; Brad E Sleebs; Carl S. Rye; George Nikolakopoulos; Chinh Bui; Sanji Kulasegaram; Wilhelmus J A Kersten; Brian J. Smith; Czabotar; Colman; David C.S. Huang; Jonathan B Baell; Keith G Watson; Lisa Hasvold; Zhi-Fu Tao; Le Wang; Andrew J. Souers; Steven W. Elmore; Flygare; Wayne J. Fairbrother; Guillaume Lessene
Molecular Pharmaceutics, ISSN: 15438384 15438392
Jason Boggs; Cornelis E. Hop; Erin McNamara; Yuzhong Deng; Kirsten Messick; Kristina West; Edna F. Choo
Drug Metabolism and Disposition, ISSN: 00909556 1521009X
Edna F. Choo; Jason Boggs; Chunqiang Zhu; Joseph W. Lubach; Nathaniel D. Catron; Gary Jenkins; Andrew J. Souers; Richard Voorman
Molecular Pharmaceutics, ISSN: 15438384 15438392
Luna Musib; Edna F. Choo; Yuzhong Deng; Stephen M. Eppler; Isabelle Rooney; Iris Chan; Mark J. Dresser
Cancer Research, ISSN: 00085472 15387445
Ted Lau; Emily Chan; Marinella G. Callow; Jo Waaler; Jason Boggs; Robert A. Blake; Steven Magnuson; Amy Sambrone; Melissa Schutten; Ron Firestein; Ondrej Machon; Vladimir Korinek; Edna F. Choo; Dolores Diaz; Mark Merchant; Paul G. Polakis; Daniel D. Holsworth; Stefan Krauss; Michael Costa
Breast Cancer Research and Treatment, ISSN: 01676806 15737217
Inna Y. Gong; Wendy A. Teft; Justin Ly; Yunghsiang Chen; Bruno Alicke; Richard B. Kim; Edna F. Choo
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Patrick Poulin; Donna M. Dambach; Dylan H. Hartley; Kevin A. Ford; Frank-Peter Theil; Eric Harstad; Jason S Halladay; Edna F. Choo; Jason Boggs; Bianca M. Liederer; Brian J. Dean; Dolores Diaz
International Journal of Pharmaceutics, ISSN: 18733476 03785173
Yong Cui; Po-Chang Chiang; Edna F. Choo; Jason Boggs; Joachim Rudolph; Jonas Grina; Steve Wenglowsky; Yingqing Ran
Toxicology and Applied Pharmacology, ISSN: 0041008X 10960333
Dolores Diaz; Kevin A. Ford; Dylan P. Hartley; Eric Harstad; Cain; Kirsten Achilles Poon; Trung Nguyen; Jing Peng; Zhong Zheng; Mark Merchant; Daniel P. Sutherlin; John J. Gaudino; Robert Kaus; Sock-Cheng Lewin-Koh; Edna F. Choo; Bianca M. Liederer; Donna M. Dambach
Cancer Chemotherapy and Pharmacology, ISSN: 03445704 14320843
Edna F. Choo; Chee Ng; Berry; Marcia Belvin; Nicholas Lewin-Koh; Mark Merchant; Laurent Salphati
Clinical Cancer Research, ISSN: 10780432 15573265
Harvey Wong; Edna F. Choo; Bruno Alicke; Xiao Ding; Hank La; Erin McNamara; Frank-Peter Theil; Jay Tibbitts; Lori S. Friedman; Cornelis E. Hop; Stephen Gould
Clinical Cancer Research, ISSN: 10780432 15573265
Harvey Wong; Laurent Vernillet; Amy Peterson; Joseph A. Ware; Lillian Lee; Jean-Francois Martini; Peiwen Yu; Congfen Li; Geoffrey Del Rosario; Edna F. Choo; Klaus P. Hoeflich; Yongchang Shi; Blake T. Aftab; Ron Aoyama; Sanh Tan Lam; Marcia Belvin; John Prescott
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Robert Heald; Philip Jackson; Pascal P. A. Savy; Mark Jones; Emanuela Gancia; Brenda Burton; Richard Newman; Jason Boggs; Emily Chan; Jocelyn Chan; Edna F. Choo; Mark Merchant; Patrick J. Rudewicz; Ultsch; Wiesmann; Qin Yue; Marcia Belvin; Steve Price
Drug Metabolism and Disposition, ISSN: 00909556 1521009X
Edna F. Choo; Marcia Belvin; Jason Boggs; Yuzhong Deng; Klaus P. Hoeflich; Justin Ly; Mark Merchant; Christine Orr; Emile G. Plise; Kirk D. Robarge; Jean-Francois Martini; Robert Kassees; Ron Aoyama; Atulkumar Ramaiya; Stuart H. Johnston
Journal of Medicinal Chemistry, ISSN: 00222623 15204804
Simon Mathieu; Stefan Gradl; Li Ren; Zhaoyang Wen; Ignacio Aliagas; Janet Gunzner; Wendy Lee; Rebecca Pulk; Guiling Zhao; Bruno Alicke; Jason Boggs; Alexandre J. Buckmelter; Edna F. Choo; Victoria Dinkel; Susan L. Gloor; Stephen Gould; Joshua D. Hansen; Gregg Hastings; Georgia Hatzivassiliou; Ellen R. Laird; David Moreno; Yingqing Ran; Walter C. Voegtli; Steve Wenglowsky; Jonas Grina; Joachim Rudolph
Xenobiotica, ISSN: 00498254 13665928
Edna F. Choo; Bruno Alicke; Jason Boggs; Victoria Dinkel; Stephen Gould; Jonas Grina; Kristina West; Kapil Menghrajani; Yingqing Ran; Joachim Rudolph; Steve Wenglowsky
ACS Medicinal Chemistry Letters, ISSN: 19485875
Steve Wenglowsky; Li Ren; Kateri Ahrendt; Ellen R. Laird; Ignacio Aliagas; Bruno Alicke; Alexandre J. Buckmelter; Edna F. Choo; Victoria Dinkel; Bainian Feng; Susan L. Gloor; Stephen Gould; Stefan Gross; Janet Gunzner; Joshua D. Hansen; Georgia Hatzivassiliou; Bonnie Liu; Kim Malesky; Simon Mathieu; Bradley J. Newhouse; Nicholas J. Raddatz; Yingqing Ran; Sumeet Rana; Nikole Randolph; Tyler Risom; Joachim Rudolph; Scott Savage; Leann T. Selby; Michael Shrag; Kyung Song; Hillary L. Sturgis; Walter C. Voegtli; Zhaoyang Wen; Brandon S. Willis; Richard D. Woessner; Wen-I. Wu; Wendy B. Young; Jonas Grina
Overview of SLC22A and SLCO families of drug uptake transporters in the context of cancer treatments
Current Drug Metabolism, ISSN: 18755453 13892002
Murray J. Cutler; Edna F. Choo
Xenobiotica, ISSN: 00498254 13665928
Edna F. Choo; Marcia Belvin; Jocelyn Chan; Klaus P. Hoeflich; Christine Orr; Kirk D. Robarge; Xiaoye Yang; Mark Zak; Jason Boggs
Xenobiotica, ISSN: 00498254 13665928
Edna F. Choo; James Driscoll; Feng; Bianca M. Liederer; Emile G. Plise; Nikole Randolph; Young G. Shin; Susan C. Wong; Yingqing Ran
Journal of Pharmacology and Experimental Therapeutics, ISSN: 00223565 15210103
Harvey Wong; Marcia Belvin; Sylvia Herter; Klaus P. Hoeflich; Lesley J. Murray; Leo Wong; Edna F. Choo
Cancer Research, ISSN: 00085472 15387445
Klaus P. Hoeflich; Sylvia Herter; Janet Y. Tien; Leo Wong; Berry; Jocelyn Chan; Carol O'Brien; Zora Modrusan; Somasekar Seshagiri; Lackner; Howard M. Stern; Edna F. Choo; Lesley J. Murray; Lori S. Friedman; Marcia Belvin
Drug Metabolism and Disposition, ISSN: 00909556 1521009X
Amit S. Kalgutkar; Bo Feng; Hang T. Nguyen; Kosea S. Frederick; Scott D. Campbell; Heather L. Hatch; Yi-An Bi; Diana C. Kazolias; Ralph E. Davidson; Rouchelle J. Mireles; David B. Duignan; Edna F. Choo; Sabrina X. Zhao
Biopharmaceutics and Drug Disposition, ISSN: 01422782 1099081X
Amit S. Kalgutkar; Heather L. Hatch; Frederick Kosea; Hang T. Nguyen; Edna F. Choo; Kim F. McClure; Timothy J. Taylor; Kirk R. Henne; Alexander V. Kuperman; Mark A. Dombroski; Michael A. Letavic
Education
- Monash University, Australia, B.Pharm (Hons), Ph.D –