Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 801 - 850 OF 15805 RESULTS

Phase-appropriate Application of Process Analytical Technology for Early Pharmaceutical Development of Oral Solid Dosage Forms—the Case Study of Uniformity Screening of Dosage Units and Blends
AAPS Journal,
Sayyeda Zeenat A. Razvi; Shengli Ma; Qiqing Zhong; Ariel Muliadi; Zhenqi Shi
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Weak to no correlation between quantitative high-resolution computed tomography metrics and lung function change in fibrotic diseases
ERJ Open Research,
Yixuan Zou; Xuefeng Hou; Neha Anegondi; Mohammadreza Negahdar; Dorothy Cheung; Paula Belloni; De Crespigny; Alexandre Coimbra
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A Phase Ib, Open-label Study Evaluating the Safety and Efficacy of Ipatasertib plus Rucaparib in Patients with Metastatic Castration-resistant Prostate Cancer
Clinical Cancer Research, ISSN: 15573265 10780432
David Pook; Daniel M Geynisman; Joan Carles; Filippo De Braud; Anthony M. Joshua; Jose Luis Perez-Gracia; Casilda Llácer Pérez; Sang Joon Shin; Bruno Fang; Minal Barve; Marco Maruzzo; Sergio Bracarda; Miso Kim; Yannick Kerloeguen; Jorge Daniel Gallo; Sophia L. Maund; Adam Harris; Kuan-Chieh Huang; Victor Poon; Dhruvitkumar S. Sutaria; Howard Gurney
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Hydrogel-Encapsulated Beads Enable Proximity-Driven Encoded Library Synthesis and Screening
ACS Central Science, ISSN: 23747943
Valerie Cavett; Alix I Chan; Christian N. Cunningham; Brian M. Paegel
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Multi-ancestry GWAS analysis identifies two novel loci associated with diabetic eye disease and highlights APOL1 as a high risk locus in patients with diabetic macular edema
PLoS Genetics, ISSN: 15537390
Amy Stockwell; Michael C. Chang; Anubha Mahajan; William F. Forrest; Neha Anegondi; Rion Pendergrass; Suresh K Selvaraj; Jens Reeder; Eric Wei; Victor A. Iglesias; Natalie M. Creps; Laura Macri; Andrea N. Neeranjan; Marcel P Van Der Brug; Suzie J. Scales; Mark I. McCarthy; Brian L. Yaspan
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An agonistic anti-signal regulatory protein α antibody for chronic inflammatory diseases
Cell Reports Medicine,
Markus M. Xie; Bingbing Dai; Jason A. Hackney; Tianhe Sun; Juan Zhang; Janet Jackman; Surinc Er Jeet; Ricardo A. Irizarry-Caro; Yongyao Fu; Yuxin Liang; Hannah Bender; Eliah R. Shamir; Mary E. Keir; Jack Bevers; Nakamura; Michael J. Townsend; David A. Fox; Alexis Scherl; Wyne P. Lee; Flavius Martin; Godowski; Rajita Pappu; Tangsheng Yi
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Author Correction: A single-cell atlas of human and mouse white adipose tissue (Nature, (2022), 603, 7903, (926-933), 10.1038/s41586-022-04518-2)
Nature, ISSN: 00280836
Margo P. Emont; Christopher Jacobs; Adam Essene; Deepti Pant; Danielle Tenen; Georgia Colleluori; Angelica Di Vincenzo; Anja M. Jørgensen; Hesam Dashti; Adam Stefek; Elizabeth McGonagle; Sophie Strobel; Samantha Laber; Saaket Agrawal; Gregory P. Westcott; Amrita Kar; Molly L. Veregge; Anton Gulko; Harini Srinivasan; Zachary Kramer; Eleanna De Filippis; Erin Merkel; Jennifer Ducie; Christopher G. Boyd; William Gourash; Anita Courcoulas; Samuel J. Lin; Bernard T. Lee; Donald Morris; Adam Tobias; Amit V. Khera; Melina Claussnitzer; Tune H. Pers; Antonio Giordano; Orr Ashenberg; Aviv Regev; Linus T. Tsai; Evan D. Rosen
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TPL2 kinase activity regulates microglial inflammatory responses and promotes neurodegeneration in tauopathy mice
eLife,
Yuanyuan Wang; Tiffany Wu; Ming-Chi Tsai; Mitchell G. Rezzonico; Alyaa M. Abdel-Haleem; Luke Xie; Vineela D. Gandham; Hai Ngu; Kimberly L. Stark; Caspar Glock; Daqi Xu; Oded Foreman; Brad A. Friedman; Morgan Sheng; Jesse E. Hanson
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Process Robustness in Lipid Nanoparticle Production: A Comparison of Microfluidic and Turbulent Jet Mixing
Molecular Pharmaceutics, ISSN: 15438384
Matthew N. O’Brien Laramy; Antonio P. Costa; Yareli Maciel Cebrero; Johnson Joseph; Apoorva Sarode; Nanzhi Zang; Lee Joon Kim; Kate Hofmann; Shirley Wang; Alexandre Goyon; Stefan G. Koenig; Michal Hammel; Greg L. Hura
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Long-term follow-up confirms the favourable prognostic impact of high numbers of tumour infiltrating CD3 T-cells in follicular lymphoma patients treated by rituximab-maintenance regimen
British Journal of Haematology, ISSN: 00071048
Camille Laurent; Maria Flores; Loic Chartier; Sarah Huet; Christopher R. Bolen; Jeffrey M. Venstrom; Catherine Chassagne-Clément; Peggy Dartigues-Cuilléres; Fréderic Charlotte; Bruno Tesson; Gilles Salles; Morschhauser; Luc Xerri
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Fit-for-Purpose Synthesis of CDK2 Inhibitor GNE-140
Helvetica Chimica Acta, ISSN: 0018019X
Andrea Ambrosi; Katarzyna A. Piechowicz; Tyler A. Tuck; Di Xu; Haiming Zhang; Francis Gosselin
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Demographics and baseline disease characteristics of Black and Hispanic patients with multiple sclerosis in the open-label, single-arm, multicenter, phase IV CHIMES trial
Multiple Sclerosis and Related Disorders, ISSN: 22110348
Mitzi J. Williams; Annette F Okai; Anne Cross; Nancy L Monson; Timothy Vartanian; Ben W Thrower; Anthony T Reder; Jeffrey B English; Gregory F Wu; Evanthia Bernitsas; Shereen Yap; Jugena Ndrio; Jinglan Pei; Ellen M. Mowry; Fabio Magrini; Juan Acosta; Lilyana Amezcua
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Development of Liposome Systems for Enhancing the PK Properties of Bivalent PROTACs
Pharmaceutics,
Ponien Kou; Elizabeth S. Levy; An D. Nguyen; Donglu Zhang; Shu Chen; Yusi Cui; Xing Zhang; Broccatelli; Jennifer Pizzano; Jennifer Cantley; Elizabeth Bortolon; Emma Rousseau; Michael Berlin; Peter Dragovich; Vijay Sethuraman
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2022 White Paper on Recent Issues in Bioanalysis: Enzyme Assay Validation, BAV for Primary End Points, Vaccine Functional Assays, Cytometry in Tissue, LBA in Rare Matrices, Complex NAb Assays, Spectral Cytometry, Endogenous Analytes, Extracellular Vesicles Part 2 - Recommendations on Biomarkers/CDx, Flow Cytometry, Ligand-Binding Assays Development & Validation; Emerging Technologies; Critical Reagents Deep Characterization
Bioanalysis, ISSN: 17576180
Giane Sumner; Steve Keller; James Huleatt; Roland F Staack; Leslie Wagner; Mitra Azadeh; Abbas Bandukwala; Liching Cao; Xiulian Du; Gabriela Franco Salinas; Fabio Garofolo; Shannon Harris; Shirley Hopper; Chad Irwin; Qin Ji; Julie Joseph; Lindsay King; Arvind Kinhikar; Yang Lu; Rosa Luo; Omar Mabrouk; Ludovic Malvaux; Jean-Claude Marshall; Kristina McGuire; Vincent Mikol; Robert J. Neely; Xiazi Qiu; Yoshiro Saito; Bruno Salaun; Ingrid Scully; John Smeraglia; Therese Solstad; Jeroen Stoop; Huaping Tang; Priscila Camillo Teixeira; Yixin Wang; Mike Wright; Luis Mendez; Chris Beaver; Jacqueline Eacret; Amelia Au-Yeung; Vilma Decman; Francis Dessy; Steven Eck; Polina Goihberg; Enrique Gomez Alcaide; Christèle Gonneau; Katharine D. Grugan; Michael Hedrick; Sumit Kar; Sarita Sehra; Erin Stevens; Chad Stevens; Yongliang Sun; Fred McCush; LaKenya Williams; Sally Fischer; Bonnie Wu; Gregor Jordan; Chris Burns; Isabelle Cludts; Kelly Coble; Grimaldi; Neil Henderson; Alison Joyce; Gregor P Lotz; Yanmei Lu; Linlin Luo; Florian Neff; Gizette Sperinde; Kay Stubenrauch; Yuting Wang; Mark Ware; Weifeng Xu
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UniDec Processing Pipeline for Rapid Analysis of Biotherapeutic Mass Spectrometry Data
Analytical Chemistry, ISSN: 00032700
Wilson Phung; Corey Bakalarski; Trent Hinkle; Wendy N. Sandoval; Michael T. Marty
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Comprehensive Analysis of Photoreceptor Outer Segments: Flow Cytometry Characterization and Stress-Driven Impact on Retinal Pigment Epithelium Phagocytosis
International Journal of Molecular Sciences, ISSN: 16616596
Haoqian Liang; Qiang Wu; Xinzheng Victor Guo; Linda Chan; Tin Mao; Cinzia Stella; Axel Guilbaud; Julien Camperi
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IMscin001 Part 2: a randomised phase III, open-label, multicentre study examining the pharmacokinetics, efficacy, immunogenicity, and safety of atezolizumab subcutaneous versus intravenous administration in previously treated locally advanced or metastatic non-small-cell lung cancer and pharmacokinetics comparison with other approved indications
Annals of Oncology, ISSN: 09237534
Mauricio Burotto; Zanete Zvirbule; Mochalova; Runglodvatana; Luis A. Herráez-Baranda; Stephanie N. Liu; Phyllis Chan; Shearer-Kang; Xiaoyan Liu; Nadia Tosti; James Zanghi; Leutgeb; Felip
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2022 White Paper on Recent Issues in Bioanalysis: ICH M10 BMV Guideline & Global Harmonization; Hybrid Assays; Oligonucleotides & ADC; Non-Liquid & Rare Matrices; Regulatory Inputs (Part 1A - Recommendations on Mass Spectrometry, Chromatography and Sample Preparation, Novel Technologies, Novel Modalities, and Novel Challenges, ICH M10 BMV Guideline & Global Harmonization Part 1B - Regulatory Agencies' Inputs on Regulated Bioanalysis/BMV, Biomarkers/CDx/BAV, Immunogenicity, Gene & Cell Therapy and Vaccine)
Bioanalysis, ISSN: 17576180
Matthew Szapacs; Wenying Jian; Spellman; Jennifer Cunliffe; Elizabeth Verburg; Surinder Kaur; John Kellie; Wenkui Li; John T. Mehl; Mark Qian; Xiazi Qiu; Federico Riccardi Sirtori; Anton I Rosenbaum; Timothy Sikorski; Sekhar Surapaneni; Jian Wang; Amanda Wilson; Jinhui Zhang; Xue; Noah Post; Yue Huang; Dina Goykhman; Long Yuan; Kasie Fang; Ellen Casavant; Lin-Zhi Chen; Yunlin Fu; Ming Huang; Allena Ji; Jay Johnson; Michael Lassman; Jing Li; Ola M. Saad; Hetal Sarvaiya; Lin Tao; Yuting Wang; Naiyu Zheng; Arindam Dasgupta; Mohsen Rajabi Abhari; Akiko Ishii-Watabe; Yoshiro Saito; Dulcyane Neiva Mendes Fernandes; Joe Bower; Chris Burns; Kevin Carleton; Seongeun Julia Cho; Xiulian Du; Marianne Scheel Fjording; Fabio Garofolo; Sumit Kar; Olga Kavetska; Elham Kossary; Yang Lu; Andrew Mayer; Nisha Palackal; Danielle Salha; Eric Thomas; Tom Verhaeghe; Stephen Vinter; Katty Wan; Yow-Ming C. Wang; Kathi Williams; Eric Woolf; Li Yang; Eric Yang; Abbas Bandukwala; Shirley Hopper; Kevin Maher; Joshua Xu; Eric Brodsky; Isabelle Cludts; Chad Irwin; Julie Joseph; Susan Kirshner; Mohanraj Manangeeswaran; Kimberly Maxfield; Joao Pedras-Vasconcelos; Therese Solstad; Seth Thacker; Omar Tounekti; Verthelyi; Meenu Wadhwa; Leslie Wagner; Takenori Yamamoto; Lucia Zhang; Lin Zhou
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An Open-label Phase I Study of GDC-0927 in Postmenopausal Women with Locally Advanced or Metastatic Estrogen Receptor–Positive Breast Cancer
Clinical Cancer Research, ISSN: 10780432
Sarat Chandarlapaty; Maura N. Dickler; José Alejandro Pérez-Fidalgo; Rafael Villanueva-Vázquez; Jennifer M. Giltnane; Mary Gates; Ching-Wei Chang; Sravanthi Cheeti; Jill Fredrickson; Xiaojing Wang; Ann Collier; Heather M. Moore; Ciara Metcalfe; Jennifer O. Lauchle; Eric W. Humke; Aditya Bardia
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Returning to Nature for the Next Generation of Antimicrobial Therapeutics
Antibiotics,
Craig R. MacNair; Caressa N. Tsai; Steven T. Rutherford; Man-Wah Tan
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Leveraging polygenic enrichments of gene features to predict genes underlying complex traits and diseases
Nature Genetics, ISSN: 10614036
Elle M. Weeks; Jacob C. Ulirsch; Nathan Cheng; Brian L. Trippe; Rebecca S. Fine; Jenkai Miao; Tejal A. Patwardhan; Masahiro Kanai; Joseph Nasser; Charles P. Fulco; Katherine Tashman; François Aguet; Taibo Li; Jose Ordovas-Montanes; Chris Smillie; Moshe Biton; Alex K. Shalek; Ashwin N. Ananthakrishnan; Ramnik J. Xavier; Aviv Regev; Rajat M. Gupta; Kasper Lage; Kristin G. Ardlie; Joel N. Hirschhorn; Eric S. Lander; Jesse M. Engreitz; Hilary Finucane
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Expanding Chemical Probe Space: Quality Criteria for Covalent and Degrader Probes
Journal of Medicinal Chemistry, ISSN: 00222623
Ingo V. Hartung; Joachim Rudolph; Mary M. Mader; Monique P. C. Mulder; Paul Workman
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Pattern recognition receptor agonists in pathogen vaccines mediate antitumor T-cell cross-priming
Journal for ImmunoTherapy of Cancer,
Mark Aleynick; Judit Svensson-Arvelund; Gvantsa Pantsulaia; Kristy Kim; Samuel A. Rose; Ranjan Upadhyay; Michael Yellin; Henry Marsh; Daniel Oreper; Suchit Jhunjhunwala; Christine Moussion; Miriam Merad; Brian Brown; Joshua D. Brody
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Development of a Cryo-Pre-Embedding Immunogold Labeling Protocol for the Ultrastructural Localization of PDL1 in Human Tonsils
Microscopy and Microanalysis,
Miriam Baca; Cecile Chalouni; Koeppen; Linda Rangell; Meredith Sagolla; Mike Reichelt
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Fluorescence In Resin Morphology (FIRM) Imaging Provides Histologic Context for Correlated Immunofluorescence and Electron Microscopy of Tissue Sections
Microscopy and Microanalysis,
Mike Reichelt; Cecile Chalouni; Miriam Baca; Webster; Meredith Sagolla
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Practical Synthesis of Reactive Immuno-PET Linker-Chelator (1R,2R)-RESCA-TFP
Organic Process Research and Development, ISSN: 10836160
Nicholas Wong; Eileen X. Zhao; Jiangyin Bao; Stefan G. Koenig; Carmela Molinaro; Jacob C. Timmerman; Haiming Zhang; C. Gregory Sowell; Francis Gosselin
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Regioselective aliphatic C–H functionalization using frustrated radical pairs
Nature, ISSN: 00280836
Zhipeng Lu; Minsoo Ju; Yi Wang; Jonathan M. Meinhardt; Jesus I. Martinez Alvarado; Elisia Villemure; Jack A. Terrett; Song Lin
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Fragment expansion with NUDELs - poised DNA-encoded libraries
Chemical Science, ISSN: 20416520
Catherine L. A. Salvini; Benoit Darlot; Jack Davison; Mathew P. Martin; Susan J. Tudhope; Shannon Turberville; Akane Kawamura; Martin E. M. Noble; Stephen R. Wedge; James J. Crawford; Michael J. Waring
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AzidoTMT Enables Direct Enrichment and Highly Multiplexed Quantitation of Proteome-Wide Functional Residues
Journal of Proteome Research, ISSN: 15353893
Taylur P. Ma; Anita Izrael-Tomasevic; Rana Mroue; Hanna G. Budayeva; Sushant Malhotra; Ryan Raisner; Marie Evangelista; Christopher M. Rose; Donald S. Kirkpatrick; Kebing Yu
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C(sp3)-C(sp2) Reductive Elimination versus β-Hydride Elimination from Cobalt(III) Intermediates in Catalytic C-H Functionalization
ACS Catalysis,
William G. Whitehurst; Junho Kim; Stefan G. Koenig; Paul J. Chirik
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Targeted alveolar regeneration with Frizzled-specific agonists
Cell, ISSN: 00928674
Ahmad N. Nabhan; Webster; Jarret J. Adams; Levi Blazer; Christine Everrett; Celine Eidenschenk; Alexander Arlantico; Isabel Fleming; Hans D. Brightbill; Paul J. Wolters; Zora Modrusan; Somasekar Seshagiri; Stephane Angers; Sachdev S. Sidhu; Kim Newton; Joseph R. Arron; Vishva M. Dixit
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Recommendations on the Selection, Development, and Modification of Performance Outcome Assessments: A Good Practices Report of an ISPOR Task Force
Value in Health, ISSN: 10983015
Edgar; Elizabeth (Nicki) Bush; Heather R. Adams; Rachel Ballinger; Bill Byrom; Michelle Campbell; Sonya Eremenco; Fiona McDougall; Elektra Papadopoulos; Ashley F. Slagle; Stephen Joel Coons
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Author Correction: Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models (Nature Biotechnology, (2023), 41, 3, (399-408), 10.1038/s41587-022-01520-x)
Nature Biotechnology, ISSN: 15461696 10870156
Rosa Allesøe; Agnete Troen Lundgaard; Ricardo Hernández Medina; Alejandro Aguayo-Orozco; Joachim Johansen; Jakob Nybo Nissen; Caroline Anna Brorsson; Gianluca Mazzoni; Lili Niu; Jorge Hernansanz Biel; Cristina Leal Rodríguez; Valentas Brasas; Henry Webel; Michael Eriksen Benros; Anders Gorm Pedersen; Piotr Jaroslaw Chmura; Ulrik Plesner Jacobsen; Andrea Mari; Robert W. Koivula; Anubha Mahajan; Ana Vinuela; Juan Fernandez Tajes; Sapna Sharma; Mark Haid; Mun-Gwan Hong; Petra B. Musholt; Federico De Masi; Josef Vogt; Helle Krogh Pedersen; Valborg Gudmundsdóttir; Angus G. Jones; Gwen Kennedy; Jimmy D. Bell; E. Louise Thomas; Gary Frost; Henrik S. Thomsen; Elizaveta Hansen; Tue H. Hansen; Henrik Vestergaard; Mirthe Muilwijk; Marieke T. Blom; Leen M. T Hart; Francois Pattou; Violeta Raverdy; Søren Brage; Tarja Kokkola; Alison Heggie; Donna McEvoy; Miranda Mourby; Jane Kaye; Andrew T. Hattersley; Timothy J. McDonald; Martin Ridderstråle; Mark Walker; Ian M. Forgie; Giuseppe N. Giordano; Imre Pavo; Hartmut Ruetten; Oluf Pedersen; Torben Hansen; Emmanouil T. Dermitzakis; Paul W. Franks; Jochen M. Schwenk; Jerzy Adamski; Mark I. McCarthy; Ewan Pearson; Karina Banasik; Simon Rasmussen; Søren Brunak; Philippe Froguel; Cecilia Engel Thomas; Ragna S. Häussler; Joline Beulens; Femke Rutters; Giel Nijpels; Sabine van Oort; Lenka Groeneveld; Petra J M Elders; Toni Giorgino; Marianne Rodriquez; Rachel Nice; Mandy Perry; Susanna Bianzano; Ulrike Graefe-Mody; Anita Hennige; Rolf Grempler; Patrick Baum; Hans-Henrik Staerfeldt; Nisha Shah; Harriet J. A. Teare; Beate Ehrhardt; Joachim Tillner; Christiane Dings; Thorsten Lehr; Nina Scherer; Iryna Sihinevich; Louise Cabrelli; Heather Loftus; Roberto Bizzotto; Andrea Tura; Koen Dekkers; Nienke van Leeuwen; Leif Groop; Roderick Slieker; Anna Ramisch; Christopher Jennison; Ian McVittie; Francesca Frau; Birgit Steckel-Hamann; Kofi Adragni; Melissa Thomas; Naeimeh Atabaki Pasdar; Hugo Fitipaldi; Azra Kurbasic; Pascal M. Mutie; Hugo Pomares-Millan; Amélie Bonnefond; Mickaël Canouil; Robert Caiazzo; Helene Verkindt; Reinhard Holl; Teemu Kuulasmaa; Harshal Deshmukh; Henna Cederberg; Markku Laakso; Jagadish Vangipurapu; Matilda Dale; Barbara Thorand; Claudia Nicolay; Andreas Fritsche; Anita Hill; Michelle Hudson; Claire Thorne; Kristine H. Allin; Manimozhiyan Arumugam; Anna Jonsson; Line Engelbrechtsen; Annemette Forman; Avirup Dutta; Nadja Sondertoft; Yong Fan; Stephen Gough; Neil Robertson; Nicky McRobert; Agata Wesolowska-Andersen; Andrew A. Brown; David Davtian; Adem Y. Dawed; Louise Donnelly; Colin Palmer; Margaret White; Jorge Ferrer; Brandon Whitcher; Anna Artati; Cornelia Prehn; Jonathan Adam; Harald Grallert; Ramneek Gupta; Peter Wad Sackett; Birgitte Nilsson; Konstantinos D. Tsirigos; Rebeca Eriksen; Bernd Jablonka; Mathias Uhlén; Johann Gassenhuber; Tania Baltauss; Nathalie de Preville; Maria Klintenberg; Moustafa Abdalla
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Author Correction: Genetic effects on the timing of parturition and links to fetal birth weight (Nature Genetics, (2023), 55, 4, (559-567), 10.1038/s41588-023-01343-9)
Nature Genetics, ISSN: 15461718 10614036
Pol Solé-Navais; Christopher Flatley; Valgerdur Steinthorsdottir; Marc Vaudel; Julius Juodakis; Jing Chen; Triin Laisk; Abigail L. LaBella; David Westergaard; Jonas Bacelis; Ben M. Brumpton; Line Skotte; Maria-Carolina Borges; Øyvind Helgeland; Anubha Mahajan; Matthias Wielscher; Frederick Lin; Catherine Briggs; Carol A Wang; Gunn-Helen Moen; Robin N Beaumont; Jonathan P. Bradfield; Abin Abraham; Gudmar Thorleifsson; Maiken E. Gabrielsen; Sisse R. Ostrowski; Dominika Modzelewska; Ellen A. Nohr; Elina Hyppönen; Amit Srivastava; Octavious Talbot; Catherine Allard; Scott M. Williams; Ramkumar Menon; Beverley M. Shields; Gardar Sveinbjornsson; Huan Xu; Mads Melbye; William Lowe; Luigi Bouchard; Emily Oken; Ole B. Pedersen; Daniel Gudbjartsson; Christian Erikstrup; Erik Sørensen; Mark I. McCarthy; Rolv T. Lie; Kari Teramo; Mikko Hallman; Thorhildur Juliusdottir; Hakon Hakonarson; Henrik Ullum; Andrew T. Hattersley; Line Sletner; Mario Merialdi; Sheryl L. Rifas-Shiman; Thora Steingrimsdottir; Denise M. Scholtens; Chris Power; Jane West; Mette Nyegaard; John A. Capra; Anne H. Skogholt; Per Magnus; Ole A. Andreassen; Unnur Thorsteinsdottir; Struan F.A. Grant; Elisabeth Qvigstad; Craig E. Pennell; Marie-France Hivert; M. Geoffrey Hayes; Marjo-Riitta Järvelin; Mark I. McCarthy; Debbie A. Lawlor; Henriette S. Nielsen; Reedik Mägi; Antonis Rokas; Kristian Hveem; Kari Stefansson; Bjarke Feenstra; Pål Njolstad; Louis J. Muglia; Rachel M. Freathy; Stefan Johansson; Ge Zhang; Bo Jacobsson
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Local Pentraxin-2 Deficit Is a Feature of Intestinal Fibrosis in Crohn’s Disease
Digestive Diseases and Sciences, ISSN: 15732568 01632116
Steven Levitte; Franklin V. Peale Jr.; Iny Jhun; Jacqueline McBride; Margaret Neighbors
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Complex PK-PD of an engineered IL-15/IL-15Rα–Fc fusion protein in cynomolgus monkeys: QSP modeling of lymphocyte dynamics
European Journal of Pharmaceutical Sciences, ISSN: 18790720 09280987
Dan Lu; Rajbharan Yadav; Patrick Holder; Eugene Chiang; Shomyseh Sanjabi; Victor Poon; Matthew Bernett; Rajat Varma; Ke Liu; Irene Leung; Liz Bogaert; John Desjarlais; Vittal Shivva; Iraj Hosseini; Ramanujan
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Population-Based Pharmacodynamic Modeling of Omalizumab in Pediatric Patients with Moderate to Severe Persistent Inadequately Controlled Allergic Asthma
AAPS Journal,
Rui Zhu; Xiaoning Wang; Eric Anderson; Michelle Deng; Scott Pivirotto; Jin Jin; Nastya Kassir; Ryan Owen
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Mass Balance of the Indoleamine 2,3-Dioxygenase Inhibitor Navoximod (GDC-0919) in Rats and Dogs: Unexpected Cyanide Release from Imidazo[5,1-a]isoindole and Species Differences in GlucuronidationS
Drug Metabolism and Disposition, ISSN: 00909556
Shuai Wang; Shuguang Ma; Eugene C. Chen; Jing Wang; Hoa Le; Steven Paul Hanlon; Martin Binder; Wendy Lee; Cyrus Khojasteh; Laurent Salphati
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Blood neurofilament light levels predict non-relapsing progression following anti-CD20 therapy in relapsing and primary progressive multiple sclerosis: findings from the ocrelizumab randomised, double-blind phase 3 clinical trials
EBioMedicine,
Amit Bar-Or; Gian-Andrea Thanei; Chris Harp; Corrado Bernasconi; Ulrike Bonati; Anne Cross; Saloumeh Kadkhodayan Fischer; Laura Gaetano; Stephen L. Hauser; Robert Hendricks; Ludwig Kappos; Jens Kuhle; Leppert; Fabian Model; Sauter; Harold Koendgen; Xiaoming Jia; Ann E. Herman
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Multicellular communities are perturbed in the aging human brain and Alzheimer’s disease
Nature Neuroscience, ISSN: 10976256
Anael Cain; Mariko F. Taga; Cristin McCabe; Gilad S. Green; Idan Hekselman; Charles C. White; Dylan I. Lee; Pallavi Gaur; Orit Rozenblatt-Rosen; Feng Zhang; Esti Yeger-Lotem; David A. Bennett; Hyun-Sik Yang; Aviv Regev; Vilas Menon; Naomi Habib; Philip L De Jager
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Survey Outcome on Immunogenicity Risk Assessment Tools for Biotherapeutics: an Insight into Consensus on Methods, Application, and Utility in Drug Development
AAPS Journal,
Jochem Gokemeijer; Yi Wen; Vibha Jawa; Shibani Mitra-Kaushik; Shan Chung; Alan Goggins; Seema Kumar; Kasper Lamberth; Karen Liao; Jennie R. Lill; Qui Phung; Robin Walsh; Brian J. Roberts; Michael Swanson; Inderpal Singh; Sophie Tourdot; Mark A. Kroenke; Bonita Rup; Theresa J. Goletz; Swati Gupta; Laurent Malherbe; Sofie Pattijn
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Geographic Atrophy Segmentation Using Multimodal Deep Learning
Translational Vision Science and Technology,
Theodore Spaide; Jiaxiang Jiang; Jasmine Patil; Neha Anegondi; Verena Steffen; Michael G. Kawczynski; Elizabeth Newton; Christina Rabe; Simon S. Gao; Aaron Y. Lee; Frank G. Holz; Srinivas Sadda; Steffen Schmitz-Valckenberg; Daniela Ferrara
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Mini-PBPK-Based Population Model and Covariate Analysis to Assess the Complex Pharmacokinetics and Pharmacodynamics of RO7449135, an Anti-KLK5/KLK7 Bispecific Antibody in Cynomolgus Monkeys
AAPS Journal,
Hao Cai; Xun Tao; Jeongsup Shim; Rebecca N. Bauer; Meire C. Bremer; Wei Bu; Jason LaMar; Rachel Basile; Edward Dere; Tien Nguyen; Steven T. Laing; Pamela Chan; Tangsheng Yi; James T. Koerber; Gizette Sperinde; Stefanich
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ALK Inhibitor Treatment Patterns and Outcomes in Real-World Patients with ALK-Positive Non-Small-Cell Lung Cancer: A Retrospective Cohort Study
Targeted Oncology, ISSN: 17762596
Michelle Wang; Shadera Slatter; Jesse Sussell; Chia-Wei Lin; Sarika Ogale; Debajyoti Datta; Atul J. Butte; Lyudmila Bazhenova; Vivek A. Rudrapatna
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CenTauR: Toward a universal scale and masks for standardizing tau imaging studies
Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring,
Victor L Villemagne; Antoine Leuzy; Sandra Sanabria Bohorquez; Santiago Bullich; Hitoshi Shimada; Christopher Rowe; Pierrick Bourgeat; Brian J Lopresti; Kun Huang; Natasha Krishnadas; Jurgen Fripp; Yuhei Takado; Alexandra Gogola; Davneet Minhas; Robby M. Weimer; Makoto Higuchi; Andrew W Stephens; Oskar Hansson; Vincent Dore
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Covariate handling approaches in combination with dynamic borrowing for hybrid control studies
Pharmaceutical Statistics, ISSN: 15391612 15391604
Chenqi Fu; Herbert Pang; Shouhao Zhou; Jiawen Zhu
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Inhibiting membrane rupture with NINJ1 antibodies limits tissue injury
Nature, ISSN: 00280836
Nobuhiko Kayagaki; Irma B. Stowe; Kamela Alegre; Ishan Deshpande; Shuang Wu; Zhonghua Lin; Opher S. Kornfeld; Bettina L. Lee; Juan Zhang; John Liu; Eric Suto; Wyne P. Lee; Kellen Schneider; Wei Yu Lin; Dhaya Seshasayee; Tushar Bhangale; Cecile Chalouni; Matthew C. Johnson; Prajakta Joshi; Jan Mossemann; Sarah Zhao; Danish Ali; Neil M. Goldenberg; Blayne A. Sayed; Benjamin E. Steinberg; Kim Newton; Webster; Ryan Kelly; Vishva M. Dixit
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Correlating the Structure and Gene Silencing Activity of Oligonucleotide-Loaded Lipid Nanoparticles Using Small-Angle X-ray Scattering
ACS Nano, ISSN: 19360851
Michal Hammel; Yuchen Fan; Apoorva Sarode; Amy E. Byrnes; Nanzhi Zang; Ponien Kou; Karthik Nagapudi; Dennis H. Leung; Casper C Hoogenraad; Tao Chen; Chun-Wan Yen; Greg L. Hura
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Btbd11 supports cell-type-specific synaptic function
Cell Reports,
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In situ tumour arrays reveal early environmental control of cancer immunity
Nature, ISSN: 00280836
Guadalupe Ortiz-Muñoz; Markus Brown; Catherine B. Carbone; Ximo Pechuan-Jorge; Vincent Rouilly; Henrik Lindberg; Alex T. Ritter; Gautham Raghupathi; Qianbo Sun; Tess Nicotra; Shreya R. Mantri; Angela Yang; Jonas Martin Doerr; Deepti R. Nagarkar; Spyros Darmanis; Benjamin Haley; Sanjeev Mariathasan; Wang; Carlos Gomez-Roca; Carlos Eduardo de Andrea; David Spigel; Thomas D Wu; Lélia Delamarre; Johannes Schöneberg; Zora Modrusan; Richard Price; Shannon J. Turley; Ira Mellman; Christine Moussion
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