Scientists / Publications

Publications

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DISPLAYING 3551 - 3600 OF 16812 RESULTS

Development and testing of the Satisfaction Questionnaire with Intravenous or Subcutaneous Hemophilia Injection and results from the Phase 3 HAVEN 3 study of emicizumab prophylaxis in persons with haemophilia A without FVIII inhibitors
Haemophilia, ISSN: 13652516 13518216
Kempton; Peter C. Trask; Aric Parnes; Markus Niggli; Avrita Campinha-Bacote; Michael U. Callaghan; Niamh O'Connell; Paz-Priel; Johnny N. Mahlangu
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Mito–managing ROS & redox to reboot the immune system: Tapping mitochondria & redox management to extend the reach of hematopoietic stem cell transplantation
Free Radical Biology and Medicine, ISSN: 18734596 08915849
Mary Mohrin
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Author Correction: High systemic and tumor-associated IL-8 correlates with reduced clinical benefit of PD-L1 blockade (Nature Medicine, (2020), 26, 5, (693-698), 10.1038/s41591-020-0860-1)
Nature Medicine, ISSN: 1546170X 10788956
Kobe Yuen; L-F Liu; Vinita Gupta; Shravan Madireddi; Shilpa Keerthivasan; Congfen Li; Deepali Rishipathak; P. Mickey Williams; Edward E. Kadel III; Koeppen; Ying-Jiun Chen; Zora Modrusan; Jane L. Grogan; Romain Banchereau; Ning Leng; AnnChristine Thåström; Xiaodong Shen; Kenji Hashimoto; Darren Tayama; Michiel S Van Der Heijden; Jonathan E. Rosenberg; David McDermott; Thomas Powles; Priti Hegde; Mahrukh Huseni; Sanjeev Mariathasan
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Safety evaluation of shorter infusion for ocrelizumab in a substudy of the Phase IIIb CHORDS trial
Annals of Clinical and Translational Neurology, ISSN: 23289503
Robert A. Bermel; Waubant; Gabriel Pardo; Ann Bass; Pavle Repovic; Scott Newsome; John W. Lindsey; Deidre Kile; Ashish Pradhan; Bruno Musch; Aram Zabeti
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Multimodal pooled Perturb-CITE-seq screens in patient models define mechanisms of cancer immune evasion
Nature Genetics, ISSN: 15461718 10614036
Chris J. Frangieh; Johannes C. Melms; Pratiksha I. Thakore; Kathryn R. Geiger-Schuller; Patricia Ho; Adrienne M. Luoma; Brian Cleary; Livnat Jerby-Arnon; Shruti Malu; Michael S. Cuoco; Maryann Zhao; Casey R. Ager; Meri Rogava; Lila Hovey; Asaf Rotem; Chantale Bernatchez; Kai W. Wucherpfennig; Bruce E. Johnson; Orit Rozenblatt-Rosen; Dirk Schadendorf; Aviv Regev; Benjamin Izar
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High-Throughput, Fluorescence-Based Esterase Activity Assay for Assessing Polysorbate Degradation Risk during Biopharmaceutical Development
Pharmaceutical Research, ISSN: 1573904X 07248741
Adithi C. Bhargava; Kathryn Mains; Albert Siu; Jie Gu; Jonathan Zarzar; Li Yi; Inn H. Yuk
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Light-Induced Histidine Adducts to an IgG1 Molecule Via Oxidized Histidine Residue and the Potential Impact of Polysorbate-20 Concentration
Pharmaceutical Research, ISSN: 1573904X 07248741
Ming Lei; Quan; John Wang; Kao; Christian Schöneich
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Risk of blindness among patients with diabetes and newly diagnosed diabetic retinopathy
Diabetes Care, ISSN: 19355548 01495992
Charles C. Wykoff; Rahul N. Khurana; Quan Dong Nguyen; Scott P. Kelly; Flora Lum; Rebecca Hall; Ibrahim Abbass; Anna M. Abolian; Ivaylo Stoilov; Tu My To; Vincent Garmo
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A Comprehensive Assessment of All-Oleate Polysorbate 80: Free Fatty Acid Particle Formation, Interfacial Protection and Oxidative Degradation
Pharmaceutical Research, ISSN: 1573904X 07248741
Nidhi Doshi; Jamie Giddings; Lin M. Luis; Arthur Wu; Kyle Ritchie; Wenqiang Liu; Wayman Chan; Rosalynn Taing; Jeff Chu; Alavattam Sreedhara; Aadithya Kannan; Pervina Kei; Ian C. Shieh; Tobias Graf; Mark Hu
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Machine-learning and chemicogenomics approach defines and predicts cross-talk of hippo and MAPK pathways
Cancer Discovery, ISSN: 21598290 21598274
Trang Pham; Thijs Hagenbeek; Ho-June Lee; Jason Li; Christopher M. Rose; Eva Lin; Mamie Yu; Scott E. Martin; Robert Piskol; Jennifer A. Lacap; Deepak Sampath; Victoria Pham; Zora Modrusan; Jennie R. Lill; Christiaan N. Klijn; Shiva Malek; Matthew T. Chang; Anwesha Dey
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2020 White Paper on Recent Issues in Bioanalysis: BAV Guidance, CLSI H62, Biotherapeutics Stability, Parallelism Testing, CyTOF and Regulatory Feedback (Part 2A - Recommendations on Biotherapeutics Stability, PK LBA Regulated Bioanalysis, Biomarkers Assays, Cytometry Validation & Innovation Part 2B - Regulatory Agencies' Inputs on Bioanalysis, Biomarkers, Immunogenicity, Gene & Cell Therapy and Vaccine)
Bioanalysis, ISSN: 17576199
Susan Spitz; Yan Zhang; Saloumeh Kadkhodayan Fischer; Kristina McGuire; Ulrike Sommer; Lakshmi Amaravadi; Abbas Bandukwala; Steven Eck; Fabio Garofolo; Rafiqul Islam; Gregor Jordan; Lindsay King; Yoshiro Saito; Giane Sumner; Linda Terry; Alessandra Vitaliti; Yow-Ming C. Wang; Grimaldi; Alison Joyce; Rachel Palmer; Matthew Andisik; Marcela Araya; Mitra Azadeh; Daniel Baltrukonis; Rebecca Elliott; Sam Haidar; Seema Kumar; Andrew Mayer; Florian Neff; Nisha Palackal; Kun Peng; Mohsen Rajabi Abhari; Christina Satterwhite; Natasha Savoie; Catherine Soo; Stephen Vinter; Jan Welink; Weili Yan; Kevin Maher; David Lanham; Sylvie Bertholet; Naveen Dakappagari; Christèle Gonneau; Cherie Green; Fabian Junker; Sumit Kar; Lisa Patti-Diaz; Shyam Sarikonda; Megan McCausland; Priscila Camillo Teixeira; Vilma Decman; Jose Estevam; Michael Hedrick; Alberto Hidalgo Robert; Gregory Hopkins; Sandra Nuti; Shabnam Tangri; Richard Wnek; Suman Dandamudi; Arindam Dasgupta; Anna Edmison; Patrick Faustino; Michael McGuinness; Gustavo Mendes Lima Santos; Tahseen Mirza; Diaa Shakleya; Susan Stojdl; Nilufer Tampal; Jinhui Zhang; Elana Cherry; Isabelle Cludts; Andrew Exley; Akiko Ishii-Watabe; Susan Kirshner; Joao Pedras-Vasconcelos; Meiyu Shen; Richard Siggers; Therese Solstad; Verthelyi; Haoheng Yan; Lucia Zhang
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Age-related changes in polycomb gene regulation disrupt lineage fidelity in intestinal stem cells
eLife, ISSN: 2050084X
Helen Tauc; Imilce A. Rodriguez-Fernandez; Jason A. Hackney; Michal Pawlak; Tal Ronnen Oron; Jerome Korzelius; Hagar F. Moussa; Subhra Chaudhuri; Zora Modrusan; Bruce A. Edgar; Heinrich Jasper
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Automated dissection protocol for tumor enrichment in low tumor content tissues
Journal of Visualized Experiments, ISSN: 1940087X
Charles Havnar; Oliver A. Zill; Jeffrey Eastham; Jeffrey Hung; Manana Javey; Emmanuel Naouri; Jennifer M. Giltnane; Justin M. Balko; Andrew Wallace; Nicolas Lounsbury; Daniel Oreper; Sarajane Saturnio; Yang; Amy Lo
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Durability of Response to Tocilizumab Therapy in Rheumatoid Arthritis: Data from the US-Based Corrona Rheumatoid Arthritis Registry
Rheumatology and Therapy, ISSN: 21986584 21986576
Dimitrios A. Pappas; Taylor Blachley; Jennie Best; Steve Zlotnick; William Reiss; Kelechi Emeanuru; Joel M. Kremer
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Computing the Hazard Ratios Associated With Explanatory Variables Using Machine Learning Models of Survival Data
JCO Clinical Cancer Informatics, ISSN: 24734276
Sameer Sundrani; James Lu
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Enrichment of circulating tumor-derived extracellular vesicles from human plasma
Journal of Immunological Methods, ISSN: 18727905 00221759
Kathryn E. Yoh; Christopher Lowe; Shilpi Mahajan; Rebecca Suttmann; Trung Nguy; Mike Reichelt; Jenny Yang; Rachel Melendez; Yijin Li; Luciana L. Molinero; Jane Ruppel; Wenfeng Xu; Vicki Plaks
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Treatment Patterns, Disease Burden, and Outcomes in Patients with Giant Cell Arteritis and Polymyalgia Rheumatica: A Real-World, Electronic Health Record-Based Study of Patients in Clinical Practice
Rheumatology and Therapy, ISSN: 21986584 21986576
Gary Craig; Keith Knapp; Bob Salim; Shalini V. Mohan; Margaret Michalska
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Multimodal pooled Perturb-CITE-seq screens in patient models define mechanisms of cancer immune evasion
Nature Genetics, ISSN: 15461718 10614036
Chris J. Frangieh; Johannes C. Melms; Pratiksha I. Thakore; Kathryn R. Geiger-Schuller; Patricia Ho; Adrienne M. Luoma; Brian Cleary; Livnat Jerby-Arnon; Shruti Malu; Michael S. Cuoco; Maryann Zhao; Casey R. Ager; Meri Rogava; Lila Hovey; Asaf Rotem; Chantale Bernatchez; Kai Wucherpfennig; Bruce E. Johnson; Orit Rozenblatt-Rosen; Dirk Schadendorf; Aviv Regev; Benjamin Izar
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Parameterization of Microsomal and Cytosolic Scaling Factors: Methodological and Biological Considerations for Scalar Derivation and Validation
European Journal of Drug Metabolism and Pharmacokinetics, ISSN: 21070180 03787966
Michael J. Doerksen; Robert S. Jones; Michael W. H. Coughtrie; Abby C. Collier
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Comment on “Use of biomaterials for sustained delivery of anti-VEGF to treat retinal diseases”
Eye, ISSN: 14765454 0950222X
Peter A. Campochiaro; Giulio Barteselli
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Head-to-head comparison of DFO* and DFO chelators: selection of the best candidate for clinical 89Zr-immuno-PET
European Journal of Nuclear Medicine and Molecular Imaging, ISSN: 16197089 16197070
Marion Chomet; Maxime Schreurs; Maria J. Bolijn; Mariska Verlaan; Wissam Beaino; Kari Brown; Alex J. Poot; Albert D. Windhorst; Herman S. Gill; Jan Marik; Simon P. Williams; Joseph Cowell; Gilles Gasser; Thomas L. Mindt; Guus van Dongen; Daniëlle Vugts
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Ultra-Response to Ranibizumab: Improvement by 4 or More Steps in Diabetic Retinopathy Severity in Diabetic Retinopathy Clinical Research Network Protocol S
Ophthalmology Retina, ISSN: 24686530
Allen Chiang; Sunir Garg; Michael A. Klufas; Allen C. Ho; Lauren Hill; Min Tsuboi; Ivaylo Stoilov
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Genetic inactivation of RIP1 kinase does not ameliorate disease in a mouse model of ALS
Cell Death and Differentiation, ISSN: 14765403 13509047
Sara L. Dominguez; Eugene Varfolomeev; Robert Brendza; Kimberly L. Stark; Joy S. Tea; Jose Imperio; Hai Ngu; Timothy K. Earr; Oded Foreman; Webster; Amy Easton; Domagoj Vucic; Baris Bingol
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Impaired RIPK1 ubiquitination sensitizes mice to TNF toxicity and inflammatory cell death
Cell Death and Differentiation, ISSN: 14765403 13509047
Matthias Kist; László Kömüves; Tatiana Goncharov; Dugger; Charles Yu; Merone Roose-Girma; Kim Newton; Webster; Domagoj Vucic
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Theoretical and Experimental Evaluation of Flow Pattern of Pharmaceutical Powder Blends Discharged From Intermediate Bulk Containers (IBCs)
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Ewa Nauka; Reto Maurer; Amilcar A. Gonzalez; Wei Zhang; Ajit S. Narang; Chen Mao
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Classification and Grading of Melanocytic Lesions in a Mouse Model of NRAS-driven Melanomagenesis
Journal of Histochemistry and Cytochemistry, ISSN: 15515044 00221554
Charles-Antoine Assenmacher; Sara F. Santagostino; Mark A. Oyama; Jean-Christophe Marine; Elise Bonvin; Enrico Radaelli
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Extended Characterization and Impact of Visible Fatty Acid Particles - A Case Study With a mAb Product
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Miguel Saggu; Barthélemy Demeule; Linda Jiang; Daniel Kammerer; Purnendu K. Nayak; Michelle Tai; Nina Xiao; Anthony Tomlinson
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Activation of NF-κB and p300/CBP potentiates cancer chemoimmunotherapy through induction of MHC-I antigen presentation
Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424
Yixuan Zhou; Ingmar Niels Bastian; Mark D. Long; Michelle Dow; Weihua Li; Tao Liu; Rachael Katie Ngu; Laura Antonucci; Jian Yu Huang; Qui Phung; Xi-He Zhao; Sourav Banerjee; Xue-Jia Lin; Hongxia Wang; Brian Dang; Sylvia Choi; Daniel Karin; Hua Su; Mark H. Ellisman; Christina Jamieson; Marcus Bosenberg; Zhang Cheng; Johannes Haybaeck; Lukas Kenner; Kathleen M. Fisch; Richard Bourgon; Genevive Hernandez; Jennie R. Lill; Song Liu; Hannah Carter; Ira Mellman; Michael Karin; Shabnam Shalapour
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Combined kinesin-1 and kinesin-3 activity drives axonal trafficking of TrkB receptors in Rab6 carriers
Developmental Cell, ISSN: 18781551 15345807
Eitan Erez Zahavi; Jessica J.A. Hummel; Yuhao Han; Citlali Bar; Riccardo Stucchi; Maarten Altelaar; Casper C Hoogenraad
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Tracking internal and external ions for constrained peptides leads to enhanced sequence coverage and disulfide bond deciphering
Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085
Steven Chin; Tao Chen; Rami N. Hannoush; Christopher M. Crittenden
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Updated Overall Survival and PD-L1 Subgroup Analysis of Patients With Extensive-Stage Small-Cell Lung Cancer Treated With Atezolizumab, Carboplatin, and Etoposide (IMpower133)
Journal of Clinical Oncology, ISSN: 15277755
Stephen V. Liu; Martin Reck; Mansfield; Tony Mok; Arnaud Scherpereel; Niels Reinmuth; Marina C. Garassino; Javier De Castro Carpeno; Califano; Makoto Nishio; Orlandi; Jorge Alatorre-Alexander; Leal; Ying Cheng; Jong-Seok Lee; Lam; Mark L. McCleland; Deng; See Phan; Leora Horn
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Tissue regeneration: Reserve or reverse?
Science, ISSN: 10959203 00368075
Ramesh A. Shivdasani; Hans Clevers; Frederic J. De Sauvage
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Loss on Drying Using Halogen Moisture Analyzer: An Orthogonal Technique for Monitoring Volatile Content for In-Process Control Samples during Pharmaceutical Manufacturing
Organic Process Research and Development, ISSN: 1520586X 10836160
Sayyeda Zeenat A. Razvi; Isabelle Kamm; Nguyen; Jackson D. Pellett; Archana Kumar
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Loss on Drying Using Halogen Moisture Analyzer: An Orthogonal Technique for Monitoring Volatile Content for In-Process Control Samples during Pharmaceutical Manufacturing
Organic Process Research and Development, ISSN: 1520586X 10836160
Sayyeda Zeenat A. Razvi; Isabelle Kamm; Tina Nguyen; Jackson D. Pellett; Archana Kumar
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Transcriptional Subtypes Resolve Tumor Heterogeneity and Identify Vulnerabilities to MEK Inhibition in Lung Adenocarcinoma
Clinical Cancer Research, ISSN: 15573265 10780432
Anneleen Daemen; Jonathan Cooper; Szymon Myrta; Matthew Wongchenko; Eva Lin; Jason E. Long; Oded Foreman; Zora Modrusan; Jarrod Tremayne; Cecile C. de la Cruz; Mark Merchant; Scott E. Martin; Yibing Yan; Melissa Junttila
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Atezolizumab for PD-L1-Selected Patients with NSCLC. Reply
New England Journal of Medicine, ISSN: 15334406
Roy S. Herbst; Hiroshi Kuriki; David Spigel
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Exploring Human Skin Aging at the Single-Cell Level
Developmental Cell, ISSN: 18781551 15345807
Mary Mohrin; Heinrich Jasper
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Multi-dimensional LC-MS: The next generation characterization of antibody-based therapeutics by unified online bottom-up, middle-up and intact approaches
Analyst, ISSN: 13645528 00032654
Julien Camperi; Alexandre Goyon; Davy Guillarme; Kelly Zhang; Cinzia Stella
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Simultaneous quantitation of water and residual solvents in pharmaceuticals by rapid headspace gas chromatography with thermal conductivity detection (GC-TCD)
Journal of Pharmaceutical and Biomedical Analysis, ISSN: 1873264X 07317085
Jacob Kay; Rekha Thomas; Jason Gruenhagen; Venkatramani
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A phase 2 study of venetoclax plus R-CHOP as first-line treatment for patients with diffuse large B-cell lymphoma
Blood, ISSN: 15280020 00064971
Morschhauser; Pierre Feugier; Ian W. Flinn; Robin Gasiorowski; Greil; Illés; Nathalie A. Johnson; Jean-François Larouche; Pieternella J. Lugtenburg; Caterina Patti; Gilles Salles; Marek Trneny; Sven De Vos; Farheen Mir; Divya Samineni; Su Young Kim; Yanwen Jiang; Elizabeth A. Punnoose; Arijit Sinha; Emma Clark; Nathalie Spielewoy; Kathryn Humphrey; Alexandra Bazeos; Zelenetz
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Personalized Cancer Vaccines: Clinical Landscape, Challenges, and Opportunities
Molecular Therapy, ISSN: 15250024 15250016
Colby S. Shemesh; Joy C. Hsu; Iraj Hosseini; Shen; Rotte; Patrick S. Twomey; Sandhya Girish; Benjamin Wu
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OCRE Domains of Splicing Factors RBM5 and RBM10: Tyrosine Ring-Flip Frequencies Determined by Integrated Use of 1H NMR Spectroscopy and Molecular Dynamics Simulations
ChemBioChem, ISSN: 14397633 14394227
Bryan T. Martin; Robert D. Malmstrom; Rommie E. Amaro; Kurt Wüthrich
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Effect of Hepatic Impairment on Cobimetinib Pharmacokinetics: The Complex Interplay Between Physiological Changes and Drug Characteristics
Clinical Pharmacology in Drug Development, ISSN: 21607648 2160763X
Sravanthi Cheeti; Yuzhong Deng; Ilsung Chang; Isabela Georgescu; Ian E. Templeton; Nicholas Choong; Kit Wun Kathy Cheung; Sandhya Girish; Luna Musib
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A phase Ib open-label dose escalation study of the safety, pharmacokinetics, and pharmacodynamics of cobimetinib (GDC-0973) and ipatasertib (GDC-0068) in patients with locally advanced or metastatic solid tumors
Investigational New Drugs, ISSN: 15730646 01676997
Geoffrey I. Shapiro; Patricia M. LoRusso; Daniel Cho; Luna Musib; Yibing Yan; Matthew Wongchenko; Ilsung Chang; Premal Patel; Iris Chan; Sandra M. Sanabria-Bohorquez; Raymond D. Meng; Bendell
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Integrated Mechanistic Model of Minimal Residual Disease Kinetics With Venetoclax Therapy in Chronic Lymphocytic Leukemia
Clinical Pharmacology and Therapeutics, ISSN: 15326535 00099236
Sathej Gopalakrishnan; William G. Wierda; Brenda Chyla; Rajeev M. Menon; Dale Miles; Rod A. Humerickhouse; Walid Awni; Ahmed Hamed Salem; Sven Mensing; Kevin J. Freise
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The Added Burden of Allergen Sensitization Among Children with Severe or Poorly Controlled Asthma
Journal of Allergy and Clinical Immunology: In Practice, ISSN: 22132198
W. Gerald Teague; Ahmar Iqbal; Yao Ding; Bradley E. Chipps; James L. Zazzali
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Dissolution of Polysorbate 20 Degradation Related Free Fatty Acid Particles in Intravenous Bag Solutions
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Nidhi Doshi; Karen Rutherford; Asil Najjar
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Strategies for Setting Patient-Centric Commercial Specifications for Biotherapeutic Products
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Margaret Ruesch; Luca Benetti; Eileen Berkay; David J. Cirelli; Neha Frantz; Martin H. Gastens; Wayne P. Kelley; Juliana Kretsinger; Mike Lewis; Shawn Novick; Barbara Rellahan; Laura Pack; Corné J.M. Stroop; Ann Subashi; Ping Yin; Ming Zeng; Stults
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An Industry Perspective on Compatibility Assessment of Closed System Drug-Transfer Devices for Biologics
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Ahmed Besheer; Lori Burton; Richard J. Galas; Kedar Gokhale; Pierre Goldbach; Qingyan Hu; Ligi Mathews; Kevin Muthurania; Chakravarthy Narasimhan; Shubhadra N. Singh; Elaine S.E. Stokes; Sarah Weiser; Camellia Zamiri; Shuxia Zhou
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Adolescent boys with constitutional delay of growth and puberty grow faster than patients with organic growth hormone deficiency
Clinical Endocrinology, ISSN: 13652265 03000664
Gerhard Binder; Theresa J. Lehrian; Elisa Hoffmann; Gunnar Blumenstock; Abdelkader Rahmaoui; Benjamin L. Trzaskoma; Thomas Reinehr
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