Scientists / Publications

Publications

Genentech scientists are encouraged to be creative and active members of the scientific community. We are proud of our publication record in Science, Nature, Cell, and other prestigious peer-reviewed journals, where our annual output consistently rivals or surpasses that of the top academic institutions.

DISPLAYING 5401 - 5450 OF 16688 RESULTS

January 1, 2018

Elevated levels of BRAFV600 mutant circulating tumor DNA and circulating hepatocyte growth factor are associated with poor prognosis in patients with metastatic melanoma

JCO Precision Oncology, ISSN: 24734284

William Lu; Luciana Burton; James Larkin; Paul B. Chapman; Paolo A. Ascierto; Antoni Ribas; Caroline Robert; Jeffrey A. Sosman; McArthur; Ilsung Chang; Ivor Caro; Elicia M. Penuel; Yibing Yan; Matthew Wongchenko

January 1, 2018

Effects of molecular heterogeneity on survival of patients with BRAFV600-mutated melanoma treated with vemurafenib with or without cobimetinib in the coBRIM study

JCO Precision Oncology, ISSN: 24734284

Matthew Wongchenko; Antoni Ribas; Paolo A. Ascierto; Brigitte Dréno; Anna Maria Di Giacomo; Claus Garbe; Ilsung Chang; Jessie Hsu; Isabelle Rooney; William Lu; Koeppen; James Larkin; Yibing Yan; McArthur

January 1, 2018

ALK testing trends and patterns among community practices in the United States

JCO Precision Oncology, ISSN: 24734284

Peter B. Illei; Wong; Ning Wu; Laura Chu; Ravindra Gupta; Katja Schulze; Gubens

January 1, 2018

Accelerated predictive stability (APS) applications: Packaging strategies for controlling dissolution performance

Accelerated Predictive Stability (APS): Fundamentals and Pharmaceutical Industry Practices,

Jackson D. Pellett; Sudharsan Dwaraknath; Ewa Nauka; Gena Dalziel

January 1, 2018

Line sterilization considerations and VHP

AAPS Advances in the Pharmaceutical Sciences Series, ISSN: 2210738X 22107371

Ulla Grauschopf; Katherine Thomas; Joerg Luemkemann; Sebastian Schneider; Ada Hui; John Wang; Kirk Eppler

January 1, 2018

Effect of binder attributes on granule growth and densification

Handbook of Pharmaceutical Wet Granulation: Theory and Practice in a Quality by Design Paradigm,

Ajit S. Narang; Li Tao; Junshu Zhao; Rekha Keluskar; Shruti Gour; Tim Stevens; Kevin Macias; Brenda Remy; Preetanshu Pandey; Richard D. LaRoche; Anna Sosnowska; Stephen Cole; Atul Dubey; Rohit Ramachandran; Jinjiang Li; Dilbir Bindra

January 1, 2018

Integrated application of quality-by-design principles to drug product and its control strategy development

Handbook of Pharmaceutical Wet Granulation: Theory and Practice in a Quality by Design Paradigm,

Sherif I.F. Badawy; Ajit S. Narang; Keirnan R. LaMarche; Ganeshkumar Subramanian; Sailesh A. Varia; Judy Lin; Tim Stevens; Pankaj A. Shah

January 1, 2018

Handbook of pharmaceutical wet granulation: Theory and practice in a quality by design paradigm

Handbook of Pharmaceutical Wet Granulation: Theory and Practice in a Quality by Design Paradigm,

Ajit S. Narang; Sherif I.F. Badawy

January 1, 2018

Real-time assessment of granule densification and application to scale-up

Handbook of Pharmaceutical Wet Granulation: Theory and Practice in a Quality by Design Paradigm,

Ajit S. Narang; Valery Sheverev; Vadim Stepaniuk; Sherif I.F. Badawy; Tim Stevens; Kevin Macias; Abraham E. Wolf; Preetanshu Pandey; Dilbir Bindra; Sailesh A. Varia

January 1, 2018

Preface

Handbook of Pharmaceutical Wet Granulation: Theory and Practice in a Quality by Design Paradigm,

Ajit S. Narang; Sherif I.F. Badawy

January 1, 2018

Inline focused beam reflectance measurement during wet granulation

Handbook of Pharmaceutical Wet Granulation: Theory and Practice in a Quality by Design Paradigm,

Ajit S. Narang; Tim Stevens; Srinivasa Paruchuri; Kevin Macias; Zhihui Gao; Sherif I.F. Badawy; Dilbir Bindra; Mario Hubert

January 1, 2018

Wet mass consistency reported by in-line drag force flow sensor compared with powder rheology and shaft amperage

Handbook of Pharmaceutical Wet Granulation: Theory and Practice in a Quality by Design Paradigm,

Ajit S. Narang; Valery Sheverev; Vadim Stepaniuk; Sherif I.F. Badawy; Dilbir Bindra; Ganeshkumar Subramanian; Tim Freeman; Douglas Both; Kevin Macias; Michael Delancy; Doug Millington-Smith

January 1, 2018

Emerging paradigms in pharmaceutical wet granulation

Handbook of Pharmaceutical Wet Granulation: Theory and Practice in a Quality by Design Paradigm,

Ajit S. Narang; Sherif I.F. Badawy

January 1, 2018

Principles of drag force flow sensor

Handbook of Pharmaceutical Wet Granulation: Theory and Practice in a Quality by Design Paradigm,

Valery Sheverev; Vadim Stepaniuk; Ajit S. Narang

January 1, 2018

Mechanistic basis for the effects of process parameters on quality attributes in high shear wet granulation

Handbook of Pharmaceutical Wet Granulation: Theory and Practice in a Quality by Design Paradigm,

Sherif I.F. Badawy; Ajit S. Narang; Keirnan R. LaMarche; Ganeshkumar Subramanian; Sailesh A. Varia

January 1, 2018

Hormone-Targeted Therapy and Resistance

Annual Review of Cancer Biology, ISSN: 24723428

Ciara Metcalfe; Lori S. Friedman; Jeffrey H. Hager

January 1, 2018

No evidence of disease activity (NEDA) analysis by epochs in patients with relapsing multiple sclerosis treated with ocrelizumab vs interferon beta-1a

Multiple Sclerosis Journal - Experimental, Translational and Clinical, ISSN: 20552173

Eva Havrdová; Douglas L. Arnold; Amit Bar-Or; Comi; Hartung; Ludwig Kappos; Lublin; Selmaj; Traboulsee; Belachew; Iain Bennett; Regine Buffels; Hideki Garren; Jian Han; Laura Julian; Julie Napieralski; Stephen L. Hauser; Giovannoni

January 1, 2018

Histology of geographic atrophy secondary to age-related macular degeneration a multilayer approach

Retina, ISSN: 15392864 0275004X

Miaoling Li; Carrie Huisingh; Jeffrey D. Messinger; Rosa Dolz-Marco; Daniela Ferrara; K. Bailey Freund; Christine A. Curcio

January 1, 2018

CXCR3/CXCL10 axis shapes tissue distribution of memory phenotype CD8+ T Cells in nonimmunized mice

Journal of Immunology, ISSN: 15506606 00221767

Cécile Alanio; Rosa Barreira da Silva; David Michonneau; Philippe Bousso; Molly A. Ingersoll; Matthew L. Albert

January 1, 2018

Sample Size, Power, and Data Simulation

Genetic Analysis of Complex Diseases: Third Edition,

Sarah A. Pendergrass; Marylyn Ritchie

January 1, 2018

Estimating velocity in Gasoline Direct Injection sprays using statistical pattern imaging velocimetry

International Journal of Spray and Combustion Dynamics, ISSN: 17568285 17568277

Yudaya R. Sivathanu; Jongmook Lim; Ariel R. Muliadi; Oana Nitulescu; Tom Shieh

January 1, 2018

No evidence of disease activity (NEDA) analysis by epochs in patients with relapsing multiple sclerosis treated with ocrelizumab vs interferon beta-1a

Multiple Sclerosis Journal - Experimental, Translational and Clinical,

Eva Havrdová; Douglas L. Arnold; Amit Bar-Or; Comi; Hartung; Ludwig Kappos; Lublin; Selmaj; Traboulsee; Belachew; Iain Bennett; Regine Buffels; Hideki Garren; Jian Han; Laura Julian; Julie Napieralski; Stephen L. Hauser; Giovannoni

January 1, 2018

Using lc retention times in organic structure determination: Drug metabolite identification

Drug Metabolism Letters, ISSN: 18723128

William L. Fitch; Cyrus Khojasteh; Ignacio Aliagas; Kevin M. Johnson

January 1, 2018

Application of CRISPR for Pooled, Vector-based Functional Genomic Screening in Mammalian Cell Lines

Genome Editing and Engineering: From TALENs, ZFNs and CRISPRs to Molecular Surgery,

Trinna L. Cuellar; Marinella G. Callow; Ted Lau; Colin Watanabe; Russell Bainer; Michael Costa; Benjamin Haley

January 1, 2018

Cytokines: Role in Homeostasis and Disease States

Comprehensive Toxicology, Third Edition: Volume 1-15,

Prell; Jacqueline M. Tarrant

January 1, 2018

Oncologists' perceptions of drug affordability using NCCN Evidence Blocks: Results from a national survey

Journal of Managed Care and Specialty Pharmacy, ISSN: 23761032 23760540

Bijal Shah-Manek; Wong; Arliene Ravelo; Marco D. Dibonaventura

January 1, 2018

The relationship between guideline-recommended initiation of therapy, outcomes, and cost for patients with metastatic non-small cell lung cancer

Journal of Managed Care and Specialty Pharmacy, ISSN: 23761032 23760540

Adrianne Casebeer; Dana Drzayich Antol; Richard W. DeClue; Sari Hopson; Yong Li; Raya Khoury; Todd Michael; Marina Sehman; Aparna R. Parikh; Stephen Stemkowski; Mikele M. Bunce

January 1, 2018

Hepatic microphysiological systems: Current and future applications in drug discovery and development

Microfluidic Cell Culture Systems,

Ajit Dash; William R. Proctor

January 1, 2018

Understanding heterogeneity in the host response to Staphylococcus aureus infection for prognostic biomarker discovery

Critical Care, ISSN: 1466609X 13648535

Dinoso; Johnny Gutierrez; David F. Choy; Sarah K. Kummerfeld; Amos Baruch; Chambers; Carrie M. Rosenberger

January 1, 2018

Predictive Biomarkers and Targeted Therapies in Immuno-oncology

Predictive Biomarkers in Oncology: Applications in Precision Medicine,

Koeppen; Mark L. McCleland; Marcin Kowanetz

January 1, 2018

Immune Signaling in Carcinogenesis

Predictive Biomarkers in Oncology: Applications in Precision Medicine,

Mahesh Yadav; Marcin Kowanetz; Koeppen

January 1, 2018

Inflammation and Hepatotoxicity

Comprehensive Toxicology, Third Edition: Volume 1-15,

James P. Luyendyk; Ganey; Aaron Fullerton; Robert Roth

December 28, 2017

A Unique Approach to Design Potent and Selective Cyclic Adenosine Monophosphate Response Element Binding Protein, Binding Protein (CBP) Inhibitors

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Sarah M. Bronner; Jeremy Murray; F. Anthony Romero; Kwong Wah Lai; Vickie Tsui; Patrick Cyr; Beresini; Gladys De Leon Boenig; Zhongguo Chen; Edna F. Choo; Clark; Terry Crawford; Hariharan Jayaram; Susan Kaufman; Ruina Li; Yingjie Li; Jiangpeng Liao; Xiaorong Liang; Wenfeng Liu; Justin Ly; Jonathan M. Maher; John Wai; Fei Wang; Aijun Zheng; Xiaoyu Zhu; Steven Magnuson

December 28, 2017

Discovery of Small-Molecule Inhibitors of Ubiquitin Specific Protease 7 (USP7) Using Integrated NMR and in Silico Techniques

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Paola Di Lello; Richard Pastor; Jeremy Murray; Robert A. Blake; Frederick Cohen; Terry Crawford; Joy Drobnick; Jason H. Drummond; Kategaya; Tracy L. Kleinheinz; Till Maurer; Lionel Rouge; Xianrui Zhao; Ingrid E. Wertz; Chudi O. Ndubaku; Vickie Tsui

December 21, 2017

Tumour lymph vessels boost immunotherapy

Nature, ISSN: 14764687 00280836

Christine Moussion; Shannon J. Turley

December 19, 2017

Kras mutant genetically engineered mouse models of human cancers are genomically heterogeneous

Proceedings of the National Academy of Sciences of the United States of America, ISSN: 10916490 00278424

Wei-Jen Chung; Anneleen Daemen; Jason H. Cheng; Jason E. Long; Jonathan Cooper; Bu-Er Wang; Christopher Tran; Mallika Singh; Florian Gnad; Zora Modrusan; Oded Foreman; Melissa Junttila; Anton Berns

December 19, 2017

Structural and Functional Characterization of a Hole-Hole Homodimer Variant in a "knob-Into-Hole" Bispecific Antibody

Analytical Chemistry, ISSN: 15206882 00032700

Hui-Min Zhang; Charlene Li; Ming Lei; Victor Lundin; Ho Young Lee; Milady Ninonuevo; Kevin Lin; Guanghui Han; Wendy N. Sandoval; Dongsheng Lei; Gang Ren; Jennifer Zhang; Hongbin Liu

December 14, 2017

Pyrrolobenzodiazepine Dimer Antibody-Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers

Journal of Medicinal Chemistry, ISSN: 15204804 00222623

Stephen J. Gregson; Luke Masterson; Binqing Wei; Thomas H. Pillow; Spencer; Gyoung-Dong Kang; Shang-Fan Yu; Helga Raab; Jeffrey Lau; Guangmin Li; Gail L. Phillips; Janet Gunzner; Brian S. Safina; Rachana Ohri; Martine Darwish; Katherine R. Kozak; Josefa Dela Cruz Chuh; Andrew G. Polson; Flygare; Philip W. Howard

December 8, 2017

TRP’ing up chronic kidney disease

Science, ISSN: 10959203 00368075

Jun-Jae Chung; Andrey S. Shaw

December 7, 2017

mTORC1 Activation during Repeated Regeneration Impairs Somatic Stem Cell Maintenance

Cell Stem Cell, ISSN: 18759777 19345909

Samantha Haller; Subir Kapuria; Rebeccah Riley; Monique N. O'Leary; Katherine H. Schreiber; Julie K. Andersen; Simon Melov; Jianwen Que; Thomas A. Rando; Jason Rock; Brian K. Kennedy; Joseph T. Rodgers; Heinrich Jasper

December 4, 2017

T Lymphocytes Expressing AlphaE Beta7 Integrin in Ulcerative Colitis: Associations With Cellular Lineage and Phenotype

Journal of Crohn's and Colitis, ISSN: 18764479

Christopher A. Lamb; John A. Kirby; Mary E. Keir; John C. Mansfield

December 1, 2017

Statistical characterization of therapeutic protein modifications

Scientific Reports, ISSN: 20452322

Tsung-Heng Tsai; Zhiqi Hao; Qiuting Hong; Benjamin Moore; Cinzia Stella; Jeffrey H. Zhang; Yan Chen; Michael Kim; Theo Koulis; Gregory Ryslik; Erik Verschueren; Fred Jacobson; William E. Haskins; Olga Vitek

December 1, 2017

Erratum to: Clinical responses to ERK inhibition in BRAF V600E-mutant colorectal cancer predicted using a computational model (npj Systems Biology and Applications, (2017), 3, 1, (14), 10.1038/s41540-017-0016-1)

npj Systems Biology and Applications, ISSN: 20567189

Kirouac; Gabriele Schaefer; Jocelyn Chan; Mark Merchant; Christine Orr; Shih-Min A. Huang; John Moffat; Lichuan Liu; Kapil Gadkar; Ramanujan

December 1, 2017

Clinical responses to ERK inhibition in BRAF V600E-mutant colorectal cancer predicted using a computational model

npj Systems Biology and Applications, ISSN: 20567189

Kirouac; Gabriele Schaefer; Jocelyn Chan; Mark Merchant; Christine Orr; Shih-Min A. Huang; John Moffat; Lichuan Liu; Kapil Gadkar; Ramanujan

December 1, 2017

TGF-β signalling attenuates tumour response to PD-L1 checkpoint blockade by contributing to retention of T cells in the peritumoural stroma

Annals of Oncology, ISSN: 15698041 09237534

Sanjeev Mariathasan; Shannon J. Turley; Dorothee Nickles; Alessandra Castiglioni; Yuen; Wang; Edward E; Koeppen; Jillian L. Astarita; Rafael Cubas; Suchit Jhunjhunwala; Yang; Yasin Senbabaoglu; Michiel S Van Der Heijden; Yohann Loriot; Ira Mellman; Daniel S. Chen; Priti Hegde; Richard Bourgon; Thomas Powles

December 1, 2017

Primary PFS and safety analyses of a randomized phase III study of carboplatin + paclitaxel +/− bevacizumab, with or without atezolizumab in 1L non-squamous metastatic nsclc (IMPOWER150)

Annals of Oncology, ISSN: 15698041 09237534

Martin Reck; Mark A. Socinski; Federico Cappuzzo; Orlandi; Stroyakovskii; Nogami; Rodriguez-Abreu; Moro-Sibilot; Thomas; Fabrice Barlesi; Finley; Kelsch; Lee; Coleman; Shen; Marcin Kowanetz; Ariel Lopez-Chavez; Alan Sandler; Jotte

December 1, 2017

TGF-β signalling attenuates tumour response to PD-L1 checkpoint blockade by contributing to retention of T cells in the peritumoural stroma

Annals of Oncology, ISSN: 15698041 09237534

Sanjeev Mariathasan; Shannon J. Turley; Dorothee Nickles; Alessandra Castiglioni; Kobe Yuen; Wang; Edward E; Koeppen; Jillian L. Astarita; Rafael Cubas; Suchit Jhunjhunwala; Yagai Yang; Yasin Senbabaoglu; Michiel S Van Der Heijden; Yohann Loriot; Ira Mellman; Daniel S. Chen; Priti Hegde; Richard Bourgon; Thomas Powles

December 1, 2017

Primary PFS and safety analyses of a randomized phase III study of carboplatin + paclitaxel +/− bevacizumab, with or without atezolizumab in 1L non-squamous metastatic nsclc (IMPOWER150)

Annals of Oncology, ISSN: 15698041 09237534

Martin Reck; Mark A. Socinski; Federico Cappuzzo; Orlandi; Stroyakovskii; Nogami; Rodriguez-Abreu; Moro-Sibilot; Thomas; Fabrice Barlesi; Finley; Kelsch; Lee; Coleman; Shen; Marcin Kowanetz; Ariel Lopez-Chavez; Alan Sandler; Jotte

December 1, 2017

Discrepancies between patient-reported outcomes, and endoscopic and histological appearance in UC

Gut, ISSN: 14683288 00175749

Jean-Frédéric Colombel; Mary E. Keir; Alexis Scherl; Rui Zhao; Gert De Hertogh; William A. Faubion Jr.; Timothy T. Lu

December 1, 2017

Real-world Direct Health Care Costs for Metastatic Colorectal Cancer Patients Treated With Cetuximab or Bevacizumab-containing Regimens in First-line or First-line Through Second-line Therapy

Clinical Colorectal Cancer, ISSN: 19380674 15330028

Stephen S. Johnston; Kathleen Wilson; Helen Varker; Elisabetta Malangone-Monaco; Paul Juneau; Ellen Riehle; Sacha Satram-Hoang; Nicolas Sommer; Sarika Ogale

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