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Publications

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DISPLAYING 51 - 100 OF 15946 RESULTS

Efficient Single and Dual Iridium-Catalyzed Stereoselective Hydrogenations to Access trans-Butane-1,2,4-triols
Journal of the American Chemical Society,
Kurt A. Püntener; Anna Lena Glass; Leonardo Tensi; Bin Chen; Katarzyna A. Piechowicz; Martin Binder; Steven Chin; Allen Y. Hong; Alceo MacChioni; Stefan Hildbrand
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Industry Perspective on Nonclinical Approaches for Hepatotoxicity Risk Assessment: Insights from Two Longitudinal Surveys Conducted in 2023 and 2017
Chemical Research in Toxicology, ISSN: 15205010 0893228X
Melanie Zea Sakatis; Leah M. Norona; Jamie Karmel; William R. Proctor; Fatou H. Sarr; Payal Rana; Doris T. Zane; Jessica M. Caverly Rae; Samantha C. Faber; Ravindra C. Kodihalli; Arie Regev; Debra Luffer-Atlas; Onyi N. Irrechukwu; David H. Alpers; Jonathan P. Jackson; Armando R. Irizarry-Rovira; Dominic P. Williams
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KDM6 Demethylases Contribute to EWSR1::FLI1-Driven Oncogenic Reprogramming in Ewing Sarcoma
Cancer Research, ISSN: 15387445
Elisabet Figuerola-Bou; Carla Ríos-Astorch; Enrique Martín Blanco; María Sánchez-Jiménez; Pablo Táboas; Guerau Fernández; Soledad Gomez-Gonzalez; Oscar Muñoz; Pol Castellano-Escuder; Sara Perez-Jaume; Marta Garcia; Estela Prada; Silvia Mateo-Lozano; Nicolò Riggi; Alexandra Avgustinova; Cinzia Emilia Lavarino; Luciano Di Croce; Sara Sánchez-Molina; Jaume Català Mora
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Discovery of Clinical Candidate GDC-8264, a Novel, Potent and Selective RIP1 Inhibitor for Amelioration of Tissue Damage and the Treatment of Inflammatory Diseases
Journal of Medicinal Chemistry, ISSN: 00222623
Snahel D. Patel; Huifen Chen; Eugene E. Varfolomeev; Youngsu Kwon; Sreemathy Ramaswamy; Pawan Bir Kohli; John G. Quinn; Joshua D. Webster; Jialin Mao; Yuan Chen; Rina Fong; F. Esra Demircioglu; Patrick J. Lupardus; Craig E. Stivala; Gregory L. Hamilton; Michael Siu; Swathi Sujatha-Bhaskar; Vishnu Mohanan; Adeyemi O. Adedeji; Sara Francesca Santagostino; Jonathan M. Maher; Brent S. McKenzie; Michael Evan Rothenberg; Adam R. Johnson; Domagoj Vucic
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Flow-through polishing of Protein A eluates: Removal of high and low molecular weight impurities by size-exclusion-mixed-mode chromatography
Journal of Chromatography A, ISSN: 00219673
Jacob P. LeBarre; Wenning Chu; Ka Zhang; Dipendra Bhandari; Cristiana Boi; Ruben Guillermo Carbonell; Xuanwen Li; Divya Chandra; Ronald W. Maurer; Xuankuo Xu; Jerome R. Bill; David J. Roush; Michael W. Phillips; Stefano Menegatti
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Protein Abundance of Clinically Relevant Drug-Metabolizing Hydrolases in Human Liver and Intestine by Targeted versus Global Proteomics Approaches: A Comparative Study
Journal of Proteome Research, ISSN: 15353893
Dilip Kumar Singh; Deepak Suresh Ahire; Robert S. Jones; Ryota Kikuchi; Bin Ma; Yu Tian; Ting Wang; Faizan Zubair; Scott A. Heyward; S. Cyrus Khojasteh; Bernard P. Murray; Bill J. Smith; David M. Stresser; Mitchell E. Taub; Michael A. Zientek; Bhagwat Prasad
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Hydrogen-Mediated Reductive Cross-Coupling of Aryl Iodides with Activated Aryl and Heteroaryl Bromides
Journal of the American Chemical Society, ISSN: 00027863
Weijia Shen; Yuhsiang Chang; Brandon I. Gonzalez; Aidan P. Looby; Jordan J. Dotson; Nicholas A. White; Brad P. Carrow; Michael J. Krísche
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Bacterial Dysbiosis Observed in the Terminal Ileum of Ulcerative Colitis
Inflammatory Bowel Diseases, ISSN: 10780998
Jordan S. Mar; Allen Nguyen; Alexis Scherl; May Wittke; Mary Doona; Christopher A. Lamb; Mary E. Keir
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Treatment Patterns and Clinical Outcomes of Patients With Systemic Light Chain Amyloidosis in the United States: Evidence From Real-World Clinical Practice
Clinical Lymphoma, Myeloma and Leukemia, ISSN: 21522669 21522650
Sophia S. Li; Anita D'Souza; Suzanne Lentzsch; Faiza Zafar; Irina Pivneva; Talissa Watson; Annie Guérin; Shaji K. Kumar
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Interpreting immunogenicity in oncology clinical trials
Cancer Treatment Reviews, ISSN: 03057372
Peter Robert Galle; Martin Reck; David James Pinato; Rosario G. Garciá-Campelo; Richard S. Finn; Sophie Cousin; James A. Zanghi; Coen A. Bernaards; Steven J. Swanson; Stefanie Morris; Yuan Song; Solange Peters
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Compound muscle action potential as an early functional in vivo measure of Sarm1 inhibition after sciatic nerve transection
Journal of Neuropathology and Experimental Neurology, ISSN: 00223069
Seong-kwon Hur; Rebecca R. Leahey; Mitchell Geringer; Chang-hoon Cho; Hilda Hernandez-Barry; Jichu Pang; William S. Sawyer; Miriam Baca; Marika Nespi; Raymond R. Asuncion; Mankin Choy; James T. Maksymetz; Stephen T. Vito; Jose Imperio; Kimberly L. Stark; Samantha A. Green; Bryan K. Chan; Luke Xie; Justin Q. Ly; Alicia A. Nugent; Jeffrey W. Hofmann; Flora I. Hinz; Martin Weber
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Strategies to reduce the use of non-human primates in development of oncology ADCs with cytotoxic payloads
Regulatory Toxicology and Pharmacology, ISSN: 02732300
Sherry Ralston; Li Li; Donna W. Lee; Darcey Clark; Andrew Dropsey; Haley Neff-LaFord; Payal Rana; Lucinda Weir; Radhakrishna Sura; Natalie Waterhouse
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A quantitative systems pharmacology model to inform clinical translation of dynamic PKPD relationships of engineered IL-15
European Journal of Pharmaceutical Sciences, ISSN: 09280987
Louis R. Joslyn; Mohammad Jafarnejad; Rajbharan Yadav; Patrick G. Holder; Shomyseh Sanjabi; Vittal Shivva; Ke Liu; Irene W.L. Leung; Nargess Kiabi; Suzanne Schubbert; Matthew J. Bernett; John R. Desjarlais; Saroja Ramanujan; Iraj Hosseini
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Quantifying Barriers to Diabetic Eye Screening: A Two-Center Study at the University of California
Diabetes Care, ISSN: 19355548 01495992
Aryan Ayati; Shadera Azzam; Stella Ko; Cobi Ben-David; Michelle Wang; Nicole Gidaya Bonine; David C. Tabano; Nina Malik; Frank L. Brodie; Mitul C. Mehta; Vivek Ashok Rudrapatna
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Beyond single-dose human mass balance study: minimizing subject confinement and enabling true steady-state assessment with a novel multiple-dose design proposal
Drug Metabolism and Disposition, ISSN: 00909556
Shuai Wang; Weiping Zhao; Sandhya V. Mandlekar; Lin Pan; Donglu Zhang; Cyrus Khojasteh; C. E.C.A. Hop
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Total drug's last stand on phospholipidosis: Unbound drug rules!
Drug Metabolism and Disposition,
Dennis A. Smith; C. E.C.A. Hop
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gReLU: a comprehensive framework for DNA sequence modeling and design
Nature Methods, ISSN: 15487105 15487091
Avantika Lal; Laura M. Gunsalus; Surag Nair; Tommaso Biancalani; Gokcen Eraslan
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Complex human model systems: from development through translation in pharma
Biofabrication, ISSN: 17585090
Kimberly A. Homan; Nikolce Gjorevski
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Developing a high-throughput capillary gel electrophoresis workflow for mRNA integrity and poly(A) tail analysis
Journal of Chromatography A, ISSN: 00219673
Wanchih Su; Zhixin Yu; Raymond Lieu; Emily C. Freund; Keiko Hokeness; Yimin Gu; Joshua Kohler; Tao Chen; Yuchen Fan; Kelly Zhang
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Emerging trends in the characterization of oligonucleotide diastereomers
Journal of Chromatography A, ISSN: 00219673
Alexandre Goyon; Daniel Ngoc Nguyen; Kelly Zhang
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S-Palmitoylation regulates signaling mediated by NLRP3 and other innate immune receptors
Molecular Cell,
Eugene E. Varfolomeev; Vishnu Mohanan; Domagoj Vucic
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Characterization of Hydrogel Drug Delivery System Stability Using Column-Switching Multimodal Liquid Chromatography–Mass Spectrometry
Analytical Chemistry, ISSN: 00032700
Brady W. Drennan; Phat Dinh; Kevin A. Schug; Kelly Zhang; Samuel H. Yang
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Online Determination of mRNA Poly(A) Tail Length and Content
Analytical Chemistry, ISSN: 00032700
Alexandre Goyon; Daniel Ngoc Nguyen; Shirley Wang; Katherine L. Hofmann; Kelly Zhang
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Progression of diabetic retinopathy in a longitudinal real-world study of patients in primary care
BMC Ophthalmology,
Geeta A. Lalwani; Charles Clifton Wykoff; Jayla Briggs; Chin Yu Lin; Verena Steffen; Zdenka Hašková
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HTRA1-dependent proteolysis induces age-related retinal degeneration and exacerbates choroidal neovascularization
DMM Disease Models and Mechanisms,
Kenneth J. Katschke; Tom Truong; Victoria C. Pham; Hongkang Xi; Wanjian Tang; Xiaowu Gu; Pooja Teotia; Jeffrey W. Hofmann; Shawnta Y. Chaney; Daniel Kirchhofer; Menno van Lookeren-Campagne; Marion Jeanne
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Correction to: Immunogenicity of Atezolizumab: Influence of Testing Method and Sampling Frequency on Reported Anti-drug Antibody Incidence Rates (The AAPS Journal, (2024), 26, 4, (84), 10.1208/s12248-024-00954-2)
AAPS Journal,
Maxime Usdin; Quarmby; James Zanghi; Coen A. Bernaards; Laura Liao; Joel Laxamana; Benjamin Wu; Steven J. Swanson; Yuan Song; Patricia Siguenza
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Blood-based pre-screening in the SKYLINE secondary prevention Ph3 gantenerumab study
Alzheimer's and Dementia,
Alina Bauer; Christina Rabe; Courtney Schiffman; Fiona Rose; Gesine Respondek; Fabiana Gullotta; Laura Schlieker; Alexander Jethwa; Isabelle Schrurs; Ekaterina Manuilova; Susanne Ostrowitzki; Tobias Bittner
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Exploring the potential of oligonucleotide mapping with liquid chromatography – mass spectrometry to study the primary structure of mRNA
TrAC - Trends in Analytical Chemistry, ISSN: 01659936
Jonathan Maurer; Helena Vanluchene; Athanasios Tsalmpouris; Kris Morreel; Julien Camperi; Koen Sandra; Davy Guillarme
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Safety, Pharmacokinetics, and Immunogenicity of Astegolimab, an Anti-ST2 Monoclonal Antibody, in Randomized, Phase I Clinical Studies
Clinical and Translational Science,
Wenhui Zhang; Dorothy S. Cheung; Alice Fong; Logan Brooks; Michele A. Grimbaldeston; Audrey Arjomandi; Xiaoying Yang; Ajit Dash; Hansen Wong; Jane R. Parnes; Divya Mohan
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The Neurolipid Atlas: a lipidomics resource for neurodegenerative diseases
Nature Metabolism, ISSN: 25225812
Femke M. Feringa; Sascha J. Koppes-den Hertog; Lian Y. Wang; Rico J.E. Derks; Iris Kruijff; Lena Erlebach; Jorin Heijneman; Ricardo Miramontes; Nadine Pömpner; Niek Blomberg; Damien Olivier-Jimenez; Lill Eva Johansen; Alexander J. Cammack; Ashling Giblin; Christina E. Toomey; Indigo V.L. Rose; Hebao Yuan; Michael E. Ward; Adrian M. Isaacs; Martin Kampmann; Deborah Kronenberg-Versteeg; Tammaryn L. Lashley; Leslie M. Thompson; Alessandro Ori; Yassene Mohammed; Martin A. Giera; Rik van der Kant
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Genome-wide association study of susceptibility to acute respiratory distress syndrome
EBioMedicine,
Beatriz Guillen-Guio; Eva Suarez-Pajes; Eva Tosco-Herrera; Tamara Hernández-Beeftink; José Miguel Lorenzo-Salazar; Diana Chang; Rafaela González-Montelongo; Luis Alberto Rubio-Rodriguez; Olivia C. Leavy; Richard James Allen; Almudena Corrales; R. Cruz; Miguel Bardají-Carrillo; Ángel M. Carracedo; Eduardo Tamayo; Vern Eric Kerchberger; Lorraine B. Ware; Brian L. Yaspan; Markus Scholz; André Scherag; Jesús Manuel Fernández Villar; Louise V. Wain; Carlos M. Flores
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Impact of copay maximizers on total patient liability among patients using specialty medicines
Journal of Managed Care and Specialty Pharmacy, ISSN: 23760540
Daniel M. Sheinson; Achal Patel; William B. Wong
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Disparities in access to systemic therapies for patients with hepatocellular carcinoma: an analysis from the International Liver Cancer Association
The Lancet Regional Health - Europe,
Manon Allaire; Leonardo G. Da Fonseca; Marco Sanduzzi-Zamparelli; Won-Mook Choi; Cecilia Monge; Ken Liu; Michael Leibfried; Sarah Manes; Zorana Maravic; Milan Mishkovikj; Jordi Bruix; Helen L. Reeves; Riad Salem; Bruno Sangro
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Selective and Potent Peptide Binders of RNF43 for Wnt Signaling Inhibition
ACS Central Science, ISSN: 23747943
Sunhee Hwang; Paula Flórez Salcedo; Antonion Korcari; John M. Nicoludis; Estefanía Martínez Valdivia; Lingling Peng; Aaron T. Balana; Justin Mak; Christopher M. Crittenden; Amin Famili; Peter S. Liu; David Castillo-Azofeifa; Rami N. Hannoush; Stephen E. Miller; Christina I. Schroeder; Xinxin Gao
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Optimization of a Parham Cyclization Aided by In Situ FTIR for an Enabling Synthesis of Tricyclo[6.2.0.03,6]deca-1,3(6),7-trien-2-amine
Organic Process Research and Development, ISSN: 10836160
Janis Jermaks; Haiming Zhang; Thomas C. Malig; Ngiapkie Lim; Johannes A. Burkhard; Chong Han; Francis Gosselin
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Clonal hematopoiesis is associated with reduced response to atezolizumab in non-small cell lung cancer
Journal for ImmunoTherapy of Cancer,
Vylyny Chat; Kipper Fletez-Brant; Minu K. Srivastava; Barzin Y. Nabet; Ira Seth Mellman; Mark I. McCarthy; Christian Hammer
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Iron(III)-Mediated C-H Alkylation: One-Electron Differentiation Increases Activity and Chemoselectivity
Journal of the American Chemical Society,
Tianyi Zhang; William G. Whitehurst; Matthew V. Pecoraro; Junho Kim; Stefan G. Koenig; Paul J. Chírik
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NOTCH1 reverses immune suppression in small cell lung cancer through reactivation of STING
Journal of Clinical Investigation,
Yoo Sun Kim; Barzin Y. Nabet; Briana Noel Cortez; Naiyun Sun; Robin Sebastian; Christophe E. Redon; Anagh Ray; Liang Liu; Afeez A. Ishola; Sarah Loew; Anjali Dhall; Sivasish Sindiri; Velimir Gayevskiy; Minjung Lee; Shraddha Rastogi; Nahoko Sato; Noémi Kedei; Thorkell Andrésson; Sudipto Das; Suresh Kumar; Alan E. Bers; Hongliang Zhang; Alberto Alejandro Chiappori; Priyanka Gopal; Mohamed E. Abazeed; Haobin Chen; Mirit I. Aladjem; Yves G. Pommier; Moises J. Velez; David S. Shames; Nitin Roper
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Modulation of fibronectin extracellular matrix enhances anti-tumor efficacy of immune checkpoint blockade
Cell Reports Medicine,
Kabir A. Khan; Maresa Caunt Mitzner; William R. Cruz-Muñoz; Grant Li; Patricia Himmels; Ping Xu; Hung Yang Kuo; Rajiv Jesudason; Alvin G. Gogineni; Robby M. Weimer; Annabelle Chow; Robert Piskol; Iacovos P. Michael; Weilan Ye; Robert S. Kerbel
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Nitrilation of carboxylic acids by PIII/PV-catalysis
Chemical Science, ISSN: 20416520
Siraj Z. Ali; Nicolás A. Manno; Jeff Shen; Alessia Schenker; Jeffrey M. Lipshultz; Nicholas A. White; Alexander T. Radosevich
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Heterogeneity of CD8 T-Cell Changes in Advanced Melanomas After Initiation of Immunotherapy
Journal of Nuclear Medicine,
Jahlisa S. Hooiveld-Noeken; Laura Kist de Ruijter; Pim P. van de Donk; Lotte M. Smit; Marjolijn N. Lub-De Hooge; Joyce van Sluis; Adriënne H. Brouwers; Hartmut K.W. Koeppen; Wim Timens; Hendrikus Hessel Boersma; Sjoerd Geert Elias; Jourik A. Gietema; Daan Geert Knapen; Geke A.P. Hospers; Simon Peter Williams; Sandra Sanabria Bohórquez; Alexander J. Ungewickell; Derk Jan A. de Groot; Mathilde Jalving; Elisabeth GE E. De Vries
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RIT1M90I Is a Driver of Lung Adenocarcinoma Tumorigenesis and Resistance to Targeted Therapy
Cancer Research,
Ashley V. DiMarco; Mirunalini Ravichandran; Jeffrey T. Lau; Anthony Nelson Lima; Jennifer Arca Lacap; Pablo Saenz Lopez-Larrocha; Eva Lin; Julie Weng; Luca Gerosa; Thomas L. Hunsaker; Yang Xiao; Monika Miś; Charles A. Havnar; Wennie Chen; Kai H. Barck; Klára Tótpál; Oded Foreman; Nicole M. Sodir; Mark Merchant; Danilo Maddalo
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Evaluating the Optic Nerve Crush Model to Understand the Function of Microglia in Glaucoma Neuroprotection
Investigative Ophthalmology and Visual Science, ISSN: 01460404
Xiaowu Gu; Tom Truong; Tiffany Heaster-Ford; Tae-hoon Kim; Gyeong-jin Kang; Joanna Yung; Miriam Baca; Shawnta Y. Chaney; Jeffrey W. Hofmann; Jeffrey Ryan Eastham; Marion Jeanne
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Phase I Study of the Anti-interleukin 33 Fragment Antigen-Binding Region RO7303359 in Geographic Atrophy Secondary to Age-Related Macular Degeneration
Ophthalmology Science,
Joel Pearlman; Veeral Sheth; Arshad M. Khanani; Vahan B. Indjeian; Flavia Brunstein; Denison Kuruvilla; Mauricio Maia; Randall Dere; Ling Ma; Hao Chen; Seema Datta; Jeffrey R. Willis; Henry E. Wiley
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Minimal Clinically Important Difference for Worsening of the University of California San Diego Shortness of Breath Questionnaire in Patients With Idiopathic Pulmonary Fibrosis With Mild or Moderate Impairment in Lung Function
CHEST Pulmonary,
Kerri I. Aronson; Ganesh Raghu; Sachin Gupta; Jinnie Ko; Jacob Devine; Jeffrey J. Swigris
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Muscle very long-chain ceramides associate with insulin resistance independently of obesity
Molecular Metabolism,
Søren Madsen; Harry B. Cutler; Kristen C. Cooke; Meg Potter; Jasmine Khor; Christoph D. Rau; Stewart WC. Masson; Anna Howell; Zora Modrusan; Anthony S. Don; Jacqueline Stöckli; Alexis Diaz Vegas; David E. James
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Real-World Validity of Tissue-Agnostic Circulating Tumor DNA Response Monitoring in Lung Cancers Treated With Chemotherapy, Immunotherapy, or Targeted Agents
JTO Clinical and Research Reports,
Chiang; Russell Madison; Zoe June Assaf; Alexander Fine; Yi Cao; Ole Gjoerup; Yanmei Huang; Jin; Jason D. Hughes; Vladan Antic; Amanda Young; David Fabrizio; David S. Shames; Sophia L. Maund; Alexia Exarchos; Shailendra Lakhanpal; Zuniga; Lincoln W. Pasquina; Katja Schulze
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A Computable Electronic Health Record ARDS Classifier and the Association Between the MUC5B Promoter Polymorphism and ARDS in Critically Ill Adults
CHEST Critical Care,
V. Eric Kerchberger; J. Brennan McNeil; Neil Zheng; Diana Chang; Carrie M. Rosenberger; Angela J. Rogers; Julie A. Bastarache; QiPing Feng; Wei-Qi Wei; Lorraine B. Ware
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The Alzheimer's Disease Cooperative Study - Activities of Daily Living dependence score: revision and validation of an algorithm evaluating patient dependence across the spectrum of AD severity
Journal of Prevention of Alzheimer's Disease,
Julie M. Chandler; Claire J. Lansdall; Wenyu Ye; Fiona McDougall; Mark A. Belger; Balazs Toth; Xiaojuan Mi; Kaycee M. Sink; Alexandra S. Atkins
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Characterization of hydrolase activity in ocular tissues of humans and preclinical species
Drug Metabolism and Disposition, ISSN: 00909556
Mengyue Li; Donglu Zhang; Robert S. Jones; Lionel E. Cheruzel; S. Cyrus Khojasteh; Hsuhsin Chen; Emel Adaligil; Treefa Shwani; Leah A. Owen; Ivana K. Kim; Margaret M. DeAngelis; Bin Ma
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