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Publications

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DISPLAYING 201 - 250 OF 16124 RESULTS

Phase I/Ib study of inavolisib (INAVO) alone and in combination with endocrine therapy ± palbociclib (PALBO) in patients (pts) with PIK3CA-mutated, hormone receptor–positive, HER2-negative locally advanced/metastatic breast cancer (HR+, HER2– LA/mBC): Analysis of hyperglycemia (HG) in prediabetic/obese pts.
Journal of Clinical Oncology, ISSN: 0732183X
Mafalda Oliveira; Melissa Kate Accordino; Andrés M.R. Cervantes; Valentina Gambardella; Erika Paige Hamilton; Antoine Italiano; Komal L. Jhaveri; Dejan Juric; Kevin M. Kalinsky; Ian E. Krop; Cristina Bandín Saura; Peter Schmid; Nicholas C. Turner; Andrea Iolanda Varga; Yanling Jin; Samuel Lim; Stephanie Royer-Joo; Noopur Shankar; Jennifer L. Schutzman; Philippe L. Bedard
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Long-Term Clinical Outcomes of Adults Hospitalized for COVID-19 Pneumonia
Emerging Infectious Diseases, ISSN: 10806040
Ivan O. Rosas; Alejandra E. Benitez; James A. McKinnell; Reena Shah; Michael Waters; Bradley D. Hunter; Robert J. Jeanfreau; Larry W. Tsai; Margaret Neighbors; Benjamin L. Trzaskoma; Rita de Cassia Castro; Fang Cai
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An Industry Perspective on the Use of Novel Excipients in Lipid Nanoparticles—Nonclinical Considerations
International Journal of Toxicology, ISSN: 1092874X 10915818
Lorrene A. Buckley; Jessica E. Sutherland; Prachi Borude; Karine Broudic; Philippe Collin; Aimee E. Hillegas; Christopher C. MacLauchlin; Amer F.Alhaj Saleh; Amy Sharma; Justina M. Thomas; Matthew N. O’Brien Laramy
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Bridging in vitro and clinical data: Experimental insights into the IC50 variability of dolutegravir as an organic cation transporter 2 inhibitor
Drug Metabolism and Disposition, ISSN: 00909556
Tomoki Koishikawa; Yukana Tomoda; Toshiaki Tsuchitani; Kunal S. Taskar; Yoshida; Jialin Mao; Tadayuki Takashima; Yurong Lai; Yuichi Sugiyama; Hiroyuki Kusuhara
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YAP/TAZ activity in PDGFRα-expressing alveolar fibroblasts modulates AT2 proliferation through Wnt4
Cell Reports, ISSN: 26391856
Jane Y. Song; Fabien Wehbe; Aaron Wong; Ben M. Hall; Jason A. Vander Heiden; Hans D. Brightbill; Joseph R. Arron; David A. Garfield; Anwesha Dey; Jason Rock
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Development and validation of a serum proteomic test for predicting patient outcomes in advanced non-small cell lung cancer treated with atezolizumab or docetaxel
Journal for ImmunoTherapy of Cancer,
Srivastava; Wei Zou; Mark L. McCleland; Joanna Roder; Senait Asmellash; Patrick Norman; Lelia Net; Laura Maguire; Heinrich Roder; Robert Georgantas; David S. Shames
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Engineering ERα degraders with pleiotropic ubiquitin ligase ligands maximizes therapeutic efficacy by co-opting distinct effector ligases
Cell Chemical Biology, ISSN: 24519456
Anna Shemorry; Willem Den Besten; Melinda M. Mulvihill; Curt J. Essenburg; Nicole Blaquiere; Tracy L. Kleinheinz; Elisia Villemure; Franklin V. Peale Jr.; Gauri Deshmukh; Danilo Maddalo; Elizabeth S. Levy; Kebing Yu; Matthew R. Steensma; Elizabeth A. Tovar; Emily Wolfrum; Karthik Nagapudi; Robert A. Blake; William F. Forrest; Steven T. Staben; Carrie R. Graveel; Wayne J. Fairbrother; Ingrid E. Wertz
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Inavolisib plus letrozole or fulvestrant in PIK3CA-mutated, hormone receptor-positive, HER2-negative advanced or metastatic breast cancer (GO39374): An open-label, multicentre, dose-escalation and dose-expansion phase 1/1b study
European Journal of Cancer, ISSN: 09598049
Philippe L. Bedard; Komal Jhaveri; Melissa Accordino; Prof Andrés Cervantes; Valentina Gambardella; Hamilton; Prof Antoine Italiano; Prof Kevin Kalinsky; Prof Ian E. Krop; Oliveira; Prof Peter Schmid; Saura; Prof Nicholas Turner; Andrea Varga; Sravanthi Cheeti; Anwesha Dey; Stephanie Hilz; Katherine E. Hutchinson; Yanling Jin; Stephanie Royer-Joo; Ubong Peters; Noopur Shankar; Jennifer L. Schutzman; Junko Aimi; Kyung Song; Dejan Juric
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Efficacy and safety of entrectinib in children with extracranial solid or central nervous system (CNS) tumours harbouring NTRK or ROS1 fusions
European Journal of Cancer, ISSN: 18790852 09598049
Ami V. Desai; Aditi Bagchi; Amy E. Armstrong; Cornelis M. van Tilburg; Ellen M. Basu; Giles W. Robinson; Huanmin Wang; Michela Casanova; Nicolas André; Quentin Campbell Hewson; Yeming Wu; Alison Cardenas; Bo Ci; Carolina Ryklansky; Clare Devlin; Georgina Meneses-Lorente; Jade Wulff; Katherine E. Hutchinson; Gajjar; Elizabeth Fox
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Drug Development Considerations for Additives to Organ Preservation Solutions
Transplantation, ISSN: 00411337
Matthew N. O’Brien Laramy; Jamie Robinson; Cadapakam J. Venkatramani; Stephanie Horn; Carine Steiner; Yoen Ju Son
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Emerging clinical evidence of a dual role for Ang-2 and VEGF-A blockade with faricimab in retinal diseases
Graefe's Archive for Clinical and Experimental Ophthalmology, ISSN: 1435702X 0721832X
Varun S. Chaudhary; Florie A. Mar; Manuel J. Amador; Andrew A. Chang; Kara Gibson; Antonia M. Joussen; Judy E. Kim; Junyeop Lee; Philippe Margaron; Insaf Saffar; David T. Wong; Charles Clifton Wykoff; Srinivas R. Sadda
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Reading Performance in Geographic Atrophy: Comparison of Different Reading Speed Measures for Capturing Longitudinal Changes
Ophthalmology Science, ISSN: 26669145
Zhichao Wu; Verena Steffen; Will Harris; Catherine A. Cukras; Daniela Ferrara; Robyn H. Guymer
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Investigation of urinary miRNA profile changes in amphotericin B-induced nephrotoxicity in C57BL/6 mouse, Sprague-Dawley rats and Beagle dogs
Toxicological Sciences, ISSN: 10966080
Adedeji; Michael R. Tackett; Genesis Tejada; James E. McDuffie
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Ethnic Sensitivity Assessment of Mosunetuzumab Pharmacokinetics and Pharmacodynamics in Chinese Patients With Relapsed or Refractory Follicular Lymphoma
Clinical and Translational Science, ISSN: 17528054
Junyi Li; Michael Z. Liao; Justin Wilkins; Elicia M. Penuel; Wang; Shweta Vadhavkar; Kun Peng; Junning Cao; Zhiming Li; Ye Zhang; Wenjin Li; Donghang Li; Mingzhu Zhou; Michael C. Wei; Antonia Kwan; Rong Zhao; Chunze Li; Chi-Chung Li; Turner
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Anatomic Outcomes with Faricimab vs Aflibercept in Head-to-Head Dosing Phase of the TENAYA/LUCERNE Trials in Neovascular Age-related Macular Degeneration
Ophthalmology, ISSN: 15494713 01616420
Chui Ming Gemmy Cheung; Jennifer I. Lim; Siegfried Georg Priglinger; Giuseppe Querques; Philippe Margaron; Shriji N. Patel; Audrey Souverain; Jeffrey Ryuta Willis; Ming Yang; Robyn Heather Guymer
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Offset Mass Carrier Proteome Improves Quantification of Multiplexed Single Cell Proteomics
Molecular and Cellular Proteomics, ISSN: 15359484 15359476
Tommy K. Cheung; Ying Zhu; Christopher M. Rose
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Leveraging Buprenorphine and Halofantrine as Tool Molecules to Develop a Novel Semi-Physiologically based Pharmacokinetic Model Accounting for Gastro-Intestinal Lymphatic Absorption and Enabling Cross-Species Translation
AAPS Journal,
Xun Tao; Shraddha Sadekar; Douglas Leipold; Gregory Z. Ferl; Stefanich; Amrita Kamath
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PAX8 Interacts with the SWI/SNF Complex at Enhancers to Drive Proliferation in Ovarian Cancer
Molecular Cancer Research, ISSN: 15417786
Kostianna Sereti; Anna E. Russo; Ryan Raisner; Taylur P. Ma; Karen Gascoigne
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A rising tide lifts all boats in the personalized cancer care continuum for mNSCLC: Bridging inequities in NGS fosters equity in targeted treatment
Oncologist, ISSN: 10837159
Victor Lin; Esprit Ma; Neha Jain; Zhiyu Xia; Daniel Sheinson; Elaine B. Yu; Davey B Daniel; Richard S.P. Huang; Gregory Vidal; Richard Lewis Martin; Zuniga; Thomas Stricker
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Real-world characteristics and survival outcomes of patients with metastatic ALK fusion-positive solid tumors treated with standard-of-care therapies
Oncologist, ISSN: 1549490X 10837159
Shirish M. Gadgeel; Otto Fajardo; Fabrice Barlési; Jeong Eun Kim; Razelle Kurzrock; David M. Thomas; Ritika Jagtiani; Johannes Noé; Sven Schwemmers; Christos Chrysanthos Nikolaidis
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In vivo functional screens reveal KEAP1 loss as a driver of chemoresistance in small cell lung cancer
Science Advances,
Lauren Brumage; Scott Best; Daniel S. Hippe; Eli Grunblatt; Pritha Chanana; Feinan Wu; Myung Chang Lee; Zhe Ying; Ali Ibrahim; Jae Heun Chung; Anna Vigil; Jackson Fatherree; Slobodan Beronja; Patrick J. Paddison; Lucas Sullivan; Barzin Y. Nabet; David MacPherson
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Scaling Organic Electrosynthesis: The Crucial Interplay between Mechanism and Mass Transport
ACS Central Science, ISSN: 23747943
Zachary J. Oliver; Dylan J. Abrams; Luana Cardinale; Chih-Jung Chen; Gregory L. Beutner; Seb Caille; Benjamin Cohen; Lin Deng; Moiz Diwan; Michael O. Frederick; Kaid Harper; Joel M. Hawkins; Dan Lehnherr; Christine Lucky; Alex Meyer; Seonmyeong Noh; Diego Nunez; Kyle Quasdorf; Jaykumar Teli; Shannon S. Stahl; Marcel Schreier
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CR1 variants contribute to FSGS susceptibility across multiple populations
iScience,
Rostislav Skitchenko; Zora Modrusan; Alexander Loboda; Jeffrey B. Kopp; Cheryl A Winkler; Alexey Sergushichev; Namrata Gupta; Christine Stevens; Mark J. Daly; Andrey S. Shaw; Mykyta Artomov
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MHC2-SCALE enhances identification of immunogenic neoantigens
iScience,
Joshua G. Gober; Aude-Hélène Capietto; Reyhane Hoshyar; Martine Darwish; Richard L. Vandlen; Jonathan L. Linehan; Lélia Delamarre; Adel ElSohly
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Efficacy and Safety of Obinutuzumab in Active Lupus Nephritis
New England Journal of Medicine, ISSN: 15334406 00284793
Richard A. Furie; Brad H. Rovin; Garg; Mittermayer B. Santiago; Gustavo Aroca-Martínez; Adolfina Elizabeth Zuta Santillán; Damaris Alvarez; Cleyber Navarro Sandoval; Alexander M. Lila; James Tumlin; Amit Saxena; Fedra Irazoque Palazuelos; Harini Raghu; Bongin Yoo; Imran Hassan; Elsa Martins; Himanshi Sehgal; Petra Kirchner; Jorge A. Ross Terres; Theodore A. Omachi; Thomas Schindler; William F. Pendergraft; Ana Malvar
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Continuous Ranibizumab via Port Delivery System vs Monthly Ranibizumab for Treatment of Diabetic Macular Edema: The Pagoda Randomized Clinical Trial
JAMA Ophthalmology, ISSN: 21686173 21686165
Arshad Mohammad Khanani; Peter Anthony Campochiaro; Jordan M. Graff; Dennis M. Marcus; Daniel M. Miller; Robert Ajit Mittra; Carl D. Regillo; Veeral S. Sheth; Ashwini Bobbala; Shamika A. Gune; Stephanie L. Lin; Carlos Quezada; Varun K. Malhotra
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Port Delivery System with Ranibizumab vs Monitoring in Nonproliferative Diabetic Retinopathy Without Macular Edema: The Pavilion Randomized Clinical Trial
JAMA Ophthalmology, ISSN: 21686173 21686165
Dante Joseph Pieramici; Carl C. Awh; Margaret A. Chang; Andrés A. Emanuelli; Nancy M. Holekamp; Allen Y.H. Hu; Iván J. Sũner; Charles Clifton Wykoff; Christopher J. Brittain; Dena Howard; Carlos Quezada; Anjana Santhanakrishnan; Paul A. Latkany
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Mechanistic Characterization of the Potency of THIOMAB Antibody-Drug Conjugates Targeting Staphylococcus aureus and ETbR-Expressing Tumor Cells Using Quantitative LC-MS/MS Analysis of Intracellular Drug Accumulation
Bioconjugate Chemistry, ISSN: 10431802
Hilda Hernandez-Barry; Josefa Dela Cruz Chuh; Kimberly K. Kajihara; Jyoti Asundi; Richard L. Vandlen; Donglu Zhang; Wouter L. W. Hazenbos; Thomas H. Pillow; Yichin Liu; Cong Wu; Katherine R. Kozak; Kelly M. Loyet
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A platform method for simultaneous quantification of lipid and nucleic acid components in lipid nanoparticles
Journal of Chromatography A, ISSN: 18733778 00219673
Wan-Chih Su; Raymond Lieu; Yige Fu; Trevor Kempen; Zhixin Yu; Kelly Zhang; Tao Chen; Yuchen Fan
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CD22 TCR-engineered T cells exert antileukemia cytotoxicity without causing inflammatory responses
Science Advances, ISSN: 23752548
Kilyna A. Nguyen; Zhihui Liu; John S. Davies; Crystal P. McIntosh; Lindsey M. Draper; Scott M. Norberg; Zachary Rae; Sooraj R. Achar; Grégoire Altan-Bonnet; Ling Zhang; Xiaolin Wu; Thomas J. Meyer; Michael C. Kelly; Naomi N. Taylor; Christian S. Hinrichs; Kazusa Ishii
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Comprehensive Protein Inference Analysis with PyProteinInference Elucidates Biological Understanding of Tandem Mass Spectrometry Data
Journal of Proteome Research, ISSN: 15353907 15353893
Trent B. Hinkle; Corey E. Bakalarski
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Discovery and characterization of potent macrocycle inhibitors of ubiquitin-specific protease-7
Structure, ISSN: 18784186 09692126
Rafael Miranda; Francesca Anson; Shannon T. Smith; Ultsch; Connie A. Tenorio; Lionel Rouge; Brennan Farrell; Emel Adaligil; Jeffrey K. Holden; Seth F. Harris; Erin C. Dueber
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Correction to: B-cell-specific checkpoint molecules that regulate anti-tumour immunity (Nature, (2023), 619, 7969, (348-356), 10.1038/s41586-023-06231-0)
Nature, ISSN: 00280836
Lloyd Bod; Yoon-Chul Kye; Jingwen Shi; Elena Torlai Triglia; Alexandra Schnell; Johannes Fessler; Stephen M. Ostrowski; Max Y. Von-Franque; Juhi R. Kuchroo; Rocky M. Barilla; Sarah Zaghouani; Elena Christian; Toni M. Delorey; Kanishka Mohib; Sheng Xiao; Nadine Slingerland; Christopher J. Giuliano; Orr Ashenberg; Zhaorong Li; David M. Rothstein; David E. Fisher; Orit Rozenblatt-Rosen; Arlene H. Sharpe; Francisco J. Quintana; Lionel Apetoh; Aviv Regev; Vijay K. Kuchroo
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Efficient, Low-Cost, and High-Throughput Sodium Dodecyl Sulfate (SDS) Removal from Protein Digests Using Weak-Anion Exchange
Journal of the American Society for Mass Spectrometry, ISSN: 18791123 10440305
Weikai Cao; Phillip Chu; Merlin L. Bruening; Rachel Liuqing Shi; Hilda Hernandez-Barry; John C. Tran
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Different PD-L1 Assays Reveal Distinct Immunobiology and Clinical Outcomes in Urothelial Cancer
Cancer immunology research,
Matthew D. Galsky; Mark Kockx; Juliette Roels; Roos Van Elzen; Xiangnan Guan; Kobe Yuen; Deepali Rishipathak; Jonathan F. Anker; Sacha Gnjatic; Sudeh Izadmehr; Shomyseh Sanjabi; Robert J. Johnston; Maureen Peterson; Koeppen; Justin M. David; Saurabh Gupta; Aristotelis Bamias; José Ángel Arranz; Eiji Kikuchi; Maria De Santis; Ian Davis; Patrick Williams; Sandrine Bernhard; Ira Mellman; Enrique Grande; Romain Banchereau; Sanjeev Mariathasan
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Personalized uncertainty quantification in artificial intelligence
Nature Machine Intelligence,
Tapabrata Chakraborti; Christopher R. S. Banerji; Ariane Marandon; Vicky Hellon; Robin Mitra; Brieuc Lehmann; Leandra Bräuninger; Sarah F. McGough; Cagatay Turkay; Alejandro F. Frangi; Ginestra Bianconi; Weizi Li; Owen Rackham; Deepak Parashar; Chris Harbron; Ben D. MacArthur
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Opportunities and insights from pharmaceutical companies on the current use of new approach methodologies in nonclinical safety assessment
Drug Discovery Today, ISSN: 18785832 13596446
Jacintha M. Shenton Dr; Imein Bousnina; Michael A. Oropallo; Rhiannon M. David; Lucinda R. Weir; Thomas K. Baker; Helen Marie Dunmore; Rémi Villenave; Mary C. McElroy; Betty A. Pettersen; Tushar Kokate; Claudette L. Fuller; Kimberly A. Homan; Eloise Hudry; Charles E.E. Wood; Sam Gunter
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Addressing Clinical Challenges in Aberrant Pharmacokinetics of Biologic Therapeutic Drugs: Investigating Sample Processing Procedure in the Immunoassays
AAPS Journal, ISSN: 15507416
Yih-Wen Chen; Olinda Davenport; Nancy Yu; Rachel Melendez; James Nugteren; Ihsan Nijem; Weili Yan; Robert Hendricks; Yuan Song
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Assessing the impacts of drug loading and polymer type on dissolution behavior and diffusive flux of GDC-6893 amorphous solid dispersions
Journal of Pharmaceutical Sciences, ISSN: 15206017 00223549
Nivedita Shetty; Jonathan Hau; Shijia Tang; Po-Chang Chiang; Jia Liu; Wei Jia; Joseph W. Lubach; Karthik Nagapudi; Hao Helen Hou
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Optimizing the discovery bioanalysis strategy for macrocyclic peptides
Analytical and Bioanalytical Chemistry, ISSN: 16182650 16182642
Xing Zhang; Stephanie Dale; Yusi Cui; Joe Napoli; Huy Nguyen; Jingwei Cai; Brian J. Dean
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Outcomes of Relapsed or Refractory Diffuse Large B-Cell Lymphoma Treated With R-GemOx: A Multicenter Cohort Study
American Journal of Hematology, ISSN: 10968652 03618609
Samuel Yamshon; Jean L. Koff; Melissa C Larson; Wojciech Jurczak; Carla Casulo; Izidore S. Lossos; Sara Haddadi; Michele Stanchina; Dai Chihara; Amy Ayers; Thomas M. Habermann; Yucai Wang; Arushi Khurana; Grzegorz S. Nowakowski; Tanner W. Reicks; Umar Farooq; Brian K. Link; Jonathon B Cohen; Peter Martin; Jia Li; Ashwini Shewade; Connie Batlevi; Andrea Lo-Rossi; David Fox; Anthony Masaquel; Yong Mun; James R. Cerhan; Christopher R. Flowers; Matthew J. Maurer; Loretta J. Nastoupil
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Cellular Kinetics and Biodistribution of Adoptive T Cell Therapies: from Biological Principles to Effects on Patient Outcomes
AAPS Journal, ISSN: 15507416
Ran Li; Abigail K. Grosskopf; Louis R. Joslyn; Stefanich; Vittal Shivva
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Visual Loss in Geographic Atrophy: Learnings from the Lampalizumab Trials
Ophthalmology, ISSN: 15494713 01616420
Neha Anegondi; Verena Steffen; Srinivas R. Sadda; Steffen Schmitz-Valckenberg; Adnan Tufail; Karl G. Csaky; Eleonora M. Lad; Peter K. Kaiser; Daniela Ferrara; Usha Chakravarthy
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Microsampling in toxicology studies-maximising the scientific, business and 3Rs advantages
Toxicology Research, ISSN: 2045452X
Helen Prior; Adedeji; Romalie Allen; Derek Angus; Daniel Baker; Hollie Blunt; David Coleman; Helen-Marie Dunmore; Elisa Passini; Tara Putnam; Marie-Luce Rosseels; Neil Spooner; Jane Stewart; Carol Strepka; Alan H. Stokes; Tom Verhaeghe; Amanda Wilson; Fiona Sewell
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Whole-Body Physiologically Based Pharmacokinetic Modeling Framework for Tissue Target Engagement of CD3 Bispecific Antibodies
Pharmaceutics,
Monica Susilo; Stephan Schaller; Luis David Jiménez-Franco; Alexander Kulesza; Wilhelmus E. A. de Witte; Shang-Chiung Chen; C. Andrew Boswell; Danielle Mandikian; Chi-Chung Li
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Effects of Socioeconomic Status and Healthcare Resource Availability on Survival in Older (≥66 years) Non-Hispanic Black Patients Versus Non-Hispanic White Patients With Multiple Myeloma
Clinical Lymphoma, Myeloma and Leukemia, ISSN: 21522669 21522650
Sophia S. Li; Robert F. Schuldt; Faiza Zafar; Tu My To; Archibong E. Yellow-Duke; Alina Levine; Allicia C. Girvan; Shelli Spence; Joseph R. Mikhael
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Structural Updates to the Implant and Refill Needle of the Port Delivery Platform
Translational Vision Science and Technology, ISSN: 21642591
Dante Joseph Pieramici; Peter Anthony Campochiaro; Margaret A. Chang; Ian A. Pearce; Carl D. Regillo; Shamika A. Gune; Nancy M. Holekamp; Carlos Quezada; Shrirang V. Ranade; Natasha Singh; Geoffrey Wise; Joshua D. Horvath
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A Similar Mutation in the AAUU-Rich Elements of the Mouse TNF Gene Results in a Distinct Ileocolitic Phenotype: A New Strain of TNF-Overexpressing Mice
Inflammatory Bowel Diseases, ISSN: 10780998
Amruth Chilukuri; Margaret Kim; Taniya Mitra; John Gubatan; Josef Urrete; Leo D. Saxon; Amber Ablack; Zbigniew Mikulski; Katarzyna Dobaczewska; Zining Shen; Mary E. Keir; Tangsheng Yi; Prabhdeep Kaur; Patricia Oliveira; Jessica Murillo-Saich; Eric Y. Chang; Calen A. Steiner; Paul Jedlicka; Mónica Guma; Jesús Rivera-Nieves
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Applying the 3Rs to urinalysis assessments in toxicity studies: refining procedures and adopting a case-by-case approach
Comparative Clinical Pathology, ISSN: 16185641
Elisa Passini; Adedeji; Romalie Allen; Paul Baldrick; Jayati Basak; Lorraine Britton; Peter Cotton; Joanna Harding; Thomas Holmes; Nina Ljumanovic; Fiona McClure; Aidan McGuire; Liz McInnes; Helen Prior; Fiona Sewell
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Current Analytical Strategies for mRNA-Based Therapeutics
Molecules,
Julien Camperi; Kamalakar Chatla; Emily C. Freund; Carolina Galan; Steffen Lippold; Axel Guilbaud
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